View (Beijing, China)最新文献_第2页

Neuroprotective effects of remote limb ischemic preconditioning through enhanced cerebral blood flow via activation of the PI3K/AKT pathway in ischemic stroke 远端肢体缺血预处理在缺血性卒中中通过激活PI3K/AKT通路增强脑血流的神经保护作用

View (Beijing, China) Pub Date : 2025-07-27 DOI: 10.1002/viw.20250019

Chaoran Dou, Diwen Tang, Yulin Yan, Wen Shui, Minzhi Zhou, Bin Chen, Lishuai Feng, Benhao Li, Tao Ying

{"title":"Neuroprotective effects of remote limb ischemic preconditioning through enhanced cerebral blood flow via activation of the PI3K/AKT pathway in ischemic stroke","authors":"Chaoran Dou, Diwen Tang, Yulin Yan, Wen Shui, Minzhi Zhou, Bin Chen, Lishuai Feng, Benhao Li, Tao Ying","doi":"10.1002/viw.20250019","DOIUrl":"https://doi.org/10.1002/viw.20250019","url":null,"abstract":"Abstract Acute ischemic stroke (AIS) remains a leading cause of mortality and disability worldwide. A key barrier to recovery is the inadequate restoration of cerebral blood flow following vascular recanalization. This study demonstrates the therapeutic efficacy of remote limb ischemic preconditioning (RLIPC) for AIS, utilizing advanced multimodal imaging techniques to visualize its effects and elucidate underlying mechanisms. In human volunteers, RLIPC modulated cerebral perfusion and reduced the arterial resistivity index, as assessed by noninvasive Transcranial Doppler ultrasound. In a rat model of middle cerebral artery occlusion/reperfusion (MCAO/R), ultrasound localization microscopy (ULM) enabled high‐resolution visualization of regional perfusion, revealing that RLIPC significantly enhanced blood flow within the M4 and M5 branches of the MCA during the hyperacute phase. RLIPC also reduced infarct volume and neuronal apoptosis, and further promoted neovascularization in the subacute and chronic stages. Importantly, behavioural assessments confirmed RLIPC's long‐term benefits on motor and cognitive function. Using ultra‐high field magnetic resonance imaging, we demonstrate for the first time that RLIPC confers neuroprotection by enhancing glymphatic clearance and neural conduction. Mechanistic studies revealed RLIPC‐mediated activation of the PI3K/AKT pathway, associated with upregulated expression of anti‐apoptotic (BCL2A1), angiogenic (HIF‐1α, VEGF), and neuroprotective (BDNF) genes. Our findings indicate that RLIPC holds significant therapeutic promise for ischemic stroke and potentially other neurological disorders.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20250019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147911209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles derived from silicate‐stimulated antler reserve mesenchymal cells alleviate kidney damage in diabetic nephropathy through inhibiting abnormal angiogenesis and apoptosis 硅酸刺激鹿角储备间充质细胞产生的细胞外囊泡通过抑制异常血管生成和细胞凋亡减轻糖尿病肾病的肾损伤

View (Beijing, China) Pub Date : 2025-07-02 DOI: 10.1002/viw.20250089

Pengfei Hu, Zhaowenbin Zhang, Dongxu Wang, Xiuying Li, Jiping Li, Jinchi Ying, Tiantian Jiang, Chen Zhao, Jiang Chang, Chunyi Li

