Women's health (London, England)最新文献

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Safety and efficacy of vilaprisan in Japanese women with fibroids: The Phase 3 ASTEROID 8 trial. vilaprisan在日本子宫肌瘤患者中的安全性和有效性:ASTEROID 8期临床试验
IF 2.9
Women's health (London, England) Pub Date : 2025-01-01 Epub Date: 2025-10-08 DOI: 10.1177/17455057251378954
Mikio Momoeda, Thomas Faustmann, Esther Groettrup-Wolfers, Masami Kondo, Masanobu Yasuda, Christian Seitz
{"title":"Safety and efficacy of vilaprisan in Japanese women with fibroids: The Phase 3 ASTEROID 8 trial.","authors":"Mikio Momoeda, Thomas Faustmann, Esther Groettrup-Wolfers, Masami Kondo, Masanobu Yasuda, Christian Seitz","doi":"10.1177/17455057251378954","DOIUrl":"10.1177/17455057251378954","url":null,"abstract":"<p><strong>Background: </strong>Vilaprisan is a selective progesterone receptor modulator with demonstrated efficacy in the management of uterine fibroids (UFs).</p><p><strong>Objectives: </strong>To evaluate the safety and efficacy of vilaprisan in Japanese women with UFs and heavy menstrual bleeding (HMB).</p><p><strong>Design: </strong>Open-label, parallel-group, Phase 3 randomized clinical trial.</p><p><strong>Methods: </strong>Japanese women with UFs and HMB were randomly assigned 1:1 to receive vilaprisan (2 mg/day) for either four treatment periods (TPs) of 12 weeks each separated by one bleeding period (Arm A1) or two TPs of 24 weeks each separated by two bleeding periods (Arm A2). The primary endpoint was the incidence of treatment-emergent adverse events (TEAEs).</p><p><strong>Results: </strong>Of 179 women enrolled, 151 were included in the full analysis set and 148 in the safety analysis set. TEAEs occurred in 79.1% of women, with the majority being mild; events were evenly distributed across both treatment arms. Study drug-related TEAEs were observed in 44.6% of women, and serious TEAEs were reported in 3.4% of women. During the treatment phase, the mean (standard deviation) number of bleeding days per 28 days decreased to 1.40 (1.34) days in Arm A1 and 1.42 (0.82) days in Arm A2 from respective baseline values of 5.1 (2.3) and 5.2 (2.0) days. Median time to onset of amenorrhea was 4 days in TP1 in both arms, and 4 days in TP2 in Arm A1. Absence of bleeding for the last 28 days was more common in TP1 (Arm A1: 91.89%, Arm A2: 89.19%) than TP2 (Arm A1: 80.85%, Arm A2: 85.71%).</p><p><strong>Conclusion: </strong>In this study, vilaprisan 2 mg/day was found to be well tolerated and efficacious in Japanese women with UFs and HMB. However, the study sponsor later terminated the overall clinical development of vilaprisan due to potential safety concerns from long-term rodent studies.</p><p><strong>Registration: </strong>The ASTEROID 8 study was registered at https://clinicaltrials.gov/ (registration number: NCT03476928).</p>","PeriodicalId":75327,"journal":{"name":"Women's health (London, England)","volume":"21 ","pages":"17455057251378954"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12511707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Women's mental health in the doctoral context: Protective function of the psychological capital and academic motivation. 博士语境下的女性心理健康:心理资本与学业动机的保护作用。
Women's health (London, England) Pub Date : 2025-01-01 DOI: 10.1177/17455057251315318
Angel Deroncele-Acosta, Roger Pedro Norabuena-Figueroa, Emerson Damian Norabuena-Figueroa
{"title":"Women's mental health in the doctoral context: Protective function of the psychological capital and academic motivation.","authors":"Angel Deroncele-Acosta, Roger Pedro Norabuena-Figueroa, Emerson Damian Norabuena-Figueroa","doi":"10.1177/17455057251315318","DOIUrl":"10.1177/17455057251315318","url":null,"abstract":"<p><strong>Background: </strong>Science recognizes the anxieties, depression, stress, and \"turbulences\" that women face in doctoral studies, but women's mental health in this context is still little addressed, even though it is a critical aspect for the well-being, persistence, and success of women doctoral candidates, who continue to be underrepresented in many professional fields.