Therapeutic advances in allergy and rhinology最新文献

{"title":"Epinephrine Administered in Anaphylaxis: The Evolution of 0.3 mg Dosage.","authors":"Peyton Coady, Kenneth L Dretchen, Michael Mesa","doi":"10.1177/27534030231161784","DOIUrl":"10.1177/27534030231161784","url":null,"abstract":"<p><strong>Background: </strong>Despite epinephrine's historical use for over a century and Food and Drug Administration (FDA) approval for EpiPen's use in 1987 to treat anaphylaxis, little information exists regarding selection of the 0.3 mg adult dose. A review of literature was conducted to provide a historical retrospective regarding the evolution of the dosage selected for today's EpiPen. The first adrenal gland extract, isolation of the epinephrine active ingredient, observation of physiological effect, selection of the intramuscular route for administration, the dosage range recommended by independent physicians based on their clinical observations and selection of the ultimate standardized dosage are profiled.</p><p><strong>Conclusion: </strong>This retrospective review illustrates the drug development process prior to the rigors required for today's clinical trials and provides clinical evidence supporting the dose in EpiPen and other similar life-saving epinephrine products.</p>","PeriodicalId":75217,"journal":{"name":"Therapeutic advances in allergy and rhinology","volume":"14 ","pages":"27534030231161784"},"PeriodicalIF":0.0,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/a4/10.1177_27534030231161784.PMC10052460.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9247418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ANRIL Gene Single-Nucleotide Polymorphisms With Allergic Rhinitis in Kurdish Population From Kermanshah, Iran.","authors":"Sara Falahi,&nbsp;Parisa Feizolahi,&nbsp;Ali Monshizadeh,&nbsp;Zahra Mahmoudi,&nbsp;Jila Mahdavi,&nbsp;Farhad Salari,&nbsp;Ali Gorgin Karaji,&nbsp;Alireza Rezaiemanesh","doi":"10.1177/27534030231170874","DOIUrl":"https://doi.org/10.1177/27534030231170874","url":null,"abstract":"<p><strong>Background: </strong>Allergic rhinitis (AR) is the most common inflammatory disorder of the upper airway caused by aberrant immune responses to allergens in genetically predisposed individuals. Recently, the long noncoding RNA (lncRNA) antisense noncoding RNA in the INK4 locus (ANRIL) has been identified as a novel genetic factor associated with increased AR risk.</p><p><strong>Objectives: </strong>This study aimed to evaluate the potential correlation of <i>ANRIL</i> gene single nucleotide polymorphisms (SNPs) with AR risk in the Kurdish population of Kermanshah, Iran.</p><p><strong>Methods: </strong>In this case-control study, 130 AR patients and 130 healthy controls were recruited to genotype for two SNPs of the <i>ANRIL</i> gene (rs1333048 and rs10757278) using the Tetra-primer amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR) method.</p><p><strong>Results: </strong>Our results showed no significant difference for the alleles and genotypes frequency distribution of lncRNA ANRIL SNPs (rs1333048 and rs10757278) between AR patients and healthy controls (<i>p</i> > 0.05). Additionally, the dominant, additive and recessive genetic models of both SNPs were not associated with altered susceptibility to AR risk (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>The results demonstrated that the <i>ANRIL</i> gene rs1333048 and rs10757278 polymorphisms might not be associated with susceptibility to AR in the Kurdish population of Kermanshah, Iran.</p>","PeriodicalId":75217,"journal":{"name":"Therapeutic advances in allergy and rhinology","volume":"14 ","pages":"27534030231170874"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7c/ac/10.1177_27534030231170874.PMC10185863.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10299685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD5 B-Cell Predominant Primary Immunodeficiency: Part of the Spectrum of <i>MAGT1</i> Deficiency.","authors":"Marija J Rowane,&nbsp;Benjamin C Stewart-Bates,&nbsp;Rayna J Doll,&nbsp;Howard J Meyerson,&nbsp;John S Venglarcik,&nbsp;Meghan Callahan,&nbsp;Lauren Fill,&nbsp;Remie Saab,&nbsp;Hans D Ochs,&nbsp;Robert W Hostoffer","doi":"10.1177/27534030231199675","DOIUrl":"https://doi.org/10.1177/27534030231199675","url":null,"abstract":"<p><strong>Background: </strong>Selective anti-polysaccharide antibody deficiency (SPAD) with CD5 B-cell predominance and autoimmune phenomena was identified in a male cohort first reported by Antall et al in 1999. The phenotypically likewise and genotypically identical X-linked immunodeficiency with magnesium defect, Epstein-Barr Virus infection, and neoplasia (XMEN) disease was defined as a novel primary immunodeficiency (PID) in 2011. Recent studies of the magnesium transporter 1 (MAGT1) gene mutation reveal glycosylation defects contributing to more phenotypic variance than the \"XMEN\" title pathologies. The updated title, \"X-linked MAGT1 deficiency with increased susceptibility to EBV-infection and N-linked glycosylation defect,\" was proposed in 2020.