British journal of diseases of the chest最新文献_第7页

The effects of long term methyldopa in patients with hypoxic cor pulmonale 长期甲基多巴对低氧性肺心病患者的影响

British journal of diseases of the chest Pub Date : 1988-01-01 Epub Date: 2004-05-19 DOI: 10.1016/0007-0971(88)90096-4

T.W. Evans, J. Waterhouse, M. Finlay, A.J. Suggett, P. Howard

{"title":"The effects of long term methyldopa in patients with hypoxic cor pulmonale","authors":"T.W. Evans, J. Waterhouse, M. Finlay, A.J. Suggett, P. Howard","doi":"10.1016/0007-0971(88)90096-4","DOIUrl":"10.1016/0007-0971(88)90096-4","url":null,"abstract":"<div>Methyldopa (alpha-methyldopa) was given to patients with cor pulmonale secondary to chronic obstructive airways disease (COAD) to determine its effect on pulmonary haemodynamics. Twenty-five patients were randomly allocated to methyldopa (750 mg daily) or placebo. Pulmonary haemodynamics were measured twice, 12 months apart. Conventional therapies were continued unchanged.The effects of the drug on pulmonary haemodynamics were inconclusive when considered overall, but total pulmonary vascular resistance (TPVR) fell in all patients on active therapy in whom measurements were obtained both at rest and upon exercise. Only one patient in the placebo group achieved this. Over the trial period there was one death in the active but five in the placebo group. Survival was unrelated to abnormalities in pulmonary haemodynamics at the commencement of the trial in this study although the numbers of patients was small. Postural hypotension developed in patients receiving methyldopa and limited the dose that could be administered.The problems involved in long term trials of vasodilators in hypoxic cor pulmonale are discussed.</div>","PeriodicalId":75618,"journal":{"name":"British journal of diseases of the chest","volume":"82 ","pages":"Pages 405-413"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0007-0971(88)90096-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14209470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Pleural effusions and pancreatico-pleural fistulae associated with asymptomatic pancreatic disease 无症状胰腺疾病相关的胸膜积液和胰胸膜瘘

British journal of diseases of the chest Pub Date : 1988-01-01 Epub Date: 2004-05-19 DOI: 10.1016/0007-0971(88)90076-9

C.B. Cooper , P.A. Bardsley , S.S. Rao , M.C. Collins

引用次数: 9

Fibreoptic bronchoscopy in the elderly: 4 years' experience 老年人纤维支气管镜检查:4年经验

British journal of diseases of the chest Pub Date : 1988-01-01 Epub Date: 2004-05-19 DOI: 10.1016/0007-0971(88)90071-X

Alan J. Knox , B. Hugo Mascie-Taylor , Richard L. Page

引用次数: 35

Anti-tuberculosis drugs (Handbook of Experimental Pharmacology, Vol. 84) 抗结核药物(《实验药理学手册》第84卷)

British journal of diseases of the chest Pub Date : 1988-01-01 DOI: 10.1016/0007-0971(88)90108-8

J. Grange

引用次数: 1

Bronchodilator therapy with nebuhaler: how important is the delay between firing the dose and inhaling? 用雾化器治疗支气管扩张剂:发射剂量和吸入之间的延迟有多重要?

British journal of diseases of the chest Pub Date : 1988-01-01 Epub Date: 2004-05-19 DOI: 10.1016/0007-0971(88)90066-6

S.P. Newman , G. Woodman , F. Morén , S.W. Clarke

{"title":"Bronchodilator therapy with nebuhaler: how important is the delay between firing the dose and inhaling?","authors":"S.P. Newman , G. Woodman , F. Morén , S.W. Clarke","doi":"10.1016/0007-0971(88)90066-6","DOIUrl":"10.1016/0007-0971(88)90066-6","url":null,"abstract":"<div>Metered dose inhalers are sometimes used in conjunction with NebuhalerR, a 750 ml holding chamber, but the permissible delay time between actuating the aerosol into Nebuhaler and commencing inhalation is unknown. We have compared in 10 asthmatic patients the bronchodilator responses following inhalations of terbutaline sulphate from Nebuhaler after delays of 1, 5 and 30 seconds and following placebo inhalation. Terbutaline sulphate was administered as 2 puffs, each of 250 μg, separated by approximately 15 minutes. After each delay time, terbutaline produced increases in forced expiratory volume in one second (FEV1), peak expiratory flow rate (PEFR) and maximum expiratory flow following exhalation of 75% of the forced vital capacity (<math><mtext>c</mtext><mtext>V_.</mtext><msub><mi></mi><mn>max25</mn></msub></math>) significantly greater than those after placebo (P<0.01). Changes in PEFR did not vary significantly among the three delay times, but the increases in FEV1 and in <math><mtext>c</mtext><mtext>V_.</mtext><msub><mi></mi><mn>max25</mn></msub></math> were significantly reduced with 30 seconds' delay. It is concluded that the delay between actuation into Nebuhaler and commencing inhalation can be extended from 1 second to 5 seconds without significant loss of drug efficacy, and that further extension to 30 seconds causes only a small loss of bronchodilatation: hence the delay time is unlikely to be of major importance in clinical practice.</div>","PeriodicalId":75618,"journal":{"name":"British journal of diseases of the chest","volume":"82 ","pages":"Pages 262-267"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0007-0971(88)90066-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14206720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Smoking: Third world alert 吸烟:第三世界警报

British journal of diseases of the chest Pub Date : 1988-01-01 Epub Date: 2004-05-19 DOI: 10.1016/0007-0971(88)90026-5

Ian A. Campbell

引用次数: 0

Getting a patient off the ventilator 让病人摘掉呼吸机

British journal of diseases of the chest Pub Date : 1988-01-01 Epub Date: 2004-05-19 DOI: 10.1016/0007-0971(88)90004-6

M.A. Branthwaite

引用次数: 1

Stopping patients smoking 阻止病人吸烟

British journal of diseases of the chest Pub Date : 1988-01-01 Epub Date: 2004-05-19 DOI: 10.1016/0007-0971(88)90003-4

I.A. Campbell

引用次数: 3

Pneumonia in hospital 住院肺炎

British journal of diseases of the chest Pub Date : 1988-01-01 Epub Date: 2004-05-19 DOI: 10.1016/0007-0971(88)90031-9

Roger White, Paul Dilworth

引用次数: 4

Stridor in childhood asthma 儿童哮喘中的喘鸣

British journal of diseases of the chest Pub Date : 1988-01-01 Epub Date: 2004-05-19 DOI: 10.1016/0007-0971(88)90044-7

J. Storr, R. Tranter, W. Lenney

引用次数: 5