{"title":"Extracellular vesicles derived from silicate‐stimulated antler reserve mesenchymal cells alleviate kidney damage in diabetic nephropathy through inhibiting abnormal angiogenesis and apoptosis","authors":"Pengfei Hu, Zhaowenbin Zhang, Dongxu Wang, Xiuying Li, Jiping Li, Jinchi Ying, Tiantian Jiang, Chen Zhao, Jiang Chang, Chunyi Li","doi":"10.1002/viw.20250089","DOIUrl":"https://doi.org/10.1002/viw.20250089","url":null,"abstract":"Abstract Extracellular vesicles (EVs) facilitate the intercellular transfer of bioactive macromolecules and are capable of traversing physiological barriers and demonstrate considerable promise as innovative cell‐free therapies for treating a variety of diseases. Here, we showed a novel approach to use silicate ions (SiO 3 2− ) to stimulate secretion of high amounts of miR‐148a‐3p enriched extracellular vesicles (Si‐RM‐EVs) from antler reserve mesenchymal cells (RM cells). We further showed that the Si‐RM‐EVs were highly effective for the treatment of kidney damage in diabetic nephropathy (DN) mice with an enhanced ability to inhibit abnormal angiogenesis and apoptosis. We attribute the therapeutic effect to the high levels of bioactive miR‐148a‐3p in the EVs. Further in vitro experiments confirmed that miR‐148a‐3p overexpression suppressed angiogenesis and apoptosis of high‐glucose‐treated human umbilical vein endothelial cells (HUVEC) through inhibiting the expression of VEGFA and BCL2L11, and caused an increase in cell viability. Our study represented a new approach of using SiO 3 2− ‐antler RM cell‐based EV engineering for the treatment of kidney damage in DN and possibly in other tissue or organ damage.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20250089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147888901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nectin4-targeted molecular imaging in solid tumors: Current status and future perspectives. 实体肿瘤中nectin4靶向分子成像：现状与未来展望

View (Beijing, China) Pub Date : 2025-06-01 Epub Date: 2025-04-16 DOI: 10.1002/VIW.20250007

Yongshun Liu, Wenpeng Huang, Jingwei Zhou, Rachel J Saladin, Youlan Lei, Weibo Cai, Lei Kang

{"title":"Nectin4-targeted molecular imaging in solid tumors: Current status and future perspectives.","authors":"Yongshun Liu, Wenpeng Huang, Jingwei Zhou, Rachel J Saladin, Youlan Lei, Weibo Cai, Lei Kang","doi":"10.1002/VIW.20250007","DOIUrl":"10.1002/VIW.20250007","url":null,"abstract":"Nectin cell adhesion molecule 4 (Nectin4), a Ca2+-independent immunoglobulin-like cell adhesion molecule, plays a role in both physiological and pathological processes. Nectin4 is physiologically expressed at minimal levels in most normal adult tissues; however, it is significantly upregulated in various solid tumors. It can drive cell proliferation, metastasis, angiogenesis, adhesion, recurrence, and DNA mismatch repair in tumors, leading to poor prognosis. Notably, the United States Food and Drug Administration has approved enfutumab vedotin, a novel antibody-drug conjugate targeting Nectin4, for the therapy of urothelial carcinoma, highlighting the significance of Nectin4 in targeted therapy. However, accurate diagnosis and evaluation of patients is also important. Visualization of Nectin4 expression levels can be achieved with molecular imaging, including positron-emission tomography, single-photon emission computed tomography, and near-infrared fluorescence imaging. Incorporating Nectin4-targeted molecular imaging into clinical practice is vital for the diagnosis, differentiation, treatment decision, efficacy evaluation, and prognosis prediction of a broad spectrum of solid tumors. We reviewed research advances in Nectin4-targeted molecular imaging, focusing on theranostic applications in different tumor types, including breast, urothelial, gastric, pancreatic, ovarian, colorectal, and other cancers. We also evaluated the present situation by investigating research progress, diagnostic performance, and limitations. Finally, we discuss the challenges associated with clinical implementation and present our views on advancing this area to guide future research.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13178933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147966100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients 解读不同的细胞死亡模式以预测肝细胞癌患者的预后和潜在的治疗靶点

View (Beijing, China) Pub Date : 2025-05-25 DOI: 10.1002/viw.20240105

Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Jie Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo

