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Acta neuropathologica. Supplementum最新文献

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Glycosaminoglycans of brain tumors transplacentally induced by ENU in the rat. ENU经胎盘诱导大鼠脑肿瘤的糖胺聚糖研究。
Acta neuropathologica. Supplementum Pub Date : 1981-01-01 DOI: 10.1007/978-3-642-81553-9_24
M T Giordana, A Mauro, D Schiffer
{"title":"Glycosaminoglycans of brain tumors transplacentally induced by ENU in the rat.","authors":"M T Giordana,&nbsp;A Mauro,&nbsp;D Schiffer","doi":"10.1007/978-3-642-81553-9_24","DOIUrl":"https://doi.org/10.1007/978-3-642-81553-9_24","url":null,"abstract":"<p><p>GAGs accumulate in the oligodendrogliomas and in the oligodendroglial component of mixed gliomas induced in rats by transplacental ENU. We studied the period between birth and the appearance of the earliest tumoral lesions and did not find any accumulation preceding the early neoplastic proliferations. These findings, together with the observation that GAGs are present only in the oligodendroglial component of tumors, are in agreement with our previous interpretation that the tumoral transformation of oligodendroglia takes place after it has acquired the ability to interfere with GAG metabolism during myelinogenesis.</p>","PeriodicalId":75397,"journal":{"name":"Acta neuropathologica. Supplementum","volume":"7 ","pages":"79-80"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17986109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Detection of glycosaminoglycans in human gliomas by histochemical methods. 组织化学方法检测人胶质瘤中糖胺聚糖。
Acta neuropathologica. Supplementum Pub Date : 1981-01-01 DOI: 10.1007/978-3-642-81553-9_25
P Böck, K Jellinger
{"title":"Detection of glycosaminoglycans in human gliomas by histochemical methods.","authors":"P Böck,&nbsp;K Jellinger","doi":"10.1007/978-3-642-81553-9_25","DOIUrl":"https://doi.org/10.1007/978-3-642-81553-9_25","url":null,"abstract":"<p><p>Sulphatized mucopolysaccharides or glycosaminoglycans (GAG) were examined by histochemical methods in biopsy specimens of 69 human cerebral gliomas. The intensity of cell-surface associated GAGs, particularly of the -SO3-groups, was highest in isomorphic oligodendrogliomas and astrocytomas except for pilocytic forms. It showed progressive decrease with increasing degree of anaplasia of these tumors. Anaplastic gliomas only rarely show a very weak reaction for -SO3-groups which was completely absent in glioblastomas, where GAGs are only found in blood vessel walls and mesenchymal stroma. In accordance with observations in experimental gliomas, the rapid loss of membrane-associated GAGs in anaplastic gliomas is considered to indicate a progressive cellular dedifferentiation of glial cells due to hitherto unknown metabolic changes.</p>","PeriodicalId":75397,"journal":{"name":"Acta neuropathologica. Supplementum","volume":"7 ","pages":"81-4"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17988500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
The fine structure of cells in astrocytomas of various grades of malignancy. 不同恶性程度星形细胞瘤细胞的精细结构。
Acta neuropathologica. Supplementum Pub Date : 1981-01-01 DOI: 10.1007/978-3-642-81553-9_27
G Ebhardt, J Cervós-Navarro
{"title":"The fine structure of cells in astrocytomas of various grades of malignancy.","authors":"G Ebhardt,&nbsp;J Cervós-Navarro","doi":"10.1007/978-3-642-81553-9_27","DOIUrl":"https://doi.org/10.1007/978-3-642-81553-9_27","url":null,"abstract":"<p><p>87 gliomas were studied electron microscopically. 9 tumors were excluded from the series as mixed gliomas. The ultrastructure of the cell cytoplasm was considered particularly relevant for the present study. According to the electron density and arrangement of organelles and cytofilaments 4 basic cell types I (Ia), II, III, and IV are defined. An attempt is made to scatch the development of immature glial cells in slowly grown tumors as well as their dedifferentiation in 2 cell types V and VI in malignant growths.</p>","PeriodicalId":75397,"journal":{"name":"Acta neuropathologica. Supplementum","volume":"7 ","pages":"88-90"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17323462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Ependymal variations in the caudal spinal cord. 尾侧脊髓室管膜变异。
Acta neuropathologica. Supplementum Pub Date : 1981-01-01 DOI: 10.1007/978-3-642-81553-9_110
G Stoltenburg-Didinger, R Bienentreu
