Acta medica Austriaca. Supplement最新文献_第3页

[Value of questionnaires for screening in diagnosis of diabetes]. [问卷筛查在糖尿病诊断中的价值]。

Acta medica Austriaca. Supplement Pub Date : 2002-01-01

Th Wascher

引用次数: 0

Prognostic value of tumour cell detection in peripheral blood of breast cancer patients. 乳腺癌患者外周血肿瘤细胞检测的预后价值。

Acta medica Austriaca. Supplement Pub Date : 2002-01-01

O Zach, H Kasparu, H Wagner, O Krieger, D Lutz

{"title":"Prognostic value of tumour cell detection in peripheral blood of breast cancer patients.","authors":"O Zach, H Kasparu, H Wagner, O Krieger, D Lutz","doi":"","DOIUrl":"","url":null,"abstract":"To investigate the prognostic value of tumour cells in peripheral blood (pB) of breast cancer (BC) patients, pB samples from 143 patients with benign lesions of the breast and from 467 BC patients were tested via a nested RT-PCR assay for mammaglobin mRNA. No sample from patients with benign lesions of the breast was found to be mammaglobin positive in contrast to 5/310 (2%) BC patients with no evidence of disease (NED) and 46/157 (29%) patients with metastatic disease (MD). Two hundred and eighteen BC patients with NED were followed for at least 12 months. All five mammaglobin-positive BC patients relapsed 1-13 months after first examination of positive pB samples in contrast to 27/213 (13%) patients without detectable tumour cells in pB. Fifty-nine BC patients with MD were tested for mammaglobin expression in pB at the time of first diagnosis of MD; 20 of them (34%) were mammaglobin positive. Patients were followed for a median of 19 months (2-51 months). During this time, 19/59 (32%) died due to tumour progression. In Kaplan-Meier survival analysis, BC patients with mammaglobin-negative pB samples at time of diagnosis of MD lived significantly longer than mammaglobin-positive patients (log-rank test: P = 0.0013). In addition, mammaglobin was an independent prognostic parameter and the difference reached significance in univariate as well as in multivariate analysis (P < 0.01). We conclude that the presence of tumour cells in pB of BC patients is of prognostic value.","PeriodicalId":75382,"journal":{"name":"Acta medica Austriaca. Supplement","volume":"59 ","pages":"32-4"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22175807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Tumor biology of primary breast cancer and minimal residual disease]. [原发性乳腺癌和微小残留病的肿瘤生物学]。

Acta medica Austriaca. Supplement Pub Date : 2002-01-01

C Schindlbeck, W Janni, P Schaffer, N Shabani, M Schmitt, N Harbeck, H Sommer, S Braun

{"title":"[Tumor biology of primary breast cancer and minimal residual disease].","authors":"C Schindlbeck, W Janni, P Schaffer, N Shabani, M Schmitt, N Harbeck, H Sommer, S Braun","doi":"","DOIUrl":"","url":null,"abstract":"The immunocytochemical detection of isolated disseminated tumor cells (ITC) in the bone marrow of breast cancer patients, what is called minimal residual disease (MRD), has been demonstrated to be of prognostic value in all stages of the disease. In order to definitely prove the origin of these cells from the primary tumor it is necessary to identify common factors on both tumor tissue and ITC, furthermore a more detailed characterization could help to improve their prognostic impact by defining certain subgroups and possibly establish new therapeutic strategies. We examined the expression/amplification of HER2neu, CD 44 adhesion molecule and CD 31 angiogenetic factor on more than 200 primary tumor tissues by immunohistochemistry or fluorescence in situ hybridisation, resp., and found no sign. correlation with the detection of ITC. After a median follow-up of 32 months only ITC in the bone marrow were of prognostic significance. In a small number of patients we examined the expression of topoisomerase II alpha, a key enzyme of DNA replication, and its predictive value of eliminating ITC by anthracyclin based chemotherapy. No correlation with the presence of ITC before or after chemotherapy could be found, yet pat. with topoisomerase II alpha neg. tumors showed a trend to reduced disease free survival. Because of the very low number of ITC per bone marrow sample, the direct characterization of these factors on ITC stays difficult without the possibility of tumor cell enrichment or cell culture. Preliminary results on multi colour stained samples indicate that a selection of certain biological factors takes place during tumor cell dissemination.","PeriodicalId":75382,"journal":{"name":"Acta medica Austriaca. Supplement","volume":"59 ","pages":"27-31"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22175806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[2002 Spring Meeting of the Austrian Society of Hematology and Oncology. Abstracts]. [2002年奥地利血液与肿瘤学会春季会议]。摘要]。

Acta medica Austriaca. Supplement Pub Date : 2002-01-01

引用次数: 0

[Internal Medicine 2002. Festschrift for University Professor Dr. Georg Geyer. 3 June 2002. Abstracts]. [内科医学2002]。2002年6月3日，大学教授乔治·盖耶博士。摘要]。

Acta medica Austriaca. Supplement Pub Date : 2002-01-01

引用次数: 0

[Significance of minimal residual disease for the estimation of the prognosis and for therapeutic decisions in solid tumors]. [微小残留病对实体瘤预后评估和治疗决策的意义]。

Acta medica Austriaca. Supplement Pub Date : 2002-01-01

W Hinterberger, Veronika Buxhofer, E Ogris, P Zelenka, P Kier, R Ruckser, S Dorner, K H Habertheuer, H Vedovelli, S Schindler, M Hinterberger-Fischer

引用次数: 0

[29th Annual Meeting of the Austrian Diabetes Society. Baden bei Wien, 28 November-1 December 2000. Abstracts]. [第29届奥地利糖尿病学会年会]。2000年11月28日至12月1日，维也纳巴登。摘要]。