Allergy, Asthma & Respiratory Disease最新文献

An 8-year-old girl with drug hypersensitivity to first triptorelin acetate administration 1例8岁女孩首次服用醋酸雷普妥林后出现药物过敏

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Allergy, Asthma & Respiratory Disease Pub Date : 2023-08-25 DOI: 10.4168/aard.2021.9.4.255

Nayoung Jung, Ji Eun Lee, D. Lim, J. Kim

引用次数: 0

Cigarette smoke extract contributes to the inception and aggravation of asthmatic inflammation by stimulating innate immunity 香烟烟雾提取物通过刺激先天免疫有助于哮喘炎症的开始和加重

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Allergy, Asthma & Respiratory Disease Pub Date : 2023-08-25 DOI: 10.4168/aard.2022.10.3.145

Yujin Kim, Jeonghyeon Kim, Y. Mo, Da-Eun Park, Hyun-Seung Lee, Jae-Woo Jung, Hye‐Ryun Kang

{"title":"Cigarette smoke extract contributes to the inception and aggravation of asthmatic inflammation by stimulating innate immunity","authors":"Yujin Kim, Jeonghyeon Kim, Y. Mo, Da-Eun Park, Hyun-Seung Lee, Jae-Woo Jung, Hye‐Ryun Kang","doi":"10.4168/aard.2022.10.3.145","DOIUrl":"https://doi.org/10.4168/aard.2022.10.3.145","url":null,"abstract":"Purpose: Smoking is a risk factor for the development of asthma and worsens the long-term prognosis of asthma. This study investigated the effect of cigarette smoke extract (CSE) on innate immune cells such as innate lymphoid cells (ILCs) and macrophages in a murine model of induced asthma. Methods: Six-week-old female BALB/C mice were exposed to ovalbumin (OVA) via an intranasal route with or without CSE for 8 weeks to establish a chronic murine asthma model. Airway hyperresponsiveness (AHR), airway inflammatory cells from bronchoalveolar lavage fluid, and the population of CD4+ T cells, ILCs, and macrophages in the lungs were studied to evaluate the effect of chronic CSE exposure on asthma. Results: Mice intranasally exposed to CSE along with OVA treatment (CSE/OVA) had significantly enhanced AHR, eosinophilic inflammation, increased IL- 13 and IL-17 producing CD4+ T cells compared to mice intranasally exposed to OVA only. On the contrary, the frequency of Foxp3+ in CD4+ T cells was reduced in the CSE/ OVA group. CSE enhanced the dendritic cell (DC) population, especially MHCII+ DC with antigen-presenting capacity. Among ILCs, the CSE/OVA group showed a significant increase of IL-13-producing type 2 ILCs, but not interferon-γ+ ILC1s and IL-17+ ILC3s. Among macrophages, alveolar macrophage and Ym-1 and FIZZ1 positive M2 macrophage populations were significantly induced by CSE exposure alone and when combined with OVA treatment. Conclusion: In this study, we showed that long-term exposure to cigarette smoke contributes to the inception and aggravation of asthmatic inflammation by enhancing DCs, ILC2, and M2 alveolar macrophage populations in the mouse model.","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87841990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics of congenital pulmonary airway malformation of the lungs: A single-center study 先天性肺气道畸形的临床特征:一项单中心研究

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Allergy, Asthma & Respiratory Disease Pub Date : 2023-08-23 DOI: 10.4168/AARD.2021.9.1.21

H. W. Yoo, Seong Heon Kim, Young Mi Kim, M. Kwak, H. Kim

{"title":"Clinical characteristics of congenital pulmonary airway malformation of the lungs: A single-center study","authors":"H. W. Yoo, Seong Heon Kim, Young Mi Kim, M. Kwak, H. Kim","doi":"10.4168/AARD.2021.9.1.21","DOIUrl":"https://doi.org/10.4168/AARD.2021.9.1.21","url":null,"abstract":"Objective: Congenital pulmonary airway malformation (CPAM) is a rare developmental abnormality of the lungs. We investigated clinical characteristics of CPAM based on patient age at diagnosis. Methods: In this retrospective study, we analyzed the medical records of 51 patients diagnosed with CPAM at Pusan National University Hospital between January 2000 and December 2019. Results: We investigated 39 children and 12 adults. The mean age at the diagnosis of the patients was 15.9 ± 14.3 years. The mean ages of children and adults at the time of diagnosis of CPAM were 6.8 ± 5.8 years and 31.2 ± 10.2 years, respectively. Among the 51 patients investigated, 20 (39%) were asymptomatic and 31 (61%) showed clinical symptoms, such as dry cough, recurrent respiratory infections, and dyspnea at the time of diagnosis. Notably, clinical symptoms at diagnosis were observed in 28 children (72%) and in only 3 adults (25%) (P = 0.006), and children were more symptomatic than adults. Children with large cysts tended to be more symptomatic than those with small cysts (P < 0.001). Combined anomalies were detected in 12 patients (23%). Patients with cystic lesions in the right lower lobe of the lung showed a higher prevalence of combined anomalies (P =0.015). Surgical resection was performed in 40 patients (78%), and all patients showed good prognosis. Conclusion: This study revealed that the presence of clinical symptoms of CPAM differed between children and adults, depending on the age at diagnosis and that patients with cysts in the right lower lobe of the lungs tended to show a higher prevalence of combined anomalies. (Allergy Asthma Respir Dis 2021, 9: 21–26)","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84355747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Desensitization for the prevention of drug hypersensitivity 脱敏预防药物超敏反应

