M A Gonzalez-Moles, R Caballero, A Rodriguez-Archilla, I Ruiz-Avila, I Bravo
{"title":"Prognosis value of the expression of Ki-67 for squamous cell carcinoma of the oral cavity.","authors":"M A Gonzalez-Moles, R Caballero, A Rodriguez-Archilla, I Ruiz-Avila, I Bravo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ki-67 is a nuclear antigen expressed in G1, S, G2 and M phase of cell cycle and absent in quiescent cells (G0). In some neoplasms, Ki-67 expression has a prognostic value. The purpose of this study was to determine the role of Ki-67 expression like prognostic factor in oral squamous cell carcinoma (OSCC). Monoclonal antibody MIB-1 that recognizes Ki-67 antigen was used. 74 OSCCs were analyzed. 49% of OSCCs did not express Ki-67 antigen. In the Ki-67 positive tumours, the expression was slight in 36.5%, moderate in 10.8% and intense in 10.8% of the cases. In all the positive OSCCs, the distribution of the marking was patchy in different zones of the tumour, moreover, in 65% of the lesions, the positive cells were located mainly in the proximity of intraoral blood vessels. A significantly more intense expression was noted on tumours that had not been differentiated (p < 0.05), with a larger nuclear pleomorphism (p < 0.05) and in lesions that invaded in the form of disassociated neoplastic cells of in small groups of neoplastic cells (p < 0.001). However, the expression of Ki-67 did not correlate with the mitosis count and it had no influence on survival.</p>","PeriodicalId":75420,"journal":{"name":"Acta stomatologica Belgica","volume":"93 4","pages":"159-65"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20576904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Remodelling of bilateral fractures of the mandibular condyle.","authors":"J G Luz, I Chilvarquer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case of complete remodelling of bilateral fractures of the mandibular condyle in an 11-year-old boy is presented. Initial radiographic examination revealed fractures of the right and left condylar neck with medial and anterior dislocation of the proximal fragment. The fractures were treated conservatively, with a short-time intermaxillary fixation and early jaw function, and thirty-five months later the patient was asymptomatic. Radiographic changes observed following treatment have revealed a gradual return to normal shape and position of the condyles.</p>","PeriodicalId":75420,"journal":{"name":"Acta stomatologica Belgica","volume":"93 4","pages":"167-70"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20576905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Swelling of the floor of the mouth: a clinical dilemma.","authors":"L Califano, A Zupi, F Longo, G Coscia, P Piombino","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Swelling of the floor of the mouth is sometime difficult to diagnose clinically. Lithiasis and neoplasm are the most frequent causes of intraoral swelling. Also after plain radiology and computed tomography the diagnosis is often dubious. A case of swelling of the floor of the mouth due to an adenoid cystic carcinoma of the sublingual gland is reported.</p>","PeriodicalId":75420,"journal":{"name":"Acta stomatologica Belgica","volume":"93 3","pages":"101-3"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20411936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Endosseous implants in the radiogenically stressed mandible after a radical operation].","authors":"E Esser","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75420,"journal":{"name":"Acta stomatologica Belgica","volume":"93 3","pages":"105-12"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20411937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M A González-Moles, A Rodríguez-Archilla, I Ruiz-Avila, S González-Moles, R Marfil-Alvarez
{"title":"Increase of proliferating cell nuclear antigen (PCNA) expression in HPV-18 positive oral squamous cell carcinomas.","authors":"M A González-Moles, A Rodríguez-Archilla, I Ruiz-Avila, S González-Moles, R Marfil-Alvarez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Several studies have established a probable relationship between HPV infections and oral neoplasia. The present study analyze the importance of the integration of DNA of HPV type 18 on the proliferative capability of oral squamous cell carcinoma (OSCC) by the study of PCNA expression. Thirty seven patients with OSCC were studied. A complete clinical history and histopathological study was performed. DNA of HPV-18 was found in 7 of the 37 oral OSCCs (19.1%). PCNA expression appeared in 75.7% of OSCCs (28 cases). 9 OSCCs (24.3%) were completely negative, whereas 13 (35.1%), 8 (21.6%) and 7 (18.9%) show minimal, moderate and intense PCNA expression. 4 HPV-18 positive OSCCs showed a intense PCNA expression, 1 OSCC showed moderate PCNA expression, whereas 2 OCSSs showed minimal PCNA expression. Statistical correlations between PCNA expression and DNA HPV-18 amplification showed a more intense PCNA expression in HPV-18 positive OSCCs (p = 0.023). Further studies are needed to establish whether the increase of cellular proliferation induced by HPV-18 has prognostic consequences.</p>","PeriodicalId":75420,"journal":{"name":"Acta stomatologica Belgica","volume":"93 3","pages":"113-8"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20411938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vital fluorescence to assess in vitro and in vivo the antibacterial effects of amalgams.","authors":"L Netuschil, M Brecx, K G Vohrer, P Riethe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of the present study was to establish an alternative methodology for testing the antibacterial effects of different amalgams. The vitality of mutans streptococci grown in vitro on various amalgam surfaces was monitored with a vital fluorescence staining technique using fluorescein diacetate and ethidium bromide. The in vivo effect of amalgam-non-gamma 2 fillings on the vitality of dental plaque was assessed with the same method and compared with samples originating from enamel. The median in vitro vitality of mutans streptococci was estimated as 70% on glass, 50% on Amalcapnon-gamma 2 and Sybraloy, 20% on Amalcap F and 10% on Neo-Silbrin. In vivo plaque vitality on enamel varied from 60 to 70%. In contrast, plaque sampled from non-gamma 2-amalgam surfaces revealed significant reductions in vitality with a minimum value of 25% of one day old supragingival plaque. The vital fluorescence technique was shown as an easy and quick method to assess the bactericidal effect against biofilm bacteria of dental materials in vitro as well as in vivo.</p>","PeriodicalId":75420,"journal":{"name":"Acta stomatologica Belgica","volume":"93 3","pages":"129-34"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20412429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M A González-Moles, S González-Moles, I Ruiz-Avila, F Esteban, P Galindo-Moreno, A Rodríguez-Archilla