{"title":"Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients","authors":"Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Jie Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo","doi":"10.1002/viw.20240105","DOIUrl":"https://doi.org/10.1002/viw.20240105","url":null,"abstract":"Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC. The construction of the prognostic models involved an analysis of eighteen PCD patterns: apoptosis, cuproptosis, entotic cell death, netotic cell death, parthanatos, pyroptosis, lysosome‐dependent cell death, autophagy‐dependent cell death, alkaliptosis, oxeiptosis, NETosis, immunogenic cell death, ferroptosis, ANOIKIS, disulfidptosis, necroptosis, macroautophagy, and methuosis. Bulk and single‐cell transcriptome, genomics, and clinical parameters were analyzed in training. Additionally, three datasets were used as validation cohorts. The hub gene in the model, SQSTM1, was discovered, and in vitro and in silico studies were performed to learn how SQSTM1 operated in PCD. A 16‐gene cell death index (CDI) was developed using machine learning. Validation across four datasets shows CDI scores distinguish cancer from adjacent tissues, with higher scores correlating to worse prognosis. Further spatial and single‐cell transcriptome investigations reveal that SQSTM1 is linked to multiple cell death pathways and interacts with inhibitory M2 macrophages. Silencing SQSTM1 induces apoptosis and increases autophagy and ferroptosis gene expression, limiting tumor growth and identifying SQSTM1 as a potent biomarker for HCC diagnosis. In summary, we created a unique CDI signature by thoroughly involving the greatest number of cell death patterns to date, eighteen, which might be effective to predict clinical prognosis and provide a novel treatment option.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147886965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Integrating construction and spatial imaging of organoid for tumor metabolic heterogeneity and interactions 整合类器官的构建和空间成像，研究肿瘤代谢异质性和相互作用

View (Beijing, China) Pub Date : 2025-05-04 DOI: 10.1002/viw.20240127

Ling Guo, Zhaohua Xia, Jiaxin Wang, YU Xiao-ling, Chuanyue Wu, Qian Luo, Chao Zhao

{"title":"Integrating construction and spatial imaging of organoid for tumor metabolic heterogeneity and interactions","authors":"Ling Guo, Zhaohua Xia, Jiaxin Wang, YU Xiao-ling, Chuanyue Wu, Qian Luo, Chao Zhao","doi":"10.1002/viw.20240127","DOIUrl":"https://doi.org/10.1002/viw.20240127","url":null,"abstract":"Abstract The metabolism of tumors is a complex network process involving multiple metabolic species and exhibits metabolic spatial heterogeneity, which poses challenges for the development of effective therapeutic strategies. Patient‐derived tumor organoids, recently developed, hold significant potential in elucidating novel aspects of cancer biology, expediting the discovery of oncology drugs, and personalizing cancer treatment. However, tracing metabolic reactions in the tumor organoid network presents a technological challenge. In this study, we propose methodologies that utilize enzymatically derived tissue debris (TD) to generate the biobank patient‐derived lung cancer organoids (LCOs) that accurately replicate the histological characteristics, stemness of lung cancer stem cells, cellular heterogeneity, and mutational patterns observed in their respective original tumors. Importantly, our LCO model can be integrated with mass spectrometry imaging to analyze tumor metabolic heterogeneity and the spatial distributions of fingerprint lipids associated with extracellular matrix homeostasis including lysophosphatidic acid (LPA), phosphatidic acid (PA), phosphatidylserine (PS), phosphatidylglycerol (PG), diacylglycerol (DAG). Furthermore, we demonstrate the effectiveness of LCOs in evaluating personalized treatment by establishing a connection between their mutational profiles and reactions to specific drugs. Our findings highlight that LCOs from TD retain crucial metabolic characteristics of lung cancer and can be readily utilized to investigate individualized treatment strategies.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20240127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147895245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Harmonizing NAD ⁺ metabolism with CeMOF nanozyme to orchestrate intraocular pressure modulation for glaucoma treatment 协调NAD +代谢与CeMOF纳米酶协调青光眼治疗的眼压调节

