View (Beijing, China)最新文献

SMILE: Extraction‐free submicron‐resolution mapping of lipid chain length and unsaturation by stimulated Raman imaging SMILE：通过受激拉曼成像对脂质链长度和不饱和进行无萃取亚微米分辨率的测绘

View (Beijing, China) Pub Date : 2026-03-04 DOI: 10.1002/viw.20250199

Yihui Zhou, Xiangjie Huang, Xingxin Liu, Ling Zhang, Jie Huang, Jing Zhao, Yongqing Zhang, Jin Zhang, Yanqing Gong, Delong Zhang, Hyeon Jeong Lee

{"title":"SMILE: Extraction‐free submicron‐resolution mapping of lipid chain length and unsaturation by stimulated Raman imaging","authors":"Yihui Zhou, Xiangjie Huang, Xingxin Liu, Ling Zhang, Jie Huang, Jing Zhao, Yongqing Zhang, Jin Zhang, Yanqing Gong, Delong Zhang, Hyeon Jeong Lee","doi":"10.1002/viw.20250199","DOIUrl":"https://doi.org/10.1002/viw.20250199","url":null,"abstract":"Abstract Lipid spatial heterogeneity is essential for linking metabolic regulation to cellular behavior. Yet, subcellular lipid profiling remains a challenge, as exogenous labels cannot detect lipid speciation and species diversity. Here, we developed submicron‐resolution mapping of intracellular lipid elements (SMILE), a vibrational spectrometry platform based on hyperspectral stimulated Raman scattering imaging with a spectral analysis pipeline for pixel‐resolved lipid profiling. SMILE enables quantitative mapping of lipid chain length and unsaturation at 300 nm resolution without the need for lipid extraction or labeling. Using SMILE, we revealed the spatial heterogeneity of lipid species and identified a distinct subset of highly aggregated lipid droplets (LDs) enriched in long‐chain polyunsaturated lipids in invasive cancer cells. Lipid elongation was found to promote LD aggregation and cancer migration/invasion, thereby defining this as a unique spatial lipid‐metabolic signature associated with cancer aggressiveness. Mechanistically, we identified linolenic acid as a key mediator driving aggressive lipid signatures and cancer invasion. Collectively, these findings demonstrate SMILE as an enabling spatial‐omics platform that expands the chemical resolution of vibrational spectroscopic imaging for fundamental and translational research.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147879002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PSMA PET-directed radiotherapy for prostate cancer: From precision planning to future innovations. 前列腺癌PSMA pet定向放疗：从精确规划到未来创新。

View (Beijing, China) Pub Date : 2026-02-01 Epub Date: 2025-10-31 DOI: 10.1002/VIW.20250143

Wenpeng Huang, Jessica C Hsu, Ruobing Li, Kexin Lan, Xin Qi, Yuchun Wei, Weibo Cai, Hongzhen Li

{"title":"PSMA PET-directed radiotherapy for prostate cancer: From precision planning to future innovations.","authors":"Wenpeng Huang, Jessica C Hsu, Ruobing Li, Kexin Lan, Xin Qi, Yuchun Wei, Weibo Cai, Hongzhen Li","doi":"10.1002/VIW.20250143","DOIUrl":"10.1002/VIW.20250143","url":null,"abstract":"Positron emission tomography (PET), particularly with prostate-specific membrane antigen (PSMA) tracers, has revolutionized the clinical management of prostate cancer (PCa). This review highlights the pivotal role of PET molecular imaging in guiding radiotherapy (RT) across diverse clinical scenarios, from postoperative biochemical recurrence to oligometastatic disease. Growing evidence shows that PET excels in lesion detection, enhances target volume delineation, enables focal dose escalation, and guides treatment intensification. PSMA PET increases the precision of RT planning, supports personalized therapeutic approaches, and is associated with improved outcomes, including biochemical recurrence-free and metastasis-free survival. The integration of PET with advanced RT technologies, including biology-guided radiotherapy (BgRT), is paving the way for real-time, biologically adaptive treatment paradigms. However, challenges remain, including the need for standardized protocols, management of tracer variability, and clinical translation of innovations such as PET-linear accelerator (LINAC) into routine practice. Future research should prioritize large-scale, prospective studies to establish the clinical efficacy, cost-effectiveness, and optimal integration of PET-guided RT in PCa care.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13028602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An engineered epididymal cell line provides a sustainable source of functional extracellular vesicles for in vitro sperm preservation: A multi‐omics and functional study 一种工程的附睾细胞系为体外精子保存提供了一个可持续的功能性细胞外囊泡来源：一项多组学和功能研究

