Therapeutic advances in reproductive health最新文献

{"title":"Luteal phase support after hCG trigger: does it support or mitigate hCG-induced potential harms?","authors":"Shahar Kol, Samer Khoury","doi":"10.1177/26334941251379935","DOIUrl":"10.1177/26334941251379935","url":null,"abstract":"","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"19 ","pages":"26334941251379935"},"PeriodicalIF":1.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of multidisciplinary care on attrition rates in weight management programs for women with polycystic ovary syndrome: a scoping review.","authors":"Nevart Terzian, Samantha Nordlund, Ereny Bassilious","doi":"10.1177/26334941251368257","DOIUrl":"10.1177/26334941251368257","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine system disorders affecting reproductive-aged women of all races and ethnicities. A high prevalence of obesity exists in women with PCOS, who are also vulnerable to attrition from weight management programs. Despite recommendations the implementation of multidisciplinary approaches in weight management programs, there is a lack of literature evaluating their usage in their treatment programs.</p><p><strong>Objectives: </strong>The objectives of this scoping review are to critically examine existing empirical literature to describe multidisciplinary approaches to weight management in populations diagnosed with PCOS and to identify potential factors associated with attrition.</p><p><strong>Eligibility criteria: </strong>This review includes prospective studies of individuals aged 15 and older diagnosed with PCOS enrolled in a multidisciplinary weight management program. Multidisciplinary interventions were defined as participants receiving two or more multidisciplinary lifestyle interventions.</p><p><strong>Sources of evidence: </strong>A systematic search of five electronic databases (MEDLINE, Cochrane, Embase, Cumulative Index to Nursing and Allied Health Literature, and Web of Science) identified articles with a multidisciplinary approach and reported data on attrition in PCOS weight management programs.</p><p><strong>Charting methods: </strong>A descriptive analytical approach and narrative synthesis was conducted to identify themes related to intervention delivery, attrition, and facilitators/barriers of PCOS lifestyle interventions.</p><p><strong>Results: </strong>From a total of 10,944 unique results, 11 articles met inclusion criteria for this review. Attrition rates ranged from 0% to 79.2%. Longer interventions were associated with higher rates of attrition. Control groups generally had lower attrition rates than their corresponding intervention groups. Studies incorporating technology-based interventions reported greater weight loss among participants.</p><p><strong>Conclusion: </strong>Attrition is inconsistently reported among PCOS weight management studies. Variation in attrition rates is likely influenced by several factors such as intervention length and intensity, identified facilitators and barriers to PCOS weight management, and the extent to which care plans are individualized.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"19 ","pages":"26334941251368257"},"PeriodicalIF":1.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaginal progesterone for luteal phase support in frozen embryo transfer cycles: does it deliver?","authors":"Samer Khoury, Raoul Orvieto, Shahar Kol","doi":"10.1177/26334941251369710","DOIUrl":"10.1177/26334941251369710","url":null,"abstract":"","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"19 ","pages":"26334941251369710"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and regional patterns of short birth intervals among women in Somalia.","authors":"Salad Halane, Abdiwali Mohamed Ahmed, Mohamed Mustaf Ahmed, Jamilu Sani, Jamal Hassan Mohamoud, Abdihakim Elmi Abdishakur, Mustaf Mohamed Ibrahim, Najib Isse Dirie","doi":"10.1177/26334941251364403","DOIUrl":"10.1177/26334941251364403","url":null,"abstract":"<p><strong>Background: </strong>Short birth intervals (SBI), defined as intervals of less than 33 months between consecutive live births, are a significant public health concern because of their association with adverse maternal and child health outcomes. Somalia has some of the highest maternal and neonatal mortality rates globally, compounded by limited access to family planning services.</p><p><strong>Objectives: </strong>This study aimed to provide a descriptive analysis of the prevalence and patterns of SBI among Somali women across regions, offering insight into maternal health policies.