{"title":"Eosinophilic granulomatosis with polyangiitis misdiagnosed as non-ST-segment elevation myocardial infarction: A case report","authors":"Y. Oh, Miyeun Han, Hye-Kyung Park, Eun-Jung Jo","doi":"10.4168/AARD.2021.9.1.50","DOIUrl":"https://doi.org/10.4168/AARD.2021.9.1.50","url":null,"abstract":"Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic disease and a potentially life‐threatening systemic necrotiz-ing vasculitis predominantly affecting small vessels. Herein, we describe a 47-year-old man with EGPA misdiagnosed as non-ST-seg-ment elevation myocardial infarction. He presented to the Emergency Department with indigestion and diarrhea. He had been diagnosed with asthma and chronic rhinosinusitis 3 years earlier and was taking antibiotics due to worsening sinusitis. In laboratory tests, peripheral blood eosinophils, serum creatinine, and serum troponin were elevated to 4,641 cells/μL, 13.40 ng/mL, and 1.26 ng/ mL, respectively. Electrocardiography showed ST-segment depression on the inferior wall, and echocardiography indicated an isch-emic insult in the right coronary artery territory. A non-ST-segment elevation myocardial infarction as well as antibiotic-associated diarrhea, eosinophilia and acute kidney injury was initially suspected. However, fever persisted and eosinophilia worsened despite cessation of antibiotics after admission. There was no significant stenosis of the coronary arteries on coronary angiography. Mean-while, abdominal computed tomography suggested medical renal disease, and magnetic resonance imaging showed late gadolinium enhancement at the mid wall and the subepicardial area in the left ventricle of the heart. As a workup for eosinophilia, serum anti-MPO was measured and turned out to be positive. A kidney biopsy was performed, which yielded membranous nephropathy superimposed on antineutrophil cytoplasmic antibodies-mediated crescent formation. He was diagnosed as EGPA with cardiac and renal involvement, and received systemic steroid, cyclophosphamide, and plasmapheresis. Then, peripheral eosinophil counts and renal function were normalized. He is now in clinical remission even after stopping the use of steroids and immunosuppressive agents. ( Allergy Asthma Respir Dis 2021;9:50-55 )","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"16 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73481310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Young-Jin Choi, J. Jeon, J. Jeong, Kyu Rang Kim, Yung-Seop Lee, Jae-Won Oh
{"title":"ERRATUM: Correction of the 4th author's English name and affiliation: Revision of threshold levels for evoking pollinosis to oak, pine, Japanese hop, and ragweed in the metropolitan area Seoul, Korea","authors":"Young-Jin Choi, J. Jeon, J. Jeong, Kyu Rang Kim, Yung-Seop Lee, Jae-Won Oh","doi":"10.4168/AARD.2021.9.1.56","DOIUrl":"https://doi.org/10.4168/AARD.2021.9.1.56","url":null,"abstract":"","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"60 1","pages":"56-56"},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90230372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ji Hye Kim, Yun-Jung Choi, Min Jung Kim, Ji Soo Park, Min Jin Jeon, D. Suh
{"title":"Descriptive analysis on sleep-disordered breathing in children with Prader-Willi syndrome","authors":"Ji Hye Kim, Yun-Jung Choi, Min Jung Kim, Ji Soo Park, Min Jin Jeon, D. Suh","doi":"10.4168/aard.2021.9.4.216","DOIUrl":"https://doi.org/10.4168/aard.2021.9.4.216","url":null,"abstract":"Purpose: Sleep-disordered breathing is one of the complicating characteristics in patients with Prader-Willi syndrome (PWS). No de-tailed description and risk factors are suggested on breathing problems during sleep in Korean children with PWS. Methods: We reviewed clinical and sleep-study data in patients with PWS who underwent polysomnography before they took the growth hormone therapy. Results: Of the 27 patients with PWS, 25 (92.6%) had sleep-disordered breathing, of whom 14 showed moderate to severe sleep apnea. Obstructive dominance was prevalent (64%), followed by central dominance (24%). The apnea-hypopnea index (AHI) increased with increasing weight-for-height z -score (WHZ) ( r =0.50, P =0.009), but did not differ by age. Apnea duration of over 12 months was longer in the patient group than in the infant group (15.1±4.3 seconds vs. 9.4±1.7 seconds, P =0.001) and in the obese than nonobese groups (16.8±4.3 seconds vs. 10.0±2.0 seconds, P =0.003). Desaturation below 70% was more common in the obese than nonobese subjects (3/9 vs. 0/18, P =0.029). Age was not different between the central and obstructive apnea groups, but patients with central apnea tended to be younger than patients with obstructive apnea (median [range]: 8.0 months [6.0–12.0 months] vs. 16.5 months [8.5–79.5 months], P =0.092). In addition, patients with obstructive apnea showed higher AHI (12.8 [5.9–19.2] vs. 3.9 [3.4–4.5], P =0.045). Conclusion: Sleep-disordered breathing is common in PWS children with different intensity and patterns according to age and BMI. Close monitoring of breathing problems during sleep is required in","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"40 7 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76985461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hana Lee, Jung-Hyun Kim, Yong-hyun Kim, Bomi Seo, Sae-Hoon Kim, Yoon-Seok Chang
