{"title":"Bronchiectasis—a management problem?","authors":"R.A. Stockley","doi":"10.1016/0007-0971(88)90060-5","DOIUrl":"10.1016/0007-0971(88)90060-5","url":null,"abstract":"","PeriodicalId":75618,"journal":{"name":"British journal of diseases of the chest","volume":"82 ","pages":"Pages 209-219"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0007-0971(88)90060-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14206715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T.J.G. Barlow , P. Graham , J.M. Harris , J.P.R. Hartley , C.W.G. Turton
{"title":"A double-blind, placebo-controlled comparison of the efficacy of standard and individually titrated doses of theophylline in patients with chronic asthma","authors":"T.J.G. Barlow , P. Graham , J.M. Harris , J.P.R. Hartley , C.W.G. Turton","doi":"10.1016/0007-0971(88)90065-4","DOIUrl":"10.1016/0007-0971(88)90065-4","url":null,"abstract":"<div><p>Forty adult patients with chronic asthma completed a 3-month double-blind crossover study to compare the effect of sustained-release theophylline given both as a fixed 300 mg twice daily dose (standard) and an individually titrated dose (titrated) with placebo. Theophylline was given in addition to other usual therapy, inhaled bronchodilators, inhaled steroids and, in 12 patients, oral steroids. The 3-month period was preceded by a run-in phase to determine the dose of theophylline which each subject required to achieve peak serum levels of 12–20 mg/litre and trough levels of 8–12 mg/litre. Doses ranged from 300 mg to 700 mg twice daily. Twenty-one patients needed more than the standard dose to achieve satisfactory serum levels. Patients recorded daily peak flow rates and symptom scores and were seen at monthly intervals to measure lung function, check serum theophylline levels and change treatments, which were given in random order. FEV<sub>1</sub> was significantly higher for the whole group after standard (2.11 litres) and titrated (2.15 litres) theophylline therapy than after placebo (1.89 litres), as was FVC, but in the large subgroup whose titrated dose was greater than the standard dose, the FEV<sub>1</sub> only improved with the titrated dose. Peak flow measurements at home showed the same pattern. Patients taking oral steroids appeared to derive less benefit from theophylline than others. It is concluded that theophylline can usefully be added as a third-line drug in chronic asthma, but that since half the patients are likely only to benefit from a dose greater than 300 mg twice daily, while the other half may have high serum levels above this dose, it is essential to measure serum levels in order to use the drug effectively and safely.</p></div>","PeriodicalId":75618,"journal":{"name":"British journal of diseases of the chest","volume":"82 ","pages":"Pages 251-261"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0007-0971(88)90065-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14206719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Heino , J. Karjalainen , J. Ylikoski , A. Laitinen , L.A. Laitinen
{"title":"Bronchial ciliogenesis and oral steroid treatment in patients with asthma","authors":"M. Heino , J. Karjalainen , J. Ylikoski , A. Laitinen , L.A. Laitinen","doi":"10.1016/0007-0971(88)90040-X","DOIUrl":"10.1016/0007-0971(88)90040-X","url":null,"abstract":"<div><p>The effect of steroids on the ciliogenesis of bronchial epithelium has not previously been studied in asthmatics. Bronchial biopsies were taken during bronchoscopy from five asthmatics before and after oral steroid treatment, and studied by transmission electron microscopy. Two untreated healthy subjects served as controls. After treatment ciliogenesis was abundant in all patients.</p></div>","PeriodicalId":75618,"journal":{"name":"British journal of diseases of the chest","volume":"82 ","pages":"Pages 175-178"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0007-0971(88)90040-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14298069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sleep apnoea","authors":"K. Prowse, M.B. Allen","doi":"10.1016/0007-0971(88)90085-X","DOIUrl":"10.1016/0007-0971(88)90085-X","url":null,"abstract":"","PeriodicalId":75618,"journal":{"name":"British journal of diseases of the chest","volume":"82 ","pages":"Pages 329-340"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0007-0971(88)90085-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14208293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Zapatero , J. López Longo , I. Monteagudo , L. Carreño
