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Bibliotheca haematologica最新文献

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[Shock in surgery]. [手术中的休克]。
Bibliotheca haematologica Pub Date : 2022-04-03 DOI: 10.21557/dsp.76807393
J. Rehn
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引用次数: 0
Entrapment of L-asparaginase in red blood cells. A strategy to improve treatment of acute lymphoblastic leukemia. l -天冬酰胺酶在红细胞中的滞留。改善急性淋巴细胞白血病治疗的策略。
Bibliotheca haematologica Pub Date : 1985-04-09 DOI: 10.1159/000410229
S. Updike
{"title":"Entrapment of L-asparaginase in red blood cells. A strategy to improve treatment of acute lymphoblastic leukemia.","authors":"S. Updike","doi":"10.1159/000410229","DOIUrl":"https://doi.org/10.1159/000410229","url":null,"abstract":"Autologous red blood cells were loaded with L-asparaginase and injected intravenously into monkeys. A single dose of 1850 IU/Kg suppressed plasma asparagine for 19 days compared to 10 days for the same dose injected free in solution. Rabbit antisera to asparaginase was used to passively immunize guinea-pigs. These animals were then challenged with RBC-entrapped asparaginase versus asparaginase free in solution. RBC entrapment allowed a ten fold greater dose of asparaginase before anaphylaxis became a problem. RBC entrapment prolongs the duration of action of asparaginase and offers protection against anaphylaxis. Clinical trial in patients with acute lymphoblastic leukemia is recommended.","PeriodicalId":75590,"journal":{"name":"Bibliotheca haematologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000410229","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64825532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
The use of erythrocytes for delivery of chemotherapeutic agents to the reticuloendothelial system. 利用红细胞将化疗药物输送到网状内皮系统。
Bibliotheca haematologica Pub Date : 1985-01-01 DOI: 10.1159/000410226
W E Lynch, G P Sartiano, S L Rosenblum, J H Calkins, C B Ramsey
{"title":"The use of erythrocytes for delivery of chemotherapeutic agents to the reticuloendothelial system.","authors":"W E Lynch,&nbsp;G P Sartiano,&nbsp;S L Rosenblum,&nbsp;J H Calkins,&nbsp;C B Ramsey","doi":"10.1159/000410226","DOIUrl":"https://doi.org/10.1159/000410226","url":null,"abstract":"<p><p>The object of our work is to define the possible role of hypotonically loaded erythrocytes as carriers to target drugs to the reticuloendothelial system. We have examined choices of drugs for loading into the erythrocytes and have considered methods of altering potentially useful agents so that they will load. We have demonstrated that the delivery of bleomycin to the reticuloendothelial system of mice, inside erythrocyte carriers, potentiates the effect of this drug on phagocytosis. We speculate, that this targeted delivery of bleomycin to phagocytes could be beneficial in the treatment of diseases characterized by an important phagocytic component.</p>","PeriodicalId":75590,"journal":{"name":"Bibliotheca haematologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000410226","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13556402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Hypotonic dialysis encapsulation in erythrocytes of mammalian species. 哺乳动物红细胞低渗透析包封。
Bibliotheca haematologica Pub Date : 1985-01-01 DOI: 10.1159/000410220
J R DeLoach
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引用次数: 5
Red cell ghost-entrapped deferoxamine as a model clinical targeted delivery system for iron chelators and other compounds. 红细胞鬼捕获去铁胺作为铁螯合剂和其他化合物的模型临床靶向递送系统。
Bibliotheca haematologica Pub Date : 1985-01-01 DOI: 10.1159/000410224
R Green
{"title":"Red cell ghost-entrapped deferoxamine as a model clinical targeted delivery system for iron chelators and other compounds.","authors":"R Green","doi":"10.1159/000410224","DOIUrl":"https://doi.org/10.1159/000410224","url":null,"abstract":"<p><p>In iron overload resulting from repeated blood transfusion, phagocytic reticuloendothelial cells are the primary and major sites of iron accumulation. Removal of this iron by the iron chelator deferoxamine can be enhanced by targeted delivery of this agent to reticuloendothelial cells. We have used resealed erythrocyte ghosts as a model system for delivery of deferoxamine to reticuloendothelial cells and have demonstrated a several-fold enhancement of urine iron excretion in children and adults with congenital or acquired iron-loading anemias. Although presently not cost-effective, this approach provides a useful, practical and safe model for [1] iron chelator targeting to reticuloendothelial cells, and [2] the clinical use of resealed erythrocyte ghosts for targeting pharmacologic agents to reticuloendothelial cells.</p>","PeriodicalId":75590,"journal":{"name":"Bibliotheca haematologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000410224","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15118228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Erythrocytes as carrier for therapeutic enzymes--an approach towards enzyme therapy of inborn errors of metabolism. 红细胞作为治疗酶的载体——酶治疗先天性代谢缺陷的一种途径。
