Therapeutic advances in reproductive health最新文献

{"title":"Development of a predictive model for severe peripartum hemorrhage in placenta accreta spectrum cases under neuraxial anesthesia: a multicenter retrospective analysis.","authors":"Yanan Li, Liang Li, Xiao Song, Fanqing Meng, Meiling Zhang, Yarong Li, Ran Chu","doi":"10.1177/26334941251317644","DOIUrl":"10.1177/26334941251317644","url":null,"abstract":"<p><strong>Background: </strong>The placenta accreta spectrum (PAS) represents a significant risk factor for severe postpartum hemorrhage. Recent studies have demonstrated the safety of neuraxial anesthesia (NA) in cesarean delivery (CD) for patients with PAS.</p><p><strong>Objectives: </strong>To evaluate the risk of severe peripartum hemorrhage in patients with PAS who underwent CD under NA.</p><p><strong>Design: </strong>A multicenter retrospective cohort study.</p><p><strong>Methods: </strong>This study analyzed 214 patients diagnosed with PAS. Logistic regression was used to identify factors increasing the risk of severe peripartum hemorrhage. A total of six machine learning (ML) algorithms were employed for model validation.</p><p><strong>Results: </strong>The predictive model includes the following risk factors: age at delivery >33 years (<i>p</i> = 0.004), history of CD >1 (<i>p</i> = 0.020), preoperative HGB ⩽ 100 g/L (<i>p</i> = 0.013), placenta previa classification (<i>p</i> = 0.001), vascular lacunae within the placenta (<i>p</i> = 0.015), and labor duration (<i>p</i> = 0.026). The validation of ML algorithms revealed that the model achieved an accuracy ranging from 0.68 to 0.71, with an area under the receiver operating characteristic curve between 0.75 and 0.79. A nomogram list and web-based calculator were constructed for clinical implementation, and a risk stratification system was established based on model scores.</p><p><strong>Conclusion: </strong>A prenatal risk assessment model was developed to estimate the likelihood of severe peripartum hemorrhage in PAS patients undergoing CD under NA. This model may provide preliminary support for clinicians in tailoring anesthetic management strategies for potentially high-risk cases, but further studies are needed to confirm its clinical utility.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"19 ","pages":"26334941251317644"},"PeriodicalIF":3.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction nomogram for antepartum hemorrhage in placenta previa women.","authors":"Dazhi Fan, Pengzhen Hu, Jiaming Rao, Dongxin Lin, Jie Yang, Zhengping Liu, Xiaoling Guo","doi":"10.1177/26334941251315127","DOIUrl":"10.1177/26334941251315127","url":null,"abstract":"<p><strong>Background: </strong>Placenta previa with antepartum hemorrhage (APH) is common and closely related to maternal and fetal morbidity and mortality. It is of the utmost importance to prepare for the possibility of APH using perinatal factors prior to delivery.</p><p><strong>Objective: </strong>To develop and validate a nomogram predicting APH in women with placenta previa based on the perinatal factors.</p><p><strong>Design: </strong>This was a retrospective and prospective cohort study of pregnant women with placenta previa.</p><p><strong>Methods: </strong>The model was developed in the retrospective and validated in the prospective cohort study. Multivariate logistic regression was applied to discover independent variables and develop a nomogram to predict the possibility of APH. An Excel form computer interface was constructed to use the model.</p><p><strong>Results: </strong>There are 1601 and 693 participants in the retrospective and prospective cohort study. Maternal age (odds ratio 0.950, 95% confidence interval 0.918-0.984), married (0.533, 0.309-0.920), parity (1.240, 1.024-1.502), threatened abortion (5.059, 3.648-7.014), and complete placenta previa (1.833, 95% CI 1.469-2.289) were independent variables for APH in placenta previa women. The area under the curve and concordance index were 0.828 and 0.676, respectively. The model was a good fit by the Hosmer-Lemeshow test (<i>p</i> = 0.352). The prospective validation proved the reliability of the prediction nomogram. The Excel form computer interface was practical.</p><p><strong>Conclusion: </strong>A nomogram based on perinatal factors was developed and validated to predict APH in women with placenta previa. The reliable tool may thereafter offer important assistance for decision-making processes.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"19 ","pages":"26334941251315127"},"PeriodicalIF":3.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of reproductive knowledge among young adults utilizing Amazon mechanical Turk survey.","authors":"Alexandra Aponte Varnum, David A Velasquez, Jason Codrington, Aymara Evans, Justin M Dubin, Ranjith Ramasamy","doi":"10.1177/26334941241309890","DOIUrl":"10.1177/26334941241309890","url":null,"abstract":"<p><strong>Background: </strong>Reproductive health technology has evolved significantly since the introduction of in vitro fertilization in 1978, enhancing the possibility of conceiving children at later stages in life. Despite these advancements, there remains a critical gap in fertility knowledge among young adults, as demonstrated by recent studies. This gap is compounded by the growing influence of social media on health information, where misinformation can distort public understanding of fertility-related issues. Addressing this knowledge deficit is essential for empowering individuals to make informed decisions about their reproductive futures.