Advances in pathobiology最新文献

Chromosome Structure 染色体结构

Advances in pathobiology Pub Date : 2004-07-30 DOI: 10.1002/0471684228.egp02285

引用次数: 14

Steroid Hormone Receptors 类固醇激素受体

Advances in pathobiology Pub Date : 2002-01-15 DOI: 10.1002/0471203076.EMM0526

Bert W. O’ Malley

引用次数: 1

Genotropic theories of aging: an overview. 衰老的基因分型理论:综述。

Advances in pathobiology Pub Date : 1980-01-01

G M Martin

{"title":"Genotropic theories of aging: an overview.","authors":"G M Martin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have considered a rather wide-ranging number of genotropic theories of aging, defined as those which specify genomic alterations as the key to the understanding of the mechanisms of senescence. The fifteen ideas we have discussed are listed in Table 1, which divides them, in a rather arbitrary fashion, into two broad classes--those which emphasize modifications in gene structure and those which emphasize modifications in gene expression. It seems probable that no single one of these ideas will emerge as \"the\" underlying mechanism of aging, but that many of them will prove to have some credence. The aging process most certainly is under highly polygenic controls. In the case of human beings, I have made crude estimates [33] based upon a analysis of the phenotypes of known or suspected alleles at 2,336 genetic loci and the assumption of an upper limit for man of 100,000 informational loci, that anywhere from about 70-7000 genes could in fact be involved. This should not discourage us from pursuing a search for those loci which may be of profound importance to human aging as it ordinarily occurs in most human beings. In my opinion, however, the most pressing short-term need for biomedical gerontologists is to discover biochemical genetic reasons to explain why certain individuals seem especially prone to one or another of the age-related debilities, such as cancer, the various forms of arteriosclerosis, diabetes mellitus, osteoporosis, osteoarthritis, senile cataracts and senile dementia. Therefore, in my view, the future of progress in geriatric medicine is likely to be closely coupled to progress in medical genetics and genetic pathology.</p>","PeriodicalId":75448,"journal":{"name":"Advances in pathobiology","volume":"7 ","pages":"5-20"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18044956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studies on the biochemistry of the brain during aging. 衰老过程中大脑生物化学的研究。

Advances in pathobiology Pub Date : 1980-01-01

C E Finch

引用次数: 0

Cellular senescence: cell proliferation and its control. 细胞衰老:细胞增殖及其控制。

Advances in pathobiology Pub Date : 1980-01-01

V J Cristofalo

引用次数: 0

The role of the cell surface and the microfibrils in transformation. 细胞表面和微原纤维在转化中的作用。

Advances in pathobiology Pub Date : 1980-01-01

T T Puck