View (Beijing, China)最新文献

PSMA PET-directed radiotherapy for prostate cancer: From precision planning to future innovations. 前列腺癌PSMA pet定向放疗：从精确规划到未来创新。

View (Beijing, China) Pub Date : 2026-02-01 Epub Date: 2025-10-31 DOI: 10.1002/VIW.20250143

Wenpeng Huang, Jessica C Hsu, Ruobing Li, Kexin Lan, Xin Qi, Yuchun Wei, Weibo Cai, Hongzhen Li

{"title":"PSMA PET-directed radiotherapy for prostate cancer: From precision planning to future innovations.","authors":"Wenpeng Huang, Jessica C Hsu, Ruobing Li, Kexin Lan, Xin Qi, Yuchun Wei, Weibo Cai, Hongzhen Li","doi":"10.1002/VIW.20250143","DOIUrl":"10.1002/VIW.20250143","url":null,"abstract":"Positron emission tomography (PET), particularly with prostate-specific membrane antigen (PSMA) tracers, has revolutionized the clinical management of prostate cancer (PCa). This review highlights the pivotal role of PET molecular imaging in guiding radiotherapy (RT) across diverse clinical scenarios, from postoperative biochemical recurrence to oligometastatic disease. Growing evidence shows that PET excels in lesion detection, enhances target volume delineation, enables focal dose escalation, and guides treatment intensification. PSMA PET increases the precision of RT planning, supports personalized therapeutic approaches, and is associated with improved outcomes, including biochemical recurrence-free and metastasis-free survival. The integration of PET with advanced RT technologies, including biology-guided radiotherapy (BgRT), is paving the way for real-time, biologically adaptive treatment paradigms. However, challenges remain, including the need for standardized protocols, management of tracer variability, and clinical translation of innovations such as PET-linear accelerator (LINAC) into routine practice. Future research should prioritize large-scale, prospective studies to establish the clinical efficacy, cost-effectiveness, and optimal integration of PET-guided RT in PCa care.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13028602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical dehydration‐induced ultrafast clearing method for human tissues 化学脱水诱导的人体组织超快速清除方法

View (Beijing, China) Pub Date : 2025-12-16 DOI: 10.1002/viw.20250104

Yi Dai, Jianyi Xu, Jie Hao, Zhang Liu, C.B. Lan, Guanghua Xu, Xizhi Meng, Yating Deng, Peng Wan, Kunxing Liu, Yingtao Yao, Fang Zhao, Peng Fei, Xiu Nie, Gang Lv, Dan Zhu, Tingting Yu

{"title":"Chemical dehydration‐induced ultrafast clearing method for human tissues","authors":"Yi Dai, Jianyi Xu, Jie Hao, Zhang Liu, C.B. Lan, Guanghua Xu, Xizhi Meng, Yating Deng, Peng Wan, Kunxing Liu, Yingtao Yao, Fang Zhao, Peng Fei, Xiu Nie, Gang Lv, Dan Zhu, Tingting Yu","doi":"10.1002/viw.20250104","DOIUrl":"https://doi.org/10.1002/viw.20250104","url":null,"abstract":"Abstract Three‐dimensional (3D) visualization and analysis of histological features in human tissue can enhance our comprehension of organ function and elevate the precision of clinical diagnosis. Tissue optical clearing technique has emerged as a potent approach for achieving 3D imaging of large human tissues at a cellular resolution. However, the utilization of tissue clearing to obtain 3D structures of human tissue is hindered by prolonged incubation periods and intricate procedural steps. To address these issues, a rapid and straightforward clearing protocol termed single‐step dehydration solvent‐based clearing (SSD) is proposed by the introduction of trimethyl borate, which is innovatively incorporated into the tissue clearing process to expedite incubation and streamline the clearing procedure via chemical dehydration. This method reduces the clearing time by 70% and exhibits ideal compatibility with a variety of probes. SSD allows 3D histological imaging and analysis of nerves and vessels, as well as 3D pathological assessment of tumors, within human organs. As an ultrafast clearing alternative, SSD promises to facilitate histological research and enhance clinical diagnostic capabilities.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20250104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147334159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theranostic applications of multifunctional carbon nanomaterials. 多功能碳纳米材料的抗肿瘤应用。

View (Beijing, China) Pub Date : 2023-04-01 Epub Date: 2023-03-03 DOI: 10.1002/viw.20220056