</p><p><strong>Objectives: </strong>The study aims to evaluate the relationship between academic motivation, psychological capital, and university academic performance (UAP) and to identify factors of female mental health success.</p><p><strong>Design: </strong>A cross-sectional, mixed-methods study was conducted with a sample of 108 female doctoral students from a university in Lima, during the first quarter of 2024.</p><p><strong>Methods: </strong>In the quantitative phase, three standardized scales were administered to assess academic motivation, psychological capital, and university academic performance (UAP). In the qualitative phase, interviews were conducted to gather relevant information on mental health.</p><p><strong>Results: </strong>The findings emphasize five important points: (1) levels and the relationship between psychological capital, academic motivation, and performance, (2) motivational behavior according to study cycles, (3) risk and protection profiles, (4) protective functions, and (5) mental health success factors. The results indicate that 36% of the women have a low level of psychological capital, 34% have a medium level of academic motivation, and 37% have a high level of UAP, likewise \"Intrinsic Motivation toward Accomplishment\" is the positive core where most of these women converge. Significant differences were found between the study cycles with academic motivation and \"University Academic Performance,\" and a significant gap between these variables. The risk profile (which limits performance) and the protective profile which allows high performance are determined; this positive profile is identified by women who present a high level of \"Self-efficacy.\" The study demonstrates that \"Psychological Capital\" and \"Academic Motivation\" along with the dimensions of \"Self-efficacy\" and \"Intrinsic Motivation to Experience Stimulation\" serve protective functions. Fourteen success factors for women's mental health were identified and organized into four main approaches: Optimism, Hope, Resilience, and Self-efficacy.</p><p><strong>Conclusion: </strong>Limitations and future projections are discussed. The practical implications include implementing psychological support programs, fostering intrinsic motivation, integrating psychological assessments, establishing support networks, and making tailored curricular adjustments.</p>","PeriodicalId":75327,"journal":{"name":"Women's health (London, England)","volume":"21 ","pages":"17455057251315318"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on the therapeutic role of metformin in the management of polycystic ovary syndrome: Effects on pathophysiologic process and fertility outcomes. 二甲双胍治疗多囊卵巢综合征的最新进展:对病理生理过程和生育结果的影响。
Women's health (London, England) Pub Date : 2025-01-01 DOI: 10.1177/17455057241311759
Kerstin Mg Brand, Ulrike Gottwald-Hostalek, Aimee Andag-Silva
{"title":"Update on the therapeutic role of metformin in the management of polycystic ovary syndrome: Effects on pathophysiologic process and fertility outcomes.","authors":"Kerstin Mg Brand, Ulrike Gottwald-Hostalek, Aimee Andag-Silva","doi":"10.1177/17455057241311759","DOIUrl":"10.1177/17455057241311759","url":null,"abstract":"<p><p>Influential guidelines have supported the role of metformin in the management of polycystic ovary syndrome (PCOS) for a number of years. However, regulatory approvals for this therapeutic indication are still exceptional and exist only in a few countries, including for the originator, Glucophage®. PCOS is an insulin-resistant state, which drives hyperandrogenism and anovulatory infertility. The metabolic action of metformin involves amelioration of insulin resistance, which helps to resolve hormonal and metabolic disturbances and increases ovulation, pregnancy, and live birth rates relative to placebo. A combination of metformin with clomifene citrate (another widely used treatment for PCOS) is more effective than either alone and is a useful option in women with clomifene-resistant PCOS. Combining metformin with letrozole (1st-line agent for ovulation induction in women with PCOS and no other infertility risk factors) is not more effective than letrozole alone. Continuing