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Propriospinal neurons involved in coordination of the bladder and urethra 参与膀胱和尿道协调的本体脊髓神经元
The neuroscience chronicles Pub Date : 2021-07-17 DOI: 10.46439/neuroscience.2.009
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引用次数: 0
Inhibition of 11β-HSD1, a key enzyme in the stress management, improves cognition by RL-118 drug treatment 通过RL-118药物治疗，抑制应激管理关键酶11β-HSD1可改善认知
The neuroscience chronicles Pub Date : 2021-07-17 DOI: 10.46439/neuroscience.2.007
Puigoriol-Illamola, Griñán-Ferré
{"title":"Inhibition of 11β-HSD1, a key enzyme in the stress management, improves cognition by RL-118 drug treatment","authors":"Puigoriol-Illamola, Griñán-Ferré","doi":"10.46439/neuroscience.2.007","DOIUrl":"https://doi.org/10.46439/neuroscience.2.007","url":null,"abstract":"In recent years, stress and stress-coping mechanisms constitute a growing public healthcare issue concerning modern society. Experiencing stress engenders a great complex mechanism named stress response, which consists of a rapid release of catecholamines by the sympathetic nervous system, followed by a slower response in which hormones, mainly glucocorticoids (GCs), are synthesized and released to the bloodstream. Once the stressful stimulus is perceived, the hypothalamus","PeriodicalId":75148,"journal":{"name":"The neuroscience chronicles","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83051113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ALS Skeletal Muscle: Victim or Culprit. 肌萎缩侧索硬化症骨骼肌:受害者还是罪魁祸首。
The neuroscience chronicles Pub Date : 2021-01-01 DOI: 10.46439/neuroscience.2.012
Agnes Badu-Mensah, Xiufang Guo, James J Hickman
{"title":"ALS Skeletal Muscle: Victim or Culprit.","authors":"Agnes Badu-Mensah, Xiufang Guo, James J Hickman","doi":"10.46439/neuroscience.2.012","DOIUrl":"https://doi.org/10.46439/neuroscience.2.012","url":null,"abstract":"Aside its function in locomotion, posture maintenance and respiration, the human skeletal muscle (hSKM) is reported to be a critical metabolic regulator [1]. The hSKM is acknowledged as the primary site of glucose metabolism and storage [1]. Additionally, it serves as a reservoir for amino acids [1,2]. In recently times, the hSKM has also been described as an endocrine organ. It is known to secrete a plethora of myokines that systemically affect other organs including the liver, pancreas, and immune system among others [3,4]. Proper function of the hSKM is therefore critical for maintaining whole body metabolic homeostasis. As such, perturbations in skeletal muscle resulting in metabolic and functional changes has deleterious consequences on the overall health of an organism. Unsurprisingly, muscle health decline is associated with poor disease prognosis in numerous conditions [2]. Thus, paying attention to muscle health may be pertinent to improving disease outcomes and overall wellbeing of an organism.","PeriodicalId":75148,"journal":{"name":"The neuroscience chronicles","volume":"2 2","pages":"31-33"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/ff/nihms-1770505.PMC8793963.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39873146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Role of Ginseng in therapeutic management of Alzheimer’s Disease 人参在老年痴呆症治疗管理中的作用
The neuroscience chronicles Pub Date : 2020-12-31 DOI: 10.46439/neuroscience.1.001
Rudrarup Bhattacharjee, Dr. Amarendranath Choudhury
{"title":"Role of Ginseng in therapeutic management of Alzheimer’s Disease","authors":"Rudrarup Bhattacharjee, Dr. Amarendranath Choudhury","doi":"10.46439/neuroscience.1.001","DOIUrl":"https://doi.org/10.46439/neuroscience.1.001","url":null,"abstract":"While much of research progress has been achieved in last century on Alzheimer’s Disease (AD), the conclusive therapy for the same is still unachieved. Several lines of therapeutic regimes have been introduced, which basically act on slowing down the disease progression. However, adverse side effects on lifelong use of such synthetic drugs are also inevitable. Rationale of such realization has attracted researchers to find alternative medicine for AD therapeutics. Natural products have shown promising response in this regard. Among handful of herbal products, Ginseng is notable and capable of recapitulating the equivalent functional attributes like other synthetic drugs available, with no side effects. In the present communication, based on available literature and reported data, we will discuss various aspects of Ginseng attribution as a potential alternative therapeutic approach for AD and whether it may serve as a novel pathway to treat AD.","PeriodicalId":75148,"journal":{"name":"The neuroscience chronicles","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90636841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parkinson’s disease - cell therapy vs gene therapy 帕金森氏症-细胞疗法与基因疗法