Shima Masoudi Asil, Erick Damian Guerrero, Georgina Bugarini, Joshua Cayme, Nydia De Avila, Jaime Garcia, Adrian Hernandez, Julia Mecado, Yazeneth Madero, Frida Moncayo, Rosario Olmos, David Perches, Jacob Roman, Diana Salcido-Padilla, Efrain Sanchez, Christopher Trejo, Paulina Trevino, Md Nurunnabi, Mahesh Narayan

{"title":"Theranostic applications of multifunctional carbon nanomaterials.","authors":"Shima Masoudi Asil, Erick Damian Guerrero, Georgina Bugarini, Joshua Cayme, Nydia De Avila, Jaime Garcia, Adrian Hernandez, Julia Mecado, Yazeneth Madero, Frida Moncayo, Rosario Olmos, David Perches, Jacob Roman, Diana Salcido-Padilla, Efrain Sanchez, Christopher Trejo, Paulina Trevino, Md Nurunnabi, Mahesh Narayan","doi":"10.1002/viw.20220056","DOIUrl":"10.1002/viw.20220056","url":null,"abstract":"Nanobiotechnology is one of the leading research areas in biomedical science, developing rapidly worldwide. Among various types of nanoparticles, carbon nanomaterials (CNMs) have attracted a great deal of attention from the scientific community, especially with respect to their prospective application in the field of disease diagnosis and therapy. The unique features of these nanomaterials, including favorable size, high surface area, and electrical, structural, optical, and chemical properties, have provided an excellent opportunity for their utilization in theranostic systems. Carbon nanotubes, carbon quantum dots, graphene, and fullerene are the most employed CNMs in biomedical fields. They have been considered safe and efficient for non-invasive diagnostic techniques such as fluorescence imaging, magnetic resonance imaging, and biosensors. Various functionalized CNMs exhibit a great capacity to improve cell targeting of anti-cancer drugs. Due to their thermal properties, they have been extensively used in cancer photothermal and photodynamic therapy assisted by laser irradiation and CNMs. CNMs also can cross the blood-brain barrier and have the potential to treat various brain disorders, for instance, neurodegenerative diseases, by removing amyloid fibrils. This review has summarized and emphasized on biomedical application of CNMs and their recent advances in diagnosis and therapy.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10187466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Portable in situ temperature-dependent spectroscopy on a low-cost microfluidic platform integrated with a battery-powered thermofoil heater. 在低成本微流体平台上集成了电池供电的热箔加热器的便携式原位温度相关光谱。

View (Beijing, China) Pub Date : 2023-04-01 Epub Date: 2023-01-11 DOI: 10.1002/viw.20220053

Sai Krishna Katla, Wan Zhou, Hamed Tavakoli, Elvia Lilia Padilla Méndez, Xiujun Li

引用次数: 0

Wearable respiratory sensors for COVID-19 monitoring. 用于 COVID-19 监测的可穿戴呼吸传感器。

View (Beijing, China) Pub Date : 2022-11-01 Epub Date: 2022-10-31 DOI: 10.1002/VIW.20220024

Guorui Chen, Sophia Shen, Trinny Tat, Xun Zhao, Yihao Zhou, Yunsheng Fang, Jun Chen

{"title":"Wearable respiratory sensors for COVID-19 monitoring.","authors":"Guorui Chen, Sophia Shen, Trinny Tat, Xun Zhao, Yihao Zhou, Yunsheng Fang, Jun Chen","doi":"10.1002/VIW.20220024","DOIUrl":"10.1002/VIW.20220024","url":null,"abstract":"Since its outbreak in 2019, COVID-19 becomes a pandemic, severely burdening the public healthcare systems and causing an economic burden. Thus, societies around the world are prioritizing a return to normal. However, fighting the recession could rekindle the pandemic owing to the lightning-fast transmission rate of SARS-CoV-2. Furthermore, many of those who are infected remain asymptomatic for several days, leading to the increased possibility of unintended transmission of the virus. Thus, developing rigorous and universal testing technologies to continuously detect COVID-19 for entire populations remains a critical challenge that needs to be overcome. Wearable respiratory sensors can monitor biomechanical signals such as the abnormities in respiratory rate and cough frequency caused by COVID-19, as well as biochemical signals such as viral biomarkers from exhaled breaths. The point-of-care system enabled by advanced respiratory sensors is expected to promote better control of the pandemic by providing an accessible, continuous, widespread, noninvasive, and reliable solution for COVID-19 diagnosis, monitoring, and management.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"3 5","pages":"20220024"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10584698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress in COVID research and developments during pandemic. COVID 研究进展和大流行期间的发展。

