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The evolution of hexokinases. 己糖激酶的进化。
Archivos de biologia y medicina experimentales Pub Date : 1999-02-01 DOI: 10.1042/BST027A056A
T. Ureta, C. Medina, A. Preller
{"title":"The evolution of hexokinases.","authors":"T. Ureta, C. Medina, A. Preller","doi":"10.1042/BST027A056A","DOIUrl":"https://doi.org/10.1042/BST027A056A","url":null,"abstract":"Recent advances in the knowledge of the structural and functional aspects of the enzymes catalyzing sugar phosphorylation by ATP are reviewed. Hexokinases may exist, mainly in prokaryotes, as sugar-specific kinases (glucokinase, fructokinase, mannokinase) or as ubiquitous hexose-kinases which are relatively unspecific for the natural hexoses. Enzymes presenting intermediate specificity (e.g. mannofructokinases) have been also described. With a few exceptions, the molecular mass of a variety of hexokinases may be either 25 kDa, 50 kDa or 100 kDa. The smaller hexokinases have been found in some microorganisms whereas the 50 kDa enzymes are found (with only one exception) in most invertebrates and in a particular isozyme from vertebrates (hexokinase D). The 100 kDa enzymes are restricted to vertebrates (hexokinases A, B and C). These facts have led to the speculation that gene duplication events have played an important role in the evolutionary development of the hexokinases from present day organisms. The fact that the 100 kDa hexokinases are allosterically inhibited by the product, glucose 6-P, may indicate that a duplicated active site has evolved to a regulatory binding site. Comparisons of the amino acid sequence of a few peptides from hexokinase C are presented to support the gene duplication hypothesis. Also, partial sequence comparisons of vertebrate hexokinases with the sequences of two hexokinase isozymes from yeast show strong similarities suggesting a rather slow amino acid substitution rate of homologous genes.","PeriodicalId":75552,"journal":{"name":"Archivos de biologia y medicina experimentales","volume":"20 3-4 1","pages":"343-57"},"PeriodicalIF":0.0,"publicationDate":"1999-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/BST027A056A","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58218047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
[Hermann Niemeyer Fernández (1918-1991) and science in Chile]. [赫尔曼·尼迈耶·费尔南德斯（Hermann Niemeyer Fernández，1918-1991）与智利的科学]。
Archivos de biologia y medicina experimentales Pub Date : 1992-01-01
{"title":"[Hermann Niemeyer Fernández (1918-1991) and science in Chile].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75552,"journal":{"name":"Archivos de biologia y medicina experimentales","volume":"25 ","pages":"1-147"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21573945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Society of Biology of Chile and the Associated Societies, 34th annual meeting. Puyehue, Chile, 27-30 November 1991. Abstracts. 智利生物学会及相关学会，第34届年会。1991年11月27日至30日，智利普耶霍。摘要。
Archivos de biologia y medicina experimentales Pub Date : 1991-11-01
{"title":"Society of Biology of Chile and the Associated Societies, 34th annual meeting. Puyehue, Chile, 27-30 November 1991. Abstracts.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75552,"journal":{"name":"Archivos de biologia y medicina experimentales","volume":"24 2","pages":"R95-202"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13005750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sagaxine, the protamine from Sardinops sagax. Characterization, sequence and secondary structure prediction. 沙丁鱼精，沙丁鱼精中的鱼精蛋白。表征、序列和二级结构预测。
Archivos de biologia y medicina experimentales Pub Date : 1991-01-01
A Arellano, H Peña-Cortés, H Cid, J Hoppe
{"title":"Sagaxine, the protamine from Sardinops sagax. Characterization, sequence and secondary structure prediction.","authors":"A Arellano,&nbsp;H Peña-Cortés,&nbsp;H Cid,&nbsp;J Hoppe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper describes the isolation, purification and full characterization of the protamine from Sardinops sagax. The protein was purified by both gel filtration and ion exchange chromatography and its amino acid composition, electrophoretic behaviour and sequence were determined. We postulate that the protamine exhibits microheterogeneity with a major and a minor component. The molecular weight for the major component is 4377, as calculated from the sequence. The N-terminal amino acid is proline and the C-terminal is arginine. The amino acid composition is: Thr-Ser-Glx-(Pro)2-Gly-(Ala)3-(Val)2-(Lys)2-(Arg)20 The secondary structure for the protamines was also predicted and a revision of our previously published results in this area is discussed. We have called this protamine Sagaxine and an overall comparison with the hitherto described fish protamines is also made.</p>","PeriodicalId":75552,"journal":{"name":"Archivos de biologia y medicina experimentales","volume":"24 1","pages":"67-74"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13007216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Concentrations of serum lipids in children with Down's syndrome]. [唐氏综合症儿童的血脂浓度]。
Archivos de biologia y medicina experimentales Pub Date : 1991-01-01
A Zamorano, M Guzmán, M Aspillaga, A Avendaño, M Gatica
{"title":"[Concentrations of serum lipids in children with Down's syndrome].","authors":"A Zamorano,&nbsp;M Guzmán,&nbsp;M Aspillaga,&nbsp;A Avendaño,&nbsp;M Gatica","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The level of blood lipids in children with Down's syndrome was determined with the purpose of establishing possible differences in total cholesterol, triglyceride and HDL-cholesterol levels with those of healthy children. LDL-cholesterol fraction was calculated. Blood samples were obtained from 66 healthy children (controls) and 72 patients who suffered from clinically diagnosed Down's syndrome. All the children were grouped according to age. The variables of body weight, height, and blood lipids gave a distribution of values that allows one to distinguish the group of children with Down's syndrome from the normal group. The values obtained for triglycerides, total cholesterol, and LDL-cholesterol ranged higher, with a constant deficit of HDL-cholesterol in all age groups. The lipid pattern encountered in the Down's syndrome patient suggests the existence of unknown, possibly genetically determined mechanisms, that provoke a disorder in lipid metabolism.</p>","PeriodicalId":75552,"journal":{"name":"Archivos de biologia y medicina experimentales","volume":"24 1","pages":"49-55"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13007211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Composition of the parotid saliva in Chilean children with Down's syndrome. 智利唐氏综合症儿童腮腺唾液的组成。