Bibliotheca haematologica Pub Date : 1985-01-01 DOI: 10.1159/000410221
U Sprandel
{"title":"Erythrocytes as carrier for therapeutic enzymes--an approach towards enzyme therapy of inborn errors of metabolism.","authors":"U Sprandel","doi":"10.1159/000410221","DOIUrl":"https://doi.org/10.1159/000410221","url":null,"abstract":"","PeriodicalId":75590,"journal":{"name":"Bibliotheca haematologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000410221","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15007382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
RBC-mediated microinjection of chromatin components into cultured mammalian cells. 红细胞介导的染色质组分显微注射到培养的哺乳动物细胞中。
Bibliotheca haematologica Pub Date : 1985-01-01 DOI: 10.1159/000410237
M Rechsteiner, L H Wu, A O Miller
{"title":"RBC-mediated microinjection of chromatin components into cultured mammalian cells.","authors":"M Rechsteiner,&nbsp;L H Wu,&nbsp;A O Miller","doi":"10.1159/000410237","DOIUrl":"https://doi.org/10.1159/000410237","url":null,"abstract":"<p><p>Radiolabeled DNA fragments or nuclear proteins were encapsulated within human erythrocytes, and the erythrocytes were then fused with cultured mammalian cells using Sendai virus. Autoradiography revealed that 125I-labeled DNA fragments remained dispersed in the cytoplasm and disappeared with a half-life of 24 hours. In contrast, the nuclear proteins, HMG1, HMG2, HMG17 and histone H1, rapidly localized within HeLa nuclei and exhibited half lives greater than 80 hours. Several biochemical criteria indicate that the association of the injected nuclear proteins with chromatin faithfully mimics the behavior of their endogenous counterparts.</p>","PeriodicalId":75590,"journal":{"name":"Bibliotheca haematologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000410237","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15118224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Use of voltage pulses for the pore opening and drug loading, and the subsequent resealing of red blood cells. 使用电压脉冲打开毛孔和药物装载，以及随后的红细胞重新密封。
Bibliotheca haematologica Pub Date : 1985-01-01 DOI: 10.1159/000410233
T Y Tsong, K Kinosita
{"title":"Use of voltage pulses for the pore opening and drug loading, and the subsequent resealing of red blood cells.","authors":"T Y Tsong,&nbsp;K Kinosita","doi":"10.1159/000410233","DOIUrl":"https://doi.org/10.1159/000410233","url":null,"abstract":"<p><p>Electric pulses in the range of 1 to 5 kV/cm and of durations 1 to 200 microseconds have been used to open up pores of limited size in various cell types. In the case of erythrocytes, these pores were shown to admit molecules as large as tetrasaccharides. Loading of clinically active drugs has also been attempted. Erythrocytes loaded with drugs can be resealed without loss of the hemoglobin content. With mouse erythrocytes, we have demonstrated the feasibility of using erythrocytes (not hemoglobin depleted ghosts) as drug carriers for prolonging the drug level in the circulation. Other possible applications of the method are also discussed.</p>","PeriodicalId":75590,"journal":{"name":"Bibliotheca haematologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000410233","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15118220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 44
Carrier erythrocytes: a prospectus for the future. 载体红细胞:未来的招股说明书。
Bibliotheca haematologica Pub Date : 1985-01-01 DOI: 10.1159/000410239
J R DeLoach, U Sprandel, R Green
{"title":"Carrier erythrocytes: a prospectus for the future.","authors":"J R DeLoach,&nbsp;U Sprandel,&nbsp;R Green","doi":"10.1159/000410239","DOIUrl":"https://doi.org/10.1159/000410239","url":null,"abstract":"","PeriodicalId":75590,"journal":{"name":"Bibliotheca haematologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000410239","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15118227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Encapsulation and pharmacokinetics of drugs in bovine and canine carrier erythrocytes. 药物在牛和犬红细胞中的包封和药代动力学。
Bibliotheca haematologica Pub Date : 1985-01-01 DOI: 10.1159/000410225
J R DeLoach
{"title":"Encapsulation and pharmacokinetics of drugs in bovine and canine carrier erythrocytes.","authors":"J R DeLoach","doi":"10.1159/000410225","DOIUrl":"https://doi.org/10.1159/000410225","url":null,"abstract":"","PeriodicalId":75590,"journal":{"name":"Bibliotheca haematologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000410225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15118229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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