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Acta cardiologica. Supplementum最新文献

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Treatment of ventricular arrhythmias: role of mexiletine: symposium held under the patronage of the Belgian Society of Cardiology and organized by Boehringer Ingelheim. 室性心律失常的治疗:美西汀的作用:由比利时心脏病学会赞助并由勃林格殷格翰组织的研讨会。
Acta cardiologica. Supplementum Pub Date : 1980-01-01
{"title":"Treatment of ventricular arrhythmias: role of mexiletine: symposium held under the patronage of the Belgian Society of Cardiology and organized by Boehringer Ingelheim.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75374,"journal":{"name":"Acta cardiologica. Supplementum","volume":" 25","pages":"1-185"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17169904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemodynamic effects of an intravenous injection of mexiletine in patients hospitalised in intensive care units. 静脉注射美西汀对重症监护病房住院患者的血流动力学影响。
Acta cardiologica. Supplementum Pub Date : 1980-01-01
L Henrard, J Carlier
{"title":"Hemodynamic effects of an intravenous injection of mexiletine in patients hospitalised in intensive care units.","authors":"L Henrard,&nbsp;J Carlier","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hemodynamic effects of mexiletine were studied in 15 patients with normal sinus rhythm; most of them had a myocardial infarction. Except for a slight increase in peripheral vascular resistance, no other significant change in hemodynamic parameters was found after an intravenous injection of 1.5 mg/kg of mexiletine at 25 mg/min.</p>","PeriodicalId":75374,"journal":{"name":"Acta cardiologica. Supplementum","volume":" 25","pages":"101-7"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18013583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical applications of antiarrhythmic drugs. 抗心律失常药物的临床应用。
Acta cardiologica. Supplementum Pub Date : 1980-01-01
F Lavenne, D de Jonghe
{"title":"Clinical applications of antiarrhythmic drugs.","authors":"F Lavenne,&nbsp;D de Jonghe","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75374,"journal":{"name":"Acta cardiologica. Supplementum","volume":" 25","pages":"27-42"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17221086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of arrhythmias and of antiarrythmic activity, with special reference to mexiletine. 心律失常和抗心律失常活性的机制，特别提到美西汀。
Acta cardiologica. Supplementum Pub Date : 1980-01-01
E Carmeliet
{"title":"Mechanisms of arrhythmias and of antiarrythmic activity, with special reference to mexiletine.","authors":"E Carmeliet","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75374,"journal":{"name":"Acta cardiologica. Supplementum","volume":" 25","pages":"5-25"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17311024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac death prevention in post-myocardial infarction patients: a review. 心肌梗死后患者心源性死亡预防的研究进展
Acta cardiologica. Supplementum Pub Date : 1980-01-01
J P Boissel, A Leizorovicz, C Faucomprez
{"title":"Cardiac death prevention in post-myocardial infarction patients: a review.","authors":"J P Boissel,&nbsp;A Leizorovicz,&nbsp;C Faucomprez","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75374,"journal":{"name":"Acta cardiologica. Supplementum","volume":" 25","pages":"147-79"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17169905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetics of mexiletine in renal insufficiency. 美西汀在肾功能不全中的药代动力学。
Acta cardiologica. Supplementum Pub Date : 1980-01-01
G Baudinet, L Henrard, N Quinaux, D El Allaf, C de Landsheere, J Carlier, A Dresse
{"title":"Pharmacokinetics of mexiletine in renal insufficiency.","authors":"G Baudinet,&nbsp;L Henrard,&nbsp;N Quinaux,&nbsp;D El Allaf,&nbsp;C de Landsheere,&nbsp;J Carlier,&nbsp;A Dresse","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mexiletine (Mexitil) is an effective antiarrhythmic drug for the treatment of ventricular dysrhythmias. The therapeutic plasma level is situated between 0.75 and 2 microgram/ml. For concentrations higher than 2 microgram/ml, the percentage of severe side effects is rapidly increasing without improvement of the therapeutic efficacy. The main pharmacokinetics parameters of mexiletine are reviewed in the first part of this publication. Contrary to lidocaine, mexiletine may be administrated orally (or intravenously). It is largely and rapidly distributed in the body. The apparent volume of distribution (Vd) is greater than 500 1. The plasma half-time is 10 to 12 hours in healthy volunteers with a 70% plasma protein