Anales de la Real Academia Nacional de Medicina最新文献

Initial Therapy of Multiple Myeloma (MM) 多发性骨髓瘤的初步治疗

Anales de la Real Academia Nacional de Medicina Pub Date : 2023-04-30 DOI: 10.32440/ar.2023.140.01.rev08

J.M. Fernández-Rañada de la Gándara

{"title":"Initial Therapy of Multiple Myeloma (MM)","authors":"J.M. Fernández-Rañada de la Gándara","doi":"10.32440/ar.2023.140.01.rev08","DOIUrl":"https://doi.org/10.32440/ar.2023.140.01.rev08","url":null,"abstract":"Multiple myeloma is a plasma cell neoplasm that accounts for approximately 1-1.8% of cancer cases. It constitutes 10% of malignant blood diseases and is the 2nd most common hematopoietic tumor. In Spain, between 2,500 and 3,000 new cases are diagnosed per year with a median age at diagnosis of 69 years. A great effort has been made to try to improve MM survival, which has ranged from 3 years in the 1990s, to 5 years in the 2000s, and is currently of around 8-9 years. This improvement is due to a better definition of diagnostic, prognostic, and response to treatment criteria and to the successive introduction of new drugs: proteasome inhibitors, immunomodulators, and monoclonal antibodies.\u0000Differences have also been established in the therapeutic strategy for multiple myeloma depending on whether the patients are eligible for autologous transplantation of peripheral blood hematopoietic progenitors (TASPE) or ineligible patients. In the first case, the current standard treatment consists of the combination Daraturumab, Velcade, Thalidomide and Dexamethasone (DVTD) – a regime approved by the EMA (European Medicines Agency) – followed by the practice of TASPE and subsequent maintenance therapy with Lenalidomide with or without post-transplant consolidation. For patients who are not candidates for transplantation, current recommendations support the combination of Daraturumab, Revlimid, Dexamethasone (DRD) as the first therapeutic option, while other alternatives are the combination Daraturumab, Velcade, Melphalan, Prednisone (DVMP) or Velcade, Revlimid, Dexamethasone (VRD).","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47457870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atherosclerosis and systemic lupus erythematosus 动脉粥样硬化和系统性红斑狼疮

Anales de la Real Academia Nacional de Medicina Pub Date : 2023-04-30 DOI: 10.32440/ar.2023.140.01.rev03

J. A. Vargas Núñez, M. Yebra Bango, S. Mellor Pita, P. Tutor de Ureta, P. Durán del Campo, R. Castejón Díaz

引用次数: 0

Aβ aggregation and propagation in transgenic models of Alzheimer’s disease 阿尔茨海默病转基因模型中Aβ的聚集和繁殖

Anales de la Real Academia Nacional de Medicina Pub Date : 2023-04-30 DOI: 10.32440/ar.2023.140.01.rev05

J. Andreo-Lopez, M. Bettinetti-Luque, C. Campos-Moreno, A. Gutiérrez, D. Baglietto-Vargas

{"title":"Aβ aggregation and propagation in transgenic models of Alzheimer’s disease","authors":"J. Andreo-Lopez, M. Bettinetti-Luque, C. Campos-Moreno, A. Gutiérrez, D. Baglietto-Vargas","doi":"10.32440/ar.2023.140.01.rev05","DOIUrl":"https://doi.org/10.32440/ar.2023.140.01.rev05","url":null,"abstract":"Alzheimer´s disease (AD) is a complex neurodegenerative disorder that affects mainly the elder population. To date, modifying therapies have not proven to be successful, and therefore, a major effort is necessary to unravel the pathogenic processes underlying AD. New evidences indicate that AD and many other neurodegenerative diseases have commonly the accumulation of misfolded proteins that have the potential to act as infectious agents, and propagate through the entire brain, affecting native proteins. The amyloid peptide (Aβ), characteristic of AD, can adopt a β-sheet conformation acquiring the potential to aggregate and generate misfolded intermediates that can act as ‘’seeds’’ to propagate disease in the brain. Recent findings suggest that these seeds are structurally different depending on the patients and AD subtype, showing different propagation capacity and toxicity. In order to find out which Aβ species or isoforms are more toxic and have greater potential to aggregate, brain extracts from AD patients have been inoculated into transgenic AD mice brains. These approaches have provided much information, however, most of the models contain one or multiple dominant mutations of familial AD cases. This is of great value to mimic the familial forms of the disease, but not the late onset AD (LOAD), which constitute the majority of the cases. Therefore, new animal models are urgently necessary to circumvent these limitations and properly dissect the pathogenic mechanisms of this common form of the disease. As such, a new humanized Aβ model, called hAβ-KI, that has been generated by UCI-MODEL AD center at California, recapitulates certain features of LOAD. This might represent a useful LOAD model to understand how Aβ spreads and favors the progression of the pathology in the brain, hopefully enabling the development of effective therapeutic interventions for AD.","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47630282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

My experience as Editor-in-Chief of Insights into Imaging 我作为《图像洞察》主编的经历

Anales de la Real Academia Nacional de Medicina Pub Date : 2023-04-30 DOI: 10.32440/ar.2023.140.01.rev02

