{"title":"As I saw it.","authors":"A E Walker","doi":"10.1159/000099378","DOIUrl":"https://doi.org/10.1159/000099378","url":null,"abstract":"","PeriodicalId":75525,"journal":{"name":"Applied neurophysiology","volume":"51 1","pages":"7-9"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000099378","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14417981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neurosurgical technique of the dorsal root entry zone operation.","authors":"B S Nashold","doi":"10.1159/000099956","DOIUrl":"https://doi.org/10.1159/000099956","url":null,"abstract":"<p><p>The dorsal root entry zone operation was introduced in 1976 to relieve the pain of brachial plexus avulsion. Since then it has been applied to pain treatment in paraplegia, postherpetic pain, phantom limb pain and other types of of deafferentation pain. Over 400 operations have been done at the Duke University Medical Center with overall good results in 60% of pain patients.</p>","PeriodicalId":75525,"journal":{"name":"Applied neurophysiology","volume":"51 2-5","pages":"136-45"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000099956","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14417984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V Silani, G Pezzoli, E Motti, A Falini, A Pizzuti, C Ferrante, A Zecchinelli, F Marossero, G Scarlato
{"title":"Primary cultures of human caudate nucleus.","authors":"V Silani, G Pezzoli, E Motti, A Falini, A Pizzuti, C Ferrante, A Zecchinelli, F Marossero, G Scarlato","doi":"10.1159/000099379","DOIUrl":"https://doi.org/10.1159/000099379","url":null,"abstract":"<p><p>It is possible to grow functional primary dissociated cultures and explants from stereotactic biopsies of human parkinsonian caudate nuclei. Two major classes of cells were identified on morphological grounds. The culture cells appear to be stimulated by an unidentified soluble factor(s) obtained from human fetal neuronal cells in vitro. Culture of primary neuronal and glial cells from human adult cerebral nuclei seems to be a useful tool for several research purposes and in particular for studying both trophic factor action and target effects on afferent neurons for prospective human brain grafting.</p>","PeriodicalId":75525,"journal":{"name":"Applied neurophysiology","volume":"51 1","pages":"10-20"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000099379","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14516167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Historical development of neural transplantation.","authors":"L F Borges","doi":"10.1159/000099972","DOIUrl":"https://doi.org/10.1159/000099972","url":null,"abstract":"<p><p>The techniques of neural transplantation are almost 100 years old. As these techniques begin to be used to treat human neurological disorders, it is important to remember the contributions of the many investigators who have advanced this fascinating area of neurobiology.</p>","PeriodicalId":75525,"journal":{"name":"Applied neurophysiology","volume":"51 6","pages":"265-77"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000099972","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14180738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deafferentation pain in man.","authors":"W H Sweet","doi":"10.1159/000099954","DOIUrl":"https://doi.org/10.1159/000099954","url":null,"abstract":"<p><p>Pains of various etiologies are described in so many overlapping ways that verbal descriptions alone do not permit a valid distinction between those pains associated with neurological injury (with or without sensory loss) and those associated with neurological compression. Nor does the fact of some sensory loss plus pain constitute a useful classification to determine either the mechanism of the pain or its treatment. Progress is more likely to ensue if we seek to characterize in detail each type of painful lesion. Evidence for these conclusions is drawn from cases of brachial plexus injury, trigeminal rhizotomy and tractotomy, postcordotomy dysesthesia and central pain treated by regional guanethidine block. Examples of the value of totally innovative approaches are drawn from the physics of elementary particles.</p>","PeriodicalId":75525,"journal":{"name":"Applied neurophysiology","volume":"51 2-5","pages":"117-27"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000099954","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14417982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of monopolar stimulation during computed-tomography-guided stereotactic biopsies.","authors":"D E Bullard, T T Makachinas, B S Nashold","doi":"10.1159/000099382","DOIUrl":"https://doi.org/10.1159/000099382","url":null,"abstract":"<p><p>44 patients underwent intraoperative stimulation with a monopolar electrode prior to computed tomography (CT)-guided stereotactic biopsy. Stimulation at 2-100 Hz resulted in functional responses in 6/21 patients with subcortical or callosal lesions, 4/6 with basal ganglion lesions, 8/10 with thalamic and 4/4 with brainstem lesions. In all but 2 patients with mesencephalic lesions, where limited biopsy sites were available, an alternative biopsy site was used if a functional response was obtained. No morbidity was seen among these patients, although postbiopsy CT scans demonstrated small 3- to 7-mm hematomas in 5/11 patients. Retrospective review of 79 patients who underwent biopsies without stimulation demonstrated hematomas in 6/10 patients and a 3.3% transient surgical morbidity. These data indicate that postbiopsy hematomas are a relatively common occurrence, that intraoperative electrical stimulation within abnormal lesions can identify functional potential, and that avoidance of biopsies within these functional areas may be associated with reduced morbidity.</p>","PeriodicalId":75525,"journal":{"name":"Applied neurophysiology","volume":"51 1","pages":"45-54"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000099382","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14419832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Functional microsurgical partial callosotomy in patients with secondary generalized epilepsies. I. Disruption of bilateral synchrony of spike and wave discharges.","authors":"P C Ragazzo, G M Manzano, R Marino","doi":"10.1159/000099974","DOIUrl":"https://doi.org/10.1159/000099974","url":null,"abstract":"<p><p>Fourteen patients with secondary generalized epilepsy suffering from multiform seizures (MS) not amenable to medication were submitted to partial section of the corpus callosum. In all patients, there was a partial disruption of the previous generalized bilateral synchronous epileptiform discharges (GBSD). The electroencephalographic findings after callosal section are discussed with respect to their implications in furthering our understanding of the mechanisms subserving the organization of GBSD.</p>","PeriodicalId":75525,"journal":{"name":"Applied neurophysiology","volume":"51 6","pages":"297-306"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000099974","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14545266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Proceedings of the 2nd International Symposium on Dorsal Root Entry Zone (DREZ) Lesions. Durham, N.C., April 24-26, 1987.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75525,"journal":{"name":"Applied neurophysiology","volume":"51 2-5","pages":"65-263"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13976920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Abnormal physiology of the dorsal horn as related to the deafferentation syndrome.","authors":"J Ovelmen-Levitt","doi":"10.1159/000099953","DOIUrl":"https://doi.org/10.1159/000099953","url":null,"abstract":"<p><p>The spinal cord dorsal horn has been implicated in the generation of pain and dysesthesias following nerve and nerve root damage and/or avulsion, as well as following damage in adjacent spinal cord regions. Alterations in the functional properties of dorsal horn neurons occur after deafferentation and may underlie the occurrence of abnormal sensations referred to the denervated body part. Abnormal activity following deafferentation has also been noted at thalamic and cortical levels. Some of these post-denervation functional changes, determined anatomically and/or electrophysiologically, are reviewed as well as the results of behavioral studies of the deafferentation syndrome in the rat.</p>","PeriodicalId":75525,"journal":{"name":"Applied neurophysiology","volume":"51 2-5","pages":"104-16"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000099953","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14033573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}