Anales de la Real Academia Nacional de Medicina最新文献_第7页

High Grade tumor vs stroke. Utility of PET and MRI corregistration 高级别肿瘤vs中风。PET和MRI配准的应用

Anales de la Real Academia Nacional de Medicina Pub Date : 2021-08-31 DOI: 10.32440/ar.2021.138.02.cc01

M. Cabrera-Martín, P. R. Fernández, M. Navas, P. Pérez-Segura, M. Y. Fuertes, J. B. Albacar, J. A. C. Sánchez, L. O. Medina, J. C. Delgado

引用次数: 0

An unusual case of acute abdomen: bilateral ovarian veins thrombophlebitis 一例罕见的急腹症：双侧卵巢静脉血栓性静脉炎

Anales de la Real Academia Nacional de Medicina Pub Date : 2021-08-31 DOI: 10.32440/ar.2021.138.02.cc02

A. Oprişan, M. Solana

引用次数: 0

Treating anemia in chronic kidney disease. ¿An ongoing revolution? 慢性肾脏疾病贫血的治疗。一场正在进行的革命?

Anales de la Real Academia Nacional de Medicina Pub Date : 2021-08-31 DOI: 10.32440/ar.2021.138.02.ed01

A. Ortiz, M. Sánchez-Niño

引用次数: 0

Allergology and COVID19 pandemic 过敏症和covid - 19大流行

Anales de la Real Academia Nacional de Medicina Pub Date : 2021-08-31 DOI: 10.32440/ar.2021.138.02.rev03

Tomás Chivato Pérez

引用次数: 1

Bariatric and metabolic surgery during the COVID-19 crisis: strategies facing two pandemics 新冠肺炎危机期间的减肥和代谢手术：应对两种流行病的策略

Anales de la Real Academia Nacional de Medicina Pub Date : 2021-08-31 DOI: 10.32440/ar.2021.138.02.rev05

Bibiana Lasses Martínez, Jana Dziakova, Antonio Torres

引用次数: 0

Update of pancreas transplantation. Experience of the Hospital Doce de Octubre 胰腺移植的最新情况。10月12日医院的经验

Anales de la Real Academia Nacional de Medicina Pub Date : 2021-08-31 DOI: 10.32440/ar.2021.138.02.rev06

C. Jiménez, E. Moreno, A. Manrique, A. Marcacuzco, Ó. Caso, I. Justo

{"title":"Update of pancreas transplantation. Experience of the Hospital Doce de Octubre","authors":"C. Jiménez, E. Moreno, A. Manrique, A. Marcacuzco, Ó. Caso, I. Justo","doi":"10.32440/ar.2021.138.02.rev06","DOIUrl":"https://doi.org/10.32440/ar.2021.138.02.rev06","url":null,"abstract":"Pancreas transplantation (PT) is considered as the only treatment that can convert a diabetic patient in a euglucemic state without the use of insulin or oral antidiabetic drugs. From 1996 to the end of 2016, more than 50,000 PT were performed in USA, and in Spain were performed 1.730 PT during the last 10 years. In this review we will perform an update of PT considering the introduction of several advances in the last years, adding our accumulated experience from the beginning of our program in the year 1995.\u0000The first PT was carried out in the Hospital of the University of Minnesota, and from that date several significant improvements have been introduced along the time due to advances in surgical technique in pancreas donors and recipients, perioperative management of patients, and introduction of more potent immunosuppressors able to reduce the rejection rate under 20%. Although PT is a therapy associated with a higher morbidity (pancreas graft thrombosis, systemic and intraabdominal infections, anastomotic leakages, etc.), currently most of the PT teams have obtained a rate of 93% of patient survival at 3-years, and between 78% and 83% of graft survival at 3-years.\u0000Additionally, the normal pancreas graft function is associated with an improvement of quality of life and most of complications related to diabetes, without the necessity to treat with antidiabetics drugs or insulin.","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":"229 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41275296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-CD19 CAR-T cell theraphy in pediatric patients with relapsed/refractory acute lymphoblastic leukemia. Experience at Hospital Infantil Universitario Niño Jesús 抗cd19 CAR-T细胞治疗小儿复发/难治性急性淋巴细胞白血病在医院婴儿大学Niño Jesús工作经验

Anales de la Real Academia Nacional de Medicina Pub Date : 2021-08-31 DOI: 10.32440/ar.2021.138.02.rev07

