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ATA Centennial Fireside Chat Expert Review Series: History of Graves' Disease Treatment 美国医学协会百年炉边谈话专家评论系列:格雷夫斯病的治疗史
VideoEndocrinology Pub Date : 2023-03-01 DOI: 10.1089/ve.2023.0005
T. Davies, Dawn M. Elfenbein
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引用次数: 0
ATA Centennial Interview Series: History of Thyroid Autoimmunity ATA百年访谈系列:甲状腺自身免疫史
VideoEndocrinology Pub Date : 2023-03-01 DOI: 10.1089/ve.2023.0003
G. Brent, S. McLachlan, B. Rapoport
{"title":"ATA Centennial Interview Series: History of Thyroid Autoimmunity","authors":"G. Brent, S. McLachlan, B. Rapoport","doi":"10.1089/ve.2023.0003","DOIUrl":"https://doi.org/10.1089/ve.2023.0003","url":null,"abstract":"","PeriodicalId":75302,"journal":{"name":"VideoEndocrinology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60542604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case Report of Poor Response to Selpercatinib in the Presence of a 632_633 RET Deletion 632_633 RET缺失对Selpercatinib不良反应1例报告
VideoEndocrinology Pub Date : 2023-03-01 DOI: 10.1089/ve.2022.0048
Ayanthi Wijewardene, Karine Bastard, Bin Wang, Matti Gild, Catherine Luxford, Anthony Gill, Bruce Robinson, Martyn Bullock, Roderick Clifton-Bligh
{"title":"A Case Report of Poor Response to Selpercatinib in the Presence of a 632_633 RET Deletion","authors":"Ayanthi Wijewardene, Karine Bastard, Bin Wang, Matti Gild, Catherine Luxford, Anthony Gill, Bruce Robinson, Martyn Bullock, Roderick Clifton-Bligh","doi":"10.1089/ve.2022.0048","DOIUrl":"https://doi.org/10.1089/ve.2022.0048","url":null,"abstract":"Background: Genomic deletions in medullary thyroid cancer (MTC) are rare. Selpercatinib is a highly selective rearranged during transfection (RET) inhibitor for treatment of metastatic RET-altered MTC.1 We report the case of a 35-year-old man with an aggressive metastatic MTC harboring p.632_633del RET that was poorly responsive to RET kinase inhibitor selpercatinib. Objective: Our objective was to understand the clinical phenotype of p.632_633del RET in MTC in context of novel RET kinase inhibitor treatment. Methods: Wild-type and p.632_633del RET sequences were modeled using a lighter version of the AlphaFold2 (AF2) software. Functional studies were performed on transfected HEK 293 cells (pCMV6-Entry, pCMV6-RET or pCMV6-RET(p.632_633del)) treated with inhibitors for 24 hours and analyzed on luciferase assays. Results: Structural modeling revealed a paucity of disulfide bridge between Cys630-Cys634 in p.632_633del RET sequences, apparent in wild type, whereas forming an intermolecular disulfide bridge between two Cys656. Proximity of juxtamembrane segments of each dimer may impede Tyr687 phosphorylation and stable conformation of intracellular RET that hosts selpercatinib. In vitro experiments confirmed a reduction in efficacy of selpercatinib upon p.632_633del RET compared with wild-type RET control. Conclusion: Clinical presentation together with structural modeling and functional studies suggest p.632_633del RET results in poor response to selpercatinib. No competing financial interests exist. No funding was received for this article. Runtime of video: 10 mins 1 secs This article has been accepted to the journal “Thyroid” in November 2022.","PeriodicalId":75302,"journal":{"name":"VideoEndocrinology","volume":"241 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135185667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective Left Neck Dissection for Lymph Node Metastases from Papillary Thyroid Cancer 癌症乳头状癌淋巴结转移的选择性左颈切除术
VideoEndocrinology Pub Date : 2022-12-01 DOI: 10.1089/ve.2022.0026
Luca Pennacchi, Francesco Cammarata, G. Montecamozzo, P. Danelli
