The Journal of community and supportive oncology最新文献

筛选
英文 中文
Finding your practice home base 找到你的练习基地
The Journal of community and supportive oncology Pub Date : 2018-09-01 DOI: 10.12788/jcso.0423
David H. Henry
{"title":"Finding your practice home base","authors":"David H. Henry","doi":"10.12788/jcso.0423","DOIUrl":"https://doi.org/10.12788/jcso.0423","url":null,"abstract":"","PeriodicalId":75058,"journal":{"name":"The Journal of community and supportive oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42583368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patterns of malignancies in patients with HIV-AIDS: a single institution observational study HIV-AIDS患者恶性肿瘤的模式:一项单一机构的观察性研究
The Journal of community and supportive oncology Pub Date : 2018-09-01 DOI: 10.12788/JCSO.0416
R. Haleshappa
{"title":"Patterns of malignancies in patients with HIV-AIDS: a single institution observational study","authors":"R. Haleshappa","doi":"10.12788/JCSO.0416","DOIUrl":"https://doi.org/10.12788/JCSO.0416","url":null,"abstract":"India has the third largest HIV epidemic in the world because of its large population size, with 0.3% of the adult population infected with HIV. at translates to 2.1 million infected people, posing a signi‚cant challenge in the management of these individuals.1 In all, 43% of the infected are currently on highly active antiretroviral therapy (HAART).1 ere has been a signi‚cant decrease in the number of HIV-AIDS–related deaths in recent years because of the remarkable increase in the use of antiretroviral therapy.2 However, the prolonged life expectancy in these patients has resulted in an increase in the risk of various new diseases such as cancers. With the complex interactions between altered immunity and infections, the risk of cancers is markedly increased in patients with HIV-AIDS.3 e spectrum of malignancies in this group of patients diŒers from that in the general population. In addition, the pattern and the magnitude of malignancies diŒer in diŒerent parts of the world.4 In this study, we have analyzed the pattern of malignancies in patients with HIVAIDS in a regional cancer center in India. e aim of the study was to analyze the pattern of malignancies in patients with HIV-AIDS based on their age and sex and to document the CD4 counts at the time the malignancy was diagnosed.","PeriodicalId":75058,"journal":{"name":"The Journal of community and supportive oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46973214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Neratinib extends adjuvant treatment of patients with HER2-positive breast cancer 奈拉替尼扩大了HER2阳性乳腺癌症患者的辅助治疗
The Journal of community and supportive oncology Pub Date : 2018-08-01 DOI: 10.12788/JCSO.0381
J. Abraham
{"title":"Neratinib extends adjuvant treatment of patients with HER2-positive breast cancer","authors":"J. Abraham","doi":"10.12788/JCSO.0381","DOIUrl":"https://doi.org/10.12788/JCSO.0381","url":null,"abstract":"THE JOURNAL OF COMMUNITY AND SUPPORTIVE ONCOLOGY e185 Volume 16/Number 4 The small-molecule tyrosine kinase inhibitor neratinib is now approved for the extended adjuvant treatment of patients with early-stage HER2 [human epidermal growth factor receptor]-positive breast cancer following postoperative trastuzumab. Trastuzumab is a HER2-targeted monoclonal antibody that has become standard of care in combination with chemotherapy for the treatment of this patient population in which it signicantly improves survival. However, disease recurrence will occur in about a quarter of trastuzumab-treated patients owing to the development of resistance. Neratinib may help overcome trastuzumab resistance thanks to its potent inhibition of the downstream phosphorylation of HER2 and other members of the HER family. Its approval was based on the phase 3 ExteNET trial, in which extended adjuvant treatment with neratinib was compared with placebo among 2,840 patients who remained disease free after 1 year of adjuvant trastuzumab.1 ‡e ExteNET trial was performed at 495 centers in Europe, Asia, Australia, New Zealand, and South America. Patients aged 18 years or older (≥20 years in Japan), with stage 1-3 HER2-positive breast cancer, who completed neoadjuvant and adjuvant trastuzumab therapy up to 1 year before randomization were eligible. Patients also had an Eastern Cooperative Oncology Group Performance Status of 0 or 1 (range, 0-5; 0, fully active, and 5, dead), normal organ function, and a left ventricular ejection fraction within normal institutional range. Patients with clinically signicant cardiac, gastrointesintal or psychiatric comorbidities and those who were not able to swallow oral medication were excluded from the study. Patients randomly received oral neratinib 240 mg per day or matching placebo, and randomization was stratied according to HR status (positive or negative), nodal status (0, 1-3, or ≥4) and trastuzumab-adjuvant regimen (sequentially or concurrently with chemotherapy). ‡e primary outcome was invasive disease-free survival (iDFS). ‡e 2-year iDFS rate was 93.9% for