metformin to the end of the 1st trimester at an effective dose (e.g. 1000-2000 mg/day) may help to reduce the rate of miscarriages. Metformin also has an adjunctive role in women with PCOS receiving assisted reproduction technology (ART) using the long gonadotrophin-releasing hormone agonist protocol, where it appears to increase the pregnancy rate and to reduce the risk of ovarian hyperstimulation syndrome. There is no role for metformin in women receiving short ART protocols. Where a successful pregnancy is achieved, metformin is generally safe for the mother and neonate. Further research is needed to define with greater precision the optimal dosage and times to initiate and discontinue metformin in women with PCOS who achieve pregnancy.</p>","PeriodicalId":75327,"journal":{"name":"Women's health (London, England)","volume":"21 ","pages":"17455057241311759"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nursing and planetary health: A discussion article. 护理与地球健康:讨论文章。
Women's health (London, England) Pub Date : 2025-01-01 Epub Date: 2025-03-12 DOI: 10.1177/17455057241311955
Salima Meherali, Saba Nisa, Yared Asmare Aynalem, Zohra S Lassi
{"title":"Nursing and planetary health: A discussion article.","authors":"Salima Meherali, Saba Nisa, Yared Asmare Aynalem, Zohra S Lassi","doi":"10.1177/17455057241311955","DOIUrl":"10.1177/17455057241311955","url":null,"abstract":"<p><p>This discussion article discusses the integration of planetary health into nursing practice and education, highlighting the transformative potential of this approach in improving global health outcomes. Planetary health emphasizes the interdependence between human health and the health of our planet's ecosystems, advocating for a sustainable approach to healthcare. This article explores how nursing practice can incorporate planetary health principles to address environmental determinants of health and promote sustainable practices. It also discusses the role of nursing education in preparing future practitioners to understand and act on the links between environmental sustainability and health. By aligning nursing education with planetary health objectives and fostering leadership in this area, the nursing profession can contribute significantly to addressing global health challenges, advocating for systemic changes, and implementing practices that protect both human and environmental health.</p>","PeriodicalId":75327,"journal":{"name":"Women's health (London, England)","volume":"21 ","pages":"17455057241311955"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intimate partner violence and physical health in England: Gender stratified analyses of a probability sample survey. 英国亲密伴侣暴力与身体健康:概率抽样调查的性别分层分析。
Women's health (London, England) Pub Date : 2025-01-01 Epub Date: 2025-03-25 DOI: 10.1177/17455057251326419
Ladan Hashemi, Anastasia Fadeeva, Nadia Khan, Sally McManus
{"title":"Intimate partner violence and physical health in England: Gender stratified analyses of a probability sample survey.","authors":"Ladan Hashemi, Anastasia Fadeeva, Nadia Khan, Sally McManus","doi":"10.1177/17455057251326419","DOIUrl":"10.1177/17455057251326419","url":null,"abstract":"<p><strong>Background: </strong>Gender differences in the associated health outcomes of different forms of intimate partner violence (IPV) are understudied. The long-term effects of IPV on specific physical health conditions are also under-researched in comparison to the effects on general health and mental health.</p><p><strong>Objectives: </strong>To examine gender differences in the association between IPV and specific physical health conditions, accounting for differences in the types and number of types of IPV experienced.</p><p><strong>Design: </strong>We used data from the 2014 Adult Psychiatric Morbidity Survey, a cross-sectional survey using a stratified, multistage random sampling design to cover the household population of England aged 16 years and older.</p><p><strong>Methods: </strong>Descriptive and multivariable regression analyses of 4120 women and 2764 men who had ever had a partner. Lifetime IPV by types (physical, sexual, psychological, and economic), any lifetime and recent IPV, the number of IPV types experienced, and multiple chronic health conditions experienced over the past 12 months were included in the analyses.