Sleep epidemiology最新文献

{"title":"A patient-centric benefit-risk assessment of daridorexant for the treatment of insomnia disorder using patient preference data collected in two phase 3 clinical trials","authors":"Sebastian Heidenreich ,&nbsp;Melissa Ross ,&nbsp;Bruno Flamion ,&nbsp;Andrea Phillips-Beyer","doi":"10.1016/j.sleepe.2025.100108","DOIUrl":"10.1016/j.sleepe.2025.100108","url":null,"abstract":"<div><h3>Study objectives</h3><div>To conduct a patient-centric benefit-risk assessment of daridorexant vs. placebo for insomnia disorder treatment.</div></div><div><h3>Methods</h3><div>A quantitative benefit-risk assessment (qBRA) combined patient preference information and clinical data collected in two multicenter placebo-controlled phase 3 trials. The qBRA weighted efficacy and adverse event data collected in the daridorexant and placebo trial arms based on the acceptable benefit-risk trade-offs patients would be willing to make in a discrete choice experiment. The preference-weighted trial arms were used to test the total net benefits of daridorexant 50 mg and daridorexant 25 mg vs. placebo. Sensitivity analyses accounted for uncertainty in both clinical trial and patient preference data.</div></div><div><h3>Results</h3><div>Preferences of 602 trial participants (68.1 % female, mean age 58.6 years) were used in the qBRA analysis. Both daridorexant 25 mg (net benefit [standard error {SE}] = 0.097 [0.022]) and daridorexant 50 mg (net benefit [SE] = 0.197 [0.025]) had a significantly higher net benefit than placebo (both p &lt; 0.001). Time to fall asleep, daytime functioning, and total time asleep provided added value for daridorexant over placebo and outweighed potential side effects. The sensitivity analyses accounting for differences in both clinical trial and patient preference data indicated that both doses of daridorexant would still be preferred over placebo.</div></div><div><h3>Conclusion</h3><div>Even when accounting for uncertainty in clinical data and patients’ preferences, both daridorexant 25 mg and 50 mg were likely to have a positive benefit-risk balance from the patient’s perspective.</div></div>","PeriodicalId":74809,"journal":{"name":"Sleep epidemiology","volume":"5 ","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between subjective and objective sleep parameters and internalizing and externalizing problems in adolescents","authors":"Roan van der Laars ,&nbsp;Diandra C. Bouter ,&nbsp;M. Elisabeth Koopman-Verhoeff ,&nbsp;Milan Zarchev ,&nbsp;Sibel Ercan ,&nbsp;Witte J.G. Hoogendijk ,&nbsp;Nina H. Grootendorst-van Mil","doi":"10.1016/j.sleepe.2025.100107","DOIUrl":"10.1016/j.sleepe.2025.100107","url":null,"abstract":"<div><div>Sleep practices change markedly in adolescence, leading to reductions in both duration and quality. Poor sleep health is a core component of many psychiatric disorders, yet most previous studies have mainly used singular rather than multidimensional sleep measures, which fail to account for all aspects of sleep as a behavior. In an adolescent cohort oversampled for high psychopathology risk (<em>n</em> = 494, mean age 17.88), we used a validated 0–6 composite sleep health score based on sleep diary and actigraphy data. The Youth Self Report (YSR) quantified psychopathology symptoms as a total score, as broadband problem scales (e.g., externalizing problems), and narrowband scales (e.g., aggressive problems). Confounder-adjusted multiple linear regression models examined the association between the sleep composite score and total, broadband, and narrowband problem scores. A higher sleep composite score, indicating better sleep health, was linked to a lower total problems score (B -3.66, 95 % CI [-5.20; -2.12]) and was inversely related to all specific problem scales, including internalizing and externalizing problems, with the sole exception of aggressive problems. Secondary analyses revealed consistent associations between subjective sleep domains and various problem subscales, whereas objective domains showed none. Our study underscores the complementary roles of subjective and objective sleep measures in mental health research, illustrating that subjective measures are consistently associated with psychopathological symptoms and may offer personal relevance, while objective measures might provide accuracy and consistency by capturing detailed sleep patterns. However, limitations include the study's cross-sectional design and potential selection bias in the sleep measurement group.