The neuroscience chronicles Pub Date : 2020-12-31 DOI: 10.46439/neuroscience.1.003
{"title":"Parkinson’s disease - cell therapy vs gene therapy","authors":"","doi":"10.46439/neuroscience.1.003","DOIUrl":"https://doi.org/10.46439/neuroscience.1.003","url":null,"abstract":"","PeriodicalId":75148,"journal":{"name":"The neuroscience chronicles","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82776686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of COVID-19 coronavirus and Kawasaki syndrome like features in 1-5 years old children 1-5岁儿童COVID-19冠状病毒与川崎综合征样特征的相关性
The neuroscience chronicles Pub Date : 2020-12-31 DOI: 10.46439/neuroscience.1.002
S. Bittmann, A. Weissenstein, G. Villalon, E. Moschüring-Alieva, E. Luchter
{"title":"Association of COVID-19 coronavirus and Kawasaki syndrome like features in 1-5 years old children","authors":"S. Bittmann, A. Weissenstein, G. Villalon, E. Moschüring-Alieva, E. Luchter","doi":"10.46439/neuroscience.1.002","DOIUrl":"https://doi.org/10.46439/neuroscience.1.002","url":null,"abstract":"In the nightmare of the coronavirus pandemic that is spreading around the world, parents could take comfort in one thing early reports that the virus mysteriously spares children, even though this often leads to critical illness in older people. An article published in the Journal “Pediatrics”, based on 2,143 young people in China, provides the most comprehensive evidence of the spread of the virus among children, and there is bad news and good news [1]. The study confirms that coronavirus infections in children are generally less severe, with more than 90 percent having mild to moderate disease or even being asymptomatic and have more transmitter function for elder people.","PeriodicalId":75148,"journal":{"name":"The neuroscience chronicles","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77993407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
MicroRNA silencing: A promising therapy for Alzheimer's disease. 微RNA沉默：一种治疗阿尔茨海默病的前景广阔的疗法。
The neuroscience chronicles Pub Date : 2020-01-01 DOI: 10.46439/neuroscience.1.004
Neelima B Chauhan
{"title":"MicroRNA silencing: A promising therapy for Alzheimer's disease.","authors":"Neelima B Chauhan","doi":"10.46439/neuroscience.1.004","DOIUrl":"10.46439/neuroscience.1.004","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a global health crisis currently afflicting ~6 million Americans (and ~40 million people worldwide). By the middle of the century, these numbers will stagger by ~16 million Americans (and ~152 million people worldwide) suffering from AD, if breakthrough disease-modifying treatments are not discovered. Currently, there are no treatments to prevent, halt or cure the disease. Multiple independent studies on brain gene expression patterns have indicated that in AD about 1/3<sup>rd</sup> of the genes are upregulated while the rest 2/3<sup>rd</sup> of the genes are downregulated. In that regard, AD therapeutics focused on antagomiR-mediated silencing of\"upregulated\"microRNAs (miRs) may be more feasible since upregulated miRs in AD continue to increase with the disease progression, as opposed to agomiR-mediated overexpression of down-regulated miRs with unpredictable reduced presence and relative short-life of 1-3h under pathological conditions in AD brain. Studies reported thus far indicate that most of the upregulated pathogenic genes in AD are regulated by pro-inflammatory microRNAs (miRs). Given the precedence of chronic neuroinflammation in triggering AD-like neurodegeneration and multifactorial nature of AD, silencing inflammation-specific micro-RNAs using antisense-microRNAs may be an effective adjuvant therapeutic strategy to prevent, halt or cure AD.</p>","PeriodicalId":75148,"journal":{"name":"The neuroscience chronicles","volume":"1 1","pages":"11-15"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40432126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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