B. Vergara, B. Herrero, L. Madero

{"title":"Anti-CD19 CAR-T cell theraphy in pediatric patients with relapsed/refractory acute lymphoblastic leukemia. Experience at Hospital Infantil Universitario Niño Jesús","authors":"B. Vergara, B. Herrero, L. Madero","doi":"10.32440/ar.2021.138.02.rev07","DOIUrl":"https://doi.org/10.32440/ar.2021.138.02.rev07","url":null,"abstract":"Acute lymphoblastic leukemia (ALL) continues to be the most frequent neoplasm in childhood, with a 5-year survival rate ranging from 78 to 91%. The increase in the survival rate in the last 40 years has been 30 to 80%, with no comparable improvement in the case of relapsed or refractory ALL. It is for this very reason that there is currently research into innovative treatments, such as CAR-T cell therapy. This treatment involves the ex vivo genetic modification of the patient’s own T cells, enhancing their specificity and cytotoxicity against antigens present in the majority of blasts, such as CD19. In clinical trials carried out worldwide, positive results have been obtained in patients with refractory or relapsed ALL treated with CAR-T 19 therapy, with disease-free survival at one year in up to 50% of patients, and overall survival at one year of 76%. The first published report in Spain with respect to this treatment reproduces the results obtained in clinical trials. The results were reported in HNJS in 2020 involving 8 patients treated with CAR-T 19. Complete remission was observed in 87.5% of patients one month after infusion followed by an overall survival of 75% at the time of analysis (7.6 months mean follow-up duration across all the patients). To date, the most frequent side effects described with the use of this therapy in the short term are cytokine release syndrome and neurotoxicity. This innovative therapy, therefore, represents a paradigm shift in the survival of pediatric patients with relapsed or refractory ALL. Further studies and evidence of its effectiveness and the long-term follow-up of patients treated with this therapy are still needed, but the results to date are encouraging.","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42978601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of selective neuronal vulnerability in Parkinson's disease 帕金森病中选择性神经元易感性的决定因素

Anales de la Real Academia Nacional de Medicina Pub Date : 2021-08-31 DOI: 10.32440/ar.2021.138.02.rev01

N. L. Rey, J. Blesa, J. Obeso

{"title":"Determinants of selective neuronal vulnerability in Parkinson's disease","authors":"N. L. Rey, J. Blesa, J. Obeso","doi":"10.32440/ar.2021.138.02.rev01","DOIUrl":"https://doi.org/10.32440/ar.2021.138.02.rev01","url":null,"abstract":"Parkinson´s disease (PD) is the second most frequent neurodegenerative disease affecting the population older than 65 years old. This incidence will greatly increase due to the progressive aging of the population in the coming years. PD diagnosis is made when there is a 50-60% dopaminergic cell loss in the substantia nigra pars compacta (SNc) and the striatal dopamine loss reaches around 70-80%, coinciding with the onset of classical parkinsonian motor signs: tremor, rigidity and slowness of movement. A significant proportion of patients present non-motor symptoms, generally associated to disfunction of non-dopaminergic regions, which can appear before, around or after diagnosis (10-15 years). Therefore, in PD both dopaminergic and non-dopaminergic groups are affected, but the motor manifestations are the main reason for consultation and causes the greatest disability for many years.\u0000There is a large heterogeneity within dopaminergic neural groups in terms of morphology, metabolism, molecular pattern, protein accumulation, inflammation levels, protein expression, etc. In this review we discuss different factors that could explain the special vulnerability of certain dopaminergic neurons in the SNc. Knowledge on the mechanisms and underlying factors of this selective vulnerability of the ventrolateral dopaminergic neuros of the SNc is essential for developing neuromodulatory and/or neuroprotective therapies, leading in turn to halt or modify the neurodegenerative process in PD.","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69671808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Splenectomy and sepsis 脾切除术与败血症

Anales de la Real Academia Nacional de Medicina Pub Date : 2021-04-30 DOI: 10.32440/AR.2021.138.01.REV04

J. Montes

引用次数: 0

Juan Valverde de Amusco in the medicine of the spanish Renaissance Juan Valverde de Amusco与西班牙文艺复兴时期的医学

Anales de la Real Academia Nacional de Medicina Pub Date : 2021-04-30 DOI: 10.32440/AR.2021.138.01.REV09

R. Burgos Lázaro, N. Burgos Frías, JA Blázquez González, F. Gilsanz Rodríguez, G. Téllez de Peralta, JA Rodríguez Montes

引用次数: 0