British journal of diseases of the chest最新文献_第7页

The use of fine bore silastic catheters to drain carcinomatous pleural effusions 使用细孔硅胶导管引流癌性胸腔积液

British journal of diseases of the chest Pub Date : 1988-01-01 DOI: 10.1016/0007-0971(88)90094-0

J. Shand , G.T. McCreath, R.D.H. Monie

引用次数: 3

The effects of long term methyldopa in patients with hypoxic cor pulmonale 长期甲基多巴对低氧性肺心病患者的影响

British journal of diseases of the chest Pub Date : 1988-01-01 DOI: 10.1016/0007-0971(88)90096-4

T.W. Evans, J. Waterhouse, M. Finlay, A.J. Suggett, P. Howard

{"title":"The effects of long term methyldopa in patients with hypoxic cor pulmonale","authors":"T.W. Evans, J. Waterhouse, M. Finlay, A.J. Suggett, P. Howard","doi":"10.1016/0007-0971(88)90096-4","DOIUrl":"10.1016/0007-0971(88)90096-4","url":null,"abstract":"<div>Methyldopa (alpha-methyldopa) was given to patients with cor pulmonale secondary to chronic obstructive airways disease (COAD) to determine its effect on pulmonary haemodynamics. Twenty-five patients were randomly allocated to methyldopa (750 mg daily) or placebo. Pulmonary haemodynamics were measured twice, 12 months apart. Conventional therapies were continued unchanged.The effects of the drug on pulmonary haemodynamics were inconclusive when considered overall, but total pulmonary vascular resistance (TPVR) fell in all patients on active therapy in whom measurements were obtained both at rest and upon exercise. Only one patient in the placebo group achieved this. Over the trial period there was one death in the active but five in the placebo group. Survival was unrelated to abnormalities in pulmonary haemodynamics at the commencement of the trial in this study although the numbers of patients was small. Postural hypotension developed in patients receiving methyldopa and limited the dose that could be administered.The problems involved in long term trials of vasodilators in hypoxic cor pulmonale are discussed.</div>","PeriodicalId":75618,"journal":{"name":"British journal of diseases of the chest","volume":"82 ","pages":"Pages 405-413"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0007-0971(88)90096-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14209470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Break free from the smoking habit: a practical guide to stopping smoking 摆脱吸烟的习惯:戒烟的实用指南

British journal of diseases of the chest Pub Date : 1988-01-01 DOI: 10.1016/0007-0971(88)90045-9

Eileen Crofton

引用次数: 0

Bronchodilator therapy with nebuhaler: how important is the delay between firing the dose and inhaling? 用雾化器治疗支气管扩张剂:发射剂量和吸入之间的延迟有多重要?

British journal of diseases of the chest Pub Date : 1988-01-01 DOI: 10.1016/0007-0971(88)90066-6

S.P. Newman , G. Woodman , F. Morén , S.W. Clarke

{"title":"Bronchodilator therapy with nebuhaler: how important is the delay between firing the dose and inhaling?","authors":"S.P. Newman , G. Woodman , F. Morén , S.W. Clarke","doi":"10.1016/0007-0971(88)90066-6","DOIUrl":"10.1016/0007-0971(88)90066-6","url":null,"abstract":"<div>Metered dose inhalers are sometimes used in conjunction with NebuhalerR, a 750 ml holding chamber, but the permissible delay time between actuating the aerosol into Nebuhaler and commencing inhalation is unknown. We have compared in 10 asthmatic patients the bronchodilator responses following inhalations of terbutaline sulphate from Nebuhaler after delays of 1, 5 and 30 seconds and following placebo inhalation. Terbutaline sulphate was administered as 2 puffs, each of 250 μg, separated by approximately 15 minutes. After each delay time, terbutaline produced increases in forced expiratory volume in one second (FEV1), peak expiratory flow rate (PEFR) and maximum expiratory flow following exhalation of 75% of the forced vital capacity (<math><mtext>c</mtext><mtext>V_.</mtext><msub><mi></mi><mn>max25</mn></msub></math>) significantly greater than those after placebo (P<0.01). Changes in PEFR did not vary significantly among the three delay times, but the increases in FEV1 and in <math><mtext>c</mtext><mtext>V_.</mtext><msub><mi></mi><mn>max25</mn></msub></math> were significantly reduced with 30 seconds' delay. It is concluded that the delay between actuation into Nebuhaler and commencing inhalation can be extended from 1 second to 5 seconds without significant loss of drug efficacy, and that further extension to 30 seconds causes only a small loss of bronchodilatation: hence the delay time is unlikely to be of major importance in clinical practice.</div>","PeriodicalId":75618,"journal":{"name":"British journal of diseases of the chest","volume":"82 ","pages":"Pages 262-267"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0007-0971(88)90066-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14206720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Pneumonia in hospital 住院肺炎

British journal of diseases of the chest Pub Date : 1988-01-01 DOI: 10.1016/0007-0971(88)90031-9

Roger White, Paul Dilworth

引用次数: 4

Stridor in childhood asthma 儿童哮喘中的喘鸣

British journal of diseases of the chest Pub Date : 1988-01-01 DOI: 10.1016/0007-0971(88)90044-7

J. Storr, R. Tranter, W. Lenney

引用次数: 5

Pulmonary tuberculosis in Behçet's syndrome 肺结核behaperet综合征

British journal of diseases of the chest Pub Date : 1988-01-01 DOI: 10.1016/0007-0971(88)90073-3

J. Efthimiou , P.E. Hay , S.G. Spiro , D.J. Lane

引用次数: 15

Renal biopsy and antineutrophil antibodies in the diagnosis and assessment of Wegener's granuloma 肾活检和抗中性粒细胞抗体对韦格纳肉芽肿的诊断和评价

British journal of diseases of the chest Pub Date : 1988-01-01 DOI: 10.1016/0007-0971(88)90095-2

David J. Harrison , Robert Simpson , Claire Neary , Christopher G. Wathen

引用次数: 11

Getting a patient off the ventilator 让病人摘掉呼吸机

British journal of diseases of the chest Pub Date : 1988-01-01 DOI: 10.1016/0007-0971(88)90004-6

M.A. Branthwaite

引用次数: 1

Stopping patients smoking 阻止病人吸烟

British journal of diseases of the chest Pub Date : 1988-01-01 DOI: 10.1016/0007-0971(88)90003-4

I.A. Campbell

引用次数: 3