{"title":"Costal chondritis in heroin addicts: a comparative study with postsurgical chondritis","authors":"J. Zapatero , J. López Longo , I. Monteagudo , L. Carreño","doi":"10.1016/0007-0971(88)90086-1","DOIUrl":"10.1016/0007-0971(88)90086-1","url":null,"abstract":"<div><p>Infection of the chondrocostal junction occurs infrequently nowadays. However, with the increasing incidence in the last years of intravenous drug addiction, more cases have been reported recently. The authors studied two groups of patients with costal chondritis, one of heroin addicts and the other of patients who had undergone thoracic surgery previously. While in the postsurgical group the patients need some kind of resection for their treatment, in the heroin addicts an early drainage is usually enough.</p></div>","PeriodicalId":75618,"journal":{"name":"British journal of diseases of the chest","volume":"82 ","pages":"Pages 341-346"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0007-0971(88)90086-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14208294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B.R.C. O'Driscoll , S.P. Ruffles , Jon G. Ayres , G.M. Cochrane
{"title":"Long term treatment of severe asthma with subcutaneous terbutaline","authors":"B.R.C. O'Driscoll , S.P. Ruffles , Jon G. Ayres , G.M. Cochrane","doi":"10.1016/0007-0971(88)90089-7","DOIUrl":"10.1016/0007-0971(88)90089-7","url":null,"abstract":"<div><p>We have investigated the use of subcutaneous terbutaline in 17 patients with brittle asthma and five patients with chronic severe asthma. Twelve of the 17 patients with brittle asthma improved both subjectively and objectively (mean lowest daily PEF rising from 142 litres/min to 297 litres/min), with reduction in oral steroid dose, nebulized β-agonist dose and number of hospital admissions. Both continuous infusion and 6-hourly divided dose regimens were equally effective.</p><p>Only one of the five with chronic severe asthma showed any lasting response.</p><p>Eighteen patients have continued to use subcutaneous terbutaline over long periods (2–40 months). Overall 11 patients suffered side-effects of usually minor degree, although one patient had to withdraw because of the development of painful subcutaneous nodules.</p><p>We conclude that subcutaneous terbutaline delivered by infusion or by intermittent injections is a useful addition to the therapy of some patients with brittle asthma.</p></div>","PeriodicalId":75618,"journal":{"name":"British journal of diseases of the chest","volume":"82 ","pages":"Pages 360-367"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0007-0971(88)90089-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14208296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Meetings announcements","authors":"","doi":"10.1016/0007-0971(88)90084-8","DOIUrl":"https://doi.org/10.1016/0007-0971(88)90084-8","url":null,"abstract":"","PeriodicalId":75618,"journal":{"name":"British journal of diseases of the chest","volume":"82 ","pages":"Page 328"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0007-0971(88)90084-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91700215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Radiology of the paediatric chest","authors":"Robert R. Cox","doi":"10.1016/0007-0971(88)90022-8","DOIUrl":"10.1016/0007-0971(88)90022-8","url":null,"abstract":"","PeriodicalId":75618,"journal":{"name":"British journal of diseases of the chest","volume":"82 ","pages":"Page 100"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0007-0971(88)90022-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52756112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exercises in chest X-ray diagnosis","authors":"A.J.R. Wightman","doi":"10.1016/0007-0971(88)90049-6","DOIUrl":"10.1016/0007-0971(88)90049-6","url":null,"abstract":"","PeriodicalId":75618,"journal":{"name":"British journal of diseases of the chest","volume":"82 ","pages":"Page 202"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0007-0971(88)90049-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52756700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Meetings announcements","authors":"","doi":"10.1016/0007-0971(88)90028-9","DOIUrl":"https://doi.org/10.1016/0007-0971(88)90028-9","url":null,"abstract":"","PeriodicalId":75618,"journal":{"name":"British journal of diseases of the chest","volume":"82 ","pages":"Page 104"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0007-0971(88)90028-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137291636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}