</p><p><strong>Objectives: </strong>To reflect the patient population more accurately, a prospective classification update may consider MAGT1 glycobiological errors contributing to phenotypic variance but also pre-genetic testing era reports with CD5 B-cell predominance.</p><p><strong>Methods: </strong>Patient 1 from Antall et al presented at 28 years of age for further immunological evaluation of his CD5/CD19 B-cell predominance diagnosed at 5 years old.</p><p><strong>Design: </strong>Immune re-evaluation done through flow cytometry and next-generation sequencing.</p><p><strong>Results: </strong>Flow cytometry B-cell phenotyping revealed persistent CD5+CD19+ (93%). Flow cytometric histogram quantified reduced activator CD16+CD56+ natural killer and CD8+ T-cell receptor, Group 2, Member D (NKG2D) glycoprotein expression. A c.923-1_934 deletion loss of function mutation was identified in the MAGT1 gene.</p><p><strong>Conclusion: </strong>We suggest the novel PID XMEN, based on its CD5 B-cell predominance, had been discovered and reported over a decade earlier as CD5+ PID based on the MAGT1 mutation found in the same. We encourage consideration of combining these labels and recent findings to offer the most accurate classification of this disease.</p>","PeriodicalId":75217,"journal":{"name":"Therapeutic advances in allergy and rhinology","volume":"14 ","pages":"27534030231199675"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1c/c5/10.1177_27534030231199675.PMC10496486.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10263018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgG3 Antibody Response to COVID-19 Vaccination in a Patient With a Large Heavy Chain Deletion.","authors":"Sandeep Sarkaria,&nbsp;Zachary Hostoffer,&nbsp;Meghan Callahan,&nbsp;John Venglarick,&nbsp;Robert Hostoffer","doi":"10.1177/27534030231156206","DOIUrl":"https://doi.org/10.1177/27534030231156206","url":null,"abstract":"<p><p>Vaccinations for pathogenic organisms have been utilized for decades in both the protection and diagnosis of immunodeficiency patients. Some of these immunodeficient patients may not create an adequate response to vaccination, although some who have significant aberrancies in their immune system may surprisingly create antibodies to immunizations. We present a patient with a large Ig heavy chain deletion (severe deficiency of serum IgG1, IgG2, IgG4, and IgA1) that showed a considerable response (presumably through IgG3) after the Pfizer BioNTech COVID-19 vaccination. This finding in this unique immunodeficient patient warrants further research into alternate antibody response pathways against COVID-19.</p>","PeriodicalId":75217,"journal":{"name":"Therapeutic advances in allergy and rhinology","volume":"14 ","pages":"27534030231156206"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ab/5d/10.1177_27534030231156206.PMC10035523.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9190960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of Vision Outcome for Allergic Fungal Sinusitis: Case Report and Literature Review.","authors":"Ahmed Alhussien,&nbsp;Abdulrahman Alghulikah,&nbsp;Hussain Albaharna,&nbsp;Abdulrahman Alserhani,&nbsp;Saud Alromaih,&nbsp;Mohammad Aloulah","doi":"10.1177/27534030231176774","DOIUrl":"https://doi.org/10.1177/27534030231176774","url":null,"abstract":"<p><p>Visual loss is a rare manifestation of allergic fungal rhinosinusitis (AFRS). We report a case of an adult male who was diagnosed with AFRS and who presented during the COVID-19 pandemic lockdown with sudden-onset complete vision loss and a lack of recovery after surgical and medical management. We reviewed the literature on reported cases of AFRS complicated by visual loss to identify factors associated with visual outcomes. We found 50 patients who were diagnosed with acute visual loss due to AFRS, with an average age of 28 ± 14 years. Complete and partial recovery after surgical intervention were reported in 17 and 10 cases, respectively. However, the absence of vision improvement was reported in 14 of the cases. Early diagnosis and prompt intervention can return vision back to normal. However, delayed presentation, complete loss of vision, and acute onset of visual loss are associated with worse outcomes.</p>","PeriodicalId":75217,"journal":{"name":"Therapeutic advances in allergy and rhinology","volume":"14 ","pages":"27534030231176774"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/18/bb/10.1177_27534030231176774.PMC10259143.