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The neuroscience chronicles最新文献

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Omics analysis of uveal melanoma: Leukocyte gene signatures reveal novel survival distinctions and indicate a prognostic role for cytolytic activity scoring 葡萄膜黑色素瘤的组学分析:白细胞基因特征揭示了新的生存差异，并表明细胞溶解活性评分的预后作用
The neuroscience chronicles Pub Date : 2022-12-31 DOI: 10.46439/neuroscience.3.018
Michael J. Diaz, A. Fadil, Giona Kleinberg, K. Root, L. Ladehoff, S. Batchu, B. Lucke-Wold
{"title":"Omics analysis of uveal melanoma: Leukocyte gene signatures reveal novel survival distinctions and indicate a prognostic role for cytolytic activity scoring","authors":"Michael J. Diaz, A. Fadil, Giona Kleinberg, K. Root, L. Ladehoff, S. Batchu, B. Lucke-Wold","doi":"10.46439/neuroscience.3.018","DOIUrl":"https://doi.org/10.46439/neuroscience.3.018","url":null,"abstract":"Objective: The significant metastatic potential of uveal melanoma (UVM) lends to high mortality. Even with successful local tumor treatment, many patients will develop metastatic disease. The present study aims to elucidate the relationship between tumor-infiltrating immune cell (TIIC) diversity and survival to identify potential therapeutic targets and improve UVM prognosis. Methods: Bulk deconvolution was used to determine the relative proportions of 22 hematopoietic TIIC from 80 UVM tumor samples. Cytolytic activity (CYT) was determined, and associated survival probabilities were mined using time-to-event data. Nominal P-values were subjected to FDR correction. Results: High relative abundance of tumor-infiltrating naïve B cells, resting memory CD4+ T cells, and monocytes correlated with better overall and disease-free survival probability. Low relative abundance of CD8+ T cells correlated with better overall survival and disease-free survival probability. CYT correlated positively with relative abundance of naïve B cells, resting memory CD4+ T cells, and monocytes. CYT correlated negatively with relative abundance of CD8+ T cells. Conclusion: Infiltrating naïve B cells, resting memory CD4+ T cells, monocytes, and CD8+ T cells are potential therapeutic targets in UVM that warrant further investigation. High CYT estimates associate with worse UVM survival outcomes.","PeriodicalId":75148,"journal":{"name":"The neuroscience chronicles","volume":"4 1","pages":"6 - 11"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84630423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of aromatic stacking in drug-drug interactions 芳香层在药物-药物相互作用中的作用
The neuroscience chronicles Pub Date : 2022-05-09 DOI: 10.46439/neuroscience.3.016
A. Woods
{"title":"The role of aromatic stacking in drug-drug interactions","authors":"A. Woods","doi":"10.46439/neuroscience.3.016","DOIUrl":"https://doi.org/10.46439/neuroscience.3.016","url":null,"abstract":"","PeriodicalId":75148,"journal":{"name":"The neuroscience chronicles","volume":"155 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75702674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Omics analysis of uveal melanoma: Leukocyte gene signatures reveal novel survival distinctions and indicate a prognostic role for cytolytic activity scoring. 葡萄膜黑色素瘤的 Omics 分析：白细胞基因特征揭示了新的存活率差异，并显示了细胞溶解活性评分的预后作用。
The neuroscience chronicles Pub Date : 2022-01-01
Michael Joseph Diaz, Angela Fadil, Giona Kleinberg, Kevin T Root, Lauren Ladehoff, Sai Batchu, Brandon Lucke-Wold
{"title":"Omics analysis of uveal melanoma: Leukocyte gene signatures reveal novel survival distinctions and indicate a prognostic role for cytolytic activity scoring.","authors":"Michael Joseph Diaz, Angela Fadil, Giona Kleinberg, Kevin T Root, Lauren Ladehoff, Sai Batchu, Brandon Lucke-Wold","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The significant metastatic potential of uveal melanoma (UVM) lends to high mortality. Even with successful local tumor treatment, many patients will develop metastatic disease. The present study aims to elucidate the relationship between tumor-infiltrating immune cell (TIIC) diversity and survival to identify potential therapeutic targets and improve UVM prognosis.</p><p><strong>Methods: </strong>Bulk deconvolution was used to determine the relative proportions of 22 hematopoietic TIIC from 80 UVM tumor samples. Cytolytic activity (CYT) was determined, and associated survival probabilities were mined using time-to-event data. Nominal <i>P</i>-values were subjected to FDR correction.</p><p><strong>Results: </strong>High relative abundance of tumor-infiltrating naïve B cells, resting memory CD4<sup>+</sup> T cells, and monocytes correlated with better overall and disease-free survival probability. Low relative abundance of CD8<sup>+</sup> T cells correlated with better overall survival and disease-free survival probability. CYT correlated positively with relative abundance of naïve B cells, resting memory CD4<sup>+</sup> T cells, and monocytes. CYT correlated negatively with relative abundance of CD8<sup>+</sup> T cells.</p><p><strong>Conclusion: </strong>Infiltrating naïve B cells, resting memory CD4<sup>+</sup> T cells, monocytes, and CD8<sup>+</sup> T cells are potential therapeutic targets in UVM that warrant further investigation. High CYT estimates associate with worse UVM survival outcomes.</p>","PeriodicalId":75148,"journal":{"name":"The neuroscience chronicles","volume":"3 1","pages":"6-11"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9078255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The protective role of dimethyltryptamine and its analogues against ischemiareperfusion injury: Commentary 二甲基色胺及其类似物对缺血再灌注损伤的保护作用
