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Seminars in neonatology : SN最新文献

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Genetic influences and neonatal lung disease 遗传影响与新生儿肺部疾病
Seminars in neonatology : SN Pub Date : 2003-02-01 DOI: 10.1016/S1084-2756(02)00196-3
Mikko Hallman, Ritva Haataja
{"title":"Genetic influences and neonatal lung disease","authors":"Mikko Hallman,&nbsp;Ritva Haataja","doi":"10.1016/S1084-2756(02)00196-3","DOIUrl":"10.1016/S1084-2756(02)00196-3","url":null,"abstract":"<div><p>Neonatal lung diseases may have a genetic background. The available studies mainly concentrate on surfactant proteins (SP-A, SP-B) and respiratory distress syndrome. Specific alleles of the <em>SP-A</em> and <em>SP-B</em> genes associate interactively with susceptibility to respiratory distress syndrome. This genetic impact on the condition is influenced by environmental, acquired and inherited factors. Other alleles and genotypes of <em>SP-A</em> and <em>SP-D</em> associate with severe respiratory infections in early infancy. Rare mutations causing an absence of the SP-B protein result in progressive respiratory failure. Dominant mutations of <em>SP-C</em> associate with chronic lung disease, with variable manifestations. The first steps towards unraveling the genetic network influencing the susceptibility to neonatal lung diseases are now being taken. Genes encoding multifunctional proteins in the distal lung are prime candidates for causing susceptibility to neonatal lung disease, including bronchopulmonary dysplasia.</p></div>","PeriodicalId":74783,"journal":{"name":"Seminars in neonatology : SN","volume":"8 1","pages":"Pages 19-27"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1084-2756(02)00196-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22315901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 50
Pathology of new bronchopulmonary dysplasia 新发支气管肺发育不良的病理分析
Seminars in neonatology : SN Pub Date : 2003-02-01 DOI: 10.1016/S1084-2756(02)00193-8
Jacqueline J. Coalson
{"title":"Pathology of new bronchopulmonary dysplasia","authors":"Jacqueline J. Coalson","doi":"10.1016/S1084-2756(02)00193-8","DOIUrl":"10.1016/S1084-2756(02)00193-8","url":null,"abstract":"<div><p>Technological advances, improved ventilatory strategies and better nursing techniques, coupled with the use of prenatal steroids and postnatal surfactant, have resulted in the survival of smaller and more immature infants. Preterm infants likely to develop bronchopulmonary dysplasia (BPD) are born during the canalicular phase of lung development at 24–26 weeks, a time when alveolar and distal vascular development commences. The histopathologic lesions of severe airway injury and alternating sites of overinflation and fibrosis in ‘old’ BPD have been replaced in ‘new’ BPD with the pathologic changes of large, simplified alveolar structures, a dysmorphic capillary configuration and variable interstitial cellularity and/or fibroproliferation. Airway and vascular lesions, when present, tend to occur in infants who over time develop more severe disease. The alveolar and capillary hypoplasia of new BPD will require the development of specific therapies, but avoiding volutrauma, oxidant injury and inflammation/infection will improve lung morphology.</p></div>","PeriodicalId":74783,"journal":{"name":"Seminars in neonatology : SN","volume":"8 1","pages":"Pages 73-81"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1084-2756(02)00193-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22315906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 514
Bronchopulmonary dysplasia—oxidative stress and antioxidants 支气管肺发育不良-氧化应激和抗氧化剂
Seminars in neonatology : SN Pub Date : 2003-02-01 DOI: 10.1016/S1084-2756(02)00194-X
Ola Didrik Saugstad
{"title":"Bronchopulmonary dysplasia—oxidative stress and antioxidants","authors":"Ola Didrik Saugstad","doi":"10.1016/S1084-2756(02)00194-X","DOIUrl":"10.1016/S1084-2756(02)00194-X","url":null,"abstract":"<div><p>There is increasing evidence that oxidative stress is implicated in the development of bronchopulmonary dysplasia. Several important factors contribute to augmented oxidative stress in the newborn and especially the preterm infant: first, because of its immaturity, the lung of preterm infants is frequently exposedto oxygen therapy and hyperoxia. Second, the antioxidant defense and its ability to be induced during an hyperoxic challenge are impaired. Third, the preterm infant has an increased susceptibility to infection and inflammation, which increases oxidative stress. Fourth, free iron, which catalyzes the production of toxic reactive oxygen species, can be detected in preterm infants. The molecular and cellular mechanisms for free radical-induced injury are now understood in more detail, and it is clear that oxidative stress plays an important role in triggering apoptosis, in serving as second messenger and in signal transduction. This new insight mightlead to novel and efficient therapies. So far, there has been no significant breakthrough regarding antioxidant therapies. Care should, however, be exercised in supplementing the preterm infant with antioxidants since this may affect growth and development.</p></div>","PeriodicalId":74783,"journal":{"name":"Seminars in neonatology : SN","volume":"8 1","pages":"Pages 39-49"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1084-2756(02)00194-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22315903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 323