{"title":"Selective Left Neck Dissection for Lymph Node Metastases from Papillary Thyroid Cancer","authors":"Luca Pennacchi, Francesco Cammarata, G. Montecamozzo, P. Danelli","doi":"10.1089/ve.2022.0026","DOIUrl":"https://doi.org/10.1089/ve.2022.0026","url":null,"abstract":"","PeriodicalId":75302,"journal":{"name":"VideoEndocrinology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42068384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parathyroid Autofluorescence During Thyroid Surgery: Utility and Limitations 甲状旁腺自身荧光在甲状腺手术:效用和局限性
VideoEndocrinology Pub Date : 2022-12-01 DOI: 10.1089/ve.2022.0032
Julian Martinez, M. Zafereo
{"title":"Parathyroid Autofluorescence During Thyroid Surgery: Utility and Limitations","authors":"Julian Martinez, M. Zafereo","doi":"10.1089/ve.2022.0032","DOIUrl":"https://doi.org/10.1089/ve.2022.0032","url":null,"abstract":"","PeriodicalId":75302,"journal":{"name":"VideoEndocrinology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48398392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transoral Endoscopic Vestibular Approach Sistrunk Procedure: Surgery Video 经口腔内窥镜前庭入路西斯干手术：手术视频
VideoEndocrinology Pub Date : 2022-12-01 DOI: 10.1089/ve.2022.0030
M. Nakai, Lucas Ribeiro Tenório, M. B. Menezes, Jonathan O. Russell, A. Gonçalves
{"title":"Transoral Endoscopic Vestibular Approach Sistrunk Procedure: Surgery Video","authors":"M. Nakai, Lucas Ribeiro Tenório, M. B. Menezes, Jonathan O. Russell, A. Gonçalves","doi":"10.1089/ve.2022.0030","DOIUrl":"https://doi.org/10.1089/ve.2022.0030","url":null,"abstract":"","PeriodicalId":75302,"journal":{"name":"VideoEndocrinology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49318245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laparoscopic Left Adrenalectomy After a Partial Nephrectomy 肾部分切除术后腹腔镜左肾上腺切除术
VideoEndocrinology Pub Date : 2022-12-01 DOI: 10.1089/ve.2022.0020
Tamanie Yeager, David Steinmetz, Aida Taye
{"title":"Laparoscopic Left Adrenalectomy After a Partial Nephrectomy","authors":"Tamanie Yeager, David Steinmetz, Aida Taye","doi":"10.1089/ve.2022.0020","DOIUrl":"https://doi.org/10.1089/ve.2022.0020","url":null,"abstract":"","PeriodicalId":75302,"journal":{"name":"VideoEndocrinology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41601427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Brief Summary: The 2022 Clinical Year in Thyroidology 综述：甲状腺学2022临床年
VideoEndocrinology Pub Date : 2022-12-01 DOI: 10.1089/ve.2022.0042
A. Leung
{"title":"A Brief Summary: The 2022 Clinical Year in Thyroidology","authors":"A. Leung","doi":"10.1089/ve.2022.0042","DOIUrl":"https://doi.org/10.1089/ve.2022.0042","url":null,"abstract":"","PeriodicalId":75302,"journal":{"name":"VideoEndocrinology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42475815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Year in Surgical Thyroidology 外科甲状腺病学年度
VideoEndocrinology Pub Date : 2022-12-01 DOI: 10.1089/ve.2022.0046
K. Patel
{"title":"The Year in Surgical Thyroidology","authors":"K. Patel","doi":"10.1089/ve.2022.0046","DOIUrl":"https://doi.org/10.1089/ve.2022.0046","url":null,"abstract":"","PeriodicalId":75302,"journal":{"name":"VideoEndocrinology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49132984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Radiofrequency Ablation Is a Thyroid Sparing Treatment Option for Primary Hyperparathyroidism Caused by an Intrathyroidal Parathyroid Adenoma 射频消融是甲状腺内甲状旁腺腺瘤引起的原发性甲状旁腺功能亢进的备用治疗方案
VideoEndocrinology Pub Date : 2022-10-21 DOI: 10.1089/ve.2022.0034
Jules Aljammal, I. Orozco, Sheharyar Raashid, Shahzad Ahmad
{"title":"Radiofrequency Ablation Is a Thyroid Sparing Treatment Option for Primary Hyperparathyroidism Caused by an Intrathyroidal Parathyroid Adenoma","authors":"Jules Aljammal, I. Orozco, Sheharyar Raashid, Shahzad Ahmad","doi":"10.1089/ve.2022.0034","DOIUrl":"https://doi.org/10.1089/ve.2022.0034","url":null,"abstract":"","PeriodicalId":75302,"journal":{"name":"VideoEndocrinology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43114146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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