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Acta paediatrica Scandinavica. Supplement最新文献

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Spanish multicentre trial of recombinant somatropin. Spanish Collaborative Group. 重组生长激素的西班牙多中心试验。西班牙语合作小组。
Acta paediatrica Scandinavica. Supplement Pub Date : 1988-01-01
E Vicens-Calvet, J M Cuatrecasas-Membrado
{"title":"Spanish multicentre trial of recombinant somatropin. Spanish Collaborative Group.","authors":"E Vicens-Calvet,&nbsp;J M Cuatrecasas-Membrado","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A total of 42 patients (22 previously untreated and 20 previously treated) with GH deficiency were included in a Spanish multicentre trial of recombinant somatropin, 0.5 IU/kg/week. In previously untreated patients typical catch-up growth was observed and the height velocity increased from 3.3 +/- 0.6 cm/year to 9.8 +/- 2.4 cm/year during 1 year of therapy. In previously treated children, the height velocity was maintained (7.2 +/- 2.0 cm/year at the start and 7.9 +/- 1.6 cm/year after 1 year). No anti-GH antibodies were detected in previously untreated patients, and they disappeared from previously treated ones. No adverse reactions were reported.</p>","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"347 ","pages":"180-3"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14208164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Child health in Saudi Arabia. 沙特阿拉伯的儿童健康。
Acta paediatrica Scandinavica. Supplement Pub Date : 1988-01-01
{"title":"Child health in Saudi Arabia.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"346 ","pages":"1-129"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14356737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
5th International Symposium on Growth and Growth Disorders. Proceedings of a meeting. Berlin (West), 8-9 April 1988. 第五届生长和生长障碍国际研讨会。会议记录。柏林(西)，1988年4月8日至9日。
Acta paediatrica Scandinavica. Supplement Pub Date : 1988-01-01
{"title":"5th International Symposium on Growth and Growth Disorders. Proceedings of a meeting. Berlin (West), 8-9 April 1988.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"347 ","pages":"1-165"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14380899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of hypopituitarism with recombinant somatropin for 1 year. 重组生长激素治疗垂体功能减退1年。
Acta paediatrica Scandinavica. Supplement Pub Date : 1988-01-01
K Takano, K Shizume, I Hibi, A Okuno, K Hanyu, S Suwa, H Nakajima, T Kondo, K Kato, N Iwatani
{"title":"Treatment of hypopituitarism with recombinant somatropin for 1 year.","authors":"K Takano,&nbsp;K Shizume,&nbsp;I Hibi,&nbsp;A Okuno,&nbsp;K Hanyu,&nbsp;S Suwa,&nbsp;H Nakajima,&nbsp;T Kondo,&nbsp;K Kato,&nbsp;N Iwatani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Twenty-five hypopituitary patients were treated with recombinant somatropin for 1 year at a dosage of 0.5 IU/kg/week. In previously untreated patients (n = 16), heights increased by between 4.5 and 10.2 cm, with a mean height velocity of 7.7 +/- 1.8 cm/year (mean +/- SD). In previously treated patients (n = 9), heights increased by between 3.9 and 7.6 cm, with a mean height velocity of 5.8 +/- 1.0 cm/year, similar to that observed during previous treatment with pituitary GH. Anti-GH antibodies were observed in two patients at a low titre. The antibodies disappeared in one patient during the treatment. These data indicate that recombinant somatropin has a growth promoting effect and low immunogenicity.</p>","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"347 ","pages":"169-75"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14380904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recombinant somatropin in treatment of growth hormone deficient children in Sweden and Finland. 重组生长激素在瑞典和芬兰治疗生长激素缺乏儿童中的应用。
Acta paediatrica Scandinavica. Supplement Pub Date : 1988-01-01
K Albertsson-Wikland, S Aronson, K O Nilsson, M Ritzén, T Tuvemo, U Westgren, O Westphal, J Perheentupa, I Sipilä, P Wilton
{"title":"Recombinant somatropin in treatment of growth hormone deficient children in Sweden and Finland.","authors":"K Albertsson-Wikland,&nbsp;S Aronson,&nbsp;K O Nilsson,&nbsp;M Ritzén,&nbsp;T Tuvemo,&nbsp;U Westgren,&nbsp;O Westphal,&nbsp;J Perheentupa,&nbsp;I Sipilä,&nbsp;P Wilton","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A total of 23 previously untreated and 28 previously treated GH deficient children were included for at least 12 months in a trial of recombinant somatropin, 0.1 IU/kg/day given by subcutaneous injection. All the children increased their height velocity over the pretreatment values, to nearly 11 cm/year, corresponding to a significant increase in height of 1 SD score for chronological age. The increase in height SD score for bone age was also statistically significant. No adverse effects were recorded, though one child experienced local itching and redness at the injection site which did not recur after a short cessation of therapy. One child developed detectable antibodies to recombinant somatropin, but the binding capacity was low and no clinical symptoms or growth attenuation occurred. Recombinant somatropin was shown to be safe and effective during the first year of therapy in children with GH deficiency.</p>","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"347 ","pages":"176-9"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14380905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variations in duration of pubertal growth: a mechanism compensating for differences in timing of puberty and minimizing their effects on final height. Belgian Study Group for Paediatric Endocrinology. 青春期生长持续时间的变化:一种补偿青春期时间差异并使其对最终身高影响最小化的机制。比利时儿科内分泌学研究组。
Acta paediatrica Scandinavica. Supplement Pub Date : 1988-01-01
J P Bourguignon