</p><p><strong>Objectives: </strong>With the increasing prevalence of older individuals becoming parents and the growing reliance on Assisted Reproductive Technologies for conception, our study aimed to assess fertility knowledge among young adults.</p><p><strong>Design: </strong>This study employed a survey-based approach using Amazon's crowd-sourcing marketing platform, Mechanical Turk (MTurk). Participants were asked to complete a 17-question survey that included a section on demographic information. The questionnaire explored various aspects of knowledge and perceptions regarding male and female fertility.</p><p><strong>Methods: </strong>The survey was completed by 983 participants aged 18-30, recruited through MTurk. Individuals outside this age range were excluded from the study. Participants received a $0.50 incentive for their participation.</p><p><strong>Results: </strong>Notably, a high percentage of respondents correctly identified the age range at which female fertility (70.4% of participants) declines, while fewer (56.4% of participants) demonstrated awareness of the age range at which male fertility declines. Furthermore, an overwhelming majority exhibited appropriate knowledge regarding the impact of lifestyle factors, such as obesity and smoking, on fertility. The findings suggest an encouragingly high level of awareness among participants regarding fundamental fertility concepts. Approximately 63% of participants reported social media as a source of this information.</p><p><strong>Conclusion: </strong>This study yields promising insights into fertility knowledge among young adults. However, it underscores a notable deficiency in understanding male fertility, emphasizing the imperative for further educational initiatives in this domain. These results also highlight the crucial role of healthcare providers in maintaining an online presence to disseminate valuable, evidence-based knowledge. By doing so, healthcare professionals can empower individuals to make informed decisions regarding fertility.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"18 ","pages":"26334941241309890"},"PeriodicalIF":3.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between chronic endometritis and fallopian tube obstruction and its influence on pregnancy outcome after fallopian tubal recanalization.","authors":"Yu Sun, Dongyan Li, Shuaihong Zhao, Mukun Yang, Guangxia Cui, Wenpei Bai","doi":"10.1177/26334941241308413","DOIUrl":"10.1177/26334941241308413","url":null,"abstract":"<p><strong>Background: </strong>Chronic endometritis (CE), frequently asymptomatic, is associated with female infertility. Fallopian tube obstruction (FTO) is also one of the factors contributing to female infertility. More than 90% of cases of proximal FTO can be successfully treated after fallopian tubal recanalization (FTR) and the spontaneous pregnancy rate of treated women after FTR is only about 30%. Potential factors affecting the success rate of FTR remain unclear. We speculate that CE may be one of the reasons affecting the recanalization of the fallopian tubes.</p><p><strong>Objectives: </strong>To identify the correlation between CE and FTO, as well as the influence of CE on pregnancy outcomes following FTR.</p><p><strong>Design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>We retrospectively analyzed 498 women of childbearing age who underwent laparoscopy and hysteroscopy surgery for infertility. Endometrial samples were collected during surgery for CD138 immunohistochemistry staining for the diagnosis of CE. Based on the results of the tubal patency test, they were divided into two groups: the fallopian tubal patency group and the proximal FTO group. The prevalence of CE was compared between these two groups. All women with FTO underwent FTR during the operation until successful treatment was achieved. Pregnancy outcomes were assessed after a 12-month follow-up period following the procedures. Logistic regression was used to analyze factors that might affect pregnancy after FTR.</p><p><strong>Results: </strong>The prevalence of CE in women with tubal obstruction was 30.5%, which was significantly higher than that in the fallopian tubal patency group (10.75%), <i>p</i> < 0.001. After FTR, the prevalence of CE in non-pregnant women was 40.18%, which was higher than that in pregnant women (40.18% vs 13.11%), and the difference was significant (<i>p</i> < 0.001). Multiple regression analysis showed that CE was a significant risk factor for FTO (OR: 2.54, 95% CI: 1.368-4.717, <i>p</i> < 0.05). In addition, CE was identified as a risk factor for infertility after FTR (OR: 4.730, 95% CI: 2.012-11.122).</p><p><strong>Conclusion: </strong>The presence of CE seems to decrease the likelihood of achieving spontaneous pregnancy following FTR. This observation underscores the clinical importance of early detection and treatment of CE, emphasizing the necessity for immediate intervention to prevent potential fertility complications.