Acta neurologica Scandinavica. Supplementum最新文献_第7页

Future research in epileptology. Proceedings of the Harry Meinardi Congress 1992. 癫痫学的未来研究。1992年Harry Meinardi大会论文集。

Acta neurologica Scandinavica. Supplementum Pub Date : 1992-01-01

引用次数: 0

Proceedings of the 29th Scandinavian Congress of Neurology. Aarhus, Denmark, June 17-20, 1992. Abstracts. 第29届斯堪的纳维亚神经病学大会论文集。丹麦奥胡斯，1992年6月17日至20日。摘要。

Acta neurologica Scandinavica. Supplementum Pub Date : 1992-01-01

引用次数: 0

Alzheimer's disease. Proceedings of the Karolinska Institute 1991. 阿尔茨海默氏症。《卡罗林斯卡学院学报》1991。

Acta neurologica Scandinavica. Supplementum Pub Date : 1992-01-01

引用次数: 0

Intermittent diazepam prophylaxis in febrile convulsions. Pros and cons. 间歇性地西泮预防热性惊厥。利与弊。

Acta neurologica Scandinavica. Supplementum Pub Date : 1991-01-01

F U Knudsen

{"title":"Intermittent diazepam prophylaxis in febrile convulsions. Pros and cons.","authors":"F U Knudsen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Major cohort studies document that the long-term prognosis for most children with febrile convulsions (FC) is excellent. The 2 main treatment alternatives so far have been long-term prophylaxis with phenobarbital or valproate or no prophylaxis at all. Phenobarbital at times of fever is ineffective and obsolete. Consensus has emerged that long-term prophylaxis with antiepileptic drugs is rarely justified in FC considering the side effects and the favourable prognosis. No treatment at all does not appear quite satisfactory either, as FC have a high recurrence rate, disrupt family life and may have emotional consequences for the family. Moreover, all FC children face a risk, although admittedly low, of subsequent long-lasting potentially central nervous system (CNS)-damaging seizures. However, 2 further options exist: treatment with rapid-acting benzodiazepines solely at times of greatest risk, i.e., at high fever or at renewed seizures. Several clinical trials have confirmed that intermittent diazepam prophylaxis by way of a few doses of the drug per year provides effective seizure control and reduces the recurrence rate by one half or two thirds. The treatment is feasible and cheap, well tolerated by the child and well accepted by the parents. Compliance problems are common and only partly abatable. Trivial side effects are frequent. Transient respiratory apnoea does occur, but 15 years' experience substantiates that serious side effects are remarkably rare. Acute anticonvulsant treatment with rectal diazepam in solution given by the parents to stop ongoing seizures and to prevent immediate recurrences is an attractive alternative. It is feasible, is probably effective and minimizes the use of drugs, but compliance problems are common and protracted seizures are not always controlled. The subsequent management should include a risk profile approach considering a combination of risk factors for new FC rather than a single factor. By means of a risk index, based on simple clinical data including age at onset, family seizure history, seizure type and frequency of fever, children may be identified as being at low, intermediate or high risk for further febrile fits. However, risk factors for new FC and not for subsequent epilepsy should be used. It is concluded that preventing or abbreviating new FC with benzodiazepines appears to be a useful, although not ideal, drug-minimizing approach in managing many children with simple or complex FC. From a health hazard viewpoint, treatment is not strictly mandatory, although advisable. A selective strategy seems rational. Intermittent diazepam prophylaxis may preferably be offered to children at high risk for new FC.(ABSTRACT TRUNCATED AT 400 WORDS)</p>","PeriodicalId":75395,"journal":{"name":"Acta neurologica Scandinavica. Supplementum","volume":"135 ","pages":"1-24"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13019556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge, attitude and practice in antiepileptic drug monitoring. 抗癫痫药物监测的知识、态度与实践。

Acta neurologica Scandinavica. Supplementum Pub Date : 1991-01-01

J W Meijer

引用次数: 0

New approaches to the treatment of early Parkinson's disease. 治疗早期帕金森病的新方法。

Acta neurologica Scandinavica. Supplementum Pub Date : 1991-01-01

引用次数: 0

Proceedings of the 28th Scandinavian Congress of Neurology. Reykjavík, Iceland June 6-9, 1990. Abstracts. 第28届斯堪的纳维亚神经病学大会论文集。Reykjavík，冰岛，1990年6月6日至9日。摘要。

Acta neurologica Scandinavica. Supplementum Pub Date : 1990-02-01 DOI: 10.1111/J.1600-0404.1990.TB08026.X

S. Thorlacius, G. Guomundsson

引用次数: 16