The European journal of cardiovascular medicine最新文献_第3页

Short, Intermediate and long term outcomes of CABG vs. PCI with DES in Patients With Multivessel Coronary Artery Disease. Meta-Analysis of Six Randomized Controlled Trials. 冠状动脉多支病变患者冠脉搭桥与PCI联合DES的短期、中期和长期预后六项随机对照试验的荟萃分析。

The European journal of cardiovascular medicine Pub Date : 2014-09-08

Zaher Fanari, Sandra A Weiss, Wei Zhang, Seema S Sonnad, William S Weintraub

{"title":"Short, Intermediate and long term outcomes of CABG vs. PCI with DES in Patients With Multivessel Coronary Artery Disease. Meta-Analysis of Six Randomized Controlled Trials.","authors":"Zaher Fanari, Sandra A Weiss, Wei Zhang, Seema S Sonnad, William S Weintraub","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Comparing outcomes of percutaneous coronary intervention (PCI) with drug eluting stent (DES) and Coronary Artery Bypass Grafting (CABG) in patients with multivessel Coronary Artery Disease (CAD) using data from randomized controlled trials (RCT).Background: PCI and CABG are established strategies for coronary revascularization in the setting of ischemic heart disease. Multiple RCT have compared outcomes of the two modalities in patients with multivessel CAD.Methods: We did a meta-analysis from six RCT in the contemporary era comparing the effectiveness of PCI with DES to at 1 year, 2 years and 5 years respectively.Results: Compared to CABG, at one year PCI was associated with a significantly higher incidence of TVR (RR= 2.31; 95% CI: [1.80 - 2.96]; P=<0.0001), lower incidence of stroke (RR= 0.35; 95% CI: [0.19 - 0.62]; P=0.0003), and no difference in death (RR= 1.02; 95% CI: [0.77 - 1.36]; P= 0.88) or MI (RR= 1.16; 95% CI: [0.72 - 1.88]; P= 0.53). At 5 years, PCI was associated with a higher incidence of death (RR= 1.3; 95% CI: [1.10 - 1.54]; P= 0.0026) and MI (RR= 2.21; 95% CI: [1.75 - 2.79]; P=<0.0001). While the higher incidence of MI with PCI was noticed in both diabetic and non-diabetics, death was increased mainly in diabetic patients.Conclusion: In patients with multi-vessel CAD, PCI with DES is associated with no significant difference in death or MI at 1 or 2 years. However at 5 years, PCI is associated with higher incidence of death and MI.","PeriodicalId":75000,"journal":{"name":"The European journal of cardiovascular medicine","volume":"3 1","pages":"382-389"},"PeriodicalIF":0.0,"publicationDate":"2014-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234175/pdf/nihms-639457.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32828282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

QTc and QTd Changes after Cardiopulmonary Bypass Surgery in Children 儿童体外循环手术后QTc和QTd的变化

The European journal of cardiovascular medicine Pub Date : 2014-02-01 DOI: 10.5083/EJCM.20424884.110

E. Aburawi, A. Souid, P. Liuba, E. Pesonen

引用次数: 0

Delayed Statin Treatment Reduces the Cardioprotective Effects on Congestive Heart Failure after Acute Myocardial Infarction 延迟他汀类药物治疗降低急性心肌梗死后充血性心力衰竭的心脏保护作用

The European journal of cardiovascular medicine Pub Date : 2014-02-01 DOI: 10.5083/ejcm.20424884.107

Tsuyoshi Honda, K. Fujimoto, Y. Miyao, Hidenobu Koga, M. Ishii

引用次数: 0

The Value of Simplified Selvester QRS Scoring System in Predicting ST-segment Resolution after Thrombolysis in Patients with Acute Myocardial Infarction 简化Selvester QRS评分系统预测急性心肌梗死患者溶栓后st段溶解的价值

The European journal of cardiovascular medicine Pub Date : 2014-02-01 DOI: 10.5083/EJCM.20424884.108

S. Ghaffari, B. Kazemi, Gholamreza Saeidi, N. Sepehrvand, L. Pourafkari

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Multiple Coronary–Cameral Fistulae in the Left Anterior Descending Coronary Artery Causing Angina Pectoris: A Clinical Case and the State of the Art 左冠状动脉前降支多发冠状-摄膜瘘致心绞痛:1例临床及最新研究进展