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10302128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgM Deficiency Associated With Connexin Mutation in an 18-Year-old Male.","authors":"Sandeep Sarkaria,&nbsp;Meghan Callahan,&nbsp;Zachary Hostoffer,&nbsp;John Venglarcik,&nbsp;Robert Hostoffer","doi":"10.1177/27534030231156116","DOIUrl":"https://doi.org/10.1177/27534030231156116","url":null,"abstract":"<p><p>IgM deficiency is characterized by remarkably low serum levels of IgM with normal IgG and IgA levels. These patients clinically present with recurrent infections, autoimmune disorders, and malignancies. While unknown, the proposed mechanisms explain the pathophysiology as an issue due to impaired IgG antibody response. The connexin genes encode for gap junctional proteins where mutations can cause hearing deficits and immune dysregulation. We present a unique case of an 18-year-old patient with recurrent sinusitis, diagnosed connexin-26 mutation and an IgM deficiency. An 18-year-old male with chronic sinusitis, Marfanoid joint hypermobility syndrome, and sensorineural hearing loss due to connexin-26 deficiency with bilateral cochlear implants. This patient's mutation is a GJB2 deletion located on chromosome 13 which encodes for the connexin-26 protein. The patient experienced recurrent infections, and serum immunoglobulins showed a normal IgA (84 mg/dL; normal: 70-400 mg/dL), IgG (922 mg/dL; normal: 700-1600 mg/dL) and reduced IgM (26 mg/dL; normal: 40-230 mg/dL) levels. The patient was responsive to Mumps, Measles, Rubella, and Diphtheria vaccinations among others, consistent with SIGMD diagnoses. Antibody responses to polysaccharide antigens were absent. The leukocyte counts were within normal limits. His parents are connexin-26 deficient carriers, and his older brother was diagnosed with SIGMD. Connexin-26 has been identified with multiple immunological mechanisms. Although mutations of this gene have no direct tie to antibody formation in relation to IgM, the presence of these 2 pathologies in 1 patient is intriguing and may suggest a pathophysiologic connection. We describe the first case of connexin mutation with an IgM deficiency in an 18-year-old male.</p>","PeriodicalId":75217,"journal":{"name":"Therapeutic advances in allergy and rhinology","volume":"14 ","pages":"27534030231156116"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/82/37/10.1177_27534030231156116.PMC10035527.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9190958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal Cavity Length or Analyzed Nasal Segment of Acoustic Rhinometry in Thai Adults.","authors":"Paraya Assanasen,&nbsp;Triphoom Suwanwech,&nbsp;Bannapuch Pinkaew,&nbsp;Anupa Khongsri,&nbsp;Phawin Keskool","doi":"10.1177/27534030231171089","DOIUrl":"https://doi.org/10.1177/27534030231171089","url":null,"abstract":"<p><strong>Background: </strong>Nasal cavity length (NCL) is important for determining analyzed nasal segment (ANS) of acoustic rhinometry (AR). AR is a technique for nasal airway assessment which nasal cross-sectional areas and nasal volume (NV) are obtained. NCL or ANS is the important parameter to determine NV measured by AR. The ANS used to calculate NV in previous literatures vary from 4 to 8 cm. However, there has not been any study regarding NCL of Asians which is probably different from that of Western countries.</p><p><strong>Objectives: </strong>To measure NCL in Thai adults using nasal telescope and compared NCL between left and right sides as well as male and female as well as among age groups.</p><p><strong>Design: </strong>Prospective study.</p><p><strong>Methods: </strong>This study was performed on patients, aged 18-95 years, who underwent nasal telescopy under local anesthesia at the Department of Otorhinolaryngology, Siriraj Hospital. Baseline characteristics (sex and age) of patients were collected. NCL (from anterior nasal spine to posterior edge of nasal septum) of both nasal cavities was measured using rigid nasal telescope of 0 degree. Mean NCL length of both nasal cavities was calculated.</p><p><strong>Results: </strong>There were 1277 patients, with 498 (39%) male and 779 (61%) female. The mean ± standard deviation (SD) of NCL of male was 6 ± 0.6 cm whereas that of female was 5.7 ± 0.5 cm. There were no significant differences in NCL between left and right sides as well as among age groups in each gender (p > 0.05 all). However, male had significantly longer NCL compared with that of female (p < 0.001). The mean ± SD of NCL of total population was 5.9 ± 0.6 cm.</p><p><strong>Conclusion: </strong>The NCL of Thais was approximately 6 cm. These data are useful to determine ANS used to calculate NV when AR is performed.</p><p><strong>Plain language summaries: </strong>The length of nasal cavity (LNC) is important variable for acoustic rhinometry (AR) which is the instrument to measure nasal volume (NV). We use AR in clinical researches to diagnose and monitor the results of treatment of nose and sinus diseasesThe LNC used to calculate NV in previous studies vary from 4 to 8 cm. However, there has not been any study of LNC of Asians which is probably different from that of Western countriesWe measured LNC in 1277 Thai adults, aged 18-95 years, with 498 (39%) male and 779 (61%) female using nasal rigid endoscope and compared LNC between male and female.The average of LNC was 5.9 cm. Male had longer LNC compared with that female. The LNC of Thais was approximately 6 cm. These data are useful for AR to calculate NV.</p>","PeriodicalId":75217,"journal":{"name":"Therapeutic advances in allergy and rhinology","volume":"14 ","pages":"27534030231171089"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f0/2c/10.1177_27534030231171089.PMC10159236.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10297849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}