The journal of cardiovascular aging最新文献

{"title":"The association between warfarin usage and international normalized ratio increase: systematic analysis of FDA Adverse Event Reporting System (FAERS)","authors":"Robert Morris, Megan Todd, Nicole Zapata Aponte, Milagros Salcedo, Matthew Bruckner, Alfredo Suarez Garcia, Rachel Webb, Kun Bu, Weiru Han, Feng Cheng","doi":"10.20517/jca.2023.33","DOIUrl":"https://doi.org/10.20517/jca.2023.33","url":null,"abstract":"Introduction: Elevated international normalized ratio (INR) has been commonly reported as an adverse drug event (ADE) for patients taking warfarin for anticoagulant therapy. Aim: The purpose of this study was to determine the association between increased INR and the usage of warfarin by using the pharmacovigilance data from the FDA Adverse Event Reporting System (FAERS). Methods: The ADEs in patients who took warfarin (N = 77,010) were analyzed using FAERS data. Association rule mining was applied to identify warfarin-related ADEs that were most associated with elevated INR (n = 15,091) as well as possible drug-drug interactions (DDIs) associated with increased INR. Lift values were used to identify ADEs that were most commonly reported alongside elevated INR based on the correlation between both item sets. In addition, this study sought to determine if the increased INR risk was influenced by sex, age, temporal distribution, and geographic distribution and were reported as reporting odds ratios (RORs). Results: The top 5 ADEs most associated with increased INR in patients taking warfarin were decreased hemoglobin (lift = 2.31), drug interactions (lift = 1.88), hematuria (lift = 1.58), asthenia (lift = 1.44), and fall (lift = 1.32). INR risk increased as age increased, with individuals older than 80 having a 63% greater likelihood of elevated INR compared to those younger than 50. Males were 9% more likely to report increased INR as an ADE compared to females. Individuals taking warfarin concomitantly with at least one other drug were 43% more likely to report increased INR. The top 5 most frequently identified DDIs in patients taking warfarin and presenting with elevated INR were acetaminophen (lift = 1.81), ramipril (lift = 1.71), furosemide (lift = 1.64), bisoprolol (lift = 1.58), and simvastatin (lift = 1.58). Conclusion: The risk of elevated INR increased as patient age increased, particularly among those older than 80. Elevated INR frequently co-presented with decreased hemoglobin, drug interactions, hematuria, asthenia, and fall in patients taking warfarin. This effect may be less pronounced in women due to the procoagulatory effects of estrogen signaling. Multiple possible DDIs were identified, including acetaminophen, ramipril, and furosemide.","PeriodicalId":75051,"journal":{"name":"The journal of cardiovascular aging","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135945028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial cell dysfunction: the culprit for cardiac denervation in aging?","authors":"Oliver M. Moore, Joshua A. Keefe, Xander H. T. Wehrens","doi":"10.20517/jca.2023.36","DOIUrl":"https://doi.org/10.20517/jca.2023.36","url":null,"abstract":"","PeriodicalId":75051,"journal":{"name":"The journal of cardiovascular aging","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135804871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The newborn heart GLAdly benefits from maternal milk.","authors":"Caitlyn E Bowman, Zoltan Arany","doi":"10.20517/jca.2023.25","DOIUrl":"10.20517/jca.2023.25","url":null,"abstract":"","PeriodicalId":75051,"journal":{"name":"The journal of cardiovascular aging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48968017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the mechanisms of cardiomyocyte proliferation and maturation in regenerative cardiac medicine","authors":"P. Heinrich, Sean M. Wu","doi":"10.20517/jca.2023.27","DOIUrl":"https://doi.org/10.20517/jca.2023.27","url":null,"abstract":"The article “Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration” by Nguyen et al. presents a significant advancement in the field of regenerative cardiac medicine by investigating the control of cardiomyocyte (CM) proliferation and maturation","PeriodicalId":75051,"journal":{"name":"The journal of cardiovascular aging","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43050007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The burden of somatic mutations in the aging heart","authors":"B. Gerull, Ruping Chen","doi":"10.20517/jca.2023.24","DOIUrl":"https://doi.org/10.20517/jca.2023.24","url":null,"abstract":"","PeriodicalId":75051,"journal":{"name":"The journal of cardiovascular aging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45849473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editing the trajectory of hypertrophic cardiomyopathy.","authors":"Mason E Sweat, William T Pu","doi":"10.20517/jca.2023.19","DOIUrl":"10.20517/jca.2023.19","url":null,"abstract":"","PeriodicalId":75051,"journal":{"name":"The journal of cardiovascular aging","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9862025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular aging: the mitochondrial influence.","authors":"Shakti Sagar,&nbsp;Asa B Gustafsson","doi":"10.20517/jca.2023.22","DOIUrl":"https://doi.org/10.20517/jca.2023.22","url":null,"abstract":"<p><p>Age-associated cardiovascular disease is becoming progressively prevalent due to the increased lifespan of the population. However, the fundamental mechanisms underlying the aging process and the corresponding decline in tissue functions are still poorly understood. The heart has a very high energy demand and the cellular energy needed to sustain contraction is primarily generated by mitochondrial oxidative phosphorylation. Mitochondria are also involved in supporting various metabolic processes, as well as activation of the innate immune response and cell death pathways. Given the central role of mitochondria in energy metabolism and cell survival, the heart is highly susceptible to the effects of mitochondrial dysfunction. These key organelles have been implicated as underlying drivers of cardiac aging. Here, we review the evidence demonstrating the mitochondrial contribution to the cardiac aging process and disease susceptibility. We also discuss the potential mechanisms responsible for the age-related decline in mitochondrial function.