</div></div>","PeriodicalId":74809,"journal":{"name":"Sleep epidemiology","volume":"5 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disparities in the United States: Comparison of logistic and linear regression with stratification by race","authors":"Irene A Doherty ,&nbsp;Mary Ellen Wells","doi":"10.1016/j.sleepe.2025.100106","DOIUrl":"10.1016/j.sleepe.2025.100106","url":null,"abstract":"<div><h3>Background</h3><div>Analyses of risk factors associated with poor sleep/deprivation often use nationally representative surveys of the United States such as the National Household and Nutrition Examination Survey (NHANES). Outcomes are dichotomized as &lt;6, &lt;7, or &lt;8 h of sleep and modeled with logistic regression where race or ethnicity is treated as an independent variable. Converting a continuous variable (sleep hours) to a categorical compromises statistical power. Treating race as a confounder fails to uncover how sleep disparities affect minorities.</div></div><div><h3>Methods</h3><div>This analysis of NHANES from 2005 to 2008 of White and Black participants compares interpretations from logistic regression models using ≤6 h of self-reported sleep to linear regression models using number of sleep minutes as the outcome. The analysis includes bivariate and multivariable models of risk factors associated with poor sleep including race, markers of low socioeconomic status (SES), sleep difficulty measures, self-reported health, and clinical comorbidities (obesity, hypertension, diabetes). All models were generated for the complete sample and stratified by race.</div></div><div><h3>Results</h3><div>Linear regression models produced quantifiable, clinically meaningful results such as women slept ∼20 additional minutes than men for both Black and White strata or were OR=0.63 times as likely to sleep ≤6 h. Markers of low SES (education, poverty) and self-reported health were associated with sleep deprivation for Whites, but not for Blacks in both linear and logistic regression.</div></div><div><h3>Conclusions</h3><div>Stratified analyses by race using the amount of sleep as a continuous outcome in linear regression is more rigorous and informative than logistic regression for sleep research using US representative surveys.</div></div>","PeriodicalId":74809,"journal":{"name":"Sleep epidemiology","volume":"5 ","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate variability, sleep quality and physical activity in medical students","authors":"Samuel Filipe Lopes Alves ,&nbsp;Thaísy Andressa Bastos Primo de Sousa Santos ,&nbsp;Marianne Lucena da Silva ,&nbsp;Katiane da Costa Cunha","doi":"10.1016/j.sleepe.2024.100105","DOIUrl":"10.1016/j.sleepe.2024.100105","url":null,"abstract":"<div><h3>Aims</h3><div>The present study aims to investigate the sleep quality, levels of physical activity, and their relationship with heart rate variability (HRV) in medical students.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study with 105 medical students from Brazil. Data were collected through sociodemographic questionnaires, Pittsburgh Sleep Quality Index (PSQI), International Physical Activity Questionnaire Short Form (IPAQ-SF), anthropometric measurements, and resting HRV. One-way ANOVA analysed sociodemographic variables, PSQI, and IPAQ scores. Spearman correlation assessed the relationship between anthropometric data and HRV parameters. Multiple Linear Regression examined the relationship between PSQI, IPAQ, and HRV, with a significance level of 5%.</div></div><div><h3>Results</h3><div>A predominance of poor sleep quality and high physical activity levels were observed in medical students. Multivariate analysis revealed a significant association between HRV, IPAQ, and sleep quality in the SDNN (F reg=3.08; <em>p</em> = 0.0486) and LF (F reg=2.95; <em>p</em> = 0.0553) components. However, when analysing each variable independently, the correlation was statistically relevant only for the PSQI. The correlation was inversely proportional, indicating poorer sleep quality associated with lower HRV values.</div></div><div><h3>Conclusion</h3><div>The results indicate that poor sleep quality is common among medical students and is correlated with a reduction in HRV, which may have an adverse impact on the cardiovascular health of this population.</div></div>","PeriodicalId":74809,"journal":{"name":"Sleep epidemiology","volume":"5 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of sleep disturbances and factors associated among school going children in Uganda, a cross-sectional study","authors":"Baluku Reagan Innocent ,&nbsp;Oriokot Lorraine ,&nbsp;Elly Katabira ,&nbsp;Martha Sajatovic ,&nbsp;Abbo Catherine ,&nbsp;Kaddumukasa Mark","doi":"10.1016/j.sleepe.2024.100104","DOIUrl":"10.1016/j.sleepe.2024.100104","url":null,"abstract":"<div><h3>Background</h3><div>Sleep disturbances greatly impact children's academic performance and social well-being. This study set out to determine the prevalence of sleep disturbances and factors associated among school going children in Kawempe division, Kampala, Uganda.