View (Beijing, China) Pub Date : 2025-04-22 DOI: 10.1002/viw.20250039

Youjia Zhang, Ming Chen, Yi Tian, Bo Qin, Xiaoxiao Chen, Yiwen Zhou, Jinhai Huang, Mei Yang, Xinghuai Sun, Yuan Lei, Yuhong Chen

{"title":"Harmonizing NAD + metabolism with CeMOF nanozyme to orchestrate intraocular pressure modulation for glaucoma treatment","authors":"Youjia Zhang, Ming Chen, Yi Tian, Bo Qin, Xiaoxiao Chen, Yiwen Zhou, Jinhai Huang, Mei Yang, Xinghuai Sun, Yuan Lei, Yuhong Chen","doi":"10.1002/viw.20250039","DOIUrl":"https://doi.org/10.1002/viw.20250039","url":null,"abstract":"Abstract Elevated intraocular pressure (IOP) is a critical risk factor for the development and progression of glaucoma. However, current treatments focus primarily on mechanical stress relief, neglecting the underlying issue of diminished cellular energy production in patients. In this study, we investigated the impact of NAD + reduction on IOP regulation and explored the potential of NAD + precursors as a therapeutic strategy. We investigated the role of NAD + metabolism in glaucoma and revealed decreased nicotinamide phosphoribosyltransferase (NAMPT) expression in both patients and the human trabecular meshwork (HTM) cell model. Supplementation with NAD + precursors, nicotinamide (NAM) or nicotinamide mononucleotide (NMN), provided protective effects in H 2 O 2 ‐treated HTM cells and reduced IOP in ocular hypertension mouse models by mitigating senescence, extracellular matrix accumulation, and oxidative stress. To optimize drug delivery, we engineered the NAM@CeMOF‐2 nanozyme system, which achieved a maximum IOP reduction in Cav1 ⁻/⁻ mice following 7 days of treatment. This localized treatment improved bioavailability and reduced systemic side effects. These findings suggest that NAD + deficiency plays a role in glaucoma development and propose novel therapeutic targets for addressing cellular dysfunction in glaucoma.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20250039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147905213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Noninvasive electrical stimulation enhances the diabetic osseointegration via alleviating mitochondrial damage 无创电刺激通过减轻线粒体损伤促进糖尿病骨整合

View (Beijing, China) Pub Date : 2025-04-16 DOI: 10.1002/viw.20240128

Dongzong Huang, Rongchen Xu, Changzhen Xu, Xue Peng, Lin Liu, Yiping Fan, Miaoshen Guan, Menglin Luo, Shaoyuan Cui, Xiaoyu Wang, Jin Liu, Chunyu Zhang, Bo Fu, Hua Jiang, Hongbo Li

{"title":"Noninvasive electrical stimulation enhances the diabetic osseointegration via alleviating mitochondrial damage","authors":"Dongzong Huang, Rongchen Xu, Changzhen Xu, Xue Peng, Lin Liu, Yiping Fan, Miaoshen Guan, Menglin Luo, Shaoyuan Cui, Xiaoyu Wang, Jin Liu, Chunyu Zhang, Bo Fu, Hua Jiang, Hongbo Li","doi":"10.1002/viw.20240128","DOIUrl":"https://doi.org/10.1002/viw.20240128","url":null,"abstract":"Abstract A high‐glucose environment induces an imbalance in mitochondrial homeostasis, and further results in decreased autophagic capacity and energy metabolism in mitochondria. This mitochondrial dysfunction inhibits the regeneration of bone tissue. Electrical stimulation (ES) is an efficient strategy to rebalance the mitochondrial homeostasis to further accelerate the bone regeneration process. However, traditional ES strategies are invasive and easily cause secondary trauma, limiting their medical application. Here, we designed a new noninvasive direct‐current electric field (DCEF) strategy. This strategy can provide ES in situ without implantation. The results show that this strategy can target and regulate mitochondrial homeostasis through the PI3K–AKT signaling pathway, activate mitochondrial autophagy, alleviate high‐glucose‐induced mitochondrial damage, and further promote the osteogenic differentiation of bone marrow mesenchymal stem cells. Consequently, this exogenous noninvasive ES strategy can effectively accelerate the repair of bone defects in a high‐glucose environment through alleviating mitochondrial damage.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20240128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147889920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Modeling fire‐related smoke inhalation injury using the human lung‐on‐a‐chip and organoid platform: Pathogenesis insights and therapeutic evaluation 使用人体肺芯片和类器官平台模拟火灾相关的烟雾吸入性损伤：发病机制和治疗评估

