Angela Hall, Andrew Robert John Mitchell, Lisa Ashmore, Carol Holland
{"title":"Atrial fibrillation prevalence and predictors in patients with diabetes: a cross-sectional screening study.","authors":"Angela Hall, Andrew Robert John Mitchell, Lisa Ashmore, Carol Holland","doi":"10.5837/bjc.2022.008","DOIUrl":"https://doi.org/10.5837/bjc.2022.008","url":null,"abstract":"<p><p>Prevalence of atrial fibrillation (AF) and diabetes is increasing worldwide. Diabetes is a risk factor for AF and both increase stroke risk. Previous AF screening studies have recruited highrisk patient groups, but not with diabetes as the target group. This study aims to determine whether people with diabetes have a higher prevalence of AF than the general population and investigate whether determinants, such as diabetes duration or diabetes control, add to AF risk. In a cross-sectional screening study, patients with diabetes were recruited via their GP surgeries or a diabetes centre. A 30-second single-lead electrocardiogram (ECG) was recorded using the Kardia<sup>®</sup> device, along with physiological measurements and details relating to risk factor variables. There were 300 participants recruited and 16 patients identified with AF (5.3% prevalence). This demonstrated a significantly greater likelihood of AF than the background population (p=0.043). People with diabetes and AF were significantly older than those who only had diabetes. More people with type 2 diabetes had AF than people with type 1. Prediction of AF diagnosis by age, sex, diabetes type, diabetes duration and level of control revealed only age as a significant predictor. In conclusion, these findings add to existing data around the association of these chronic conditions, supporting AF screening in this high-risk group, particularly in those of older age. This can contribute to appropriate management of both conditions in combination, not least with regards to stroke prevention.</p>","PeriodicalId":74959,"journal":{"name":"The British journal of cardiology","volume":"29 1","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196068/pdf/BJC-29-01-bjc.2022.008.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40392262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carys Barton, Simon Gordon, Afsana Safa, Carla M Plymen
{"title":"Heart failure care pathways: the power of collaboration and marginal gains.","authors":"Carys Barton, Simon Gordon, Afsana Safa, Carla M Plymen","doi":"10.5837/bjc.2022.005","DOIUrl":"https://doi.org/10.5837/bjc.2022.005","url":null,"abstract":"<p><p>Heart failure (HF) is increasingly common and incurs a substantial cost, both in terms of quality and length of life, but also in terms of societal and economic impact. While significant gains are being made in the therapeutic management of HF, we continue to diagnose most patients when they are acutely unwell in hospital, often with advanced disease. This article presents our experience in working collaboratively with primary care colleagues to redesign our HF pathway with the aim of facilitating earlier, community, diagnosis of HF. In so doing, and, thus, starting prognostic therapy much earlier in the course of the disease, we seek to avoid both the cost of emergency hospitalisation and the cost of poorer outcomes.</p>","PeriodicalId":74959,"journal":{"name":"The British journal of cardiology","volume":"29 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196069/pdf/BJC-29-01-bjc.2022.005.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40392260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sachintha Perera, Sudhir Rathore, Joanne Shannon, Peter Clarkson, Matthew Faircloth, Vinod Achan
{"title":"Effect of the COVID-19 pandemic on ST-elevation myocardial infarction presentation and survival.","authors":"Sachintha Perera, Sudhir Rathore, Joanne Shannon, Peter Clarkson, Matthew Faircloth, Vinod Achan","doi":"10.5837/bjc.2022.004","DOIUrl":"https://doi.org/10.5837/bjc.2022.004","url":null,"abstract":"<p><p>Presentation and outcomes of patients with ST-elevation myocardial infarction (STEMI) may change during viral pandemics. We compared symptom-tocall (STC), call-to-balloon (CTB), doorto-balloon (DTB) times; high-sensitivity troponin (hs-cTnI) levels; and survival of patients (n=39) during the first wave of the COVID-19 pandemic (defined as a 'COVID period' starting four weeks before lockdown) to historical controls from a 'pre-COVID period' (n=45). STEMI admissions fell one week before lockdown by 29%. Median STC times began to rise one month before lockdown (54 <i>vs</i>. 25 min, p=0.06), with peak increases between 9 March and 5 April (166 <i>vs</i>. 