</p><p><strong>Design: </strong>A descriptive cross-sectional study design was employed.</p><p><strong>Methods: </strong>Data from 9288 women aged 15-49 years drawn from the Somali Demographic and Health Survey were analyzed. Descriptive statistics were used to examine the prevalence and distribution of SBI across regions and sociodemographic groups.</p><p><strong>Results: </strong>The overall prevalence of SBI was 77%, with regional disparities ranging from 82% in Togdheer and Hiraan to 74% in the Middle Shabelle. Women with no formal education and those in lower wealth quintiles exhibited a higher SBI prevalence than their counterparts. Rural and nomadic populations reported a higher SBI prevalence than urban residents, reflecting potential barriers to accessing family planning services.</p><p><strong>Conclusion: </strong>This study highlights the widespread prevalence of SBI in Somalia, with notable variations according to region, education, and economic status. These findings underscore the need for targeted interventions to address the geographic, educational, and economic barriers to family planning access.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"19 ","pages":"26334941251364403"},"PeriodicalIF":1.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnant women and health professionals' perceptions toward birth preparedness and complication readiness in Oromia, Ethiopia.","authors":"Mengesha Solomon Tejineh, Thanyani Lumadi","doi":"10.1177/26334941251345951","DOIUrl":"10.1177/26334941251345951","url":null,"abstract":"<p><strong>Background: </strong>Birth preparedness and complication readiness (BPCR) is a strategy that promotes the timely use of skilled maternal and neonatal care among pregnant women. Positive pregnancy outcomes can be achieved by appropriate birth preparedness and emergency complication readiness planning.</p><p><strong>Objective: </strong>To explore the perceptions, benefits, awareness, and barriers of BPCR among pregnant women and health professionals at the antenatal care (ANC) clinic in the Oromia Region, Ethiopia.</p><p><strong>Design: </strong>An exploratory, phenomenological descriptive qualitative study conducted from March 20 to April 24, 2022.</p><p><strong>Methods: </strong>Three focus group discussion (FGD) sessions were conducted with 36 purposefully selected pregnant women attending ANC clinics. Key informant in-depth interviews (KIIs) were held with nine health professionals in Arsi Zone, Oromia, Ethiopia, using an interview guide. The data were analyzed using an inductive thematic analysis approach.</p><p><strong>Results: </strong>Among the FGD participants, 19 reside in urban areas and 17 in rural areas. The KII participants comprised six midwives, two health officers, and a nurse. The participants mentioned their perception of BPCR during pregnancy, childbirth, the postpartum period, obstetric danger signs, and barriers to BPCR. Different sources of information on BPCR were mentioned, including friends, neighbors, health professionals, and family. The study showed that the participants were unfamiliar with the major BPCR components. The health professionals planned to educate pregnant women during ANC visits to enhance the adequacy of their BPCR plans. Facilitating husband support, increasing health facility accessibility, economic empowerment, and transport access will enable pregnant women to develop adequate BPCR plans.</p><p><strong>Conclusion: </strong>This study's findings indicated that most participants did not focus strongly on BPCR plans because of low awareness, lack of support from husbands, family, and the community, poor infrastructure, and improper handling by health professionals. To increase service utilization, husbands, families, and the community should be informed about the benefits of the BPCR plan for pregnant women.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"19 ","pages":"26334941251345951"},"PeriodicalIF":3.1,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of preterm premature rupture of membranes among pregnant women at public hospitals in the Sidama Region, Ethiopia.","authors":"Kidist Gebre, Desalegn Dawit Assele, Ephrem Lejore, Wondwosen Teklesilasie","doi":"10.1177/26334941251349378","DOIUrl":"10.1177/26334941251349378","url":null,"abstract":"<p><strong>Background: </strong>Preterm premature rupture of membranes (PPROM) is a significant risk factor for perinatal morbidity and mortality. It is the main cause of preterm birth and affects approximately 10% of all pregnancies. The occurrence of PPROM has recently increased significantly. However, there is limited data on the determinants of PROM in the study area.