Advances in metabolic disorders最新文献_第2页

Insulin binding to brain microvessels. 胰岛素与脑微血管的结合。

Advances in metabolic disorders Pub Date : 1983-01-01 DOI: 10.1016/b978-0-12-027310-2.50016-5

H J Frank, W M Pardridge

引用次数: 33

Reciprocal innervation of the liver: its significance in metabolic control. 肝脏的互向神经支配:在代谢控制中的意义。

Advances in metabolic disorders Pub Date : 1983-01-01 DOI: 10.1016/b978-0-12-027310-2.50019-0

T Shimazu

引用次数: 90

Hypothalamic pathways involved in metabolic regulatory functions, as identified by track-tracing methods. 下丘脑通路参与代谢调节功能，通过追踪方法确定。

Advances in metabolic disorders Pub Date : 1983-01-01 DOI: 10.1016/b978-0-12-027310-2.50007-4

J A Ricardo

{"title":"Hypothalamic pathways involved in metabolic regulatory functions, as identified by track-tracing methods.","authors":"J A Ricardo","doi":"10.1016/b978-0-12-027310-2.50007-4","DOIUrl":"https://doi.org/10.1016/b978-0-12-027310-2.50007-4","url":null,"abstract":"The present review of the fiber connections of the hypothalamus has been concerned basically with recent data obtained by the aid of the autoradiographic and HRP tracer techniques. Evidence presented has shown that, besides confirming many of the older data, recent studies have resulted in the introduction of several conceptual modifications into the classic picture of hypothalamic hodological relationships. Among these conceptual modifications, the following can be mentioned: (1) the medially placed nuclei of the hypothalamus have a great number of long efferent and afferent connections with many extrahypothalamic structures; (2) many hypothalamic nuclei send direct projections to cell territories in the brainstem and spinal cord that contain preganglionic autonomic motor neurons; (3) several neural districts that lie caudal to the mesencephalon send direct projections to the hypothalamus; (4) in addition to the olfactory channel, other sensory pathways (including interoceptive and gustatory conduction lines) have a relatively direct access to hypothalamic mechanisms; (5) the hypothalamus sends fibers to several brainstem territories that give rise to widespread monoaminergic projections; and (6) there are anatomical pathways that establish reciprocal connections between the hypothalamus and the basal ganglia. Some of the possible physiological correlates of these anatomical findings in the context of metabolic regulatory functions have been briefly indicated.","PeriodicalId":75445,"journal":{"name":"Advances in metabolic disorders","volume":"10 ","pages":"1-30"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17263589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Conditioned hypoglycemia and conditioned insulin secretion. 条件性低血糖和条件性胰岛素分泌。

Advances in metabolic disorders Pub Date : 1983-01-01 DOI: 10.1016/b978-0-12-027310-2.50026-8

S C Woods

引用次数: 14

Autoradiographic determination of local cerebral glucose metabolism: physiological and pathological studies. 局部脑糖代谢的放射自显影测定:生理和病理研究。

Advances in metabolic disorders Pub Date : 1983-01-01 DOI: 10.1016/b978-0-12-027310-2.50009-8

J H Greenberg, M Reivich

引用次数: 7

CNS regulation of carbohydrate metabolism. 中枢神经系统对碳水化合物代谢的调节。

Advances in metabolic disorders Pub Date : 1983-01-01 DOI: 10.1016/c2013-0-07074-0

A. J. Szabo

引用次数: 26

CNS regulation of carbohydrate metabolism. 中枢神经系统对碳水化合物代谢的调节。

Advances in metabolic disorders Pub Date : 1983-01-01

引用次数: 0

Glucose transfer across the blood--brain barrier. 葡萄糖通过血脑屏障转移。

Advances in metabolic disorders Pub Date : 1983-01-01 DOI: 10.1016/b978-0-12-027310-2.50011-6

M M Hertz, O B Paulson

引用次数: 18

Insulin in the central nervous system. 中枢神经系统中的胰岛素。

Advances in metabolic disorders Pub Date : 1983-01-01 DOI: 10.1016/b978-0-12-027310-2.50018-9

R S Yalow, J Eng

{"title":"Insulin in the central nervous system.","authors":"R S Yalow, J Eng","doi":"10.1016/b978-0-12-027310-2.50018-9","DOIUrl":"https://doi.org/10.1016/b978-0-12-027310-2.50018-9","url":null,"abstract":"In summary, before hypothesizing synthesis of insulin in nonpancreatic tissues, one must determine with some accuracy the insulin concentrations in tissues such as the brain of various species or in IM-9 lymphocytes, or of non-guinea pig insulin in guinea pig tissues. If the concentrations are no more than a few percentage points of the levels initially reported by the NIH laboratory (Havrankova et al., 1978, 1979; Rosenzweig et al., 1980a,b), then some explanation should be given for the erroneously high concentrations that they earlier reported. If the very much lower concentrations that we have reported (Eng and Yalow, 1979, 1980, 1981, 1982; Bauman et al., 1982) are the true levels, then attempts to demonstrate synthesis in extrapancreatic tissues either by amino acid incorporation or by the methodology that has been described by Giddings et al. (1982) are doomed to failure. Our observations that transfer from the periphery can result in insulin levels in the brains of small-brained but not of large-brained animals comparable to or even, on occasion, higher than plasma levels when plasma levels are falling can account for our earlier observations (Eng and Yalow, 1979, 1980) that in rat but not in dog or rabbit brain insulin concentrations may be comparable to plasma levels. Furthermore, the absence of mechanisms in nonendocrine cells for the complex processing of insulin precursors to the 6000-dalton peptide and the absence of proinsulin in the extracts of the variety of tissues reported from the NIH laboratory suggest that the insulin found in these extracts was ultimately derived from pancreatic insulin.","PeriodicalId":75445,"journal":{"name":"Advances in metabolic disorders","volume":"10 ","pages":"341-54"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17424328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of insulin as a satiety factor in the central nervous system. 胰岛素在中枢神经系统中作为饱足因子的作用。

Advances in metabolic disorders Pub Date : 1983-01-01 DOI: 10.1016/b978-0-12-027310-2.50024-4

S C Woods, D Porte

引用次数: 80