59 min, p=0.04). Median CTB and DTB times were unchanged. Mean peak hs-cTnI increased during COVID-19 (15,225 <i>vs</i>. 8,852 ng/ml, p=0.004). Six-month survival following all STEMI reduced (82.1% <i>vs</i>. 95.6%, p<0.05). STC times are the earliest indicator that STEMI-patient behaviour changed four weeks before lockdown, correlating with higher troponin levels and reduced survival. These early signals could guide public health interventions during future pandemics.</p>","PeriodicalId":74959,"journal":{"name":"The British journal of cardiology","volume":"29 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196070/pdf/BJC-29-01-bjc.2022.004.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40392261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arsalan Khalil, Tamara Naneishvili, Abigail Mayo-Evans, James Glancy
{"title":"Improving DVLA advice upon discharge after cardiac device implantation.","authors":"Arsalan Khalil, Tamara Naneishvili, Abigail Mayo-Evans, James Glancy","doi":"10.5837/bjc.2022.006","DOIUrl":"10.5837/bjc.2022.006","url":null,"abstract":"","PeriodicalId":74959,"journal":{"name":"The British journal of cardiology","volume":"29 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196067/pdf/BJC-29-01-bjc.2022.006.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40392263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Observational case series of postural tachycardia syndrome (PoTS) in post-COVID-19 patients.","authors":"Nicholas P Gall, Stephen James, Lesley Kavi","doi":"10.5837/bjc.2022.003","DOIUrl":"https://doi.org/10.5837/bjc.2022.003","url":null,"abstract":"<p><p>There is emerging evidence that a proportion of patients who develop long (post)-COVID-19 have abnormalities in the regulation of their autonomic nervous system manifesting as postural tachycardia syndrome (PoTS). We report a series of 14 patients who developed symptoms and signs compatible with PoTS following clinically diagnosed COVID-19 infection. Their symptoms and clinical findings were consistent with those of patients with non-COVID-related PoTS. The authors recommend an active stand test for patients who present after COVID-19 infection with cardiovascular symptoms including chest pain, palpitations, lightheadedness and breathlessness that are worse with the upright posture. They further recommend training of clinicians and investment in health services to provide for the anticipated significant increase in patients presenting with PoTS and other forms of autonomic dysfunction due to the COVID-19 pandemic.</p>","PeriodicalId":74959,"journal":{"name":"The British journal of cardiology","volume":"29 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196071/pdf/BJC-29-01-bjc.2022.003.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40392265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New agents for DOAC reversal: a practical management review.","authors":"Katie White, Uzma Faruqi, Alexander Ander T Cohen","doi":"10.5837/bjc.2022.001","DOIUrl":"https://doi.org/10.5837/bjc.2022.001","url":null,"abstract":"<p><p>Bleeding is the commonest and most concerning adverse event associated with anticoagulants. Bleeding, depending on the severity, is managed in various ways, and for severe or life-threatening bleeding, specific antidotes are indicated and recommended. This review provides guidance relating to specific direct oral anticoagulant (DOAC) reversal agents, the antidotes. We discuss their indications for use, dosing, and potential side effects.</p>","PeriodicalId":74959,"journal":{"name":"The British journal of cardiology","volume":"29 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196076/pdf/BJC-29-01-bjc.2022.001.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40392266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Foundational drugs for HFrEF: the growing evidence for a rapid sequencing strategy.","authors":"Kieran F Docherty, John J V McMurray","doi":"10.5837/bjc.2022.002","DOIUrl":"https://doi.org/10.5837/bjc.2022.002","url":null,"abstract":"<p><p>In randomised, placebo- or active-controlled trials in patients with heart failure with reduced ejection fraction (HFrEF), each of the combination of a neprilysin inhibitor and an angiotensin-receptor blocker (i.e. sacubitril/valsartan), a beta blocker, a mineralocorticoidreceptor antagonist and a sodium-glucose co-transporter 2 (SGLT2) inhibitor have been shown to reduce morbidity and mortality, firmly establishing the role of these five agents, prescribed as four pills, as foundational therapy for HFrEF. Traditionally, the guideline-advocated strategy