</p><p><strong>Results: </strong>Gender differences were observed in both the prevalence of IPV and associated health conditions. Women were more likely to experience any type and a higher number of IPV types than men. Women's exposure to any lifetime and 12-month IPV were significantly associated with an increased likelihood of reporting 12 and 11 conditions, respectively, while men's exposure to any lifetime and 12-month IPV were significantly associated with 4 and 1 conditions, respectively. Specific IPV types had varied health impacts, particularly among women. A cumulative association was evident for women but not for men.</p><p><strong>Conclusion: </strong>Healthcare systems need to be mobilised to address IPV as a priority health issue for the female population. Our findings highlight the need for gender-informed approaches in IPV intervention strategies and healthcare provision, emphasising the development of IPV-responsive healthcare systems and comprehensive IPV curricula in medical and health training.</p>","PeriodicalId":75327,"journal":{"name":"Women's health (London, England)","volume":"21 ","pages":"17455057251326419"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11946296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A robust cross-sectional assessment of the impacts of COVID-19 pandemic on the prevalence of female genital mutilation among 0-14 years old girls in Nigeria. 对2019冠状病毒病大流行对尼日利亚0-14岁女童切割女性生殖器官流行率的影响进行强有力的横断面评估。
Women's health (London, England) Pub Date : 2025-01-01 Epub Date: 2025-05-26 DOI: 10.1177/17455057241311948
Corentin Visée, Camille Morlighem, Chibuzor Christopher Nnanatu
{"title":"A robust cross-sectional assessment of the impacts of COVID-19 pandemic on the prevalence of female genital mutilation among 0-14 years old girls in Nigeria.","authors":"Corentin Visée, Camille Morlighem, Chibuzor Christopher Nnanatu","doi":"10.1177/17455057241311948","DOIUrl":"10.1177/17455057241311948","url":null,"abstract":"<p><strong>Background: </strong>Female genital mutilation (FGM) is a human rights violation that still affects more than 3 million girls aged 0-14 years each year. To achieve the Sustainable Development Goal 2030 agenda, efforts have been made at the local, national and international levels to end the practice by the year 2030. However, the recent COVID-19 pandemic may have reversed the progress made due to increased rates of early marriage of girls, violence against children and school closures during lockdowns. Although some surveys have examined changes in FGM prevalence over the COVID-19 period, changes at the national and sub-national levels among 0-14 years old girls have not been quantified.</p><p><strong>Objectives: </strong>This study aimed to understand the potential impacts of the COVID-19 pandemic on the likelihood of FGM among girls aged 0-14 years, and whether it affected progress towards the elimination of FGM.</p><p><strong>Design: </strong>We used Bayesian hierarchical regression models implemented within the integrated nested Laplace approximations frameworks.</p><p><strong>Methods: </strong>We modelled the likelihood and prevalence of FGM among girls aged 0-14 years before and after the COVID-19 pandemic in Nigeria, with respect to individual- and community-level characteristics, using Bayesian hierarchical models. We used the 2018 Demographic and Health Survey as the pre-COVID-19 period and the 2021 Multiple Indicator Cluster Survey as the post-COVID-19 period.</p><p><strong>Results: </strong>At the state level, FGM prevalence varied geographically and increased by 23% and 27% in the northwestern states of Katsina and Kana, respectively. There were 11% increase in Kwara and 14% increase in Oyo. However, at the national level, the prevalence of FGM was found to decrease from 19.5% to 12.3% between 2018 and 2021. Cultural factors were identified as the key drivers of FGM among 0-14 years old girls in Nigeria. The changes in the likelihood of girls undergoing FGM across the two time periods also varied across ethnic and religious groups following COVID-19 pandemic.