</div></div><div><h3>Methods</h3><div>In a community cross-sectional study, 548 study participants using random cluster sampling were enrolled. The children start lessons at 8am and end the days classes at 5pm. Random cluster sampling method was used to select participants from the 19 parishes in Kawempe district. Data was collected using a semi-structured questionnaire and Sleep Disturbance Scale for Children (SDSC). Descriptive statistics and multivariate binary logistic regression were performed with a <em>p</em> &lt; 0.05 level of significance, and a 95 % confidence interval as a measure of association between the sleep disturbance.</div></div><div><h3>Results</h3><div>Abnormal total sleep score (T- score &gt;70) was at 3.5 %, and overall, 21.7 % of the children had an abnormal score on at least one SDSC factor. Among the children with sleep disturbances, we noted the following factors; use of an electronic device before bed, sleeping &lt;7 h at night, having unemployed parents and lack of regular parental interaction.</div></div><div><h3>Conclusion</h3><div>Better understanding of sleep disturbances in needed to address challenges associated with sleep among children in Uganda.</div></div>","PeriodicalId":74809,"journal":{"name":"Sleep epidemiology","volume":"5 ","pages":"Article 100104"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal study of chronic nausea and vomiting and its associations with sleep-related leg cramps in the US general population","authors":"MM Ohayon ,&nbsp;YJ Chen ,&nbsp;R Fass ,&nbsp;ML Cote","doi":"10.1016/j.sleepe.2024.100103","DOIUrl":"10.1016/j.sleepe.2024.100103","url":null,"abstract":"<div><h3>Introduction</h3><div>Chronic nausea and vomiting (CNV) can have a long-term impact on people's health and quality of life. This study aims to investigate whether CNV is involved in the development of sleep-related leg cramps (SRLCs) in a longitudinal study involving 10,931 participants representative of the US general population.</div></div><div><h3>Methods</h3><div>Participants were interviewed three years apart over the telephone using the Sleep-EVAL expert system. It collected information on sleep habits/disturbances (International Classification of Sleep Disorders), mental disorders (DSM-IV-TR) and medical conditions. CNV was defined as episodes of nausea and vomiting occurring at least five times a month for at least one month (outside pregnancy) as per the ROME IV recommendations.</div></div><div><h3>Results</h3><div>At the initial interview, 3% (95%CI:2.7%-3.3%) of the participants reported CNV, and 2.5% (95%CI:2.2%-2.8%) at follow-up. The 3-year incidence for CNV was 1.4%. SRLCs was found in 12.4% (95%CI:11.9%-13.1%) of the sample at the first-interview and 11.5% (95%CI:10.1%-12.1%) at follow-up. Multivariate models show that individuals with CNV at both interviews had a relative risk 4.1 times higher (95%CI:2.7–6.2; <em>p</em> &lt; 0.0001) to have SRLCs at follow-up compared to those without nausea or vomiting. Magnesium intake at the initial interview was a protective factor for SRLCs (RR 0.4; 95%CI: 0.2–0.7; <em>p</em> = 003).</div></div><div><h3>Discussion</h3><div>Symptoms of CNV lasting for years is highly predictive of SRLC based on this longitudinal survey. The link between the two pathologies could be partially explained by potential potassium/magnesium depletion from muscles as a result of CNV. The findings of this study call for physician awareness of the association between CNV and SRLC.</div></div>","PeriodicalId":74809,"journal":{"name":"Sleep epidemiology","volume":"5 ","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Modeling and Feature Assessment of the Sleep Quality among Chronic Kidney Disease Patients” [Sleep Epidemiology Volume 2, December 2022, 100041]","authors":"Surani Matharaarachchi ,&nbsp;Mike Domaratzki ,&nbsp;Chamil Marasinghe ,&nbsp;Saman Muthukumarana ,&nbsp;Varuni Tennakoon","doi":"10.1016/j.sleepe.2024.100072","DOIUrl":"10.1016/j.sleepe.2024.100072","url":null,"abstract":"","PeriodicalId":74809,"journal":{"name":"Sleep epidemiology","volume":"4 ","pages":"Article 100072"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139632780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Obstructive Sleep Apnea (OSA) and contact sports: A systematic review and meta-analysis” [Sleep