{"title":"A case of anaphylaxis caused by exposure to walnuts","authors":"Hana Lee, Jung-Hyun Kim, Yong-hyun Kim, Bomi Seo, Sae-Hoon Kim, Yoon-Seok Chang","doi":"10.4168/aard.2021.9.4.245","DOIUrl":"https://doi.org/10.4168/aard.2021.9.4.245","url":null,"abstract":"","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"203 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82819547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of inhalant allergen sensitization between children, adolescents, and adults with asthma and allergic rhinitis","authors":"Na Gyeom Lee, Hee-Kyoo Kim, G. Choi","doi":"10.4168/aard.2021.9.3.148","DOIUrl":"https://doi.org/10.4168/aard.2021.9.3.148","url":null,"abstract":"","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"24 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74003992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yong-hyun Kim, Jang-Ho Seo, K. Ahn, Min-Suk Yang, Sae-Hoon Kim, Sang-Heon Cho, Yoon-Seok Chang
{"title":"Frequency and clinical characteristics of adverse transfusion reactions in hospitalized patients: A retrospective review of electronic medical records","authors":"Yong-hyun Kim, Jang-Ho Seo, K. Ahn, Min-Suk Yang, Sae-Hoon Kim, Sang-Heon Cho, Yoon-Seok Chang","doi":"10.4168/aard.2021.9.4.225","DOIUrl":"https://doi.org/10.4168/aard.2021.9.4.225","url":null,"abstract":"Purpose: Adverse transfusion reactions (ATRs) are unfavorable reactions to the transfused unit, and the severity may be different among individuals, depending upon the type of reactions and the patient’s susceptibility. It is necessary to operate and manage a systematic monitoring system to minimize these ATRs and increase the safety. This study was conducted to evaluate clinical features of transfusion-related adverse events and morbidities. Methods: We retrospectively analyzed transfusion data from electronic medical records during the recent 3 years (April 2017 to April 2020) at Seoul National University Bundang Hospital. The electronic search strategy was applied to search for the type of blood prod-ucts prescribed and identify symptoms that occurred during transfusion as recorded in the nursing chart which is based on the International Classification for Nursing Practice. Results: A total of 18,772 people were transfused during the study period. A total of 524 people were reported as suspected ATRs, of whom 466 were finally confirmed. Red blood cell was the most frequent culprit blood product (59.9%), followed by apheresis platelet (25.1%), fresh frozen plasma (10.1%), and platelet (4.9%). Clinical symptoms included fever (54.9%), urticaria and itching (34.7%), chillness and shivering (21.9%), and chest discomfort (6.0%), dyspnea (5.3%), cold sweating (3.8%), hypotension (2.1%), and palpita-tions (1.9%). The severity of ATRs were mild (91.8%), moderate (7.1%), and severe (1.1%). Conclusion: ATRs are mostly mild, but life-threatening reactions may occur. Physicians should be aware of various features of ATRs to appropriately recognize and treat such patients. ( Allergy Asthma Respir Dis 2021;9:225-230 )","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"448 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76485552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of an electronic system for the management of adverse reactions to iodinated contrast media","authors":"Eun-Jung Jo, Hye-Kyung Park","doi":"10.4168/aard.2021.9.3.164","DOIUrl":"https://doi.org/10.4168/aard.2021.9.3.164","url":null,"abstract":"","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"87 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83061629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Coronavirus disease 2019 vaccines and relevant adverse reactions","authors":"E. Chung","doi":"10.4168/aard.2021.9.3.124","DOIUrl":"https://doi.org/10.4168/aard.2021.9.3.124","url":null,"abstract":"In order to overcome the global pandemic of the new pathogen, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), intensive research has been conducted to understand viral pathogenicity, establish effective treatment strategies, and develop vaccines against coronavirus disease 2019 (COVID-19). To prevent COVID-19, a variety of COVID-19 vaccines have been rapidly developed and are currently being administered worldwide. When developing new vaccines, monitoring for adverse events following immunization (AEFIs) has always been important, and some COVID-19 vaccines are particularly effective as new types of vaccines that have not been used before, thus attracting attention to AEFIs. Vaccine administration is carefully conducted while monitoring for AEFI that are being reported from time to time. AEFIs are largely divided into local reactions, systemic reactions, allergic reactions, and adverse reactions to specific diseases or disease- attributable events. In addition, it is classified according to causes, but it is very difficult to confirm the association with the vaccine. Anaphylaxis, which is a systemic reaction among serious allergic reactions, requires immediate treatment and may require testing to determine the cause. In order to increase the vaccination rate and secure herd immunity, there should be no fear of vaccination due to unidentified side effects. Therefore, monitoring of AEFIs is important and causal relationships must be well established based on reliable epidemiological investigations. Current data show that the benefits of a COVID-19 vaccine far outweigh the risk of AEFIs. Future studies should continue to understand the mechanisms and risk factors of identified adverse reactions.","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"31 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81916682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}