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Allergy, Asthma & Respiratory Disease Pub Date : 2023-08-22 DOI: 10.4168/aard.2023.11.2.63

J. Yun, Jiung Jeong, H. Kang

{"title":"Desensitization for the prevention of drug hypersensitivity","authors":"J. Yun, Jiung Jeong, H. Kang","doi":"10.4168/aard.2023.11.2.63","DOIUrl":"https://doi.org/10.4168/aard.2023.11.2.63","url":null,"abstract":"Drug desensitization is a treatment strategy for patients with hypersensitivity to essential drugs without alternatives. The gradual increase in the drug dosage from low doses to therapeutic levels induces a transient immune tolerance to the culprit drug. Although desensitization has traditionally been recommended for IgE-mediated immediate hypersensitivity, this indication has recently been expanded to include non-IgE-mediated immediate responses, nonimmunological responses, and T-cell mediated delayed hypersensitivity reactions. Although the exact mechanism behind desensitization remains unclear, the process is thought to attenuate various intracellular signals in target cells through the high-affinity IgE receptor (FcɛRI) internalization, alteration in signaling pathways in mast cells and basophils, reduction in Ca2+ influx, and production of anti-drug IgG4 blocking antibody. Desensitization can be used for the safe administration of anti-neoplastic agents, antibiotics, aspirin, and nonsteroidal anti-inflammatory drugs. Various desensitization protocols have been proposed for each drug. The optimization of drug concentration, target dosage, administration interval, and route of administration is key to successful desensitization. In addition, the desensitization protocol should be individualized for each patient with consideration of the severity of the initial hypersensitivity response, the characteristics of the culprit drug, and the nature of the breakthrough reactions.","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78898390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Report on the methacholine bronchial provocation test protocol: An updated statement of Korean Academy of Asthma, Allergy and Clinical Immunology 甲胆碱支气管激发试验方案报告:韩国哮喘、过敏和临床免疫学学会的最新声明

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Allergy, Asthma & Respiratory Disease Pub Date : 2023-01-01 DOI: 10.4168/aard.2023.11.2.56

Kyoung-Hee Sohn, H. Kim, Byung-Keun Kim, Joo-Hee Kim, Sang Min Lee, Jae-Hyun Lee, S. Woo, Cheol Hong Kim, J. Jung, Sae-Hoon Kim

引用次数: 0

Behavioral problems in Korean children and adolescents with atopic dermatitis 韩国儿童和青少年特应性皮炎的行为问题

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Allergy, Asthma & Respiratory Disease Pub Date : 2023-01-01 DOI: 10.4168/aard.2023.11.3.144

Sang Hyun Park, Jue Seoung Lee, Young Hye Kim, J. Byeon, W. Yoon, Y. Yoo

引用次数: 0

Comparison of the characteristics of macrolide-sensitive and macrolide-resistant Mycoplasma pneumoniae pneumonia requiring hospitalization in children 大环内酯敏感型和耐大环内酯型肺炎支原体肺炎患儿住院的特点比较

Allergy, Asthma & Respiratory Disease Pub Date : 2023-01-01 DOI: 10.4168/aard.2023.11.4.187

Eun Lee, Seo-Hee Kim

引用次数: 1

Management of hypersensitivity reactions to contrast media 造影剂超敏反应的处理

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Allergy, Asthma & Respiratory Disease Pub Date : 2023-01-01 DOI: 10.4168/aard.2023.11.1.9

Jang-Ho Seo, Jiung Jeong, Jeong-Eun Yun, S. Lee, H. Kang

引用次数: 45

Environmental measures and healthcare service utilization against laboratory animal allergy in Korean laboratory animal researchers 韩国实验动物研究人员对实验动物过敏的环境措施及保健服务利用

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Allergy, Asthma & Respiratory Disease Pub Date : 2023-01-01 DOI: 10.4168/aard.2023.11.1.18

Sung-Yoon Kang, Ha-Kyeong Won, So-Young Park, Sang Min Lee, S. Lee

引用次数: 0

An unexpected association between the blood bilirubin level and eosinophil count 血液胆红素水平和嗜酸性粒细胞计数之间的意外关联

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Allergy, Asthma & Respiratory Disease Pub Date : 2023-01-01 DOI: 10.4168/aard.2023.11.3.151

S. Chung, S. Lee, So-Hee Lee, Sun Sin Kim

引用次数: 0