neratinib, compared with 91.6% for placebo (hazard ratio [HR], 0.66; P < .008). Recently, a 5-year analysis of the ExteNET trial showed that after a median follow-up of 5.2 years, the iDFS rates were 90.2% vs 87.7% (HR, 0.73; P = .0083).2 Adverse events ‡e most common adverse event (AE) was diarrhea, in 95% of patients, 40% of whom had grade 3 diarrhea, leading to dose reduction in 26% of patients and discontinuation in 16.8% of patients. Serious AEs occurred in 7% of patients in the neratinib and 6% of those in the placebo arms. In the 5-year analysis, there was no evidence of increased risk of long-term toxicity or adverse consequences of neratinibassociated diarrhea. Furthermore, the ongoing, open-label phase 2 CONTROL trial suggests that the occurrence and severity of neratinib-associated diarrhea can be e£ectively controlled with antidiarrheal prophylaxis, with drugs such","PeriodicalId":75058,"journal":{"name":"The Journal of community and supportive oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47351301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
More biosimilars reach the market in efforts to improve access and cut costs 越来越多的生物仿制药进入市场,以改善获取和降低成本
The Journal of community and supportive oncology Pub Date : 2018-08-01 DOI: 10.12788/JCSO.0417
J. Abraham
{"title":"More biosimilars reach the market in efforts to improve access and cut costs","authors":"J. Abraham","doi":"10.12788/JCSO.0417","DOIUrl":"https://doi.org/10.12788/JCSO.0417","url":null,"abstract":"","PeriodicalId":75058,"journal":{"name":"The Journal of community and supportive oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46946746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Durable response to pralatrexate for aggressive PTCL subtypes 普拉特雷沙对侵袭性PTCL亚型的持久反应
The Journal of community and supportive oncology Pub Date : 2018-03-01 DOI: 10.12788/JCSO.0369
A. Farhan
{"title":"Durable response to pralatrexate for aggressive PTCL subtypes","authors":"A. Farhan","doi":"10.12788/JCSO.0369","DOIUrl":"https://doi.org/10.12788/JCSO.0369","url":null,"abstract":"Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of mature Tand natural killer-cell neoplasms that comprise about 10%-15% of all non-Hodgkin lymphomas in the United States.1,2 The development of effective therapies for PTCL has been challenging because of the rare nature and heterogeneity of these lymphomas. Most therapies are a derivative of aggressive B-cell lymphoma therapies, including CHOP (cyclophosphamide, hydroxydaunorubicin, vinicristine, prednisone) and CHOEP (cyclophosphamide, hydroxydaunorubicin, vinicristine, etoposide, prednisone).1 Many centers use autologous or allogeneic stem cell transplant in this setting,1 but outcomes remain poor and progress in developing effective treatments has been slow. Pralatrexate is the first drug to have been approved by the US Food and Drug Administration specifically for treating patients with relapsed or refractory PTCL.3 As a folate analog metabolic inhibitor, pralatrexate competitively inhibits dihydrofolate reductase and reduces cellular levels of thymidine monophosphate, which prevents the cell from synthesizing genetic material and triggers it to undergo apoptosis.4 The agency’s approval of pralatrexate was based on results from the PROPEL study, which is possibly the largest prospective study conducted in patients with relapsed or refractory PTCL (109 evaluable patients).2 Findings from the study showed an overall response rate (ORR) of 29%, and a median duration of response (DoR) of 10 months.2 Pralatrexate is administered intravenously at 30 mg/m2 once weekly for 6 weeks of a 7-week treatment cycle. It is generally continued until disease progression or an unacceptable level of toxicity.2 Alternative dosing schedules have been described, including 15 mg/m2 once weekly for 3 weeks of a 4-week treatment cycle for cutaneous T-cell lymphomas.5 In this case series, we examine the outcomes of 2 patients with particularly aggressive subtypes of PTCL who were treated with pralatrexate. The significance of this report is in describing the long duration of response and reporting on a PTCL subtype – subcutaneous panniculitis-like T-cell lymphoma, alpha/beta type – that was underrepresented in the PROPEL study and is underreported in the literature.","PeriodicalId":75058,"journal":{"name":"The Journal of community and supportive oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49425479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of patient education on consideration of enrollment in clinical trials 患者教育对临床试验注册考虑的影响
The Journal of community and supportive oncology Pub Date : 2018-03-01 DOI: 10.12788/JCSO.0396
J. Mancini
{"title":"The impact of patient education on consideration of enrollment in clinical trials","authors":"J. Mancini","doi":"10.12788/JCSO.0396","DOIUrl":"https://doi.org/10.12788/JCSO.0396","url":null,"abstract":"","PeriodicalId":75058,"journal":{"name":"The Journal of community and supportive oncology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42462093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Integrating survivorship care planning in radiation oncology workflow. 在放射肿瘤学工作流程中整合生存护理计划。