</p><p><strong>Objective: </strong>To assess the determinants of PPROM, among pregnant women admitted to maternity wards of public hospitals in the Sidama Region.</p><p><strong>Design: </strong>An institution-based, unmatched case-control study.</p><p><strong>Methods: </strong>The study was conducted in public hospitals in the Sidama Region from March 1st to May 15th, 2023. The consecutive cases were recruited until the required sample size was reached, and controls were randomly selected. Face-to-face interviews were used to collect data from 69 cases and 207 controls. Binary logistic regression analysis was used to identify determinants of PPROM. An adjusted odds ratio (AOR) with a 95% confidence interval (CI) was reported to show the strength of the association. The significance of the association was declared at a <i>p</i> value <0.05. The goodness-of-fit model was checked by the Hosmer-Lemeshow test.</p><p><strong>Results: </strong>A total of 69 cases and 207 controls were included in the study. Pregnancy-induced hypertension (AOR: 2.65; 95% CI: 1.12-6.27), a history of abortion (AOR: 3.1; 95% CI: 1.41-7.08), a history of abortion (AOR: 3.78; 95% CI: 1.75-8.15), a history of cesarean section (AOR: 2.57, 95% CI: 1.10-5.99), a mid-upper arm circumference <23 cm (AOR: 2.1; 95% CI: 1.02-4.54), a history of urinary tract infection (AOR: 2.42; 95% CI: 1.10-5.32), and a hemoglobin level <11 mg/dl (AOR: 2.68; 95% CI: 1.15-6.23) were determinants of PPROM.</p><p><strong>Conclusion: </strong>Past obstetric history, nutritional status, and risks in the index pregnancy have an association with PPROM. Therefore, strategies to reduce the occurrence of PPROM should target women in rural areas and emphasize the early identification and treatment of urinary tract infections, anemia, and pregnancy-induced hypertension.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"19 ","pages":"26334941251349378"},"PeriodicalIF":3.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contraceptive use and associated factors among women with HIV receiving care at a faith-based tertiary hospital in Northern Uganda: a cross-sectional study.","authors":"Judith P Acayo, Simon Peter Oryema, Robert Edilu, Henry Ochola, Sande Ojara, Pebalo Francis Pebolo, Felix Bongomin, Raymond Otim, Harriet Akello, Emmanuel Ochola","doi":"10.1177/26334941251338139","DOIUrl":"10.1177/26334941251338139","url":null,"abstract":"<p><strong>Background: </strong>Preventing unintended pregnancies among reproductive-aged women with HIV (WWH) is crucial in combating mother-to-child transmission (MTCT) of HIV. We assessed the utilization of modern contraceptives and related factors among WWH attending the antiretroviral therapy (ART) clinic at a faith-based tertiary hospital in northern Uganda.</p><p><strong>Objectives: </strong>To determine the proportion of and factors associated with the utilization of modern contraceptives among WWH of reproductive age attending the ART clinic in St. Mary's Hospital Lacor.</p><p><strong>Design: </strong>This cross-sectional study was conducted at the HIV clinic within St. Mary's Hospital Lacor, from February to May 2023.</p><p><strong>Methods: </strong>Between February and May 2023, we conducted a cross-sectional study among randomly selected WWH of reproductive age attending the ART clinic at a faith-based health facility, St. Mary's Hospital Lacor in Gulu city, northern Uganda. Quantitative data were collected using semi-structured questionnaires and analyzed using STATA version 16. Factors associated with the utilization of modern contraceptives were assessed using multivariable logistic regression. <i>p</i> < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Of the 385 enrolled participants, 94 (24.4%) reported current modern contraceptive use, and 58 (15.1%) were using natural methods. Being referred to another facility to access modern contraceptives (adjusted odds ratio (aOR): 2.60, 95% confidence interval (CI): 1.31-5.17, <i>p</i> < 0.01), prior use of modern contraceptive (aOR: 32.47, 95% CI: 3.56-300.94, <i>p</i> < 0.01), and age (aOR: 0.92, 95% CI: 0.87-0.98, <i>p</i> < 0.01) were all statistically associated with uptake of modern contraceptives.