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Rapid tolerance to formation of authentic NO from nitroglycerin in vivo. 体内对硝化甘油形成真NO的快速耐受性。
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7346-8_31
M G Persson, P Agvald, L E Gustafsson
{"title":"Rapid tolerance to formation of authentic NO from nitroglycerin in vivo.","authors":"M G Persson,&nbsp;P Agvald,&nbsp;L E Gustafsson","doi":"10.1007/978-3-0348-7346-8_31","DOIUrl":"https://doi.org/10.1007/978-3-0348-7346-8_31","url":null,"abstract":"<p><p>Direct evidence for in vivo NO formation from nitroglycerin (GTN) was obtained by measurements of exhaled nitric oxide in anaesthetized. Infusions of GTN (1-100 micrograms kg-1 min-1 i.v.) induced dose-dependent and biphasic increments in exhaled NO parallelled by reductions in systemic blood pressure. The NO detected during GTN infusion was unaffected by the nitric oxide synthase inhibitor L-NAME or acute i.v. administration of L-cysteine, N-acetyl-L-cysteine or glutathione. The present data demonstrate that NO is formed from GTN in vivo, and that tolerance in vivo is due to decreased formation of NO.</p>","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"45 ","pages":"213-7"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18719111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Vasodilator effects of PGE1 in the coronary and systemic circulation of the rat are mediated by ATP-sensitive potassium (K+) channels. PGE1在大鼠冠状动脉和体循环中的血管扩张作用是通过atp敏感的钾离子通道介导的。
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7346-8_11
P Ney, M Feelisch
{"title":"Vasodilator effects of PGE1 in the coronary and systemic circulation of the rat are mediated by ATP-sensitive potassium (K+) channels.","authors":"P Ney,&nbsp;M Feelisch","doi":"10.1007/978-3-0348-7346-8_11","DOIUrl":"https://doi.org/10.1007/978-3-0348-7346-8_11","url":null,"abstract":"<p><p>This study was undertaken to investigate the possible involvement of K+ channels in PGE1-mediated vasodilatation. The increase in coronary flow elicited by PGE1 in isolated working rat hearts was attenuated by phentolamine and glibenclamide, inhibitors of ATP-regulated K+ channels, whereas apamin and charybdotoxin, inhibitors of calcium-activated K+ channels, were ineffective. In the anaesthetized rat, the duration of the hypotensive action of PGE1 was markedly attenuated by glibenclamide. It is concluded that the vasodilatory action of PGE1 in the coronary and systemic circulation of the rat is, at least in part, mediated via an opening of ATP-sensitive K+ channels.</p>","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"45 ","pages":"71-6"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18544616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Nitric oxide: what role does it play in inflammation and tissue destruction? 一氧化氮:它在炎症和组织破坏中起什么作用?
