Boletin chileno de parasitologia最新文献_第9页

[Current prospects of specific treatment of Chagas' disease]. [恰加斯病特异性治疗的当前前景]。

Boletin chileno de parasitologia Pub Date : 1996-07-01

J R Coura

{"title":"[Current prospects of specific treatment of Chagas' disease].","authors":"J R Coura","doi":"","DOIUrl":"","url":null,"abstract":"The evolution of the specific treatment of Chagas' disease, including the numerous drugs tested, is briefly summarized. Since 1969 laboratory and clinical studies have persistently demonstrated that nifurtimox (NFX) and benznidazole (BNL) are the best agents for treating Trypanosoma cruzi human infection, even though they cannot be considered ideal drugs. The main indications for NFX and BNL are: acute phase of the infection, congenital form, reactivation associated with immunosuppression, recently acquired infection, mostly in children and young adults, and in transfusions and organ transplant situations. Both drugs may also be indicated for the treatment of some patients in the undetermined asymptomatic form of the chronic infection with mild heart involvement, or in clinical megaesophagus patients who previously need symptomatic treatment to ensure the appropriate absorption of the medication. The most used dosage schedules are: NFX for 60-90 days, 8-10 mg/kg/day in adults and < 15 mg/kg/day in children. BNL, for 60 days, 5 mg/kg/day in adults and < 10 mg/kg/day in children. Both drugs are taken orally and must be given divided into 2-3 fractions after meals. Both drugs are well tolerated by children, and particularly in the acute phase of the disease. Adverse reactions may be observed, i.e. disturbances associated to the digestive tract such as hyporexia, nausea, vomiting and loss of weight with NFX, and dermopathy and polyneuropathy, with BNL. The main limitations of both drugs are in the long course of administration and the occurrence of adverse side effects. A series of promising new drugs for the treatment of human Chagas' disease is being tested. Because the relative lack of interest of the pharmaceutical industry in the research for new drugs for the treatment of the parasitosis--which affects 16-18 million people in Latin America--Universities and Research Governmental Institution should stimulate the investigation for the development of new drugs and the clinical evaluation of drugs experimentally known and not yet tested.","PeriodicalId":75607,"journal":{"name":"Boletin chileno de parasitologia","volume":"51 3-4","pages":"69-75"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20242911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Various epidemiological aspects of Enterobius vermicularis infection inpatients served at public outpatient clinics and hospitals from the northern section of Santiago, Chile, 1995]. [1995年智利圣地亚哥北部公共门诊诊所和医院住院病人的蠕状肠虫感染的各种流行病学方面]。

Boletin chileno de parasitologia Pub Date : 1996-07-01

R Mercado, M García

引用次数: 0

America's Southern Cone countries initiative for interrupting vectorial and transfusional transmission of Chagas' disease. 美国南锥国家阻断恰加斯病病媒传播和输血传播的倡议。

Boletin chileno de parasitologia Pub Date : 1996-07-01

引用次数: 0

[New sites with Triatominae infected by Trypanosoma cruzi in the Mexican Republic]. [墨西哥共和国克氏锥虫感染锥虫的新地点]。

Boletin chileno de parasitologia Pub Date : 1996-07-01

J Tay Zavala, J T Sánchez Vega, L Robert Guerrero, T Alonso Guerrero, R Romero-Cabello

引用次数: 0

[Evaluation of vectors of Chagas' disease eradication programs in Chile by serological study of children under 10 years old]. [通过对10岁以下儿童的血清学研究评估智利恰加斯病根除计划的媒介]。

Boletin chileno de parasitologia Pub Date : 1996-07-01

M Lorca, H Schenone, M C Contreras, A García, A Rojas, J Valdés

{"title":"[Evaluation of vectors of Chagas' disease eradication programs in Chile by serological study of children under 10 years old].","authors":"M Lorca, H Schenone, M C Contreras, A García, A Rojas, J Valdés","doi":"","DOIUrl":"","url":null,"abstract":"Chagas' disease is a parasitic zoonosis with high prevalence in Chile. It is distributed in rural and periurban section in the northern most seven out of thirteen regions in which the country is divided, and affects about 142,000 individuals dispersed in most of the 165 counties sited in the chagasic zone. Triatoma infestans--intradomiciliary species--is the main and practically exclusive vector of Trypanosoma cruzi. Diverse tools may be utilized in order to interrupt the domestic cycle of transmission of T. cruzi: health education, housing improvement and elimination of vectors by dwelling insecticide sprayings. This last resource has received priority in Chile in the last 12 years. To evaluate the effectivity of the programs for eliminating T. infestans a serological study for Chagas' disease--comprising 8,767 children less than 10 years old from 27 rural counties insecticide sprayed in the last 12 years--was carried out. A global total of 125 (1.4%) children resulted positive, figure significantly lower than 5.4% found in 1982-1990 in the same age group. Distribution by regions of positive individuals showed a decrease of prevalence in each of them: III Region, from 9.8 to 1.0%, IV Region, 7.2 to 2.0%, V Region, 5.2 to 1.9%, and Metropolitan Region, 1.4% to 0.6. Even though positive children have still been found in 46.7% of localities of the studied counties, it is possible to affirm that the vector control programs have been effective and must be maintained, and increased in those localities with T. cruzi infection in children under 10 years of age, with the general aim of eradicate Chagas' disease transmission in Chile before 2000.","PeriodicalId":75607,"journal":{"name":"Boletin chileno de parasitologia","volume":"51 3-4","pages":"80-5"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20242913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Cammalanus Railliet and Henry, 1915 (Nematoda, Camallanidae). Parasite from Hydrodynastes gigas (Reptilia, Serpentes, Colubridae) from Argentine Chaco]. [Cammalanus Railliet和Henry，1915（线虫目，Camallanidae）。来自阿根廷Chaco的Hydrodynstes gigas（爬行纲，蛇形，Colubridae）的寄生虫]。

Boletin chileno de parasitologia Pub Date : 1996-07-01

G Ramallo

引用次数: 0

[Hydatidosis/echinococcosis in General Acha, La Pampa Province, Argentina]. [阿根廷拉潘帕省阿查将军的包虫病/包虫病]。

Boletin chileno de parasitologia Pub Date : 1996-07-01

E Larrieu, R Lamberti, J Casaza, T Alvarez, C Fonts, L Cavagion, C Calvo, L Gino

引用次数: 0

[Current human and canine seroprevalence of Chagasic infection in San Pedro de Atacama County, II Region of Antofagasta, Chile, 1995]. [1995年智利安托法加斯塔第二大区圣佩德罗德阿塔卡马县目前人类和犬血吸虫感染的血清患病率]。

Boletin chileno de parasitologia Pub Date : 1996-07-01

L Burchard, J Cáceres, H Sagua, M Inés Bahamonde, I Neira, J Araya, M Goycolea