Archivos de biologia y medicina experimentales Pub Date : 1991-01-01
L Jara, A Ondarza, R Blanco, L Rivera
{"title":"Composition of the parotid saliva in Chilean children with Down's syndrome.","authors":"L Jara,&nbsp;A Ondarza,&nbsp;R Blanco,&nbsp;L Rivera","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Parotid gland saliva was collected from three groups of Chilean human subjects: Down syndrome, non-Down mentally retarded, and normal individuals. Their salivary flows, pH and electrolyte concentrations were determined. Variables were subjected to ANOVA statistical tests that showed no differences between Down and control groups in salivary flow, pH, chloride, sodium and bicarbonate concentrations. The potassium concentration in the saliva from Down syndrome patients was significantly lower than that of control individuals. Student's t-tests showed significant differences between Down syndrome individuals and controls for potassium and sodium. These last differences may be indicative of a characteristic trait of the trisomic state or of the syndrome itself.</p>","PeriodicalId":75552,"journal":{"name":"Archivos de biologia y medicina experimentales","volume":"24 1","pages":"57-60"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13007213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the scientific strength of Chile. 评估智利的科学实力。
Archivos de biologia y medicina experimentales Pub Date : 1991-01-01
C G Brown, H R Coward, R C Stowe
{"title":"Assessing the scientific strength of Chile.","authors":"C G Brown,&nbsp;H R Coward,&nbsp;R C Stowe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We use analysis of co-citation and relative citation rates to assess the scientific strength of Chile as compared with other developing countries and to evaluate the potential for increased international collaboration between Chile and the United States in science and engineering. Co-citation is the citation of two scientific papers by a third paper. By examining frequency and patterns of co-citation, the intellectual structure and evolution of scientific disciplines and research specialties can be traced. Chile is especially \"strong\", as defined by the co-citation model we employ, in biomedicine and clinical medicine, and in astronomy. A relative citation rate is the ratio of the number of citations a paper receives to the average number of citations for all papers published in the same journal over time. Analysis of relative citation rates of papers published by authors with Chilean addresses show that Chilean physics, including earth and space sciences, is of unusually high quality, considerably higher than any other developing country and comparable to several industrialized countries. We conclude that Chile's scientific capacity is advanced enough to absorb and benefit significantly from strategic additions to the country's resources and capabilities for research. These would include increases in: exchanges of researchers in specific fields with U.S. and other Latin American academic, industrial, and government scientists and engineers; training at outstanding U.S. and Latin American institutions; laboratory equipment, computer time, communications links, and library materials; and funding from U.S. and international organizations. It is also apparent that Chile is strong enough in certain fields to cooperate with the U.S. in mutually beneficial international efforts.</p>","PeriodicalId":75552,"journal":{"name":"Archivos de biologia y medicina experimentales","volume":"24 1","pages":"37-47"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13005971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Neurochemical substrate of the behavioral pharmacology of ethanol]. [乙醇行为药理学的神经化学基础]。
Archivos de biologia y medicina experimentales Pub Date : 1991-01-01
R Nadal Alemany, M Pallares Año, N Ferre Suana
{"title":"[Neurochemical substrate of the behavioral pharmacology of ethanol].","authors":"R Nadal Alemany,&nbsp;M Pallares Año,&nbsp;N Ferre Suana","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75552,"journal":{"name":"Archivos de biologia y medicina experimentales","volume":"24 1","pages":"11-35"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12852995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Preparation and characterization of a monoclonal peroxidase-antiperoxidase complex]. [单克隆过氧化物酶-抗过氧化物酶复合物的制备与表征]。
Archivos de biologia y medicina experimentales Pub Date : 1991-01-01
J Villegas, G Eller, V Leyan, P Esquivel, H Folch
{"title":"[Preparation and characterization of a monoclonal peroxidase-antiperoxidase complex].","authors":"J Villegas,&nbsp;G Eller,&nbsp;V Leyan,&nbsp;P Esquivel,&nbsp;H Folch","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75552,"journal":{"name":"Archivos de biologia y medicina experimentales","volume":"24 1","pages":"61-6"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12834513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[III Annual Reunion of the Chilean Society of Reproduction and Development. Santiago, 3 August 1990. Abstracts]. [三]智利生殖与发展协会年度聚会。圣地亚哥，1990年8月3日。摘要]。
Archivos de biologia y medicina experimentales Pub Date : 1990-12-01
{"title":"[III Annual Reunion of the Chilean Society of Reproduction and Development. Santiago, 3 August 1990. Abstracts].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75552,"journal":{"name":"Archivos de biologia y medicina experimentales","volume":"23 4","pages":"R343-51"},"PeriodicalIF":0.0,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13142758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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