Translational medicine communications最新文献

{"title":"Cervical catheter placement leads to improved rostral distribution of a radiolabeled 18F-baclofen analog in cynomolgus monkeys","authors":"B. Duclos, Cindy S. Roegge, H. Dobson, S. Haller, J. Bodner, Sanjana Pannem, Janelle Gesaman, Amin Nourmohammadi","doi":"10.1186/s41231-023-00136-w","DOIUrl":"https://doi.org/10.1186/s41231-023-00136-w","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"8 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41494853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting EphA2 and DDR signaling can overcome the BRAF and MEK inhibitors acquired resistance in melanoma cell lines","authors":"V. Belli, S. Napolitano, V. De Falco, G. Suarato, A. Perrone, L. Guerrera, G. Martini, C. D. Della Corte, E. Martinelli, F. Morgillo, M. Turano, M. Furia, G. Argenziano, D. Ciardiello, F. Ciardiello, T. Troiani","doi":"10.1186/s41231-022-00133-5","DOIUrl":"https://doi.org/10.1186/s41231-022-00133-5","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"8 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49376684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of HIF-1α and markers of angiogenesis and metabolic adaptation in molecular subtypes of breast cancer","authors":"Muzamil Farooq, G. Bhat, S. Besina, N. Thakur, Sheikh Zahoor, Rafiq A. Rather, I. Mushtaq, S. Dar, B. Rah, Ajaz A. Bhat, M. Macha, D. Afroze","doi":"10.1186/s41231-023-00135-x","DOIUrl":"https://doi.org/10.1186/s41231-023-00135-x","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"8 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43323842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RLS-0071, a dual-targeting anti-inflammatory peptide - biomarker findings from a first in human clinical trial","authors":"Jessica Goss, P. Hair, Parvathi Kumar, Giuseppina Iacono, L. Redden, G. Morelli, N. Krishna, U. Thienel, K. Cunnion","doi":"10.1186/s41231-022-00134-4","DOIUrl":"https://doi.org/10.1186/s41231-022-00134-4","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2023-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44152144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accessing and utilizing clinical and genomic data from an electronic health record data warehouse.","authors":"Cosby G Arnold, Brandon Sonn, Frederick J Meyers, Alexis Vest, Richie Puls, Estelle Zirkler, Michelle Edelmann, Ian M Brooks, Andrew A Monte","doi":"10.1186/s41231-023-00140-0","DOIUrl":"10.1186/s41231-023-00140-0","url":null,"abstract":"<p><p>Electronic health records (EHRs) and linked biobanks have tremendous potential to advance biomedical research and ultimately improve the health of future generations. Repurposing EHR data for research is not without challenges, however. In this paper, we describe the processes and considerations necessary to successfully access and utilize a data warehouse for research. Although imperfect, data warehouses are a powerful tool for harnessing a large amount of data to phenotype disease. They will have increasing relevance and applications in clinical research with growing sophistication in processes for EHR data abstraction, biobank integration, and cross-institutional linkage.</p>","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10786622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46408486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating neutrophil extracellular trap (NET)-forming 'rogue' neutrophil subset, immunotype [DEspR + CD11b +], mediate multi-organ failure in COVID-19-<i>an observational study</i>.","authors":"Victoria L M Herrera, Nicholas A Bosch, Judith J Lok, Mai Q Nguyen, Kaitriona A Lenae, Joanne T deKay, Sergey V Ryzhov, David B Seder, Nelson Ruiz-Opazo, Allan J Walkey","doi":"10.1186/s41231-023-00143-x","DOIUrl":"10.1186/s41231-023-00143-x","url":null,"abstract":"<p><strong>Background: </strong>Cumulative research show association of neutrophils and neutrophil extracellular traps (NETs) with poor outcomes in severe COVID-19. However, to date, there is no curative intent therapy able to block neutrophil/NETs-mediated progression of multi-organ dysfunction. Because of emerging neutrophil heterogeneity, the study of subsets of circulating NET-forming neutrophils [NET + Ns] as mediators of multi-organ failure progression among patients with COVID-19 is critical to identification of therapeutic targets.</p><p><strong>Methods: </strong>We conducted a prospective observational study of circulating levels of CD11b + [NET + N] immunotyped for dual endothelin-1/signal peptide receptor (DEspR ±) expression by quantitative immunofluorescence-cytology and causal mediation analysis. In 36 consented adults hospitalized with mod-severe COVID-19, May to September 2020, we measured acute multi-organ failure via SOFA-scores and respiratory failure via SaO2/FiO2 (SF)-ratio at time points t1 (average 5.5 days from ICU/hospital admission) and t2 (the day before ICU-discharge or death), and ICU-free days at day28 (ICUFD). Circulating absolute neutrophil counts (ANC) and [NET + N] subset-specific counts were measured at t1. Spearman correlation and causal mediation analyses were conducted.