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"18 ","pages":"26334941241308413"},"PeriodicalIF":3.1,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chlamydia trachomatis infections in Kenya - sexually transmitted and ocular infections: a scoping review.","authors":"Aarman Sohaili, Servaas A Morre, Pierre P M Thomas","doi":"10.1177/26334941241305825","DOIUrl":"10.1177/26334941241305825","url":null,"abstract":"<p><strong>Background: </strong><i>Chlamydia trachomatis</i> (CT), a Gram-negative intracellular bacterium, is differentiated into three biovars associated with distinct clinical syndromes, ranging from trachoma, the world's cause of preventable blindness, to the most common sexually transmitted infection. This variability underscores CT's significant impact on public health, particularly in low-resource settings. In Kenya, where the demographic is predominantly younger, the burden of CT remains poorly understood and potentially underestimated.</p><p><strong>Objectives: </strong>This study aimed to assess the prevalence of both sexually transmitted and ocular CT across various regions and populations within Kenya.</p><p><strong>Eligibility criteria: </strong>Articles on CT population testing and laboratory detection, from 2014 to date, in English or Swahili only.</p><p><strong>Sources of evidence: </strong>Electronic databases of PubMed and Google Scholar were used.</p><p><strong>Design: </strong>A scoping review.</p><p><strong>Charting methods: </strong>This study conducted a systematic scoping review, following Arksey and O'Malley's framework and adhering to PRISMA guidelines for scoping reviews (PRISMA-ScR).</p><p><strong>Results: </strong>This study incorporates findings from 19 original studies on sexually transmitted CT and seven on ocular CT. CT prevalence for four identified populations: sexually active females 2%-13%, men who have sex with men 1.3%-51%, pregnant women 2.5%-14.9% and other population groups 2.8%-16.4%. By contrast, studies on ocular CT, all performed in rural settings, found prevalence surpassing the WHO's 10% threshold primarily amongst children and mothers.</p><p><strong>Conclusion: </strong>The variability in CT prevalence across different demographics and geographical regions emphasizes the impact of socio-economic, environmental and diagnostic factors on disease transmission and detection. The insights gained here can serve as a foundation for evidence-based health policies and interventions aimed at mitigating the burden of CT in Kenya.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"18 ","pages":"26334941241305825"},"PeriodicalIF":3.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital knowledge translation tools for sexual and reproductive health information to adolescents: an evidence gap-map.","authors":"Salima Meherali, Amber Hussain, Komal Abdul Rahim, Sobia Idrees, Soumyadeep Bhaumik, Megan Kennedy, Zohra S Lassi","doi":"10.1177/26334941241307881","DOIUrl":"10.1177/26334941241307881","url":null,"abstract":"<p><strong>Background: </strong>Digital knowledge translation (KT) interventions play a crucial role in advancing adolescent sexual and reproductive health (ASRH). Despite the extensive literature on their effectiveness, there's a lack of synthesized evidence on the efficacy of digital KT tools for adolescent ASRH globally.</p><p><strong>Objectives: </strong>This review aimed to systematically identify and map existing empirical evidence on digital KT tools targeting ASRH outcomes and identify research gaps.</p><p><strong>Design: </strong>The review employed an evidence gap-map (EGM) approach following 2020 PRISMA reporting guidelines.</p><p><strong>Data sources and methods: </strong>A comprehensive literature search was conducted across databases including Medline, EMBASE, Global Health, CINAHL, Scopus, and Cochrane. Covidence software was used for data management. EPPI-Mapper software was used to synthesize findings and develop a graphical EGM.</p><p><strong>Results: </strong>The EGM comprises 68 studies: 59 experimental and 9 systematic reviews, predominantly from African (19 studies) and American regions (22 studies), with limited research from the Eastern Mediterranean and South East Asian regions. It examines digital KT tools' influence on sexual and reproductive health (SRH) outcomes, identifying research gaps. Websites are extensively studied for their impact on adolescent behavior, knowledge, attitude, and self-efficacy, yet research on their effects on ASRH and health services access is limited. Similarly, mobile apps and short message service (SMS)/text messages impact various aspects of SRH outcomes, but research on their effects on health services utilization is insufficient. Interventions like digital pamphlets and gaming lack exploration in health service access. OTT media and social media need further investigation. Mass media, including radio, television, and podcasts, are largely unexplored in adolescent SRH outcomes. Topics such as menstrual hygiene, abortion, and sexual and intimate partner violence also lack research.