The European journal of cardiovascular medicine Pub Date : 2014-02-01 DOI: 10.5083/EJCM.20424884.111

G. Musuraca, R. Albiero, C. Terraneo, E. Boldi, C. Angheben

引用次数: 0

Identifying Heart Valve Disease In Primary Care: Differences Between Practice In Germany, France And The United Kingdom 在初级保健中识别心脏瓣膜疾病:德国、法国和英国实践的差异

The European journal of cardiovascular medicine Pub Date : 2014-01-01 DOI: 10.5083/EJCM.20424884.124

J. Webb, Martin Theones, J. Chambers

引用次数: 12

ACE I/D and ADD1 Polymorphisms in Individuals with Cardiovascular Diseases: Prospects on Risk Assessment and Pharmacogenetics 心血管疾病患者ACE I/D和ADD1多态性:风险评估和药物遗传学研究前景

The European journal of cardiovascular medicine Pub Date : 2013-12-01 DOI: 10.5083/EJCM.20424884.106

R. M. Guia, F. Aguirre, Angeli Kaye M. Calderon, H. Gamboa, L. Ching, B. Madamba, L. Mangahas, Ma. Victoria P. Policina, R. R. Santos, J. A. Serrano, Bob Brain O. Sotingco, Earl Louis Sempio, M. G. Gabona

引用次数: 0

Pericardial Abscess with Tamponade Caused by S. Enteritidis Infection 肠炎沙门氏菌感染致心包脓肿伴填塞

The European journal of cardiovascular medicine Pub Date : 2013-12-01 DOI: 10.5083/EJCM.20424884.105

P. Artemiou, Frantisek Sabo, B. Bílý, V. Kováčová, D. Ondušová

引用次数: 0

Hearing Loss Due to Familial Hypercholesterolemia and Statin Treatment 家族性高胆固醇血症引起的听力损失和他汀类药物治疗

The European journal of cardiovascular medicine Pub Date : 2013-10-01 DOI: 10.5083/EJCM.20424884.104

M. Oylumlu, Faris M. Lolan, S. Ercan, G. Altunbas, Z. Karataş, V. Davutoglu

引用次数: 1

Cardiometabolic interventions - focus on transcriptional regulators. 心脏代谢干预--关注转录调节因子。

The European journal of cardiovascular medicine Pub Date : 2013-08-13 DOI: 10.5083/ejcm.20424884.102

Joshua T Chai, Robin P Choudhury

{"title":"Cardiometabolic interventions - focus on transcriptional regulators.","authors":"Joshua T Chai, Robin P Choudhury","doi":"10.5083/ejcm.20424884.102","DOIUrl":"10.5083/ejcm.20424884.102","url":null,"abstract":"Cardiovascular disease (CVD) remains the largest healthcare burden in the Western world; and the increasing prevalence of type II diabetes mellitus, at least partially driven by a trend in lifestyle changes associated with global economic development, is likely to fuel this CVD burden worldwide. Over the past two decades, there has been an increased awareness of the convergence of risk factors contributing to both cardiovascular disease and diabetes leading to the concept of the metabolic syndrome, and the realisation of the opportunity to intervene at this intersection to simultaneously target CVD and metabolic dysfunction. This brings together the fields of cardiovascular medicine, diabetology, and increasingly clinical immunology for a unified and concerted effort to reduce risk for both conditions simultaneously. The discovery of the targeted pathways of drugs already in clinical use such as fibrates and thiazolidinediones (TZD) has led to accelerated basic and clinical research into selective and dual PPAR-α and PPAR-γ agonists, which can theoretically target glucose, lipid and lipoprotein metabolism, as well as potentially exerting inhibitoryeffects in vascular inflammation, all of which might be predicted to reduce atherosclerosis. In this article, we will discuss the basic science as well as recent clinical development in the pursuit of optimal cardiometabolic intervention along with insight into strategies for future drug development.","PeriodicalId":75000,"journal":{"name":"The European journal of cardiovascular medicine","volume":"2 3","pages":"212-218"},"PeriodicalIF":0.0,"publicationDate":"2013-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769682/pdf/emss-54521.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9642344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0