{"title":"Ependymal variations in the caudal spinal cord.","authors":"G Stoltenburg-Didinger,&nbsp;R Bienentreu","doi":"10.1007/978-3-642-81553-9_110","DOIUrl":"https://doi.org/10.1007/978-3-642-81553-9_110","url":null,"abstract":"<p><p>The lumbosacral spinal cord including the cauda equina was examined in 100 unselected autopsied cases of infants dying at or near term. A striking finding in 10% of these cases was the occurrence of bilateral collections of ependymal cells lying in rows on the surface of the lumbosacral cord. In another 25% the central canal was forked or duplicate. These foci were not associated with evidence of defective neural tube closure or spina bifida; the central canal was of normal length. There was no relationship between the ependymal structures and systemic clinical or pathological findings. The pathogenesis and significance of these lesions is unclear. Our observations suggest that they occur regularly and are not associated with neurological disturbances. The relationship of the ependymal cell collections to ependymomas of the caudal spinal cord is open to speculation.</p>","PeriodicalId":75397,"journal":{"name":"Acta neuropathologica. Supplementum","volume":"7 ","pages":"386-8"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-642-81553-9_110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17990145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
"Thalamic" dementia in herpes encephalitis: clinico-pathological report. 疱疹性脑炎的“丘脑”痴呆:临床病理报告。
Acta neuropathologica. Supplementum Pub Date : 1981-01-01 DOI: 10.1007/978-3-642-81553-9_47
G Pilleri, V Pietrini, F Tagliavini, G Trabattoni, A Lechi
{"title":"\"Thalamic\" dementia in herpes encephalitis: clinico-pathological report.","authors":"G Pilleri,&nbsp;V Pietrini,&nbsp;F Tagliavini,&nbsp;G Trabattoni,&nbsp;A Lechi","doi":"10.1007/978-3-642-81553-9_47","DOIUrl":"https://doi.org/10.1007/978-3-642-81553-9_47","url":null,"abstract":"<p><p>Herpes zoster (HZ) primary affections of the CNS are rare and, in most of the reported patients, are representing variously extended forms of ascending myelitis. Our examination concerns a man who at the age of 37 developed apathy after a feverish episode with iridocyclitis. Six months later an ophthalmic HZ was diagnosed and thenceforth the patient showed a dementia with Korsakow's syndrome, apathy and a right hemipalsy, and diplopia appeared; the later symptoms remitted after steroid therapy. Post-mortem examination revealed a slowly progressive encephalitis with symmetrical impairment of the anterior ventral, medial, and centrum medianum of the thalamus. The HZ origin of the lesions and the relation between their site and the peculiar form of dementia, to be ascribed to the \"thalamic\" ones, are discussed. A vasculitis process can be hypothesized considering both the symmetrical localisation and the microscopical aspects of the lesions.</p>","PeriodicalId":75397,"journal":{"name":"Acta neuropathologica. Supplementum","volume":"7 ","pages":"156-9"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18020625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Progressive oil-spot-like lesion in multiple sclerosis. 多发性硬化症的进行性油斑样病变。
Acta neuropathologica. Supplementum Pub Date : 1981-01-01 DOI: 10.1007/978-3-642-81553-9_55
A. Petrescu
{"title":"Progressive oil-spot-like lesion in multiple sclerosis.","authors":"A. Petrescu","doi":"10.1007/978-3-642-81553-9_55","DOIUrl":"https://doi.org/10.1007/978-3-642-81553-9_55","url":null,"abstract":"","PeriodicalId":75397,"journal":{"name":"Acta neuropathologica. Supplementum","volume":"7 1","pages":"182-4"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51188936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Sensorimotor polyneuropathy in light chain multiple myeloma. 轻链多发性骨髓瘤的感觉运动多神经病变。
Acta neuropathologica. Supplementum Pub Date : 1981-01-01 DOI: 10.1007/978-3-642-81553-9_75
G Pellegrini, G Scarlato, M Moggio, C Bettinelli, S M Gaini
{"title":"Sensorimotor polyneuropathy in light chain multiple myeloma.","authors":"G Pellegrini,&nbsp;G Scarlato,&nbsp;M Moggio,&nbsp;C Bettinelli,&nbsp;S M Gaini","doi":"10.1007/978-3-642-81553-9_75","DOIUrl":"https://doi.org/10.1007/978-3-642-81553-9_75","url":null,"abstract":"<p><p>The authors describe an adult onset sensorimotor polyneuropathy in a woman with light chain K-type myeloma. Neurophysiological investigation showed a severe reduction of conduction velocity of the peripheral nerve to the four limbs. A muscle and sural nerve biopsy were performed. Sural nerve displayed a severe loss of myelinated and unmyelinated fibers. No amyloid deposit was observed in vessels, perineurium and endomysium by electron microscopy examination. No onion bulb formation was present in nerve tissue, but many demyelinated fibers were surrounded by circumferentially disposed Schwann cell processes without any interposition of collagen fibrils. Some fibers exhibit signs of active remyelination; axonal alterations were rarely seen. Collagen pockets were frequently observed among proliferated collagen fibrils. The mechanism of peripheral nerve lesions in various categories of multiple myeloma is till now an unsolved problem. In this case the unusual association with a light chain myeloma suggest that these immunoglobulins play a role in the pathogenesis of the polyneuropathy as supported by experimental studies.</p>","PeriodicalId":75397,"journal":{"name":"Acta neuropathologica. Supplementum","volume":"7 ","pages":"255-7"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17836588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Effect of prolonged acetylcholinesterase inhibition on postnatal brain development in rabbit. I. Level of serotonin in different brain regions. 长期抑制乙酰胆碱酯酶对家兔出生后脑发育的影响。1 .不同脑区的血清素水平。
