Bulletin et memoires de l'Academie royale de medecine de Belgique最新文献_第4页

[Cognitive and behavioral consequences of epilepsy during the course of brain development]. [癫痫在大脑发育过程中的认知和行为后果]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2010-01-01

Th Deonna

{"title":"[Cognitive and behavioral consequences of epilepsy during the course of brain development].","authors":"Th Deonna","doi":"","DOIUrl":"","url":null,"abstract":"The notion that cognitive and behavioural dysfunctions of epileptic origin can be prolonged and with an insidious onset, has meant a radical conceptual change about epilepsy considered so far uniquely as a paroxysmal disorder. Also, these dysfunctions can be the only observable manifestations of the disorder. It is particularly true in some epileptic syndromes with onset in childhood. Epileptic dysfunctions are characterized by a discontinuity in time (intermittent, recurrent), in space (cerebral localization of the dysfunction and its spread). They often have a significant relationship with sleep. These features, with sometimes the existential dimension of some symptoms (intermittent loss of the flux of consciousness, intermittent perceptual distortions or cognitive-emotional dysfunction) are not seen in any other congenital or acquired disorders of the human brain. Longitudinal clinical studies in which the epileptic variable can be directly correlated with the precise study of the cognitive dysfunction (also with increasingly complex methods of brain imaging) are a difficult, relatively new multidisciplinary task, especially in the very young child. Case examples of children followed from early childhood to adulthood will illustrate the diversity of observed cognitive and behavioural abnormalities directly caused by the epileptic activity which can be massive or very discrete. One is only beginning to document precisely the late consequences (or absence of) of some early childhood epilepsies that had a direct impact on developing brain function at some point.","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"165 3-4","pages":"165-71; discussion 171-2"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29546314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The struggle against AIDS: between new paradigms and inertia]. [防治艾滋病的斗争:在新范例和惰性之间]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2010-01-01

N Clumeck

引用次数: 0

Non-alcoholic fatty liver disease. 非酒精性脂肪肝。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2010-01-01

I Leclercq

引用次数: 0

["I'm not crazy!" Studies of agnosia in Alzheimer's disease]. “我没疯!”阿尔茨海默病中失认症的研究]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2010-01-01

E Salmon

{"title":"[\"I'm not crazy!\" Studies of agnosia in Alzheimer's disease].","authors":"E Salmon","doi":"","DOIUrl":"","url":null,"abstract":"Anosognosia corresponds to a lack of awareness about the own clinical disease of a patient. Anosognosia is frequent in Alzheimer's disease (AD). Researchers explore several hypotheses, psychological (deny) or cognitive (an association of memory and executive impairment), and recently models describing the dynamics of self representation provided convincing interpretations. Self models are modular. They comprise a central executive organising information processing according to subject's objectives. The central executive takes into account personal beliefs and social schemata and it uses autobiographical memory. The analysis of information by the self system leads to decision taking that relies on two principles, self continuity and adaptation. Neuroimaging studies showed that self reflection activates specific brain regions, comprising the ventromedial prefrontal cortex, the medial parietal and posterior cingulate cortex and the inferior parietal lobule. Other studies demonstrated that the same regions are particularly affected by AD. Experimental data currently allows making relationships between regional brain involvement, diverse difficulties in self representation and different forms of anosognosia for clinical status in AD patients.","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"165 7-9","pages":"339-48; discussion 349-50"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29833271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New insights into urinary acidification and regulation of acid-base balance. 关于尿酸化和酸碱平衡调节的新见解。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2010-01-01

C Wagner

{"title":"New insights into urinary acidification and regulation of acid-base balance.","authors":"C Wagner","doi":"","DOIUrl":"","url":null,"abstract":"Systemic acid-base balance is primarily controlled by the renal excretion of acids and the exhalation of CO2 and both processes are tightly regulated and coordinated. Acid excretion into urine requires the formation of ammonium and its transport into urine as gaseous ammonia. Until recently it has been believed that NH3 would move across membranes by free diffusion according to Overton's rule. Recent structural, functional, and in vivo data show now that Rhesus proteins act as gas channels for NH3 and mediate renal acid excretion. Lack of the renal isoform RhCG in mice causes reduced ammonium excretion and metabolic acidosis. Breathing and exhalation of CO2 is stimulated and regulated by CO2 and acid sensors in the carotid bodies and the brain stem. GPR4 belongs to a small subfamily of G protein-coupled receptors and is activated by extracellular protons. Mice lacking GPR4 develop respiratory acidosis and are not able to increase ventilation appropriately in response to high CO2 levels or systemic acidosis. Thus, RhCG and GPR4 present novel paradigms of membrane proteins involved in controlling and regulating systemic acid-base balance in the major organs involved in this task.","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"165 5-6","pages":"259-64; discussion 265-6"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29831061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Role of PDGF and FGF receptors in cancer]. PDGF和FGF受体在癌症中的作用。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2010-01-01

J B Demoulin, Sandrine Medves, Federica Toffalini, Ahmed Essaghir, Anders Kallin, Carmen Montano, Amélie Velghe, François Duhoux

引用次数: 0

[Homeostasis of peripheral blood cells during infection by the bovine leukemia virus]. [牛白血病病毒感染期间外周血细胞的内稳态]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2010-01-01

A Florins

引用次数: 0

[Study of mechanisms dependent on interleukin-17 and their modulation in development of bronchiolitis obliterans after experimental transplantation]. [实验性移植后闭塞性毛细支气管炎发生的白介素-17依赖性机制及其调控研究]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2010-01-01

P Lemaître

引用次数: 0

Metabolic syndrome--from controversies to ectopic fat syndrome. 代谢综合征——从争议到异位脂肪综合征。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2010-01-01

L Van Gaal

引用次数: 0

[Genetics of inflammatory bowel disease]. [炎症性肠病的遗传学]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2010-01-01

D Franchimont, E Louis

{"title":"[Genetics of inflammatory bowel disease].","authors":"D Franchimont, E Louis","doi":"","DOIUrl":"","url":null,"abstract":"Inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), result from an inappropriate immune response towards the microbial flora in a genetically susceptible host. Several epidemiological and animal studies have demonstrated the essential role of the microbial flora in the triggering and perpetuation of intestinal inflammation. IBD are multigenic and heterogeneous diseases, and result from multiple low penetrant genes or group of genes. The genetic strategy for gene hunting in multigenic studies relies on two separate approaches. A candidate gene approach which is based on a robust biological hypothesis. A more systematic/global approach is either based on linkage studies (in late 90s) on IBD families or, since 2000 on gene arrays, the genome wide arrays (GWAS) on patients and controls. In 2001, the first CD susceptible gene, NOD2, was discovered, and found to be a pattern recognition receptor for bacteria, shedding light on the role of bacterial recognition in the triggering of the disease. Since 2000, GWAs have greatly accelerated the discoveries of new genes or signalling pathways in Crohn's disease and ulcerative colitis, confirming the importance of bacterial recognition, but also of bacterial defence (i.e. autophagy genes) as well as the role of the adaptive immune response (i.e. IL-23R/Th17 pathway). Despite the role of genetics in the development of IBD, changes in the development and composition of the microbial flora, known as dysbiosis, (possibly induced by our Western life style) must alter the development and function of the mucosal immune system, and leads to disease expression.","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"165 10-12","pages":"435-49; discussion 450-2"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30423051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0