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7343-7_9
C H Evans
{"title":"Nitric oxide: what role does it play in inflammation and tissue destruction?","authors":"C H Evans","doi":"10.1007/978-3-0348-7343-7_9","DOIUrl":"https://doi.org/10.1007/978-3-0348-7343-7_9","url":null,"abstract":"<p><p>Large amount of nitric oxide (NO) are produced at sites of inflammation through the action of inducible nitric oxide synthase (iNOS) present in both infiltrating leucocytes and activated, resident tissue cells. However, the role of NO in inflammation remains unclear. NO is a vasodilator, which inhibits the adhesion of neutrophils to the vascular endothelium; it reduces the production of IL-6 by Kupffer cells and chondrocytes, and the production of gamma-IFN and TNF-alpha by splenocytes. The literature provides contradictory information on the effect of NO on vascular leakiness, chemotaxis, prostaglandin production and tissue damage. Increasingly, data suggest that NO is immunosuppressive. Inhibitors of NOS have potent prophylactic activity in several but not all, animal models of inflammatory disease. However, in rat adjuvant arthritis, therapeutic activity is weak. Whether inhibitors of iNOS will be therapeutically useful in human inflammatory diseases cannot be predicted on the basis of present information.</p>","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"47 ","pages":"107-16"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18546323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 91
Inflammation, Mechanisms and Therapeutics. Proceedings of the 7th International Conference of the Inflammation Research Association. White Haven, Pennsylvania, September 25-29, 1994. 炎症，机制和治疗。第七届国际炎症研究协会会议录。怀特黑文，宾夕法尼亚州，1994年9月25日至29日。
Agents and actions. Supplements Pub Date : 1995-01-01
{"title":"Inflammation, Mechanisms and Therapeutics. Proceedings of the 7th International Conference of the Inflammation Research Association. White Haven, Pennsylvania, September 25-29, 1994.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"47 ","pages":"1-211"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18785656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of lipid mediator biosynthesis in human inflammatory cells by BIRM 270. birm270对人炎症细胞脂质介质生物合成的抑制作用
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7276-8_14
T P Parks, A F Hoffman, C A Homon, A G Graham, E S Lazer, F H Chilton, P Borgeat, D Raible, E Schulman, D A Bass
{"title":"Inhibition of lipid mediator biosynthesis in human inflammatory cells by BIRM 270.","authors":"T P Parks,&nbsp;A F Hoffman,&nbsp;C A Homon,&nbsp;A G Graham,&nbsp;E S Lazer,&nbsp;F H Chilton,&nbsp;P Borgeat,&nbsp;D Raible,&nbsp;E Schulman,&nbsp;D A Bass","doi":"10.1007/978-3-0348-7276-8_14","DOIUrl":"https://doi.org/10.1007/978-3-0348-7276-8_14","url":null,"abstract":"<p><p>BIRM 270 was developed as a potent and enantioselective inhibitor of LTB4 biosynthesis by human neutrophils, and was also found to inhibit LTC4 production by human eosinophils and lung mast cells. BIRM 270 inhibited LTB4 synthesis in neutrophils by preventing arachidonate release from membrane phospholipids, and over the same concentration range, inhibited PAF biosynthesis. BIRM 270 did not directly inhibit acylhydrolases which have been implicated in eicosanoid and PAF biosynthesis, suggesting an indirect mode of action.</p>","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"46 ","pages":"139-46"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18615890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effects of pentaerythrityl-tetranitrate and isosorbide-5-mononitrate in experimental atherosclerosis. 四硝酸季戊四酯和5-单硝酸异山梨酯在实验性动脉粥样硬化中的作用。
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7346-8_29
G Kojda, E Noack
{"title":"Effects of pentaerythrityl-tetranitrate and isosorbide-5-mononitrate in experimental atherosclerosis.","authors":"G Kojda,&nbsp;E Noack","doi":"10.1007/978-3-0348-7346-8_29","DOIUrl":"https://doi.org/10.1007/978-3-0348-7346-8_29","url":null,"abstract":"<p><p>This study was performed to determine whether long-term treatment with organic nitrovasodilators exhibit pharmacological effects on the development of atherosclerotic lesions and endothelial dysfunction in the cholesterol fed rabbit. The major finding of this study is that PETN, but not ISMN, decreases the extent of aortic intimal lesions and the development of endothelial dysfunction. In addition, 15 weeks of feeding a diet enriched with either PETN or ISMN did not induce a measurable extent of vascular in-vitro tolerance to the vasodilator activity of these drugs.</p>","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"45 ","pages":"201-6"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18718522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Interplay of nitric oxide and histamine in the regulation of coronary reactive hyperemia and coronary autoregulation. 一氧化氮和组胺在冠状动脉反应性充血和冠状动脉自身调节中的相互作用。