View (Beijing, China) Pub Date : 2026-01-16 DOI: 10.1002/viw.20250186

Long Li, Haonan Zhao, Haonan Zhao, Yibo Li, Qixin Xu, Yang Zi, Tingting Chu, Heran Cao, S. Liu, Zifang Wu, Huanqiang Zhao, Huanqiang Zhao, Wuzi Dong

{"title":"An engineered epididymal cell line provides a sustainable source of functional extracellular vesicles for in vitro sperm preservation: A multi‐omics and functional study","authors":"Long Li, Haonan Zhao, Haonan Zhao, Yibo Li, Qixin Xu, Yang Zi, Tingting Chu, Heran Cao, S. Liu, Zifang Wu, Huanqiang Zhao, Huanqiang Zhao, Wuzi Dong","doi":"10.1002/viw.20250186","DOIUrl":"https://doi.org/10.1002/viw.20250186","url":null,"abstract":"ABSTRACT This study investigated the function of epididymal extracellular vesicles (EVs) in overcoming sperm post‐testicular modification deficiencies. Although EVs derived from the epididymis play a crucial role in intercellular communication and molecular exchange, there is limited research addressing how EVs released by in vitro cultured epididymal epithelial cells affect sperm function. Pig epididymal caput epithelial cells (pEECs) were successfully established and verified through immunofluorescence, Western blotting, semiquantitative analyses, and RNA sequencing. EVs from pEECs were isolated by low‐temperature ultracentrifugation and characterized using NanoSight and scanning electron microscopy. Proteomic sequencing showed that these EVs are enriched in cargoes beneficial to sperm, including antioxidants, motility modulators, sperm‒egg recognition molecules, and proteins associated with antigen processing and presentation. To validate their function, sperm were incubated with EVs at 17°C, demonstrating that EVs could attach to sperm, enhance antioxidant capacity and motility, and reduce plasma membrane oxidation, mitochondrial impairment, and DNA damage. These findings indicate that pEECs can sustainably secrete multifunctional EVs in vitro and that these EVs confer protective effects on sperm in a time‐dependent manner.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"7 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147898153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanobody–chlorin e6 conjugate for Nectin‐4‐mediated tumor targeting and enhanced photodynamic therapy 纳米-氯- e6缀合物用于Nectin - 4介导的肿瘤靶向和增强光动力治疗

View (Beijing, China) Pub Date : 2025-12-31 DOI: 10.1002/viw.20250185

Haodian Wan, Tao Ye, Yawei Bi, Jiayu Zhang, Wei Wu, Aochi Liu, Li Sun, Jie Lin, Ningli Chai, Manjie Zhang, Jian Ma

{"title":"Nanobody–chlorin e6 conjugate for Nectin‐4‐mediated tumor targeting and enhanced photodynamic therapy","authors":"Haodian Wan, Tao Ye, Yawei Bi, Jiayu Zhang, Wei Wu, Aochi Liu, Li Sun, Jie Lin, Ningli Chai, Manjie Zhang, Jian Ma","doi":"10.1002/viw.20250185","DOIUrl":"https://doi.org/10.1002/viw.20250185","url":null,"abstract":"Abstract Photodynamic therapy (PDT) holds promise for tumor ablation, but the clinical translation of photosensitizers, such as chlorin e6 (Ce6), is limited by poor aqueous solubility, low bioavailability, and insufficient tumor selectivity. To address these limitations, we constructed a nanobody–photosensitizer conjugate (NPC) by covalently linking Ce6 to a variable heavy‐chain domain targeting Nectin‐4, a clinically relevant tumor biomarker. Cell‐based assays demonstrated that NPC exhibited markedly enhanced aqueous solubility, efficient cellular uptake, and strong Nectin‐4‐dependent binding compared with free Ce6. Upon light activation, NPC generated abundant reactive oxygen species (ROS), triggered lysosomal disruption, and induced apoptosis and immunogenic cell death. In xenograft mouse models, NPC displayed prolonged circulation, rapid and selective tumor‐specific accumulation, and potent PDT to inhibit tumor growth, whereas free Ce6 displayed weak tumor retention and limited therapeutic benefit. Importantly, NPC treatment caused no measurable systemic toxicity or body weight loss during repeated administration. Collectively, these findings demonstrate that nanobody conjugation can overcome key pharmacological limitations of conventional photosensitizers by improving solubility, tumor targeting, and therapeutic index. NPC, thus, represents a promising next‐generation PDT agent with potential for tumor‐selective and clinically translatable phototherapy.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20250185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147912069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solamargine induces acute myeloid leukemia differentiation through TLR8 activation Solamargine通过激活TLR8诱导急性髓系白血病分化