The neuroscience chronicles Pub Date : 2021-11-26 DOI: 10.46439/neuroscience.2.015
{"title":"The protective role of dimethyltryptamine and its analogues against ischemiareperfusion injury: Commentary","authors":"","doi":"10.46439/neuroscience.2.015","DOIUrl":"https://doi.org/10.46439/neuroscience.2.015","url":null,"abstract":"","PeriodicalId":75148,"journal":{"name":"The neuroscience chronicles","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81490376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oligodendrocyte regulation of synaptogenesis may contribute to epilepsy development both in multiple sclerosis and polymicrogyria 少突胶质细胞对突触发生的调节可能有助于多发性硬化症和多小回症的癫痫发展
The neuroscience chronicles Pub Date : 2021-11-26 DOI: 10.46439/neuroscience.2.013
{"title":"Oligodendrocyte regulation of synaptogenesis may contribute to epilepsy development both in multiple sclerosis and polymicrogyria","authors":"","doi":"10.46439/neuroscience.2.013","DOIUrl":"https://doi.org/10.46439/neuroscience.2.013","url":null,"abstract":"","PeriodicalId":75148,"journal":{"name":"The neuroscience chronicles","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89427650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence and the future of transfusion medicine 人工智能和输血医学的未来
The neuroscience chronicles Pub Date : 2021-11-26 DOI: 10.46439/neuroscience.2.011
{"title":"Artificial intelligence and the future of transfusion medicine","authors":"","doi":"10.46439/neuroscience.2.011","DOIUrl":"https://doi.org/10.46439/neuroscience.2.011","url":null,"abstract":"","PeriodicalId":75148,"journal":{"name":"The neuroscience chronicles","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85928156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Attitudes toward people with epilepsy in Libya: The conundrum continues 利比亚对癫痫患者的态度:难题仍在继续
The neuroscience chronicles Pub Date : 2021-11-26 DOI: 10.46439/neuroscience.2.014
{"title":"Attitudes toward people with epilepsy in Libya: The conundrum continues","authors":"","doi":"10.46439/neuroscience.2.014","DOIUrl":"https://doi.org/10.46439/neuroscience.2.014","url":null,"abstract":"","PeriodicalId":75148,"journal":{"name":"The neuroscience chronicles","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81133022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A commentary on telehealth and telemedicine in the COVID-19 era: A world of opportunities for the neurosurgeon COVID-19时代的远程医疗和远程医疗评论:神经外科医生的机会世界
The neuroscience chronicles Pub Date : 2021-07-17 DOI: 10.46439/neuroscience.2.008
{"title":"A commentary on telehealth and telemedicine in the COVID-19 era: A world of opportunities for the neurosurgeon","authors":"","doi":"10.46439/neuroscience.2.008","DOIUrl":"https://doi.org/10.46439/neuroscience.2.008","url":null,"abstract":"","PeriodicalId":75148,"journal":{"name":"The neuroscience chronicles","volume":"33 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72926253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Investigating putative psychoactive compounds using planarians as an animal model using the environmental place conditioning protocol 以涡虫为动物模型，使用环境场所条件反射协议研究假定的精神活性化合物
The neuroscience chronicles Pub Date : 2021-07-17 DOI: 10.46439/neuroscience.2.010
{"title":"Investigating putative psychoactive compounds using planarians as an animal model using the environmental place conditioning protocol","authors":"","doi":"10.46439/neuroscience.2.010","DOIUrl":"https://doi.org/10.46439/neuroscience.2.010","url":null,"abstract":"","PeriodicalId":75148,"journal":{"name":"The neuroscience chronicles","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81064771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of educational level on Alzheimer’s disease-related biomarkers: Commentary 教育水平对阿尔茨海默病相关生物标志物的影响:评论
The neuroscience chronicles Pub Date : 2021-07-17 DOI: 10.46439/neuroscience.2.006
{"title":"Effect of educational level on Alzheimer’s disease-related biomarkers: Commentary","authors":"","doi":"10.46439/neuroscience.2.006","DOIUrl":"https://doi.org/10.46439/neuroscience.2.006","url":null,"abstract":"","PeriodicalId":75148,"journal":{"name":"The neuroscience chronicles","volume":"28 26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80472902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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