</p><p><strong>Conclusion: </strong>Only about one in every four WWH was currently using modern methods of contraceptives. There is a need to provide regular counseling to WWH on modern contraceptive methods to create awareness of the vital connection between modern contraceptive use and MTCT, as well as strengthen referral of clients opting to use modern contraceptives to facilities providing these services.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"19 ","pages":"26334941251338139"},"PeriodicalIF":3.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revitalizing reproductive health: innovations and future frontiers in restorative medicine.","authors":"Francesco Maria Bulletti, Evaldo Giacomucci, Maurizio Guido, Antonio Palagiano, Maria Elisabetta Coccia, Carlo Bulletti","doi":"10.1177/26334941251345844","DOIUrl":"10.1177/26334941251345844","url":null,"abstract":"<p><strong>Background: </strong>Infertility affects around 17.5% of reproductive-aged individuals worldwide, posing significant personal and public health challenges. Although Medically Assisted Reproduction and Assisted Reproductive Technology (ART; e.g., in vitro fertilization) have advanced outcomes, many couples fail to conceive due to unaddressed pelvic, uterine, or systemic factors.</p><p><strong>Objectives: </strong>We aim to (1) define the current usage of Restorative Reproduction Medicine (RRM) in clinical practice, (2) compare RRM outcomes with conventional ART, and (3) propose an integrated model of RRM plus ART for optimal fertility care.</p><p><strong>Design: </strong>A systematic review following PRISMA guidelines was conducted (INPLASY registration no. INPLASY2024110069).</p><p><strong>Data sources and methods: </strong>We searched PubMed, Scopus, and Web of Science (January 1995-October 2024), combining terms such as \"restorative reproductive medicine,\" \"intrauterine adhesions,\" \"myomas,\" \"polyps,\" \"hydrosalpinx,\" \"endometritis,\" \"BMI,\" \"thyroid dysfunction,\" \"microbiome,\" and \"assisted reproductive technology.\" Inclusion criteria: studies on uterine/systemic factors affecting infertility, focusing on surgical/pharmacological RRM interventions and ART limitations. Exclusion criteria: male-only infertility, case reports, narrative reviews, non-English publications. Quality assessment employed the Newcastle-Ottawa Scale and the Cochrane Risk of Bias Tool. We also briefly noted potential publication bias due to language and study-type restrictions.</p><p><strong>Results: </strong>From >25,000 initial titles, 3 sequential screenings yielded 145 key articles addressing uterine (septum, myomas, polyps, adhesions) and systemic (body mass index (BMI) extremes, thyroid dysfunction, microbiome imbalance) factors. Surgical corrections (e.g., hysteroscopic removal of polyps/myomas, salpingectomy for hydrosalpinx) significantly improved natural conception and ART success (⩾20%-40% increase in clinical pregnancy). Chronic endometritis treatment, endometrial microbiome modulation, and BMI/thyroid optimization further improved pregnancy rates by 15%-20%. Comparisons of RRM versus ART alone indicated that RRM often lowers overall cost and may reduce miscarriage, while ART offers immediate embryo transfer. Combining RRM to correct pathologies prior to ART can boost implantation and live birth rates (⩾40%-70% improvement in some studies).</p><p><strong>Conclusion: </strong>Restorative Reproductive Medicine comprehensively addresses pelvic and systemic abnormalities, thereby enhancing fertility outcomes and complementing ART. A proposed integrated model-RRM diagnostics/interventions followed by ART if needed-maximizes success, reduces time/cost, and emphasizes holistic reproductive health. Further multicenter trials are warranted to standardize protocols and fully realize RRM's potential in modern fertility care.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"19 ","pages":"26334941251345844"},"PeriodicalIF":3.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse birth outcomes and associated factors among Sub-Saharan African grand multiparas: a systematic review and meta-analysis.","authors":"Agerie Mengistie Zeleke, Getnet Azanaw Takele, Yosef Aragaw Gonete, Yeshiwas Ayale Ferede, Worku Chekol Tassew","doi":"10.1177/26334941251342121","DOIUrl":"10.1177/26334941251342121","url":null,"abstract":"<p><strong>Background: </strong>Adverse birth outcomes associated with grand multiparity are more ambiguous than those linked to multiparity. The primary literature on this issue reveals inconsistent findings across various studies. A paucity of data is evident in systematic reviews and meta-analyses that assess adverse birth outcomes specifically for African grand multiparas.