</p>","PeriodicalId":75051,"journal":{"name":"The journal of cardiovascular aging","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10373266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The secretome as a biomarker and functional agent in heart failure.","authors":"Obed O Nyarko,&nbsp;Carmen C Sucharov","doi":"10.20517/jca.2023.15","DOIUrl":"https://doi.org/10.20517/jca.2023.15","url":null,"abstract":"<p><p>Heart failure (HF) is a complex and multifactorial disease. Recent advances have been made in understanding the underlying molecular processes involved in HF pathogenesis. These scientific advancements have brought to light the importance of the secretome. This paper presents a thorough overview of the state of science regarding the secretome's involvement in the onset, progression, and possibility of improved diagnosis and therapeutic interventions in HF. We explore the various types of secreted factors, including novel proteins, growth factors, cytokines, and microRNAs. We also discuss how they affect cellular signaling, angiogenesis, fibrosis, pathological cardiac remodeling, and inflammation in HF. Furthermore, we examine the role of the secretome in cardioprotection and cardiotoxicity. This review emphasizes the potential of the secretome for biomarker discovery. This might enable better HF diagnosis, risk stratification, monitoring and treatment. The review also discusses the difficulties on investigating the role of secreted factors and novel directions on secretome research. It highlights its potential as a target for novel therapeutic approaches and biomarker development.</p>","PeriodicalId":75051,"journal":{"name":"The journal of cardiovascular aging","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9864399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of atrial and ventricular remodeling in an improved minimally invasive mouse model of transverse aortic constriction.","authors":"Jose Alberto Navarro-Garcia,&nbsp;Satadru K Lahiri,&nbsp;Yuriana Aguilar-Sanchez,&nbsp;Anilkumar K Reddy,&nbsp;Xander H T Wehrens","doi":"10.20517/jca.2023.18","DOIUrl":"https://doi.org/10.20517/jca.2023.18","url":null,"abstract":"<p><strong>Introduction: </strong>Heart failure (HF) is the leading cause of death worldwide. Most large and small animal disease models of HF are based on surgical procedures. A common surgical technique to induce HF is transverse aortic constriction (TAC), which induces pressure overload. The conventional TAC (cTAC) procedure is a highly invasive surgery that is associated with severe inflammation and excessive perioperative deaths.</p><p><strong>Aim: </strong>To establish an improved, minimally invasive TAC (mTAC) procedure that does not require thoracotomy.</p><p><strong>Methods and results: </strong>Following anesthesia, mice were intubated, and a small incision was made at the neck and chest. After cutting the sternum about 4 mm, the aortic arch was approached without opening the pleural cavity. A suture was placed between the brachiocephalic artery and the left common carotid artery. This model was associated with low perioperative mortality and a highly reproducible constriction evidenced by an increased right-to-left carotid blood flow velocity ratio in mTAC mice (5.9 ± 0.2) <i>vs</i>. sham controls (1.2 ± 0.1; <i>P</i> < 0.001). mTAC mice exhibited progressive cardiac remodeling during the 8 weeks post-TAC, resulting in reduced left ventricular (LV) contractility, increased LV end-systolic diameter, left atrial enlargement and diastolic dysfunction, and an increased heart weight to tibia length ratio (mTAC: 15.0 ± 0.8 <i>vs</i>. sham: 10.1 ± 0.6; <i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>Our data show that the mTAC procedure yields a highly reproducible phenotype consisting of LV contractile dysfunction and enlargement, combined with left atrial enlargement and diastolic dysfunction.</p><p><strong>Potential impact of the findings: </strong>This model may be used to test the molecular mechanisms underlying atrial remodeling associated with HF development or to evaluate therapeutic strategies to treat these conditions.</p>","PeriodicalId":75051,"journal":{"name":"The journal of cardiovascular aging","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9936852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding cardiac senescence one cell type at a time.","authors":"Payel Sen,&nbsp;Priyatansh Gurha","doi":"10.20517/jca.2023.16","DOIUrl":"https://doi.org/10.20517/jca.2023.16","url":null,"abstract":"Cellular senescence, a hallmark of aging, is defined as a state of stress-induced proliferative arrest while maintaining viability and metabolic activity [1,2] . Senescence was first characterized in vitro by Leonard Hayflick in WI-38 lung fibroblasts after replicative exhaustion and critical telomere shortening [3] . Eventually, senescence was observed in multiple cell types including those of cardiovascular origin (cardiomyocytes, cardiac fibroblasts, endothelial cells, etc.), and in multiple contexts [4] . For example, acute senescence was found to be critical for embryogenesis, injury response, and wound healing [2] , whereas chronic senescence, while initially tumor suppressive, appeared to be associated with a decline in tissue function and even tumor promotion in aging [5] . Acute cellular senescence plays an important physiological role in cardiac development and regeneration, while senescent cells accumulate in the heart with age, leading to an age-related decline in cardiac function [1,4] . Accordingly, recent studies have linked cellular senescence and the associated release of inflammatory components to cardiac pathologies. However, the exact role of senescent cells in these diseases is unclear, and in some cases, both adverse and beneficial effects have been reported. Therefore, a more complete understanding of cellular senescence promises new insights into disease pathophysiology and will provide new avenues for disease prevention and treatment.","PeriodicalId":75051,"journal":{"name":"The journal of cardiovascular aging","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9955590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}