fixation. Mexiletine is largely metabolized to conjugates after N-methylation and hydroxylation. In the second part of the work, the influence of renal insufficiency on the plasma half-time of mexiletine has been investigated in 11 patients presenting a creatinine clearance situated between 2 and 38 ml/min. The mean plasma half-time for these patients is 11.1 +/- 1.7 hours after a single i.v. injection of 1.5 mg/kg. This value is comparable to the normal values found in the literature. Our control group containing convalescents from acute myocardial infarct has a plasma half-time of only 5.9 hours. In conclusion, the renal insufficiency has not modified the plasma elimination half-time of mexiletine after a single i.v. injection.</p>","PeriodicalId":75374,"journal":{"name":"Acta cardiologica. Supplementum","volume":" 25","pages":"55-65"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18013585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the antiarrhythmic efficacy of mexiletine in patients with chronic ventricular arrhythmias. 美西汀对慢性室性心律失常患者的抗心律失常疗效评价。
Acta cardiologica. Supplementum Pub Date : 1980-01-01
J P Van Durme
{"title":"Evaluation of the antiarrhythmic efficacy of mexiletine in patients with chronic ventricular arrhythmias.","authors":"J P Van Durme","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>For the evaluation of arrhythmias and the assessment of antiarrhythmic therapy prolonged periods of recording, as provided by the Holter system, are needed. The 12 lead electrocardiogram and rhythm strips are unsuitable for these purposes. However an exercise test may provide useful additional information. In two trials mexiletine was compared with other antiarrhythmic drugs (atenolol, disopyramide, lorcainide) and placebo. In both trials mexiletine was shown to have a good antiarrhythmic efficacy on chronic ventricular premature beats. The high incidence of side-effects was probably due to the high dosage used.</p>","PeriodicalId":75374,"journal":{"name":"Acta cardiologica. Supplementum","volume":" 25","pages":"121-5"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18040018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mexiletine in clinical practice. 美西汀的临床应用。
Acta cardiologica. Supplementum Pub Date : 1980-01-01
D M Boyle
{"title":"Mexiletine in clinical practice.","authors":"D M Boyle","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mexilitine is an antiarrhythmic drug with pharmacological properties similar to lignocaine. It is effective against ventricular arrhythmias, both parenterally and orally, and has been used in acute myocardial infarction, in the convalescence following myocardial infarction and in ventricular arrhythmias of different aetiology. The incidence of serious side-effects is sufficiently low to warrant its use.</p>","PeriodicalId":75374,"journal":{"name":"Acta cardiologica. Supplementum","volume":" 25","pages":"137-45"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18040019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mexiletine in the treatment of ventricular arrhythmias. 美西汀治疗室性心律失常。
Acta cardiologica. Supplementum Pub Date : 1980-01-01
L Henrard, J Carlier
{"title":"Mexiletine in the treatment of ventricular arrhythmias.","authors":"L Henrard,&nbsp;J Carlier","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of mexiletine, a new antiarrhythmic drug, was studied by oral (600 to 1200 mg/day) or intravenous (250 mg in 10 minutes) route in 45 patients; most of them had coronary insufficiency. Our results show that mexiletine is a potent ventricular antiarrhythmic drug which is efficient on several types of xylocaine resistant ventricular arrhythmias. In our experience, mexiletine is reliable when administered intravenously; there are frequent and sometimes severe side-effects when given orally.</p>","PeriodicalId":75374,"journal":{"name":"Acta cardiologica. Supplementum","volume":" 25","pages":"127-35"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18013584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polyunsaturated fatty acids and cardiovascular diseases. Part I. Conclusion. 多不饱和脂肪酸与心血管疾病。第一部分，结论。
Acta cardiologica. Supplementum Pub Date : 1979-01-01
Z M Bacq
{"title":"Polyunsaturated fatty acids and cardiovascular diseases. Part I. Conclusion.","authors":"Z M Bacq","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75374,"journal":{"name":"Acta cardiologica. Supplementum","volume":" 23","pages":"72-3"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11529137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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