Epidemiology, 2C (2022) 100036]","authors":"Nathan E. Howarth ,&nbsp;Adam J. White ,&nbsp;Alan J. Pearce ,&nbsp;Chris Nowinski ,&nbsp;Robert Cantu ,&nbsp;Chen Ji ,&nbsp;Michelle A Miller","doi":"10.1016/j.sleepe.2024.100094","DOIUrl":"10.1016/j.sleepe.2024.100094","url":null,"abstract":"","PeriodicalId":74809,"journal":{"name":"Sleep epidemiology","volume":"4 ","pages":"Article 100094"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety symptoms, sleep disturbance, and academic achievement among Afghan female school students: A cross-sectional study","authors":"Ahmad Neyazi ,&nbsp;Bilal Ahmad Rahimi ,&nbsp;Abdul Qadim Mohammadi ,&nbsp;Nosaibah Razaqi ,&nbsp;Laila Qanawezi ,&nbsp;Shaharah Sarem ,&nbsp;Saida Said ,&nbsp;Raz Mohammad Tabib ,&nbsp;Habibah Afzali ,&nbsp;Mehrab Neyazi ,&nbsp;Mark D. Griffiths","doi":"10.1016/j.sleepe.2024.100102","DOIUrl":"10.1016/j.sleepe.2024.100102","url":null,"abstract":"<div><h3>Background</h3><div>Anxiety is a common psychological disorder in school-aged children and adolescents. The present study aimed to assess the prevalence of anxiety symptoms and sleep disturbances and their relationship with academic achievement among female students in Herat, Afghanistan.</div></div><div><h3>Methods</h3><div>A cross-sectional survey of 737 female students (mean age 11.8 years old) was conducted across 10 randomly selected schools in Herat, Afghanistan, covering Grades 1 to 6. Students were randomly chosen within these schools. The Depression Anxiety Stress Scale for Youth (DASS-Y) and Pittsburgh Sleep Quality Index (PSQI) assessed anxiety and sleep disturbance, while academic achievement ratings were provided by schoolteachers.</div></div><div><h3>Results</h3><div>Using the DASS-Y and the PSQI, 65.5% reported anxiety symptoms and 46.4% reported sleep disturbance. Low academic achievement correlated significantly with anxiety (<em>r</em> = 0.228) and sleep issues (<em>r</em> = 0.161). Multiple logistic regression analysis identified predictors for anxiety and sleep disturbance. Predictors for anxiety included being aged 13–16 years, having lower class grade, being of low economic status, and having unemployed parents. Predictors for sleep disturbance included being aged 13–16 years, having lower class grade, having an uneducated father, being of low economic status, and having unemployed parents.</div></div><div><h3>Conclusion</h3><div>There is a high prevalence of anxiety symptoms and sleep disturbances among female school students in Herat, Afghanistan. Significant correlations exist between students' academic achievement, anxiety, and sleep disturbances. Addressing anxiety and sleep disturbances among Afghan female school students could be facilitated by revising current government policies concerning students' health. Educational campaigns focused on sleep hygiene and anxiety management for both students and their parents may also prove beneficial.</div></div>","PeriodicalId":74809,"journal":{"name":"Sleep epidemiology","volume":"4 ","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Listening to patients: Incidence and distribution of sleep disorders in Prader-Willi syndrome","authors":"Amee Revana ,&nbsp;E. Robert Wassman ,&nbsp;Niva Haber ,&nbsp;Lara C. Pullen ,&nbsp;Terry Jo Bichell ,&nbsp;Jessica Duis ,&nbsp;Randy Bartlett ,&nbsp;Christopher DeFelice ,&nbsp;Maria Picone","doi":"10.1016/j.sleepe.2024.100101","DOIUrl":"10.1016/j.sleepe.2024.100101","url":null,"abstract":"<div><div>While the medical community continues to recognize the contributions of disordered sleep to the burden of Prader-Willi syndrome (PWS), the medical literature lacks characterization of the patient burden of sleep disorders by people living with PWS and their caregivers. We developed and fielded a 72-question survey to the online PWS community, to query caregivers about their experiences with sleep symptoms. Respondents for all age groups reported sleep-disordered breathing (40 %), cataplexy-like symptoms (28.4 %), and insomnia (43.5 %). The presentation of cataplexy-like symptoms tended to change as children aged, presenting initially (ages 0–4 years) as head bobbing while eating, then transitioning to knee buckling between the ages of 5–12 years. Finally, loss of generalized tone associated with extreme emotions became more common in the teenage years. Frequent screening for potentially treatable sleep disorders should be considered the standard of care for individuals with PWS.</div></div>","PeriodicalId":74809,"journal":{"name":"Sleep epidemiology","volume":"4 ","pages":"Article 100101"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}