Acta neuropathologica. Supplementum Pub Date : 1981-01-01 DOI: 10.1007/978-3-642-81553-9_16
D Maślińska, I Lewandowska, J Prokopczyk
{"title":"Effect of prolonged acetylcholinesterase inhibition on postnatal brain development in rabbit. I. Level of serotonin in different brain regions.","authors":"D Maślińska,&nbsp;I Lewandowska,&nbsp;J Prokopczyk","doi":"10.1007/978-3-642-81553-9_16","DOIUrl":"https://doi.org/10.1007/978-3-642-81553-9_16","url":null,"abstract":"<p><p>Studies were performed on young rabbits treated with dichlorvos (organophosphorus pesticide) 9 mg/kg/day by oral gavage. Pesticide was given for 10 days starting on the 6th day of life or as a single dose on the 16th day of life. Animals were sacrificed 30 min, 3 und 24 h after treatment. The spinal cord and the brain were removed and 6 regions (neocortex, hippocampus, basal ganglia, mesencephalon, brain stem, cerebellum) were isolated. Acethylcholinesterase activity was estimated by biochemical and histochemical methods. The concentration of serotonin in brain regions was determined. Acute and prolonged intoxication with dichlorvos inhibited acethylcholinesterase activity. As revealed the histochemical studies, single dose decreased activity of enzyme mainly in neuropil. Prolonged intoxication decreased the acethylcholinesterase in neuropil and in neurons. The single dose of dichlorvos caused the increase of serotonin concentration in all brain regions. After prolonged intoxication the decrease of serotonin concentration in brain stem, mesencephalon and hippocampus for 78, 74, 41% respectively was observed. The cholinergic-serotonergic link is discussed.</p>","PeriodicalId":75397,"journal":{"name":"Acta neuropathologica. Supplementum","volume":"7 ","pages":"52-5"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17986104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Subsequent morphological changes in periodic paralysis. A study of seven cases. 周期性麻痹后的形态学改变。对七个案例的研究。
Acta neuropathologica. Supplementum Pub Date : 1981-01-01 DOI: 10.1007/978-3-642-81553-9_86
M C Faugere, J F Pellissier, M Toga
{"title":"Subsequent morphological changes in periodic paralysis. A study of seven cases.","authors":"M C Faugere,&nbsp;J F Pellissier,&nbsp;M Toga","doi":"10.1007/978-3-642-81553-9_86","DOIUrl":"https://doi.org/10.1007/978-3-642-81553-9_86","url":null,"abstract":"<p><p>Muscle biopsies were studied in seven patients with various types of periodic paralysis. A sequence for the histopathological feature is suggested: 1. Histology may be normal early in the disease. 2. Vacuolation is found during the active phase characterized by frequent attacks. 3. Tubular aggregates appear later when the frequency of the attacks decreases. 4. Degenerative changes are correlated with the presence of permanent myopathic weakness.</p>","PeriodicalId":75397,"journal":{"name":"Acta neuropathologica. Supplementum","volume":"7 ","pages":"301-4"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17989132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Morphometric comparison of Duchenne's muscular dystrophy and experimental bupivacaine myopathy. 杜氏肌营养不良症与实验性布比卡因肌病的形态学比较。
Acta neuropathologica. Supplementum Pub Date : 1981-01-01 DOI: 10.1007/978-3-642-81553-9_87
W J Cumming, P Hudgson
{"title":"Morphometric comparison of Duchenne's muscular dystrophy and experimental bupivacaine myopathy.","authors":"W J Cumming,&nbsp;P Hudgson","doi":"10.1007/978-3-642-81553-9_87","DOIUrl":"https://doi.org/10.1007/978-3-642-81553-9_87","url":null,"abstract":"<p><p>The findings of this study confirm the role of the hyaline fibre in D.M.D. and support the concept of continuing necrosis with progressive failure of regeneration as the major factor in the aetiology of the pathological changes. The persistence of internal nuclei , \"split\" fibres and progressive fibrosis are secondary phenomenon. Comparison of the changes in D.M.D. with those seen in experimental Bupivacaine myopathy shows that the changes in the experimental myopathy are comparable to those seen in D.M.D. between the ages of 4 and 6 years. It is suggested that Bupivacaine myopathy is an acceptable animal model for D.M.D.</p>","PeriodicalId":75397,"journal":{"name":"Acta neuropathologica. Supplementum","volume":"7 ","pages":"305-7"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17989133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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