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7346-8_20
M M Kostić, M R Petronijević
{"title":"Interplay of nitric oxide and histamine in the regulation of coronary reactive hyperemia and coronary autoregulation.","authors":"M M Kostić,&nbsp;M R Petronijević","doi":"10.1007/978-3-0348-7346-8_20","DOIUrl":"https://doi.org/10.1007/978-3-0348-7346-8_20","url":null,"abstract":"<p><p>Reactive hyperemia following 30 s of coronary occlusion in the isolated guinea pig heart is accompanied by a two-fold increase of nitric oxide (NO) and histamine release, which are significantly reduced in the presence of L-NAME, cimetidine and thioperamide, respectively. Great changes of histamine release occur during autoregulation. However, histamine seems much more important for metabolic dilation below the autoregulatory range. Inhibition of NO synthesis, but not blockade of histamine receptors, widens the autoregulatory range. Changes of the released NO and histamine under conditions employed in this study suggest a positive feed-back relationship between NO and histamine in the regulation of coronary circulation.</p>","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"45 ","pages":"145-9"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18718605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Clinical relevance of endothelial dysfunction in cardiovascular disorders. 心血管疾病中内皮功能障碍的临床意义。
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7346-8_33
D J Stewart
{"title":"Clinical relevance of endothelial dysfunction in cardiovascular disorders.","authors":"D J Stewart","doi":"10.1007/978-3-0348-7346-8_33","DOIUrl":"https://doi.org/10.1007/978-3-0348-7346-8_33","url":null,"abstract":"<p><p>The potential role of endothelial dysfunction, defined by an imbalance in the production of endothelium-derived vasodilator and constrictor factors is discussed. Evidence is presented that increased endothelin-1 production plays an important role in the clinical and morphological manifestations of pulmonary hypertension, particularly in primary disease. As well, the potential contribution of a relative decrease in nitric oxide production to inappropriately elevated pulmonary vascular resistance in patients with secondary causes of pulmonary hypertension, particularly those with congestive heart failure is discussed.</p>","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"45 ","pages":"227-35"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18719113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Pituitary adenylate cyclase activating peptides are endothelium-independent dilators of human and porcine coronary arteries. 垂体腺苷酸环化酶激活肽是人类和猪冠状动脉内皮不依赖的扩张剂。
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7346-8_38
A Kästner, L Bruch, L Will-Shahab, D Modersohn, G Baumann
{"title":"Pituitary adenylate cyclase activating peptides are endothelium-independent dilators of human and porcine coronary arteries.","authors":"A Kästner,&nbsp;L Bruch,&nbsp;L Will-Shahab,&nbsp;D Modersohn,&nbsp;G Baumann","doi":"10.1007/978-3-0348-7346-8_38","DOIUrl":"https://doi.org/10.1007/978-3-0348-7346-8_38","url":null,"abstract":"<p><p>The PACAPs have been shown to be potent vasodilators in different animal species. Data in humans are still lacking. Therefore we investigated the effects of PACAP 38, PACAP 27 and VIP on isolated human and porcine coronary arteries (HCA and PCA). Our data show, that the PACAPs are endothelium-independent vasorelaxants, which in HCA are slightly more potent than VIP. The N-terminal shortened peptides PACAP 6-38 and PACAP 6-27 also show relatively potent vasorelaxant effects, acting as partial agonists. Glibenclamide, a selective inhibitor of ATP-sensitive potassium channels, partially reverses the effects of the PACAPs, indicating an involvement of these channels in the mechanism of action.</p>","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"45 ","pages":"283-9"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18721089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Coupling of hepoxilin A3-specific binding with calcium-mobilizing actions in human neutrophils. 人中性粒细胞中hepoxilin a3特异性结合与钙动员作用的偶联。
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7346-8_39
D Reynaud, P M Demin, C R Pace-Asciak
{"title":"Coupling of hepoxilin A3-specific binding with calcium-mobilizing actions in human neutrophils.","authors":"D Reynaud,&nbsp;P M Demin,&nbsp;C R Pace-Asciak","doi":"10.1007/978-3-0348-7346-8_39","DOIUrl":"https://doi.org/10.1007/978-3-0348-7346-8_39","url":null,"abstract":"","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"45 ","pages":"291-6"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18721090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
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