发布求助
文献互助 智能选刊 最新文献

Agents and actions. Supplements最新文献

筛选
英文 中文
Effects of prolonged L-arginine administration on blood pressure in patients with essential hypertension (EH). 延长l -精氨酸给药对原发性高血压患者血压的影响。
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7346-8_22
M Malczewska-Malec, P Goldsztajn, K Kawecka-Jaszcz, D Czarnecka, A Siedlecki, T Siemienska, A Dembinska-Kiec
{"title":"Effects of prolonged L-arginine administration on blood pressure in patients with essential hypertension (EH).","authors":"M Malczewska-Malec,&nbsp;P Goldsztajn,&nbsp;K Kawecka-Jaszcz,&nbsp;D Czarnecka,&nbsp;A Siedlecki,&nbsp;T Siemienska,&nbsp;A Dembinska-Kiec","doi":"10.1007/978-3-0348-7346-8_22","DOIUrl":"https://doi.org/10.1007/978-3-0348-7346-8_22","url":null,"abstract":"<p><p>L-arginine (L-Arg) was administered intravenously through 4 consecutive days to 20 males (40-63 years old) with essential hypertension (EH). Significant decrease (p < 0.02) of systolic blood pressure (SBP) was observed only during the first day of the therapy and tachyphylaxis against L-Arg was noticed. The reduction of diastolic blood pressure (DBP) was more marked (p < 0.001). Significant changes in cGMP plasma level and the nitrite/nitrate urine concentration were not observed. L-Arg caused a significant activation of fibrinolysis (p < 0.005). The decrease of platelet activity, measured by the ADP-induced aggregation, after L-Arg administration was not statistically significant. Therefore, L-Arg may play only a secondary role in the treatment of EH.</p>","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"45 ","pages":"157-62"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18718515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
The similarity in action of hypoxia and platelet-activating factor on smooth muscle cells of coronary arteries: possible explanation for hypoxic coronary spasm development. 缺氧和血小板活化因子对冠状动脉平滑肌细胞作用的相似性:对缺氧冠状动脉痉挛发展的可能解释。
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7346-8_37
A Soloviev, P Braquet
{"title":"The similarity in action of hypoxia and platelet-activating factor on smooth muscle cells of coronary arteries: possible explanation for hypoxic coronary spasm development.","authors":"A Soloviev,&nbsp;P Braquet","doi":"10.1007/978-3-0348-7346-8_37","DOIUrl":"https://doi.org/10.1007/978-3-0348-7346-8_37","url":null,"abstract":"<p><p>Studies in isolated smooth muscles and single cells of coronary arteries have demonstrated that both hypoxia and platelet activating factor (PAF) in a similar manner increased contractile force and Ca-activated K currents. The specific antagonists of PAF receptors BN 52021 and WEB 2886 significantly decreased contractile responses of vascular smooth muscle (VSM) to PAF and hypoxia. Taken together, these data allow to suggest that endogenous PAF can produce both phasic and tonic contraction in coronary arteries under hypoxic condition.</p>","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"45 ","pages":"275-82"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18721088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of alpha 6 beta 1 integrin-mediated migration in macrophages. α 6 β 1整合素介导巨噬细胞迁移的调控。
Agents and actions. Supplements Pub Date : 1995-01-01
L M Shaw, A M Mercurio
{"title":"Regulation of alpha 6 beta 1 integrin-mediated migration in macrophages.","authors":"L M Shaw,&nbsp;A M Mercurio","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Several integrin alpha subunits have structural variants that are identical in their extracellular and transmembrane domains but that differ in their cytoplasmic domains. In the present study, we examined the possibility that the A and B variants of the alpha 6 beta 1 integrin laminin receptor differ in function. P388D1 macrophages that had been transfected with the alpha A integrin subunit were 3-4 fold more migratory than P388D1 macrophages that had been transfected with the alpha 6 B integrin subunit. Deletion of the alpha 6 cytoplasmic domain markedly inhibited the ability of the alpha 6 beta 1 receptor to promote migration.</p>","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"47 ","pages":"101-6"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18785658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New drugs in phase I and beyond workshop. 处于I期及以后阶段的新药。
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7343-7_19
R Griffiths, C Lanni
{"title":"New drugs in phase I and beyond workshop.","authors":"R Griffiths,&nbsp;C Lanni","doi":"10.1007/978-3-0348-7343-7_19","DOIUrl":"https://doi.org/10.1007/978-3-0348-7343-7_19","url":null,"abstract":"","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"47 ","pages":"177-9"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18784867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential phospholipase A2s involved in inflammatory diseases. 参与炎性疾病的潜在磷脂酶A2s。
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7276-8_4
E A Dennis
{"title":"Potential phospholipase A2s involved in inflammatory diseases.","authors":"E A Dennis","doi":"10.1007/978-3-0348-7276-8_4","DOIUrl":"https://doi.org/10.1007/978-3-0348-7276-8_4","url":null,"abstract":"","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"46 ","pages":"35-9"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18615895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Vasodilator effects of PGE1 in the coronary and systemic circulation of the rat are mediated by ATP-sensitive potassium (K+) channels. PGE1在大鼠冠状动脉和体循环中的血管扩张作用是通过atp敏感的钾离子通道介导的。
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7346-8_11
P Ney, M Feelisch
{"title":"Vasodilator effects of PGE1 in the coronary and systemic circulation of the rat are mediated by ATP-sensitive potassium (K+) channels.","authors":"P Ney,&nbsp;M Feelisch","doi":"10.1007/978-3-0348-7346-8_11","DOIUrl":"https://doi.org/10.1007/978-3-0348-7346-8_11","url":null,"abstract":"<p><p>This study was undertaken to investigate the possible involvement of K+ channels in PGE1-mediated vasodilatation. The increase in coronary flow elicited by PGE1 in isolated working rat hearts was attenuated by phentolamine and glibenclamide, inhibitors of ATP-regulated K+ channels, whereas apamin and charybdotoxin, inhibitors of calcium-activated K+ channels, were ineffective. In the anaesthetized rat, the duration of the hypotensive action of PGE1 was markedly attenuated by glibenclamide. It is concluded that the vasodilatory action of PGE1 in the coronary and systemic circulation of the rat is, at least in part, mediated via an opening of ATP-sensitive K+ channels.</p>","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"45 ","pages":"71-6"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18544616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Nitric oxide: what role does it play in inflammation and tissue destruction? 一氧化氮:它在炎症和组织破坏中起什么作用?
