[实验性移植后闭塞性毛细支气管炎发生的白介素-17依赖性机制及其调控研究]。

P Lemaître
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引用次数: 0

摘要

肺移植受者的生存目前受到原发性移植物功能障碍的限制,移植物功能障碍是在移植后72小时内发生的急性现象,但也受到一年多后出现的慢性排斥反应的限制。IL-17可能与这两种疾病有关。小鼠异位气管移植产生的上皮病变模仿人的病理。通过这个模型,我们发现IL-17在移植后的早期病变中起关键作用,而不是慢性病变。IL-17的主要植入细胞来源是受体衍生的γ δ T细胞。然而,在我们的模型中,IL-17依赖性病变不是由IL-17对供体来源细胞的直接作用介导的。然而,它的抑制作用保护了CK-14+基底上皮干细胞,这些细胞已知能够更新整个上皮。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Study of mechanisms dependent on interleukin-17 and their modulation in development of bronchiolitis obliterans after experimental transplantation].

Survival of lung transplant recipients is currently limited by the primary graft dysfunction, an acute phenomenon occurring within 72 hours after the transplantation, but also by the chronic rejection that appears more than one year later. IL-17 might be implicated in these two diseases. The heterotopic trachea transplantation in mice generates epithelial lesions mimicking the human pathology. Using this model, we show that IL-17 was crucially implicated in early, but not chronic lesions after transplantation. The main intragraft cellular sources of IL-17 are recipient-derived gammadelta T cells. However, the IL17-dependent lesions in our model are not mediated by a direct effect of IL-17 on donor-derived cells. Nevertheless, its inhibition protects CK-14+ basal epithelial stem cells that are known to be capable of renewing of the whole epithelium.

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