View (Beijing, China) Pub Date : 2022-07-20 DOI: 10.1002/VIW.20210020

Sudheesh K Shukla, Santanu Patra, Trupti R Das, Dharmesh Kumar, Anshuman Mishra, Ashutosh Tiwari

{"title":"Progress in COVID research and developments during pandemic.","authors":"Sudheesh K Shukla, Santanu Patra, Trupti R Das, Dharmesh Kumar, Anshuman Mishra, Ashutosh Tiwari","doi":"10.1002/VIW.20210020","DOIUrl":"10.1002/VIW.20210020","url":null,"abstract":"The pandemic respiratory disease COVID-19 has spread over the globe within a small span of time. Generally, there are two important points are being highlighted and considered towards the successful diagnosis and treatment process. The first point includes the reduction of the rate of infections and the next one is the decrease of the death rate. The major threat to public health globally progresses due to the absence of effective medication and widely accepted immunization for the COVID-19. Whereas, understanding of host susceptibility, clinical features, adaptation of COVID-19 to new environments, asymptomatic infection is difficult and challenging. Therefore, a rapid and an exact determination of pathogenic viruses play an important role in deciding treatments and preventing pandemic to save the people's lives. It is urgent to fix a standardized diagnostic approach for detecting the COVID-19. Here, this systematic review describes all the current approaches using for screening and diagnosing the COVID-19 infectious patient. The renaissance in pathogen due to host adaptability and new region, facing creates several obstacles in diagnosis, drug, and vaccine development process. The study shows that adaptation of accurate and affordable diagnostic tools based on candidate biomarkers using sensor and digital medicine technology can deliver effective diagnosis services at the mass level. Better prospects of public health management rely on diagnosis with high specificity and cost-effective manner along with multidisciplinary research, specific policy, and technology adaptation. The proposed healthcare model with defined road map represents effective prognosis system.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":" ","pages":"20210020"},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350081/pdf/VIW2-9999-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40691711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection, prevention and treatment of COVID-19 and opportunities for nanobiotechnology. 新冠肺炎的检测、预防和治疗以及纳米生物技术的机会。

View (Beijing, China) Pub Date : 2022-07-01 Epub Date: 2022-03-15 DOI: 10.1002/VIW.20200181

Qing Bao, Tao Yang, Mingying Yang, Chuanbin Mao

{"title":"Detection, prevention and treatment of COVID-19 and opportunities for nanobiotechnology.","authors":"Qing Bao, Tao Yang, Mingying Yang, Chuanbin Mao","doi":"10.1002/VIW.20200181","DOIUrl":"10.1002/VIW.20200181","url":null,"abstract":"Since the outbreak of COVID-19, the number of confirmed cases and deaths has increased globally at a dramatic speed. In view of the serious health threat to humans, this review discusses the state-of-the-art studies about fighting this disease. It summarizes the current strategies and recent advances in detecting, preventing, and treating COVID-19 and interprets the underlying mechanisms in detail. Detection of COVID-19 can be successfully achieved by multiple techniques such as polymerase chain reaction, computed tomography imaging, and nano-biosensing. Inactivated virus vaccine, nucleic acid vaccine, and different nanoparticles have been employed to effectively prevent COVID-19. A variety of agents such as antiviral agents, neutralizing antibodies, and nanotherapeutics have been developed to treat COVID-19 with exciting efficacy. Although nanobiotechnology has shown great potential in the diagnosis, prevention, and treatment of COVID-19, efforts should be made to explore new biocompatible nano-biomaterials to advance this field to clinical applications. Hence, nanobiotechnology paves a new way to detect, prevent, and treat COVID-19 effectively.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"3 4","pages":"20200181"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9111118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10265510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoantidote for repression of acidosis pH promoting COVID-19 infection. 抑制酸中毒 pH 值促进 COVID-19 感染的纳米解毒剂。

View (Beijing, China) Pub Date : 2022-07-01 Epub Date: 2022-05-01 DOI: 10.1002/VIW.20220004

Qidong Liu, Huitong Ruan, Zhihao Sheng, Xiaoru Sun, Siguang Li, Wenguo Cui, Cheng Li