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7343-7_9
C H Evans
{"title":"Nitric oxide: what role does it play in inflammation and tissue destruction?","authors":"C H Evans","doi":"10.1007/978-3-0348-7343-7_9","DOIUrl":"https://doi.org/10.1007/978-3-0348-7343-7_9","url":null,"abstract":"<p><p>Large amount of nitric oxide (NO) are produced at sites of inflammation through the action of inducible nitric oxide synthase (iNOS) present in both infiltrating leucocytes and activated, resident tissue cells. However, the role of NO in inflammation remains unclear. NO is a vasodilator, which inhibits the adhesion of neutrophils to the vascular endothelium; it reduces the production of IL-6 by Kupffer cells and chondrocytes, and the production of gamma-IFN and TNF-alpha by splenocytes. The literature provides contradictory information on the effect of NO on vascular leakiness, chemotaxis, prostaglandin production and tissue damage. Increasingly, data suggest that NO is immunosuppressive. Inhibitors of NOS have potent prophylactic activity in several but not all, animal models of inflammatory disease. However, in rat adjuvant arthritis, therapeutic activity is weak. Whether inhibitors of iNOS will be therapeutically useful in human inflammatory diseases cannot be predicted on the basis of present information.</p>","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"47 ","pages":"107-16"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18546323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 91
Elevation of circulating NO: its effects on hemodynamics and vascular smooth muscle cell proliferation in rats. 循环一氧化氮升高对大鼠血流动力学和血管平滑肌细胞增殖的影响。
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7346-8_24
G Hecker, D Denzer, S Wohlfeil
{"title":"Elevation of circulating NO: its effects on hemodynamics and vascular smooth muscle cell proliferation in rats.","authors":"G Hecker,&nbsp;D Denzer,&nbsp;S Wohlfeil","doi":"10.1007/978-3-0348-7346-8_24","DOIUrl":"https://doi.org/10.1007/978-3-0348-7346-8_24","url":null,"abstract":"<p><p>Object of our study was to characterize the effects of elevated circulating NO on hemodynamics and vascular smooth muscle cell proliferation in rats. Administration of molsidomine (10, 25, 50 mg/kg, bid p.o.) was followed by pharmacodynamic effects: elevation of plasma nitrite/nitrate levels and reduction of blood pressure (25 and 50 mg/kg, bid p.o.). Under these conditions no antiproliferative activity occurred in a model of \"air dried\" carotid artery injury. From these results we conclude that NO does not act as an antiproliferative agent under conditions where smooth muscle cell injury predominates.</p>","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"45 ","pages":"169-76"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18718516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Molecular regulation and augmentation of prostacyclin biosynthesis. 前列环素生物合成的分子调控与增强。
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7346-8_2
K K Wu
{"title":"Molecular regulation and augmentation of prostacyclin biosynthesis.","authors":"K K Wu","doi":"10.1007/978-3-0348-7346-8_2","DOIUrl":"https://doi.org/10.1007/978-3-0348-7346-8_2","url":null,"abstract":"<p><p>Prostacyclin is a major vasoprotective molecule. It has multiple physiological functions. Its synthesis is determined by several enzymes of which cyclooxygenase (COX) plays a key role. Two isoforms of COX have been identified. Their expression and regulation are controlled by different mechanisms. COX-1 is constitutively expressed and physiologically important. PGI2 synthesis can be augmented by virus-mediated transfer COX-1 gene. This strategy may be useful for therapy of vascular thrombosis and tissue ischemia.</p>","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"45 ","pages":"11-7"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18718601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Metabolism and excretion of nitric oxide in man: basal studies and clinical applications. 人体一氧化氮的代谢和排泄:基础研究和临床应用。
Agents and actions. Supplements Pub Date : 1995-01-01 DOI: 10.1007/978-3-0348-7346-8_18
A Wennmalm
{"title":"Metabolism and excretion of nitric oxide in man: basal studies and clinical applications.","authors":"A Wennmalm","doi":"10.1007/978-3-0348-7346-8_18","DOIUrl":"https://doi.org/10.1007/978-3-0348-7346-8_18","url":null,"abstract":"","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"45 ","pages":"129-38"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18718603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书