The pulmonary circulation in bronchopulmonary dysplasia 支气管肺发育不良患者的肺循环
Seminars in neonatology : SN Pub Date : 2003-02-01 DOI: 10.1016/S1084-2756(02)00191-4
Thomas A. Parker, Steven H. Abman
{"title":"The pulmonary circulation in bronchopulmonary dysplasia","authors":"Thomas A. Parker,&nbsp;Steven H. Abman","doi":"10.1016/S1084-2756(02)00191-4","DOIUrl":"10.1016/S1084-2756(02)00191-4","url":null,"abstract":"<div><p>Abnormalities of the pulmonary circulation are increasingly being recognized as a major contributor to the high morbidity and mortality of bronchopulmonary dysplasia. Historically, studies have focused on the importance of pulmonary hypertension to the pathophysiology of BPD, with the assumption that pulmonary vascular abnormalities are a secondary consequence of primary injury to the airspace. Recent studies suggest, however, that abnormalities of the pulmonary vasculature, including altered growth and structure, may directly contribute to the abnormal alveolarization that characterizes the condition. In this article, we briefly outline mechanisms of pulmonary vascular injury in infants at risk of BPD. We then focus on the recognition and management of pulmonary hypertension in these infants. Finally, we review how disordered pulmonary vascular growth may contribute to the pathogenesis of BPD and emphasize the importance of the reciprocal development of the airspace and the pulmonary circulation.</p></div>","PeriodicalId":74783,"journal":{"name":"Seminars in neonatology : SN","volume":"8 1","pages":"Pages 51-61"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1084-2756(02)00191-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22315904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 83
Developmental progression of feeding skills: an approach to supporting feeding in preterm infants 喂养技巧的发展进展:支持早产儿喂养的方法
Seminars in neonatology : SN Pub Date : 2002-12-01 DOI: 10.1053/siny.2002.0152
Erin Sundseth Ross , Joy V Browne
{"title":"Developmental progression of feeding skills: an approach to supporting feeding in preterm infants","authors":"Erin Sundseth Ross ,&nbsp;Joy V Browne","doi":"10.1053/siny.2002.0152","DOIUrl":"10.1053/siny.2002.0152","url":null,"abstract":"<div><p>Infants born prematurely, with congenital or acquired medical conditions, or who have extended stays in the neonatal intensive care unit (NICU) are at higher risk of developing feeding and nutritional problems than are full-term, healthy newborns. Because of the complex nature of feeding, it is necessary to have a thorough understanding of the developmental nature of this skill. The importance of recognizing stability in the physiologic, motor and state systems and using stability to determine both readiness to begin nipple feeding and progress in feeding, is discussed. Intervention strategies to promote stability leading to successful feeding are also described. Viewing infant feeding from a developmental skill acquisition perspective can guide the caregiver in determining how challenging it is for the infant, and therefore is useful in supporting the progression of feeding.</p></div>","PeriodicalId":74783,"journal":{"name":"Seminars in neonatology : SN","volume":"7 6","pages":"Pages 469-475"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1053/siny.2002.0152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22268649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 77
Preterm infant massage therapy studies: an American approach 早产儿按摩治疗研究:美国方法
Seminars in neonatology : SN Pub Date : 2002-12-01 DOI: 10.1053/siny.2002.0153
Tiffany Field
{"title":"Preterm infant massage therapy studies: an American approach","authors":"Tiffany Field","doi":"10.1053/siny.2002.0153","DOIUrl":"10.1053/siny.2002.0153","url":null,"abstract":"<div><p>Preterm infants have been noted to benefit from massage therapy. Following massage therapy protocols using moderate pressure preterm infants have gained 31–49% more weight on average. Some studies have also shown length and head circumference growth and bone mineral density increases associated with massage therapy. These studies are reviewed in this paper along with discussion of potential underlying mechanisms.</p></div>","PeriodicalId":74783,"journal":{"name":"Seminars in neonatology : SN","volume":"7 6","pages":"Pages 487-494"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1053/siny.2002.0153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22268651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 67