{"title":"Epithelial response to the immunitary aggression in oral lichen planus.","authors":"M A González-Moles, S González-Moles, I Ruiz-Avila, F Esteban, P Galindo-Moreno, A Rodríguez-Archilla","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Oral lichen planus is an inflammatory disease with mucous and cutaneous affects caused by cellular immune reaction. Basal cell vacuolation degeneration is the result of T-cell aggression. As the clinical and histopathological alterations of OLP range from epithelial hyperplasia to epithelial atrophy and erosion, it could be that different forms of OLP finally express differences in the intensity of immune attack. The aim of the present study was to analyse the relationship between the clinical and histopathological behaviour and the intensity of the immune response to OLP by means of basal cell vacuolation and inflammatory infiltrate intensity measurement. We analysed 47 patients with OLP. Requirements for inclusion were histopathological diagnosis of OLP from an oral biopsy. Clinical and histopathological correlations were made. OLP's with an intense inflammatory infiltrate were correlated with a high grade of basal cell vacuolations (p < 0.01). A positive statistical correlation between basal cell vacuolation and epithelial atrophy (p < 0.01), and between inflammatory infiltrate intensity and epithelial atrophy (p < 0.01) were observed. An inverse statistical correlation was found when the inflammatory infiltrate intensity and the degree of basal cell vacuolation were compared with epithelial hyperplasia (p < 0.05 and p < 0.01 respectively). In the present study, OLPs with intense immune aggression frequently show epithelial atrophy and erosion on microscopic examination and vice versa.</p>","PeriodicalId":75420,"journal":{"name":"Acta stomatologica Belgica","volume":"93 3","pages":"119-23"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20412427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mediastinitis as a rare complication of an odontogenic infection. Report of a case.","authors":"M Morey-Mas, J Caubet-Biayna, J I Iriarte-Ortabe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mediastinitis occasionally develops as a complication of cervical or odontogenic infections resulting in neck sepsis, which spreads to the mediastinum via the cervical facial planes. Nowadays, this rare complication of pyogenic orofacial infections has an high-unchanged mortality rate. Delayed diagnosis and inadequate mediastinal drainage are the primary causes of this high mortality rate. Aggressive empirical antibiotic combinations should be directed towards this polymicrobial process. Antibiotic therapy alone is inadequate and the mainstay of treatment is aggressive surgical drainage through cervical and thoracic approaches. The assessment and management of the airway is critical; most authors recommend early tracheostomy in a controlled fashion in all cases of serious neck infections with or without thoracic involvement. However, we consider tracheostomy not always necessary and we only perform it in patients with severe dyspnea from upper airway obstruction.</p>","PeriodicalId":75420,"journal":{"name":"Acta stomatologica Belgica","volume":"93 3","pages":"125-8"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20412428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Is it necessary to reform the laws of compensation in the matter of medical professional responsibility?].","authors":"J P Werquin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75420,"journal":{"name":"Acta stomatologica Belgica","volume":"93 2","pages":"79-84"},"PeriodicalIF":0.0,"publicationDate":"1996-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20222882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L Netuschil, K G Vohrer, P Riethe, Z Kasloff, M Brecx
{"title":"Antibacterial effects of amalgams on mutans streptococci in an in vitro biofilm test procedure.","authors":"L Netuschil, K G Vohrer, P Riethe, Z Kasloff, M Brecx","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Conflicting data continue to be presented in the literature regarding the antibacterial potential of various amalgam alloy compositions. The aim of the present study was to compare the antibacterial effects of 4 different amalgam samples on mutans streptococci using two in vitro test procedures. Glass and bovine enamel served as negative controls. The first test, one commonly used, consisted of immersing freshly prepared disks of the six materials in culture broth inoculated with mutans streptococci. Optical density measurements of the broth served to evaluate bacterial growth. This was followed by a biofilm technique which provided more intimate contact between the bacteria and specimen surfaces. With the exception of one high-copper lathe-cut amalgam, the first test revealed no antibacterial potential of the samples whereas the second test with the biofilm design elucidated significant differences in antibacterial potential between the amalgam alloy compositions and the controls. The biofilm technique, used in an in vitro test procedure, reflects the conditions of the oral environment more accurately than conventional test designs.</p>","PeriodicalId":75420,"journal":{"name":"Acta stomatologica Belgica","volume":"93 2","pages":"73-8"},"PeriodicalIF":0.0,"publicationDate":"1996-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20196346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}