{"title":"Applications of totally implantable telemetry systems to chronic medical research.","authors":"J P Claude, J W Knutti, H V Allen, J D Meindl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The motivation for the development of advanced totally implantable telemetry systems is to improve the quality of medical care through a more detailed understanding of basic physiological processes. Three research protocols in electrophysiology, hepatic hemodynamics, and cardiac pharmacology are described which rely on new implantable instrumentation; these devices allow chronic measurements in the conscious animal of such diverse parameters as aortic and ventricular pressures; atrial, ventricular, and bundle of HIS electrograms; aortic and coronary blood flow, and total hepatic blood flow by measuring velocity profiles in the portal vein and the hepatic artery. The compact size and high reliability now achievable with these telemetry systems provides new tools to the researcher for the study of the body in health and disease.</p>","PeriodicalId":75603,"journal":{"name":"Biotelemetry and patient monitoring","volume":"6 3","pages":"160-71"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11713655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Totally implantable directional Doppler flowmeters.","authors":"H V Allen, J W Knutti, J D Meindl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two totally implantable Doppler blood flowmeters have been developed for the chronic measurement of deep-body flows; made possibly by two custom-integrated circuits. The CW and pulsed Doppler instruments are small (less than 2.5 cm3), use little power (less than 30 mW), and have excellent baseline stability. The pulsed Doppler flowmeter is applied principally when velocity-profile information or a nonencircling transducer assembly is required but where minimal restraint of the animal for inductive telemetry is permissible. Using a circumferential cuff, the CW Doppler flowmeter monitors Doppler data over a at least a 3-meter range by means of RF telemetry and produces a single velocity estimate. These instruments compliment each other and other telemetry systems by proving the researcher with alternatives for the long-term measurement of deep-body flow without percutaneous leads.</p>","PeriodicalId":75603,"journal":{"name":"Biotelemetry and patient monitoring","volume":"6 3","pages":"118-32"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11378780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Integrated power controllers and RF data transmitters for totally implantable telemetry.","authors":"H V Allen, J W Knutti, J D Meindl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Data transmitters and power/source controllers are common elements in all totally implantable instrumentation systems. Two custom-designed integrated circuits have been developed for these elements and have significant impact on the realization of compact reliable telemetry packages. The first is an elapsed-time power switch that can remotely turn on implanted battery-powered systems with a short RF burst; to prevent accidental battery drainage, it will automatically turn off after a preprogrammed time (1-5 min). The second is a precision RF transmitter capable of operation up to 125 MHz in either FM or pulse-coded format and requires only two nonintegrated inductors. These IC systems are basic building blocks for a large number of totally implantable telemetry applications.</p>","PeriodicalId":75603,"journal":{"name":"Biotelemetry and patient monitoring","volume":"6 3","pages":"147-59"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11713135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Practical experiences with the routine application of the intravascular PO2 probe.","authors":"W Büttner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The practical experience with the routine use of 53 Roche PO2 probes, introduced through the radial artery in artificially ventilated patients of all age groups, during up to 8 1/2 days, is described. It may be concluded that many observations are only possible by continuous measurement, which, for example, makes possible a quicker and more accurate control of breathing and respiration. In some cases the cost-benefit calculation even favors continuous measurement.</p>","PeriodicalId":75603,"journal":{"name":"Biotelemetry and patient monitoring","volume":"6 1-2","pages":"44-50"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11691563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An electrochemical sensor for continuous intravascular oxygen monitoring.","authors":"P Eberhard, W Fehlmann, W Mindt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The intravascular PO2 sensor described in this paper essentialal routine use. The small dimensions of the sensor permit its introduction into the vessel through a conventional guiding catheter size 4 F or larger. With 5 F catheters, simultaneous blood sampling and/or blood pressure measurement is possible. The accuracy and stability of the sensor permit continuous PO2 measurement to be performed over several days.</p>","PeriodicalId":75603,"journal":{"name":"Biotelemetry and patient monitoring","volume":"6 1-2","pages":"16-31"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11691561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current trends in continuous blood gas monitoring.","authors":"J W Severinghaus","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75603,"journal":{"name":"Biotelemetry and patient monitoring","volume":"6 1-2","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11692418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An integrated circuit approach to totally implantable telemetry systems.","authors":"J W Knutti, H V Allen, J D Meindl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A series of totally implantable telemetry systems has been developed to determine such key physiological parameters as blood flow, pressure, dimensions, temperature, and bioelectrical activity in chronic research animals. Custom integrated circuits provide the signal-processing complexity and performance required to sufficiently instrument the animals for an accurate prediction of human responses. Additional implant and transducer technologies are necessary to complete the instrument package. Although the costs of these technologies are high, they are more than offset by the unique information obtained and overall reduction in the expenses of medical research because fewer animals can be studied over longer periods. A number of the IC-based implants are in use in several physiology and experimental drug studies where adequate reliability and performance could not be achieved by alternate approaches.</p>","PeriodicalId":75603,"journal":{"name":"Biotelemetry and patient monitoring","volume":"6 3","pages":"95-106"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11378782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intraarterial vs. transcutaneous PO2 monitoring in newborn infants. Indications and limitations.","authors":"K P Riegel, H T Versmold","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>For continuous PO2 monitoring as a valuable diagnostic tool in intensive care of newborn infants two methods are available, namely transcutaneous and intravascular monitoring. Both methods have advantages and limitations, but they are rather complementary than competing. The necessity of these new methods and the clinical implications are described.</p>","PeriodicalId":75603,"journal":{"name":"Biotelemetry and patient monitoring","volume":"6 1-2","pages":"32-43"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11691562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}