</p><p><strong>Conclusion: </strong>The review underscores the dominance of certain KT tool interventions like SMS and websites. Despite advancements, research gaps persist in exploring diverse digital platforms on underrepresented outcomes globally. Future research should expand exploration across digital platforms and broaden the scope of outcome measures.</p><p><strong>Trial registration: </strong>The protocol is registered with PROSPERO (CRD42022373970).</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"18 ","pages":"26334941241307881"},"PeriodicalIF":3.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of adequate antenatal care among immediate postpartum mothers in Eastern Uganda: a multicenter cross-sectional study.","authors":"Seungwon Lee, Ritah Nantale, Solomon Wani, Samuel Kasibante, Andrew Marvin Kanyike","doi":"10.1177/26334941241305074","DOIUrl":"10.1177/26334941241305074","url":null,"abstract":"<p><strong>Background: </strong>Antenatal care is essential for reducing maternal and neonatal mortality, particularly in low-income regions. However, the adequacy of the care provided is crucial for achieving maternal health goals. Maternal mortality rates in Uganda are still among the highest globally. Thus, evaluating the adequacy of antenatal care (ANC) services, especially in high-risk regions is imperative.</p><p><strong>Objective: </strong>To determine the prevalence of adequate ANC and associated factors in Eastern Uganda.</p><p><strong>Design: </strong>A multicenter quantitative cross-sectional study was conducted at four healthcare facilities in Eastern Uganda from July to August 2022.</p><p><strong>Methods: </strong>We included immediate postpartum mothers who had given birth within 48 h with a record of their ANC information on a card or book. Adequate ANC was measured by a composite index of 10 core components per WHO guidelines on ANC for a positive pregnancy experience. Data were collected using a structured questionnaire designed with Kobo Toolbox and analyzed using Stata 15.0. Bivariable and multivariable logistic regression analyses assessed factors associated with receiving adequate ANC. Statistical significance was determined by a <i>p</i> value <0.05.</p><p><strong>Results: </strong>We recruited 1104 postnatal mothers, most aged 20-34 years (<i>n</i> = 805, 72.9%). Only 5.9% received adequate ANC, with most mothers receiving an average of 6.9 (±2.0) of the 10 assessed ANC components. Receiving adequate ANC was associated with urban residency (AOR: 2.3; 95% CI: 1.16-4.38, <i>p</i> = 0.017), age between 20 and 34 years (AOR: 3.5; 95% CI: 1.07-11.30, <i>p</i> = 0.038), current or previous complications (AOR: 1.8; 95% CI: 1.02-3.29, <i>p</i> = 0.043), and delivery at a general hospital (AOR: 4.8; 95% CI: 2.60-8.83, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>There is a critical gap in providing adequate ANC in Eastern Uganda, especially for rural and younger mothers. Policy efforts should focus on expanding access, enhancing maternal education, and strengthening healthcare infrastructure to meet the recommended ANC standards.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"18 ","pages":"26334941241305074"},"PeriodicalIF":3.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and practice toward menstrual hygiene management and associated factors among visual impaired adolescent girls: a case of two selected institutions in Rwanda.","authors":"Marie Laetitia Ishimwe Bazakare, Bernard Ngabo Rwabufigiri, Cyprien Munyanshongore","doi":"10.1177/26334941241303518","DOIUrl":"10.1177/26334941241303518","url":null,"abstract":"<p><strong>Background: </strong>Menstruation is a universal and normal phenomenon during the reproductive age of females; adolescence is an essential period where females are preparing and adjusting themselves to manage their menstrual bleeding safely and cleanly. Menstrual hygiene management (MHM) is an issue that is insufficiently acknowledged and has not received adequate attention among visually impaired adolescent girls (VIAGs).</p><p><strong>Objectives: </strong>The purpose of this study was to determine the knowledge and practice of MHM and associated factors among VIAGs of selected institutions in Rwanda.</p><p><strong>Design: </strong>This study consisted of a cross-sectional study design using a quantitative approach.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in April and May 2021 on 92 VIAGs. They were recruited from educational institutions in two Provinces in Rwanda. Voluntary participation and confidentiality were assured. Socioeconomic and demographic data, menstruation, and menstrual hygiene questionnaires were used to obtain the required information. Statistical Packages for the Social Sciences (SPSS) for Windows version 25 was used. Descriptive statistics, Chi-square test, and logistic regressions were used for data analysis.</p><p><strong>Results: </strong>The study reached 92 respondents. The majority of the respondents, 67.4% had a poor level of menstruation and menstrual hygiene knowledge while only 32.6% had a good level of menstruation and menstrual hygiene knowledge. Also, it is confirmed that the majority of respondents, 52.1% had a good level of practice, while 47.8% had a poor level of menstrual hygiene practice. The multivariable analysis revealed that factors associated with the menstrual hygiene practice were as follows: the mother's education (odds ratio (OR): 5.979; 95% CI: [1.700-21.032]; <i>p</i> value: 0.005) and level of knowledge of menstruation and menstrual hygiene (OR: 0.132; 95% CI: [0.028-0.622]; <i>p</i> value: 0.010).