View (Beijing, China) Pub Date : 2025-03-20 DOI: 10.1002/viw.20240114

Junmin Li, Dezhong Zhang, Yan Meng, Yong-Qing Chang, Wenbo Wei, Peng Wu, Lin Peng, Wei Chang, Wei Wang, Jie Huang, Jingjing Fang, Keming Zhu, X. Wan

{"title":"Modeling fire‐related smoke inhalation injury using the human lung‐on‐a‐chip and organoid platform: Pathogenesis insights and therapeutic evaluation","authors":"Junmin Li, Dezhong Zhang, Yan Meng, Yong-Qing Chang, Wenbo Wei, Peng Wu, Lin Peng, Wei Chang, Wei Wang, Jie Huang, Jingjing Fang, Keming Zhu, X. Wan","doi":"10.1002/viw.20240114","DOIUrl":"https://doi.org/10.1002/viw.20240114","url":null,"abstract":"Abstract Fire‐related smoke inhalation‐induced acute lung injury (SI‐ALI) is a prevalent condition in modern fires, characterized by high mortality and a lack of targeted therapeutic options. Previous research has been hindered by instability in smoke generation and modeling methods, limiting the investigation of SI‐ALI mechanisms. This study, for the first time, utilized organ‐on‐a‐chip and organoid technologies, optimizing chip design and precisely controlling smoke generation from non‐metallic materials to establish a human‐relevant, physiologically accurate model of fire‐related SI‐ALI. The results demonstrate that this model effectively simulates the alveolar‒capillary barrier and replicates key pathological features of lung injury, including oxidative stress, apoptosis, immune cell adhesion, inflammatory responses, capillary leakage, and mitochondrial damage. Injury responses of endothelial and epithelial cells to smoke exposure were thoroughly assessed at the organ level. Integrating proteomics and molecular biology techniques, along with comparisons to animal models, identified disease‐specific pathways related to the spliceosome and carbon metabolism, as well as pathogenic molecules such as catechol‐O‐methyltransferase (COMT) and nitrilase 1 (NIT1). Furthermore, molecular docking of COMT revealed potential therapeutic candidates from the FDA‐approved drug library, including Ractopamine HCl and Bimatoprost. The efficacy of intravenous vitamin C combined with nebulized budesonide was validated on the chip model, establishing a foundation for clinical applications. This study provides a robust model for investigating fire‐related SI‐ALI and offers novel insights into underlying mechanisms and therapeutic development.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20240114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147916347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A lasting antibacterial, pro‐angiogenic, and pro‐osteogenic zirconium‐based bulk metallic glass for dental implants 一种持久抗菌、促血管生成和促成骨的植牙用锆基大块金属玻璃

View (Beijing, China) Pub Date : 2025-03-16 DOI: 10.1002/viw.20240099

Feifei Wang, Yunshu Wu, Zheng Fu, Yuhao Zeng, Zifan Zhao, Yao Huang, Xu Zhang, Baoan Sun, Yuchun Sun