</p><p><strong>Conclusion: </strong>Our findings highlight that FGM is still a social norm in some states/regions and groups in Nigeria, thereby highlighting the need for a continued but accelerated FGM interventions throughout the country.</p>","PeriodicalId":75327,"journal":{"name":"Women's health (London, England)","volume":"21 ","pages":"17455057241311948"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The need for more research into health information technology and maternal health outcomes. 需要对保健信息技术和孕产妇保健结果进行更多研究。
Women's health (London, England) Pub Date : 2025-01-01 Epub Date: 2025-06-06 DOI: 10.1177/17455057251338929
Jamie Kim, Marcia Chen, Robert White
{"title":"The need for more research into health information technology and maternal health outcomes.","authors":"Jamie Kim, Marcia Chen, Robert White","doi":"10.1177/17455057251338929","DOIUrl":"10.1177/17455057251338929","url":null,"abstract":"<p><p>Racial and ethnic disparities in maternal health persist in the United States despite continued efforts to make healthcare more equitable. The COVID-19 pandemic and overturning of Roe v Wade have further widened existing disparities in maternal healthcare. In this era of advanced technology, innovative tools like health information technology (IT) should be leveraged to address and reduce disparities in maternal health outcomes. Ongoing projects have demonstrated the potential for collaboration to prioritize patient autonomy in improving maternal health. However, further research is necessary to evaluate the effectiveness of these interventions in achieving equitable outcomes.</p>","PeriodicalId":75327,"journal":{"name":"Women's health (London, England)","volume":"21 ","pages":"17455057251338929"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repercussions of gastrointestinal microbiota in postmenopausal osteoporosis. 胃肠道微生物群对绝经后骨质疏松症的影响。
IF 2.9
Women's health (London, England) Pub Date : 2025-01-01 Epub Date: 2025-08-19 DOI: 10.1177/17455057251363684
Fatima Iftikhar Shah, Fatima Akram, Somia Shehzadi
{"title":"Repercussions of gastrointestinal microbiota in postmenopausal osteoporosis.","authors":"Fatima Iftikhar Shah, Fatima Akram, Somia Shehzadi","doi":"10.1177/17455057251363684","DOIUrl":"10.1177/17455057251363684","url":null,"abstract":"<p><p>Osteoporosis, characterized by diminished bone mass and microarchitectural degeneration, increases fracture risk, particularly in postmenopausal women (postmenopausal osteoporosis), leading to reduced quality of life and increased mortality. Recent research has highlighted the gut-bone axis, showing how the gut microbiota influences bone health through immune modulation, endocrine regulation, and calcium absorption. Dysbiosis, an imbalance in gut microbiota (e.g., decreased Bacteroidetes and increased Firmicutes), has been linked to osteoporosis by enhancing osteoclast activity and bone loss. Probiotics, such as <i>Lactobacillus</i> strains, promise to increase bone density and alter immune responses. Still, challenges remain in translating these findings to human applications due to issues with dosage and tolerability. Future studies will seek to clarify the function of the gut microbiome in bone health, hence opening the path for tailored therapies aimed at gut flora. Emphasizing postmenopausal osteoporosis, this article will investigate how gut microbiota influences calcium absorption, endocrine regulation, immunological modulation, and bone metabolism. The goal is to develop treatments aimed at gut microbiota to enhance patient outcomes and osteoporosis management. A review of existing literature was conducted, focusing on experimental studies and clinical trials that investigate the relationship between gut microbiota and bone health, including immune and endocrine mechanisms. Relevant studies were selected based on their focus on gut microbiota and bone metabolism, and their findings were synthesized to explore the impact of microbiota modulation on bone health outcomes.</p>","PeriodicalId":75327,"journal":{"name":"Women's health (London, England)","volume":"21 ","pages":"17455057251363684"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors associated with hepatitis B virus infection among pregnant women attending antenatal clinic in Western Area Urban District, Sierra Leone. 塞拉利昂西部城区产前门诊孕妇乙型肝炎病毒感染的相关因素