View (Beijing, China) Pub Date : 2025-12-16 DOI: 10.1002/viw.20250161

Qiaoyan Han, Yuting Chen, Zheyi Li, Yonglin Peng, Hu Zhang, Yuliang Deng, Yanli Fu, Ming Cheng, Sheng Tan, Jing Tian, Xiaodong Zhao, Miao Sun

引用次数: 0

Chemical dehydration‐induced ultrafast clearing method for human tissues 化学脱水诱导的人体组织超快速清除方法

View (Beijing, China) Pub Date : 2025-12-16 DOI: 10.1002/viw.20250104

Yi Dai, Jianyi Xu, Jie Hao, Zhang Liu, C.B. Lan, Guanghua Xu, Xizhi Meng, Yating Deng, Peng Wan, Kunxing Liu, Yingtao Yao, Fang Zhao, Peng Fei, Xiu Nie, Gang Lv, Dan Zhu, Tingting Yu

{"title":"Chemical dehydration‐induced ultrafast clearing method for human tissues","authors":"Yi Dai, Jianyi Xu, Jie Hao, Zhang Liu, C.B. Lan, Guanghua Xu, Xizhi Meng, Yating Deng, Peng Wan, Kunxing Liu, Yingtao Yao, Fang Zhao, Peng Fei, Xiu Nie, Gang Lv, Dan Zhu, Tingting Yu","doi":"10.1002/viw.20250104","DOIUrl":"https://doi.org/10.1002/viw.20250104","url":null,"abstract":"Abstract Three‐dimensional (3D) visualization and analysis of histological features in human tissue can enhance our comprehension of organ function and elevate the precision of clinical diagnosis. Tissue optical clearing technique has emerged as a potent approach for achieving 3D imaging of large human tissues at a cellular resolution. However, the utilization of tissue clearing to obtain 3D structures of human tissue is hindered by prolonged incubation periods and intricate procedural steps. To address these issues, a rapid and straightforward clearing protocol termed single‐step dehydration solvent‐based clearing (SSD) is proposed by the introduction of trimethyl borate, which is innovatively incorporated into the tissue clearing process to expedite incubation and streamline the clearing procedure via chemical dehydration. This method reduces the clearing time by 70% and exhibits ideal compatibility with a variety of probes. SSD allows 3D histological imaging and analysis of nerves and vessels, as well as 3D pathological assessment of tumors, within human organs. As an ultrafast clearing alternative, SSD promises to facilitate histological research and enhance clinical diagnostic capabilities.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20250104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147334159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol attenuates areca nut extract‐induced chronic colitis by suppressing pyroptosis of intestinal epithelial cells via modulating cGAS/STING signaling 白藜芦醇通过调节cGAS/STING信号通路抑制肠上皮细胞的焦亡，从而减轻槟榔提取物诱导的慢性结肠炎

View (Beijing, China) Pub Date : 2025-11-29 DOI: 10.1002/viw.20250106

Jing Zhang, Muhammad Tufail, Yuqi Huang, Canhua Jiang, Ning Li

{"title":"Resveratrol attenuates areca nut extract‐induced chronic colitis by suppressing pyroptosis of intestinal epithelial cells via modulating cGAS/STING signaling","authors":"Jing Zhang, Muhammad Tufail, Yuqi Huang, Canhua Jiang, Ning Li","doi":"10.1002/viw.20250106","DOIUrl":"https://doi.org/10.1002/viw.20250106","url":null,"abstract":"Abstract Areca nut extract (ANE) worsens chronic colitis by disrupting gut barrier integrity; however, the underlying mechanisms remain unclear. In this study, we investigate whether resveratrol (RSV) can protect against ANE‐induced colonic injury by specifically targeting intestinal epithelial pyroptosis through the cGAS/STING signaling pathway. To explore this, chronic colitis mouse models were established through ANE treatment, with or without RSV administration. Disease severity, gut barrier function, inflammatory responses, microbiota composition, and metabolite profiles were comprehensively evaluated. Additionally, pyroptosis and the activation of the cGAS/STING pathway were examined in detail to clarify the potential mechanisms involved. Our results demonstrate that RSV significantly alleviated ANE‐induced colitis in a dose‐dependent manner. This was evidenced by a marked reduction in proinflammatory cytokines and the restoration of gut barrier function. Furthermore, RSV reshaped the gut microbiota composition and elevated levels of beneficial metabolites, such as linoleic acid. Notably, RSV also suppressed epithelial pyroptosis. Transcriptomic analysis further confirmed that RSV inhibited cGAS/STING signaling, thereby linking microbial and metabolic changes to improved mucosal health. In conclusion, RSV protects against ANE‐induced chronic colitis by modulating gut microbiota and metabolites and preserving gut barrier integrity through the inhibition of cGAS/STING‐mediated pyroptosis.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20250106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147886717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attenuation of arsenic trioxide‐induced endothelial injury: unveiling the protective role of ginkgolic acid through inhibition of TRPM4 SUMOylation: Evidence from Raman cellular imaging 三氧化二砷诱导的内皮损伤的衰减：揭示银杏酸通过抑制TRPM4 SUMOylation的保护作用：来自拉曼细胞成像的证据