for the initiation of these therapies was based on the historical order in which the landmark clinical trials were performed, and the requirement to uptitrate each individual drug to the target dose (or maximally tolerated dose below this) prior to initiation of another therapy. This process could take six months or more to complete, during which time patients would not be taking one or more of these life-saving drugs. Recently an alternative, evidence-based, rapid three-step sequencing strategy has been proposed with the aim of establishing HFrEF patients on low-doses of all four foundational treatments within four weeks. This strategy is based on the premise that the benefits of each of these therapies are independent and additive to the others, the benefits are apparent at low doses early following initiation, and a specific ordering of therapies may increase likelihood of tolerance of others. This article will outline this novel rapid-sequencing strategy and provide an evidence-based framework to support its adoption into clinical practice.</p>","PeriodicalId":74959,"journal":{"name":"The British journal of cardiology","volume":"29 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198897/pdf/BJC-29-01-bjc.2022.002.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40391666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saad Ahmad, Shwe Win Hlaing, Muhammad Haris, Nadeem Attar
{"title":"Marijuana: cardiovascular effects and legal considerations. A clinical case-based review.","authors":"Saad Ahmad, Shwe Win Hlaing, Muhammad Haris, Nadeem Attar","doi":"10.5837/bjc.2022.011","DOIUrl":"https://doi.org/10.5837/bjc.2022.011","url":null,"abstract":"<p><p>Though coronary artery disease primarily occurs in those over the age of 40 years, younger individuals who use recreational drugs may be afflicted with coronary events. Cannabis is one such perilous agent that can cause myocardial infarction (MI) and is one of the most common psychoactive drugs used worldwide. Cannabis (also known as marijuana, weed, pot, dope or grass) is the most widely used illegal drug in the UK. The desired euphoric effects are immediate, as are life-threatening hazardous ones. In this article, we briefly describe a case series of two unique but similar cases of cannabis-induced ST-elevation MI witnessed at our hospital in quick succession. We will analyse the composite pathophysiology in acute coronary syndromes provoked by cannabis and discuss the evolving legality around the use of the drug.</p>","PeriodicalId":74959,"journal":{"name":"The British journal of cardiology","volume":"29 2","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534111/pdf/BJC-29-02-bjc.2022.011.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9641062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mark Boyle, Charlene Tennyson, Achyut Guleri, Antony Walker
{"title":"Infective endocarditis: acne to zoonoses on the valve, an A to Z perspective.","authors":"Mark Boyle, Charlene Tennyson, Achyut Guleri, Antony Walker","doi":"10.5837/bjc.2022.025","DOIUrl":"https://doi.org/10.5837/bjc.2022.025","url":null,"abstract":"<p><p><i>Cutibacterium acnes (C. acnes)</i>, previously known as <i>Propionibacterium acnes</i>, is a rare cause of infective endocarditis (IE). We provide a review of the literature and describe two recent cases from a single centre to provide insight into the various clinical presentations, progression and management of patients with this infection. The primary objective of our review is to highlight the difficulty in the initial assessment of these patients with an aim to improve the time and accuracy of diagnosis and expedite subsequent treatment. There are currently no guidelines in the literature specific to the management of IE caused by C. <i>acnes</i>. Our secondary objectives are to disseminate information about the indolent course of the disease and add to the growing body of evidence around this rare, yet complex, cause of IE.</p>","PeriodicalId":74959,"journal":{"name":"The British journal of cardiology","volume":"29 3","pages":"25"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982663/pdf/BJC-29-03-bjc.2022.025.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10844522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How to measure lipoprotein(a) and in whom","authors":"","doi":"10.5837/bjc.2022.s04","DOIUrl":"https://doi.org/10.5837/bjc.2022.s04","url":null,"abstract":"","PeriodicalId":74959,"journal":{"name":"The British journal of cardiology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74443851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}