IF 2.9
Women's health (London, England) Pub Date : 2025-01-01 Epub Date: 2025-08-18 DOI: 10.1177/17455057251360510
Solomon Aiah Sogbeh, Alexander Ansah-Manu, Adel Elduma, Gebrekrstos Negash Gebru, Delia Akosua Bandoh, Yakubu Alhassan, James Sylvester Squire, Adolphina Addo-Lartey
{"title":"Factors associated with hepatitis B virus infection among pregnant women attending antenatal clinic in Western Area Urban District, Sierra Leone.","authors":"Solomon Aiah Sogbeh, Alexander Ansah-Manu, Adel Elduma, Gebrekrstos Negash Gebru, Delia Akosua Bandoh, Yakubu Alhassan, James Sylvester Squire, Adolphina Addo-Lartey","doi":"10.1177/17455057251360510","DOIUrl":"10.1177/17455057251360510","url":null,"abstract":"<p><strong>Background: </strong>Hepatitis B virus infection remains a global health concern, particularly in resource-constrained countries such as Sierra Leone. Understanding the risk factors for hepatitis B virus among pregnant women can guide public health initiatives, prenatal care, and maternal-child health policies.</p><p><strong>Objectives: </strong>We assessed the prevalence and risk factors for hepatitis B virus infection among pregnant women in Sierra Leone's Western Area Urban District.</p><p><strong>Design: </strong>We conducted a facility-based cross-sectional study in five randomly selected hospitals in the Western Area Urban District.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in five randomly selected hospitals in May 2021. Data were collected from 320 pregnant women using structured questionnaires. Hepatitis B virus infection, identified by hepatitis B surface antigen positivity, was analyzed using descriptive statistics, Pearson's chi-square test, and logistic regression. Variables that were significant in bivariate analysis were included in the multivariable model. All tests were computed with 95% confidence intervals.</p><p><strong>Results: </strong>The mean age of participants was 26.0 ± 5.7 years, and the prevalence of hepatitis B virus infection was 13.8% (95% confidence interval: 10.4-18.0). Women with no formal education (adjusted odds ratio: 3.69, 95% confidence interval: 1.33-10.22) or primary education (adjusted odds ratio: 8.30, 95% confidence interval: 2.69-25.63) had significantly higher odds of infection. Single women (adjusted odds ratio: 3.05, 95% confidence interval: 1.29-7.22) and those engaging in risky practices, such as toothbrush sharing (adjusted odds ratio: 1.37) or tattooing (adjusted odds ratio: 2.09), were more likely to be infected. Conversely, a history of stillbirth (adjusted odds ratio: 0.20, 95% confidence interval: 0.04-0.99) was associated with reduced odds of infection.</p><p><strong>Conclusion: </strong>Hepatitis B virus infection was common among pregnant women in Sierra Leone's Western Area Urban District. Education level, marital status, and unsafe practices such as tattooing and toothbrush sharing were significantly associated with hepatitis B virus infection risk. The findings emphasize the urgent need for targeted public health interventions to reduce hepatitis B virus transmission in this population.</p>","PeriodicalId":75327,"journal":{"name":"Women's health (London, England)","volume":"21 ","pages":"17455057251360510"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Where best practice pain care and patient expectations for care meet: Exploring patient expectations around chronic pelvic pain, physiotherapy, and the biopsychosocial model of care. 最佳实践疼痛护理和患者对护理的期望:探索患者对慢性盆腔疼痛、物理治疗和生物心理社会护理模式的期望。
IF 2.9
Women's health (London, England) Pub Date : 2025-01-01 Epub Date: 2025-06-25 DOI: 10.1177/17455057251349626
Michelle Hong, Allison Crone, Elza Gashi, Meghan Pietluch, Maddy Reinders, Jayden Uchida, Adriano Nella, Crystal MacKay, Olivia Drodge, Rachael Bosma
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