View (Beijing, China) Pub Date : 2025-11-12 DOI: 10.1002/viw.20250049

Ting‐Ting Tong, Yadong Xue, Yuyao Zhang, Chunxiao Yu, Xin‐Yu Yao, Yu‐Xuan Han, Kai Zhang, Mei‐Mei Shen, Yu Zhao, Yunfeng Cui, Ziyue Ma, Yuyang Fu, Yongzhen Wang, Jing Jin, Ke Tang, Yang Liu, Yang Li, Rong Huo, Tao Ban

{"title":"Attenuation of arsenic trioxide‐induced endothelial injury: unveiling the protective role of ginkgolic acid through inhibition of TRPM4 SUMOylation: Evidence from Raman cellular imaging","authors":"Ting‐Ting Tong, Yadong Xue, Yuyao Zhang, Chunxiao Yu, Xin‐Yu Yao, Yu‐Xuan Han, Kai Zhang, Mei‐Mei Shen, Yu Zhao, Yunfeng Cui, Ziyue Ma, Yuyang Fu, Yongzhen Wang, Jing Jin, Ke Tang, Yang Liu, Yang Li, Rong Huo, Tao Ban","doi":"10.1002/viw.20250049","DOIUrl":"https://doi.org/10.1002/viw.20250049","url":null,"abstract":"Abstract Arsenic trioxide (ATO) therapy is limited by its severe vascular toxicity, which manifests as endothelial injury through mechanisms that remain poorly defined. This study identifies the SUMOylation of the Transient Receptor Potential Melastatin 4 (TRPM4) channel as a pivotal pathological driver of this process. We demonstrate that the SUMOylation inhibitor ginkgolic acid (GA) confers protection by attenuating ATO‐induced TRPM4 overactivation, thereby rescuing endothelial cells from ionic dysregulation (Ca 2 ⁺, Na⁺), oxidative stress, membrane depolarization, and apoptosis. Critically, we identified lysine 618 (K618) as the key SUMOylation site on TRPM4. Expression of a SUMOylation‐deficient TRPM4 mutant (K618R) phenocopied the protective effects of GA, significantly mitigating ATO‐induced endothelial dysfunction. This confirms that the detrimental effects of TRPM4 are strictly dependent on its SUMOylation at this residue. The protective efficacy of GA was further validated ex vivo, where it restored endothelium‐dependent vasodilation in rat mesenteric arteries impaired by ATO. Complementing these findings, Raman microimaging provided unique, label‐free insights into the biochemical alterations induced by ATO and their reversal by GA at the single‐cell level. Our findings unveil TRPM4‐SUMOylation at K618 as a fundamental mechanism underlying ATO‐induced endothelial injury. These results position the inhibition of this specific post‐translational modification as a promising therapeutic strategy for managing the vascular toxicity associated with ATO chemotherapy.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20250049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bionic nanobombs target nasopharyngeal carcinoma to enhance the efficacy of chemoradiotherapy by destroying DNA damage repair systems 仿生纳米炸弹通过破坏DNA损伤修复系统来增强鼻咽癌放化疗的疗效

