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Advances in veterinary science and comparative medicine最新文献

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Fasting hyperbilirubinemia in Bolivian squirrel monkeys with a Gilbert's-like syndrome. 患有吉尔伯特氏综合征的玻利维亚松鼠猴的空腹高胆红素血症。
Advances in veterinary science and comparative medicine Pub Date : 1993-01-01
C E Cornelius
{"title":"Fasting hyperbilirubinemia in Bolivian squirrel monkeys with a Gilbert's-like syndrome.","authors":"C E Cornelius","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fasting unconjugated hyperbilirubinemia in Bolivian squirrel monkeys is most likely due to two mechanisms. First, a twofold increase in bilirubin production/turnover occurs during fasting. Increased bilirubin production is subsequently accompanied by increased amounts of unconjugated bilirubin in the hepatic cytosol, which requires conjugation for excretion. The presence of a twofold greater concentration of bilirubin in the livers of fed BoSM with the Gilbert's-like syndrome than in fed control Brazilian squirrel monkeys (BrSM) clearly establishes the presence of an innate subspecies difference, even without the effects of fasting. A second mechanism, which is responsible in part for FH in BoSM, is the presence of a hepatic enzyme, UDP-glucuronyl transferase, which has a higher apparent UDPGAKm and a lower Vm; this results in higher steady-state plasma and hepatic bilirubin levels during a fast when hepatic UDP-glucuronic acid levels are low. The BoSM provides the investigator with an excellent animal model for human Gilbert's syndrome type I in which to study rate-limiting mechanisms in the transport of bilirubin from plasma to bile.</p>","PeriodicalId":75456,"journal":{"name":"Advances in veterinary science and comparative medicine","volume":"37 ","pages":"127-47"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19261434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transhepatic solute transport and bile formation. 肝内溶质转运和胆汁形成。
Advances in veterinary science and comparative medicine Pub Date : 1993-01-01
M S Anwer
{"title":"Transhepatic solute transport and bile formation.","authors":"M S Anwer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75456,"journal":{"name":"Advances in veterinary science and comparative medicine","volume":"37 ","pages":"1-29"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19262236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gunn rat: a model for inherited deficiency of bilirubin glucuronidation. 遗传胆红素糖醛酸化缺乏症大鼠模型。
Advances in veterinary science and comparative medicine Pub Date : 1993-01-01
J R Chowdhury, R Kondapalli, N R Chowdhury
{"title":"Gunn rat: a model for inherited deficiency of bilirubin glucuronidation.","authors":"J R Chowdhury,&nbsp;R Kondapalli,&nbsp;N R Chowdhury","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Experiments in Gunn rats have provided important insights into physiological, biochemical, and molecular mechanisms of bilirubin conjugation and disposition. The Gunn rat is a natural model for bilirubin encephalopathy, and much of our knowledge of bilirubin toxicity and its treatment has come from studies performed in Gunn rats. The genetic lesion in Gunn rats closely parallel those in Crigler-Najjar syndrome, Type I. Presently, the Gunn rat model is being used to develop methods for gene therapy for inherited bilirubin-UGT deficiency. Thus, Gunn rats continue to be a valuable model for the investigation of inherited UGT deficiency and severe nonhemolytic unconjugated hyperbilirubinemia.</p>","PeriodicalId":75456,"journal":{"name":"Advances in veterinary science and comparative medicine","volume":"37 ","pages":"149-73"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19261435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic fatty liver of ruminants. 反刍动物代谢脂肪肝。
Advances in veterinary science and comparative medicine Pub Date : 1993-01-01
M L Bruss
{"title":"Metabolic fatty liver of ruminants.","authors":"M L Bruss","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75456,"journal":{"name":"Advances in veterinary science and comparative medicine","volume":"37 ","pages":"417-49"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19261445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiologic jaundice of the newborn: animal models of perinatal development. 新生儿生理性黄疸:围产期发育的动物模型。
Advances in veterinary science and comparative medicine Pub Date : 1993-01-01
L M Gartner, E Alonso
{"title":"Physiologic jaundice of the newborn: animal models of perinatal development.","authors":"L M Gartner,&nbsp;E Alonso","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75456,"journal":{"name":"Advances in veterinary science and comparative medicine","volume":"37 ","pages":"61-86"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19261447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Portosystemic hepatic encephalopathy related with congenital and acquired hepatopathies in the dog. 门系统性肝性脑病与先天性和获得性肝病的狗。
Advances in veterinary science and comparative medicine Pub Date : 1993-01-01
J Rothuizen
{"title":"Portosystemic hepatic encephalopathy related with congenital and acquired hepatopathies in the dog.","authors":"J Rothuizen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75456,"journal":{"name":"Advances in veterinary science and comparative medicine","volume":"37 ","pages":"403-16"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19261444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Animal models of bilirubin encephalopathy. 胆红素脑病的动物模型。
Advances in veterinary science and comparative medicine Pub Date : 1993-01-01
R P Wennberg
{"title":"Animal models of bilirubin encephalopathy.","authors":"R P Wennberg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75456,"journal":{"name":"Advances in veterinary science and comparative medicine","volume":"37 ","pages":"87-113"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19261448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Animal models of liver fibrosis. 肝纤维化动物模型。
Advances in veterinary science and comparative medicine Pub Date : 1993-01-01
M Rojkind, P Greenwel
{"title":"Animal models of liver fibrosis.","authors":"M Rojkind,&nbsp;P Greenwel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75456,"journal":{"name":"Advances in veterinary science and comparative medicine","volume":"37 ","pages":"333-55"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19261441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative transfusion medicine. 比较输血医学。
Advances in veterinary science and comparative medicine Pub Date : 1991-01-01
{"title":"Comparative transfusion medicine.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75456,"journal":{"name":"Advances in veterinary science and comparative medicine","volume":"36 ","pages":"1-343"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12922147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histocompatibility and bone marrow transplantation. 组织相容性与骨髓移植。
Advances in veterinary science and comparative medicine Pub Date : 1991-01-01 DOI: 10.1016/b978-0-12-039236-0.50010-2
R C Rosenthal
{"title":"Histocompatibility and bone marrow transplantation.","authors":"R C Rosenthal","doi":"10.1016/b978-0-12-039236-0.50010-2","DOIUrl":"https://doi.org/10.1016/b978-0-12-039236-0.50010-2","url":null,"abstract":"","PeriodicalId":75456,"journal":{"name":"Advances in veterinary science and comparative medicine","volume":"36 ","pages":"151-69"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12923421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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