</p><p><strong>Objectives: </strong>To address the pooled adverse birth outcomes and their associated factors among African grand multiparas.</p><p><strong>Design: </strong>Systematic review and meta-analysis.</p><p><strong>Data sources and methods: </strong>Studies were systematically searched from April 20, 2024, to June 15, 2024, using Scopus, Web of Science, PubMed, Science Direct, African Journal Online, and the Wiley Online Library. The Joanna Briggs Institute tool was used for a quality assessment of each primary study. Data were extracted using Excel and analyzed with Stata 11 software. A random-effects model was employed to calculate the pooled estimates. The paper employs appropriate statistical techniques to assess publication bias and heterogeneity, such as the symmetry of the funnel plot, Egger's test, and Cochran's <i>Q</i> test. The study addresses a critical public health issue in Africa, contributing valuable data that could inform policy and healthcare practices aimed at reducing adverse birth outcomes among grand multiparas. A subgroup analysis was performed based on the publication years.</p><p><strong>Results: </strong>The pooled prevalence of adverse birth outcomes among African grand multiparas was 24.97%; 95% CI: 19.97-31.99. Pregnancy-related complications (AOR: 3.17; 95% CI: 2.35-4.28), a history of home births (AOR: 3.30; 95% CI: 1.70-6.40), and rural residence (AOR: 4.12; 95% CI: 3.12-5.44) were significantly associated with adverse birth outcomes among African grand multiparas.</p><p><strong>Conclusion: </strong>Overall, the pooled prevalence of adverse birth outcomes among grand multiparas was comparably high. Variables such as rural residence, previous pregnancy-related complications, and a history of home births were significantly associated with adverse birth outcomes. Strengthening institutional births, providing high-quality prenatal care, and early pregnancy follow-ups are recommended to reduce adverse birth outcomes in grand multiparous women. In addition, improving the availability of comprehensive contraceptive options for rural-residing African grand multiparous women is essential.</p><p><strong>Prospero registration: </strong>CRD42024569768.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"19 ","pages":"26334941251342121"},"PeriodicalIF":3.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian tissue cryopreservation: a narrative review on cryopreservation and transplantation techniques, and the clinical outcomes.","authors":"Zahra Karimizadeh, Zohreh Saltanatpour, Azadeh Tarafdari, Mahroo Rezaeinejad, Amir Ali Hamidieh","doi":"10.1177/26334941251340517","DOIUrl":"10.1177/26334941251340517","url":null,"abstract":"<p><p>Fertility preservation (FP) includes all the methods to preserve germ cells, reproductive tissues, or embryos for the future reproduction of patients at risk of infertility. Cryopreservation is an essential step of FP, storing the specimens in subzero temperatures to suppress cellular metabolism and restore cryopreserved specimens for future use. Although oocyte cryopreservation (OC) and embryo cryopreservation (EC) are two accepted methods of FP in women, ovarian tissue cryopreservation (OTC) is a novel method that is favorable in patients who are not appropriate candidates for OC and EC, and those who suffer from irritating menopause symptoms caused by estradiol deficiency. OTC has shown promising results in restoring fertility and the endocrine function of ovaries. Slow freezing and vitrification are two well-established methods for cryopreservation of biological specimens. Despite recent developments in the vitrification of ovarian tissue and comparable results to slow freezing, we lack a standard protocol for ovarian tissue vitrification, and slow freezing is still the preferred method in most centers. Under an acceptable medical condition and desirability, transplantation of cryopreserved tissue is performed either in orthotopic sites (orthotopic transplantation, OT) such as the original site of the ovaries and uterus, or heterotopic sites (heterotopic transplantation, HT) like abdominal wall, forearm, and peritoneal lining. Although both sites of transplantation are associated with endocrine function recovery, OT better restores fertility. This review will focus on OTC and its types, ovarian tissue transplantation, and efficacy in clinical practice.</p>","PeriodicalId":75219,"journal":{"name":"Therapeutic advances in reproductive health","volume":"19 ","pages":"26334941251340517"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}