L. Martí-Bonmatí

引用次数: 2

Climate change, health and the elderly 气候变化、健康和老年人

Anales de la Real Academia Nacional de Medicina Pub Date : 2023-04-30 DOI: 10.32440/ar.2023.140.01.rev06

J. R. Ribera Casado

引用次数: 0

Organoids: a powerful evolutive tool 类器官:一个强大的进化工具

Anales de la Real Academia Nacional de Medicina Pub Date : 2023-04-30 DOI: 10.32440/ar.2023.140.01.ed01

B. Fernández-Gutiérrez

引用次数: 0

Uteroglobine and IL2R polymorphisms are associated with articular damaged and surgical joint in patients with Rheumatoid Arthritis 子宫球蛋白和IL2R多态性与类风湿性关节炎患者的关节损伤和手术关节有关

Anales de la Real Academia Nacional de Medicina Pub Date : 2023-04-30 DOI: 10.32440/ar.2023.140.01.org01

N. Oreiro, R. Cáliz, A. Balsa, J. Andreu, R. Sanmartí, F. Blanco

{"title":"Uteroglobine and IL2R polymorphisms are associated with articular damaged and surgical joint in patients with Rheumatoid Arthritis","authors":"N. Oreiro, R. Cáliz, A. Balsa, J. Andreu, R. Sanmartí, F. Blanco","doi":"10.32440/ar.2023.140.01.org01","DOIUrl":"https://doi.org/10.32440/ar.2023.140.01.org01","url":null,"abstract":"Introduction and Objectives. Of all clinical manifestations that mark prognosis of a patient with RA, radiological damaged is considered one of the most important variables. In addition to clinical and laboratory markers are increasingly studying the influence of genetic factors in the predictive ability of the RA forecast. Previous studies have reported misleading results about polymorphisms in different genes associated with radiological damage in RA. The aim of this study was to assess the involvement of the clinical, analytical and genetic variables in the radiological damage in a Spanish RA population.\u0000Methods. Six hundred thirty-two Spanish RA patients were included. SNP genotyping was performed using an oligonucleotide microarray. Allele and genotype association analyses with articular damage and a haplotype association test were performed.\u0000Results. This study includes retrospectively 604 Spanish RA patients with articular erosions and 616 with surgery due to RA. The A587G polymorphism (rs3741240) in uteroglobin gene was associated with increased radiological damage defined by phenotypes RX2 (multiple erosions on hands and feet) and surgery due to RA (OR 1.6 and 1.7 respectively). IL2R polymorphism was associated with RX2 phenotype (OR 2.95). Disease duration, painful joints, ESR, RF and ACPA are the analytical and clinical variables significantly associated with articular damage.\u0000Conclusions. These results demonstrate that the A587G and C4599T polymorphism in uteroglobin and IL2R genes respectively are associated with radiological damage in a Spanish RA population.","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42809557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuronal Aging – Is it reversible? 神经元老化-是可逆的吗?

Anales de la Real Academia Nacional de Medicina Pub Date : 2023-04-30 DOI: 10.32440/ar.2023.140.01.rev04

J. Ávila

引用次数: 0

Coexistence of herpesviridae family viruses in vesicular skin lesions of COVID-19 patients 疱疹病毒家族病毒在新冠肺炎患者水疱性皮肤病变中的共存

Anales de la Real Academia Nacional de Medicina Pub Date : 2023-04-30 DOI: 10.32440/ar.2023.140.01.cc01

A. Reolid, B. Butrón, R. Sampedro, A. Miguélez, E. Daudén, M. Llamas‐Velasco

引用次数: 0

Modifications or organ transplantation due to viral infection by Covid 19 Covid - 19病毒感染导致的器官移植或修饰

Anales de la Real Academia Nacional de Medicina Pub Date : 2023-04-30 DOI: 10.32440/ar.2023.140.01.rev01

E. Moreno gonzález, A. García Sesma, C. Jiménez Romero, C. Loinaz Segurola, A. Manrique, J. Calvo, A. Marcacuzco

{"title":"Modifications or organ transplantation due to viral infection by Covid 19","authors":"E. Moreno gonzález, A. García Sesma, C. Jiménez Romero, C. Loinaz Segurola, A. Manrique, J. Calvo, A. Marcacuzco","doi":"10.32440/ar.2023.140.01.rev01","DOIUrl":"https://doi.org/10.32440/ar.2023.140.01.rev01","url":null,"abstract":"On 31 December 2019 COVID-19 Viral infection was diagnoses. On june 2020 only in 188 countries 33 millons of infected people were detected. Unfortunately in Spain the results of the treatment has been worse than in Germany, Italy, Corea, Taiwan., Grece, Portugal, France, Japan, and others. 778 transplanted patients were infected. 249 of them in Madrid area. Organ donation was reduced. National Organization of Organ Trasplantation diminished donation, and transplantation of kidney, liver, heart, lung close to 90% (in april, 0%) from march to july 2020. Living rolated or split, and cluster trasplantation was not permited. In Madrid area, on 2020 were done 37 transplantation less than in 2019 the causes of that were the reduction of UCI beds, time in the OR, reduction of doctors and nurses. 861.112 infected people, 32.992 died and from the total number of patients, 36.000 were included as, doctors, nurses and other related with health care areas new protocols, hospitals, intensive care areas, etc were established along 2020 going back to the previous results obtained during 2018-2019.","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46442588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0