</p><p><strong>Conclusion: </strong>The knowledge and practice of MHM among VIAGs were poor. Recommendations included the need for mothers to assist their daughters in improving learning and practice of menstrual hygiene, as well as the integration of MHM into school curricula. Further research is suggested to better understand MHM among Rwandan adolescent girls, both visually impaired and non-blind.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"18 ","pages":"26334941241303518"},"PeriodicalIF":3.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sperm morphology value in assisted reproduction: dismantling an enigma and key takeaways for the busy clinician.","authors":"Christine Wyns, Paraskevi Vogiatzi, Ramadan Saleh, Rupin Shah, Ashok Agarwal","doi":"10.1177/26334941241303888","DOIUrl":"10.1177/26334941241303888","url":null,"abstract":"<p><p>The ideal morphology of the sperm cell was initially described based on the characteristics of sperm able to migrate through the endocervical canal assuming these had the best fertilization potential. Sperm morphology assessment has moved over the years toward stricter criteria based on the findings from studies that underline its value in successful reproductive outcomes. While treatment options are clear for some conditions related to abnormal sperm morphology, the value of sperm morphology in assisted reproduction requires further investigation. The objective of this review is to offer care providers updated guidance for choosing appropriate treatment strategies based on sperm morphology assessment and morphological deviations. Issues to be considered for a reliable determination and interpretation of sperm morphology using the current thresholds and criteria are discussed. In addition, key knowledge on morphological abnormalities relevant to the clinical care of infertile patients, distinguishing between monomorphic and polymorphic forms as well as the isolated or non-isolated occurrence of teratozoospermia in semen is presented. Furthermore, the impact of impaired morphology on assisted reproductive technique outcomes is summarized in light of the latest research.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"18 ","pages":"26334941241303888"},"PeriodicalIF":3.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The magnitude of short interpregnancy intervals and associated factors among women who delivered in North Wollo Zone public hospitals, northeastern Ethiopia, 2023: A facility-based cross-sectional study.","authors":"Mulugeta Wodaje Arage, Samrawit Shimels, Abebe Tarekegn Kassaw, Gizachew Yilak","doi":"10.1177/26334941241301392","DOIUrl":"10.1177/26334941241301392","url":null,"abstract":"<p><strong>Background: </strong>Maternal and child mortality rates remain a serious public health challenge in Ethiopia. Short interpregnancy intervals are known to negatively impact perinatal and child health; therefore, improving this practice is a key strategy to reduce mortality and adverse outcomes.</p><p><strong>Objective: </strong>This study aimed to evaluate the extent of short intervals between pregnancies and the factors associated with them among women who gave birth at public hospitals in the North Wollo Zone of northeastern Ethiopia in 2023.</p><p><strong>Design: </strong>A facility-based cross-sectional study was conducted in the North Wollo Zone of northeastern Ethiopia in 2023.</p><p><strong>Methods: </strong>This study was conducted on mothers who delivered at public hospitals in the North Wollo Zone of northeastern Ethiopia. The study participants were selected using a systematic random sampling technique between February 1, 2023, and April 1, 2023. Data were collected through an interviewer-administered questionnaire using the Kobo Collect tool and analyzed using SPSS version 27.0. Bivariable and multivariable analyses were performed to determine the relationship between the outcome and predictor variables. A <i>p</i> value of less than 0.05 was considered significant in the multivariable analysis.</p><p><strong>Results: </strong>The study found that 51.5% of participants had short interpregnancy intervals. Several independent factors were associated with a short birth interval, including the status of the last pregnancy (adjusted odds ratio (AOR): 9.51; 95% CI: 3.932-23.0028), educational status of the woman (AOR: 4.545; 95% CI: 1.208-17.108), and use of modern contraceptives in previous pregnancies (AOR: 6.460, 95% CI: 3.882-23.008).</p><p><strong>Conclusion: </strong>Despite the efforts made through public health interventions in Ethiopia, the prevalence of short interpregnancy intervals in this study was high. Therefore, increasing the utilization of modern contraceptives and promoting health education at both health facilities and community levels could contribute to addressing this issue.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"18 ","pages":"26334941241301392"},"PeriodicalIF":3.1,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}