{"title":"A lasting antibacterial, pro‐angiogenic, and pro‐osteogenic zirconium‐based bulk metallic glass for dental implants","authors":"Feifei Wang, Yunshu Wu, Zheng Fu, Yuhao Zeng, Zifan Zhao, Yao Huang, Xu Zhang, Baoan Sun, Yuchun Sun","doi":"10.1002/viw.20240099","DOIUrl":"https://doi.org/10.1002/viw.20240099","url":null,"abstract":"Abstract Bacterial infection and mismatched mechanical properties are important factors that increase the risk of dental implant failure. However, zirconium (Zr)‐based bulk metallic glasses (BMGs) can have both high strength and low modulus, as well as good biocompatibility, due to their unique atomic arrangement structure. Based on these common characteristics, different elemental compositions can endow zirconium‐based amorphous alloys with different properties. Here, we present a Zr‐based BMG containing silver (Ag) with good amorphous process ability, exhibiting lasting antibacterial, proangiogenic, and pro‐osteogenic properties. This newly developed Zr 61 Cu 23 Al 12 Ti 2 Ag 2 (at.%) BMG has higher strength and lower modulus than pure Titanium (Ti). Furthermore, it could exert antibacterial effects through both contact inhibition and metal ion sterilization. And this antibacterial property could last over 3 months. The systematically in vitro and in vivo results thus demonstrate the advantages and application potentials of Zr‐based BMG as a highly promising oral implant material for dental implantation.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20240099","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147896063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Enhanced activation of retinal progenitor cells by zinc silicate bioceramics for effective functional restoration in retinal degenerative diseases 硅酸锌生物陶瓷增强视网膜祖细胞的激活，用于视网膜退行性疾病的有效功能恢复

View (Beijing, China) Pub Date : 2025-01-29 DOI: 10.1002/viw.20240068

Na Sun, Zhaowenbin Zhang, Jiajing Wang, Yuan Yang, Jianhui Wang, Tianxing Chen, Yiqi Wang, Haodong Xiao, Ping Gu, Zhaoyang Wang, Jiang Chang, Jing Ji

{"title":"Enhanced activation of retinal progenitor cells by zinc silicate bioceramics for effective functional restoration in retinal degenerative diseases","authors":"Na Sun, Zhaowenbin Zhang, Jiajing Wang, Yuan Yang, Jianhui Wang, Tianxing Chen, Yiqi Wang, Haodong Xiao, Ping Gu, Zhaoyang Wang, Jiang Chang, Jing Ji","doi":"10.1002/viw.20240068","DOIUrl":"https://doi.org/10.1002/viw.20240068","url":null,"abstract":"Abstract Retinal degenerative diseases, primarily owing to the gradual loss of neuronal cells, could lead to blindness. Transplantation of retinal progenitor cells (RPCs), which had the unique ability to differentiate into neuronal cells, offered promising therapeutic potential for these diseases. However, a critical challenge in stem cell therapy was the efficient promotion of the directed proliferation and differentiation of progenitor cells. To overcome this limitation, we formulated a zinc silicate bioceramic (ZS) composite hydrogel. The experimental outcomes demonstrated that this novel material possessed substantial advantages and immense possibilities for mimicking the extracellular matrix environment, thereby effectively modulating stem cell proliferation and differentiation. Notably, it enhanced the differentiation of RPCs into neurons while suppressing glial cell differentiation. In particular, ZS had an exceptional capacity to induce the differentiation of RPCs into photoreceptor cells, a specialized type of neuronal cell. It was important to highlight that the ZS composite hydrogel predominantly facilitated the differentiation of RPCs through activation of the Tiam2‐Rac signaling pathway. Concurrently, it stimulated proliferation via activation of the AKT and ERK signaling pathways. The Zn ions in the ZS composite hydrogel primarily promoted the proliferation of RPCs, while the synergistic effect of Zn ions and Si ions contributed to reducing inflammatory factor expression and promoting the neuronal differentiation of RPCs. In conclusion, the meticulous modulation of RPC proliferation and differentiation mediated by ZS bioceramics held promise for novel therapeutic strategies of retinal degenerative diseases and neurodegenerative disorders.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147912096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6