{"title":"Variations in duration of pubertal growth: a mechanism compensating for differences in timing of puberty and minimizing their effects on final height. Belgian Study Group for Paediatric Endocrinology.","authors":"J P Bourguignon","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It is unclear how important age at onset of puberty is for adult stature. The growth effects of differences in timing of puberty have been studied on a bone age basis in 22 hypopituitary boys and on a chronological age basis in male subjects with early, normal or delayed onset of puberty. Very early onset of puberty results in short adult stature. This is because a marked reduction of prepubertal height gain is only partially compensated for by an increase in pubertal height gain. In contrast, very late onset of puberty determines no increase or a minor increase in adult stature. This results from a reduction in pubertal height gain, counterbalancing the increased prepubertal height gain. Differences in duration of growth are the major factor accounting for the different height gains observed in relation to timing of puberty, while mean growth rate shows only minor changes. The differences in duration of pubertal growth are paralleled by differences in the rate of bone maturation, which therefore do not account for differences in duration of puberty. It is concluded that, except in severely precocious puberty, manipulation of the timing of puberty is unlikely to affect final height to any great extent.</p>","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"347 ","pages":"16-24"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14380903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time series analysis in endocrinology. 内分泌学中的时间序列分析。
Acta paediatrica Scandinavica. Supplement Pub Date : 1988-01-01
D R Matthews
{"title":"Time series analysis in endocrinology.","authors":"D R Matthews","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Many hormones are secreted in pulses or oscillations. If deductions about amplitude or frequency of these oscillations are to be made, then the oscillatory attributes must be analysed. The method of doing this is known as time series analysis. Samples for such analysis need to be properly spaced, taken for a sufficient period of time and de-trended. The techniques of pulse counting, autocorrelation or Fourier transformation may then be applied to demonstrate dominant features in groups of subjects. The advantages and disadvantages of these methods are discussed.</p>","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"347 ","pages":"55-62"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14380907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maturation of steroidogenic cells: a target for IGF-I. 类固醇生成细胞的成熟:IGF-I的靶标。
Acta paediatrica Scandinavica. Supplement Pub Date : 1988-01-01
P Chatelain, A Penhoat, M H Perrard-Sapori, C Jaillard, D Naville, J Saez
{"title":"Maturation of steroidogenic cells: a target for IGF-I.","authors":"P Chatelain,&nbsp;A Penhoat,&nbsp;M H Perrard-Sapori,&nbsp;C Jaillard,&nbsp;D Naville,&nbsp;J Saez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Using primary culture of steroidogenic cells in vitro, in serum-free chemically defined medium, strong evidence has been provided for actions of IGF-I on the differentiation of immature Leydig cells and on the maintenance of a differentiated function of mature adrenocortical cells. These data point to the steroidogenic cells as a target for IGF-I action. They also add further evidence for a role of IGF-I in the differentiation process. These actions can be of importance in normal physiological situations as well as in abnormal conditions where IGF-I is decreased, such as hypopituitarism and malnutrition.</p>","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"347 ","pages":"104-9"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13992014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New concepts of the growth spurt of puberty. 青春期生长突增的新概念。
Acta paediatrica Scandinavica. Supplement Pub Date : 1988-01-01
R Stanhope, M A Preece, D B Grant, C G Brook
{"title":"New concepts of the growth spurt of puberty.","authors":"R Stanhope,&nbsp;M A Preece,&nbsp;D B Grant,&nbsp;C G Brook","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The timing of the growth spurt of normal children does not affect their final height attainment. Growth rate during the growth acceleration of puberty correlates with changes in GH, and not sex steroid, secretion. GH secretion during puberty is pulse amplitude, and not frequency, modulated. In both central precocious puberty and normal puberty suppressed with a GnRH analogue, the rate of epiphyseal maturation is decreased as are GH pulse amplitude and growth, but with no influence on final height.</p>","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"347 ","pages":"30-7"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14208167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Growth promoting activity of IGF-I in the rat. igf - 1在大鼠体内的促生长活性。
Acta paediatrica Scandinavica. Supplement Pub Date : 1988-01-01
I C Robinson, R G Clark
{"title":"Growth promoting activity of IGF-I in the rat.","authors":"I C Robinson,&nbsp;R G Clark","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>According to the original somatomedin hypothesis, GH promotes growth by generating 'somatomedins' or insulin-like growth factors (IGFs) in the liver. The advent of large amounts of IGF-I produced by recombinant DNA technology has now allowed testing of this hypothesis, by comparing the growth promoting activity of IGF-I and GH in three animal models of growth deficiency. When injected or infused subcutaneously, or infused intravenously, IGF-I is a weak growth promoter in the hypophysectomized rat compared with GH, even when infused in combination with small amounts of GH. Growth arrest in the diabetic rat was corrected by insulin infusion which also restored GH secretion. Insulin or IGF-I caused a large initial weight gain in diabetic rats, accompanied by a partial correction of food and water balance, even in the presence of persistent hyperglycaemia. A new mutant GH deficient dwarf rat grows in response to both GH and IGF-I infusions, but these agents elicit different patterns of organ growth. For the same overall body growth, GH was more effective in stimulating bone growth, whereas IGF-I stimulated renal and splenic growth. This new dwarf rat may prove useful for the study of the relative growth promoting effects of IGF-I and GH in more detail in future.</p>","PeriodicalId":75408,"journal":{"name":"Acta paediatrica Scandinavica. Supplement","volume":"347 ","pages":"93-103"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14208170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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