View (Beijing, China) Pub Date : 2025-10-30 DOI: 10.1002/viw.20250149

Junhua Zhang, Xinying Xiang, Xinmin Nie, Jian Li, Rong Gui

{"title":"Bionic nanobombs target nasopharyngeal carcinoma to enhance the efficacy of chemoradiotherapy by destroying DNA damage repair systems","authors":"Junhua Zhang, Xinying Xiang, Xinmin Nie, Jian Li, Rong Gui","doi":"10.1002/viw.20250149","DOIUrl":"https://doi.org/10.1002/viw.20250149","url":null,"abstract":"Abstract Due to the concealed location of the nasopharynx, early diagnosis and treatment of nasopharyngeal carcinoma are relatively difficult. Although nasopharyngeal carcinoma is sensitive to radiation, normal tissues and organs are inevitably damaged by radiation. Patients who cannot tolerate radiation often need to be treated with chemotherapy drugs. Thus, how to improve the sensitivity of chemoradiotherapy and reduce the toxicity of chemoradiotherapy is an urgent need for us to study. In this study, we designed bionic nanobombs with a core‐shell structure (Nm‐pAu/CP/KU): PEGylated gold nanoparticles (pAu) were loaded with cisplatin (CP) and a radiochemotherapy sensitizer (KU‐60019) to form core pAu/CP/KU, and homologous nasopharyngeal carcinoma cell membrane vesicles (Nm) were used as the shell. Nm endows pAu/CP/KU with good biocompatibility and immune escape function. Through adhesion molecules, Nm‐pAu/CP/KU showed targeted aggregation in nasopharyngeal carcinoma sites. In the acidic tumor microenvironment, after PEG detachment, CP and KU‐60019 were released. AuNPs promoted X‐ray absorption at the tumor site and combined with CP to induce DNA breakage. KU‐60019, as a specific inhibitor of ATM proteins, inhibited ATM‐mediated DNA damage repair and enhanced radiochemotherapy sensitivity to X‐ray and CP treatment. Nm‐pAu/CP/KU provides a promising therapeutic strategy for targeted dual sensitization to radiochemotherapy in nasopharyngeal carcinoma.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20250149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147897577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triggering self‐supplied nanocatalytic reaction on Ti ₃ C ₂ MXene@CaO ₂ ‐TiO _2‐x for synergistic oral cancer therapy, antibacterial infection, and bone regeneration 在ti3c_2 MXene@CaO上触发自供给纳米催化反应，用于协同口腔癌治疗、抗菌感染和骨再生

View (Beijing, China) Pub Date : 2025-09-03 DOI: 10.1002/viw.20250031

Chao Liu, Huiping Li, Guangxin Sun, Yucheng Wang, Jiahao Zhang, Xinyi Huang, Yu Chen, Xuzhuo Chen, Xiuming Liu, Zixian Jiao, Shanyong Zhang

{"title":"Triggering self‐supplied nanocatalytic reaction on Ti 3 C 2 MXene@CaO 2 ‐TiO 2‐x for synergistic oral cancer therapy, antibacterial infection, and bone regeneration","authors":"Chao Liu, Huiping Li, Guangxin Sun, Yucheng Wang, Jiahao Zhang, Xinyi Huang, Yu Chen, Xuzhuo Chen, Xiuming Liu, Zixian Jiao, Shanyong Zhang","doi":"10.1002/viw.20250031","DOIUrl":"https://doi.org/10.1002/viw.20250031","url":null,"abstract":"Abstract After oral carcinoma resection, postoperative cancer recurrence, bacterial infection, and craniomaxillofacial bone defect threaten patients’ health. Current treatment is mainly to repair bone defects by bone substitute implantation, but that ignores the side effects caused by residual tumor cells and oral bacteria. To reach a better therapeutic effect, this paper develops a novel self‐supplied catalytic nanocomposite (MX@Ca‐Ti) that mainly consists of Ti 3 C 2 MXene nanosheets and CaO 2 nanoparticles with the purpose of synergistically promoting osteogenesis, inhibiting tumor cell growth, and preventing bacterial infection. Herein, the CaO 2 activation creates TiO 2‐x with Ti 3+ and Ti 4+ on MX@Ca‐Ti, which is structurally composed of porous, monolayer nanosheet and TiO 2‐x nanodots. The self‐supplied catalytic effects of sonodynamic therapy by Ti 4+ and chemodynamic therapy by Ti 3+ , enhance the therapeutic efficiency of tumor recurrence and bacterial infection. More importantly, this nanocomposite is demonstrated to have good cytocompatibility and osteogenesis‐promoting capability because of the release of O 2 and Ca 2+ . In conclusion, MX@Ca‐Ti not only defeats tumor cells and bacteria but also strengthens osteogenesis, which is an ideal treatment for avoiding postoperative complications and promoting bone defect repair from an oral carcinoma excision.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20250031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147904204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5