{"title":"Nanoantidote for repression of acidosis pH promoting COVID-19 infection.","authors":"Qidong Liu, Huitong Ruan, Zhihao Sheng, Xiaoru Sun, Siguang Li, Wenguo Cui, Cheng Li","doi":"10.1002/VIW.20220004","DOIUrl":"10.1002/VIW.20220004","url":null,"abstract":"Acidosis, such as respiratory acidosis and metabolic acidosis, can be induced by coronavirus disease 2019 (COVID-19) infection and is associated with increased mortality in critically ill COVID-19 patients. It remains unclear whether acidosis further promotes SARS-CoV-2 infection in patients, making virus removal difficult. For antacid therapy, sodium bicarbonate poses great risks caused by sodium overload, bicarbonate side effects, and hypocalcemia. Therefore, new antacid antidote is urgently needed. Our study showed that an acidosis-related pH of 6.8 increases SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) expression on the cell membrane by regulating intracellular microfilament polymerization, promoting SARS-CoV-2 pseudovirus infection. Based on this, we synthesized polyglutamic acid-PEG materials, used complexation of calcium ions and carboxyl groups to form the core, and adopted biomineralization methods to form a calcium carbonate nanoparticles (CaCO3-NPs) nanoantidote to neutralize excess hydrogen ions (H+), and restored the pH from 6.8 to approximately 7.4 (normal blood pH). CaCO3-NPs effectively prevented the heightened SARS-CoV-2 infection efficiency due to pH 6.8. Our study reveals that acidosis-related pH promotes SARS-CoV-2 infection, which suggests the existence of a positive feedback loop in which SARS-CoV-2 infection-induced acidosis enhances SARS-CoV-2 infection. Therefore, antacid therapy for acidosis COVID-19 patients is necessary. CaCO3-NPs may become an effective antacid nanoantidote superior to sodium bicarbonate.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":" ","pages":"20220004"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40609149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quickly evolving near-infrared photoimmunotherapy provides multifaceted approach to modern cancer treatment. 快速发展的近红外光免疫疗法为现代癌症治疗提供了多方面的方法。

View (Beijing, China) Pub Date : 2022-05-01 Epub Date: 2021-08-27 DOI: 10.1002/VIW.20200110

Hailey Monaco, Shinya Yokomizo, Hak Soo Choi, Satoshi Kashiwagi

{"title":"Quickly evolving near-infrared photoimmunotherapy provides multifaceted approach to modern cancer treatment.","authors":"Hailey Monaco, Shinya Yokomizo, Hak Soo Choi, Satoshi Kashiwagi","doi":"10.1002/VIW.20200110","DOIUrl":"10.1002/VIW.20200110","url":null,"abstract":"Among modalities of cancer immunotherapy, near-infrared photoimmunotherapy (NIR-PIT) has reached significant preclinical and clinical stages and quickly evolved over the last 5 years. NIR-PIT uses deep-penetrable NIR light to induce physicochemical changes in the antibody-photosensitizer conjugate (APC), leading to resultant necrosis and immunogenic cell death (ICD) of the cancer cells. Alternatively, other types of photomedicine use photosensitizers to convert absorbed light energy either into reactive oxygen species for photodynamic therapy (PDT) or into heat for photothermal therapy (PTT). ICD is a unique and relevant outcome of NIR-PIT because it induces long-lasting antitumor host immunity, which overcomes the immunosuppressive network of cancer. Due to its high specificity and durable antitumor effects, NIR-PIT is now considered a promising cancer therapy, and optimized NIR-PIT is readily expanding its applicability to many different types of cancer. Along with the traditional method of NIR-PIT, new avenues in its realm of treatment are currently being explored, such as the targeting of other immunosuppressive elements, delivery of NIR light through a catheter, real-time imaging for tumor detection, and the use of tumor-seeking small molecules for improved efficacy and safety. In addition, its effect on hyperpermeability has opened a door for a wide array of combination therapies with other modalities. This review summarizes the recent findings in clinical and preclinical studies of NIR-induced photomedicine and its future significance in the field of cancer research.","PeriodicalId":75305,"journal":{"name":"View (Beijing, China)","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9822966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodiagnostics in an era of global pandemics-From biosensing materials to data management. 全球大流行病时代的生物诊断--从生物传感材料到数据管理。

View (Beijing, China) Pub Date : 2022-03-01 Epub Date: 2021-06-18 DOI: 10.1002/VIW.20200164

Yoav Y Broza, Hossam Haick

引用次数: 0