Benefits of infant massage for mothers with postnatal depression 婴儿按摩对产后抑郁症母亲的好处
Seminars in neonatology : SN Pub Date : 2002-12-01 DOI: 10.1053/siny.2002.0154
Vivette Glover , Katsuno Onozawa, Alison Hodgkinson
{"title":"Benefits of infant massage for mothers with postnatal depression","authors":"Vivette Glover ,&nbsp;Katsuno Onozawa,&nbsp;Alison Hodgkinson","doi":"10.1053/siny.2002.0154","DOIUrl":"10.1053/siny.2002.0154","url":null,"abstract":"<div><p>Infant massage by the mother has been popular in many cultures, especially India, and is growing in popularity in the West. Mothers with postnatal depression often have problems interacting with their infants. A small controlled study has shown that attending a massage class can help such mothers relate better to their babies. The mechanisms by which this is achieved are not clear but may include learning to understand their babies' cues and the release of oxytocin.</p></div>","PeriodicalId":74783,"journal":{"name":"Seminars in neonatology : SN","volume":"7 6","pages":"Pages 495-500"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1053/siny.2002.0154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22268652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 87
AUTHOR INDEX TO VOLUME 7 第七卷的作者索引
Seminars in neonatology : SN Pub Date : 2002-12-01 DOI: 10.1053/siny.2002.0162
{"title":"AUTHOR INDEX TO VOLUME 7","authors":"","doi":"10.1053/siny.2002.0162","DOIUrl":"https://doi.org/10.1053/siny.2002.0162","url":null,"abstract":"","PeriodicalId":74783,"journal":{"name":"Seminars in neonatology : SN","volume":"7 6","pages":"Pages i-ix"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1053/siny.2002.0162","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137407082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated Nursing Care: vital issues important in the humane care of the newborn 综合护理:在新生儿的人道关怀至关重要的问题
Seminars in neonatology : SN Pub Date : 2002-12-01 DOI: 10.1053/siny.2002.0148
Gretchen Lawhon
{"title":"Integrated Nursing Care: vital issues important in the humane care of the newborn","authors":"Gretchen Lawhon","doi":"10.1053/siny.2002.0148","DOIUrl":"10.1053/siny.2002.0148","url":null,"abstract":"<div><p>Neonatal nurses are in a unique and powerful position to influence the lives of infants and families. The essence of the profession of nursing is an obligation to care. The art and science of caring demands individualization and flexibility in judgment and decision-making. Nursing is a process of facilitation that involves mutual interactive communication toward an individual, family, community, or system and is directed toward further development. When the nurse's relationship is one of mutuality with the family there is a synchronous process of the nurse supporting the family in supporting the infant's emerging development. The neurobehaviourally supportive approach is one that is individualized and therefore the plan of care for each infant must be thoroughly designed. This humane and integrated approach to care ensures families' competence and confidence in their readiness for the infant's discharge from the intensive care nursery.</p></div>","PeriodicalId":74783,"journal":{"name":"Seminars in neonatology : SN","volume":"7 6","pages":"Pages 441-446"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1053/siny.2002.0148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22269927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Neonatal individualized care in practice: a Swedish experience 新生儿个体化护理的实践:瑞典的经验
Seminars in neonatology : SN Pub Date : 2002-12-01 DOI: 10.1053/siny.2002.0150
Björn Westrup , Karin Stjernqvist , Agneta Kleberg , Lena Hellström-Westas , Hugo Lagercrantz
{"title":"Neonatal individualized care in practice: a Swedish experience","authors":"Björn Westrup ,&nbsp;Karin Stjernqvist ,&nbsp;Agneta Kleberg ,&nbsp;Lena Hellström-Westas ,&nbsp;Hugo Lagercrantz","doi":"10.1053/siny.2002.0150","DOIUrl":"10.1053/siny.2002.0150","url":null,"abstract":"<div><p>A family-centred, developmentally supportive approach to newborn intensive care referred to as NIDCAP (Newborn Individualized Developmental Care and Assessment Programme) has caught considerable interest during recent years. In this paper we review the scientific context behind its conceptual framework and summarize our experience from 10 years of training, implementation and research. We present the short- and long-term medical and developmental outcome of our Swedish NIDCAP studies as well as attitudes of nursing staff and neonatologists. Furthermore, ethical issues and scientific obstacles concerning this concept of care are discussed.</p></div>","PeriodicalId":74783,"journal":{"name":"Seminars in neonatology : SN","volume":"7 6","pages":"Pages 447-457"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1053/siny.2002.0150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22269928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 59
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