Studies on the biochemistry of the brain during aging.

There is little doubt that aging changes occur in specific brain cells and neural pathways. Since some of these changes occur in short-lived rodents which probably have no major vascular pathology [48], there may be a general phenomenon of aging in the brain neurotransmitter functions in short- and long-lived mammals. It remains to be discovered how the genome regulates the changes in catecholamine neurotransmitter functions and, further, how these changes relate to normal and pathologic age changes.