</p><p><strong>Results: </strong>Spearman correlation analyses showed correlations of t1-SOFA with t2-SOFA (<i>rho r</i> _<i>S</i>  = 0.80) and ICUFD (<i>r</i> _<i>S</i>  = -0.76); circulating DEspR + [NET + Ns] with t1-SOFA (<i>r</i> _<i>S</i>  = 0.71), t2-SOFA (<i>r</i> _<i>S</i>  = 0.62), and ICUFD (<i>r</i> _<i>S</i>  = -0.63), and ANC with t1-SOFA (<i>r</i> _<i>S</i>  = 0.71), and t2-SOFA (<i>r</i> _<i>S</i>  = 0.61).Causal mediation analysis identified DEspR + [NET + Ns] as mediator of 44.1% [95% CI:16.5,110.6] of the causal path between t1-SOFA (exposure) and t2-SOFA (outcome), with 46.9% [15.8,124.6] eliminated when DEspR + [NET + Ns] were theoretically reduced to zero. Concordantly, DEspR + [NET + Ns] mediated 47.1% [22.0,72.3%] of the t1-SOFA to ICUFD causal path, with 51.1% [22.8,80.4%] eliminated if DEspR + [NET + Ns] were reduced to zero. In patients with t1-SOFA > 1, the indirect effect of a hypothetical treatment eliminating DEspR + [NET + Ns] projected a reduction of t2-SOFA by 0.98 [0.29,2.06] points and ICUFD by 3.0 [0.85,7.09] days. In contrast, there was no significant mediation of SF-ratio through DEspR + [NET + Ns], and no significant mediation of SOFA-score through ANC.</p><p><strong>Conclusions: </strong>Despite equivalent correlations, DEspR + [NET + Ns], but not ANC, mediated progression of multi-organ failure in acute COVID-19, and its hypothetical reduction is projected to improve ICUFD. These translational findings warrant further studies of DEspR + [NET + Ns] as potential patient-stratifier and actionable therapeutic target for multi-organ failur","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"8 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9409960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncolytic virus-based suicide gene therapy for cancer treatment: a perspective of the clinical trials conducted at Henry Ford Health.","authors":"Shivani Thoidingjam, Sushmitha Sriramulu, Svend Freytag, Stephen L Brown, Jae Ho Kim, Indrin J Chetty, Farzan Siddiqui, Benjamin Movsas, Shyam Nyati","doi":"10.1186/s41231-023-00144-w","DOIUrl":"10.1186/s41231-023-00144-w","url":null,"abstract":"<p><p>Gene therapy manipulates or modifies a gene that provides a new cellular function to treat or correct a pathological condition, such as cancer. The approach of using gene manipulation to modify patient's cells to improve cancer therapy and potentially find a cure is gaining popularity. Currently, there are 12 gene therapy products approved by US-FDA, EMA and CFDA for cancer management, these include Rexin-G, Gendicine, Oncorine, Provange among other. The Radiation Biology Research group at Henry Ford Health has been actively developing gene therapy approaches for improving clinical outcome in cancer patients. The team was the first to test a replication-competent oncolytic virus armed with a therapeutic gene in humans, to combine this approach with radiation in humans, and to image replication-competent adenoviral gene expression/activity in humans<i>. </i>The adenoviral gene therapy products developed at Henry Ford Health have been evaluated in more than 6 preclinical studies and evaluated in 9 investigator initiated clinical trials treating more than100 patients. Two phase I clinical trials are currently following patients long term and a phase I trial for recurrent glioma was initiated in November 2022. This systematic review provides an overview of gene therapy approaches and products employed for treating cancer patients including the products developed at Henry Ford Health.</p>","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"8 1","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9311084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of an SPM-enriched marine oil and bioavailable curcumin combination on inflammation-associated discomfort in generally healthy individuals: a virtual open-label pilot study","authors":"A. Jaja-Chimedza, Steven P. Hirsh, Dainian Bruce, Tony Bou-Sliman, S. Joyal, A. Swick","doi":"10.1186/s41231-022-00131-7","DOIUrl":"https://doi.org/10.1186/s41231-022-00131-7","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"7 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46344473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Planning preclinical confirmatory multicenter trials to strengthen translation from basic to clinical research – a multi-stakeholder workshop report","authors":"N. Drude, Lorena Martinez-Gamboa, M. Danziger, Anja Collazo, S. Kniffert, Janine Wiebach, G. Nilsonne, F. Konietschke, S. K. Piper, Samuel Pawel, Charlotte Micheloud, L. Held, F. Frommlet, D. Segelcke, E. Pogatzki-Zahn, B. Voelkl, T. Friede, Edgar Brunner, A. Dempfle, Bernhard Haller, M. J. Jung, L. B. Riecken, Hans-Georg Kuhn, M. Tenbusch, L. M. Higuita, E. Remarque, Servan Luciano Grüninger-Egli, K. Manske, S. Kobold, M. Rivalan, L. Wedekind, J. Wilcke, A. Boulesteix, M. Meinhardt, R. Spanagel, S. Hettmer, I. von Lüttichau, C. Regina, U. Dirnagl, U. Toelch","doi":"10.1186/s41231-022-00130-8","DOIUrl":"https://doi.org/10.1186/s41231-022-00130-8","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49107193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of different patterns of dyslipidemia in patients with type 2 diabetes in an Iranian population","authors":"Amirhossein Yadegar, F. Mohammadi, S. Rabizadeh, Reihane Qahremani, A. Esteghamati, M. Nakhjavani","doi":"10.1186/s41231-022-00129-1","DOIUrl":"https://doi.org/10.1186/s41231-022-00129-1","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"7 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2022-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42279262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}