The Journal of community and supportive oncology Pub Date : 2018-03-01 DOI: 10.12788/jcso.0392
Karol J Huenerberg, Bethany M Anderson, Amye J Tevaarwerk, Heather B Neuman, Lee G Wilke, Lori A Seaborne, Mary Sesto
{"title":"Integrating survivorship care planning in radiation oncology workflow.","authors":"Karol J Huenerberg,&nbsp;Bethany M Anderson,&nbsp;Amye J Tevaarwerk,&nbsp;Heather B Neuman,&nbsp;Lee G Wilke,&nbsp;Lori A Seaborne,&nbsp;Mary Sesto","doi":"10.12788/jcso.0392","DOIUrl":"https://doi.org/10.12788/jcso.0392","url":null,"abstract":"<p><p>Various groups, including the American College of Surgeons' Commission on Cancer and the National Accreditation Program for Breast Centers, are mandating the provision of a survivorship care plan (SCP) to cancer survivors who have completed curative-intent treatment as a requirement for oncology practice accreditation. This article reviews the development of survivorship care, including survivorship care in radiation oncology. Challenges of developing treatment summaries and SCPs and implementing their delivery are explored. Details of the article include how the University of Wisconsin Health radiation oncology department integrated a survivorship visit into the existing radiation oncology workflow. Oncology practices may benefit from the model described here to meet accreditation requirements for SCP delivery to cancer survivors.</p>","PeriodicalId":75058,"journal":{"name":"The Journal of community and supportive oncology","volume":"16 2","pages":"e66-e71"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322695/pdf/nihms-1002325.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36853816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Bevacizumab-awwb becomes first biosimilar approved for cancer treatment 贝伐单抗awwb成为首个获批用于癌症治疗的生物仿制药
The Journal of community and supportive oncology Pub Date : 2018-03-01 DOI: 10.12788/JCSO.0397
J. D. Lartigue
{"title":"Bevacizumab-awwb becomes first biosimilar approved for cancer treatment","authors":"J. D. Lartigue","doi":"10.12788/JCSO.0397","DOIUrl":"https://doi.org/10.12788/JCSO.0397","url":null,"abstract":"","PeriodicalId":75058,"journal":{"name":"The Journal of community and supportive oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44801039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Immunotherapy may hold the key to defeating virally associated cancers 免疫治疗可能是战胜病毒相关癌症的关键
The Journal of community and supportive oncology Pub Date : 2018-03-01 DOI: 10.12788/jcso.0399
J. D. Lartigue
{"title":"Immunotherapy may hold the key to defeating virally associated cancers","authors":"J. D. Lartigue","doi":"10.12788/jcso.0399","DOIUrl":"https://doi.org/10.12788/jcso.0399","url":null,"abstract":"The link between viruses and cancer Suspicions about a possible role of viral infections in the development of cancer were fi rst aroused in the early 1900s. Th e seminal discovery is traced back to Peyton Rous, who showed that a malignant tumor growing in a chicken could be transferred to a healthy bird by injecting it with tumor extracts that contained no actual tumor cells.1 Th e infectious etiology of human cancer, however, remained controversial until many years later when the fi rst cancer-causing virus, Epstein-Barr virus (EBV), was identifi ed in cell cultures from patients with Burkitt lymphoma. Shortly afterward, the Rous sarcoma virus was unveiled as the oncogenic agent behind Rous’ observations.2 Seven viruses have now been linked to the development of cancers and are thought to be responsible for around 12% of all cancer cases worldwide. Th e burden is likely to increase as technological advancements make it easier to establish a causal link between viruses and cancer development.3 In addition to making these links, researchers have also made signifi cant headway in understanding how viruses cause cancer. Cancerous transformation of host cells occurs in only a minority of those who are infected with oncogenic viruses and often occurs in the setting of chronic infection. Viruses can mediate carcinogenesis by direct and/ or indirect mechanisms (Figure 1). Many of the","PeriodicalId":75058,"journal":{"name":"The Journal of community and supportive oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49422819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biosimilars: same ol’ – but with a suffix, and cheaper 生物仿制药:同样的“ol”,但加了一个后缀,而且更便宜
The Journal of community and supportive oncology Pub Date : 2018-03-01 DOI: 10.12788/jcso.0400
David H. Henry
{"title":"Biosimilars: same ol’ – but with a suffix, and cheaper","authors":"David H. Henry","doi":"10.12788/jcso.0400","DOIUrl":"https://doi.org/10.12788/jcso.0400","url":null,"abstract":"","PeriodicalId":75058,"journal":{"name":"The Journal of community and supportive oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44206067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信