Rhinology online最新文献_第9页

Nasal symptoms in patients with NSAID hypersensitivity NSAID超敏反应患者的鼻部症状

Rhinology online Pub Date : 2019-06-01 DOI: 10.4193/RHINOL/19.009

B. Lange, C. Mortz, C. Bindslev‐Jensen, A. Kjeldsen

{"title":"Nasal symptoms in patients with NSAID hypersensitivity","authors":"B. Lange, C. Mortz, C. Bindslev‐Jensen, A. Kjeldsen","doi":"10.4193/RHINOL/19.009","DOIUrl":"https://doi.org/10.4193/RHINOL/19.009","url":null,"abstract":"Background : Approximately 1 to 2% of the general population suffers from nonsteroidal anti-inflammatory drugs (NSAID) hypersensitivity. NSAID hypersensitivity is closely associated with concomitant respiratory disease. Exact knowledge of sino-nasal symptoms among patients with NSAID hypersensitivity is important as patients with NSAID hypersensitivity are at risk of having underdiagnosed, undertreated chronic rhinosinusitis with affected QoL. The aim of this study was to estimate the prevalence of chronic rhinosinusitis in patients with NSAID hypersensitivity and to evaluate QoL and the need of ENT intervention. Methodology : Patients with confirmed NSAID hypersensitivity at the Allergy Centre were referred to the Department of Otorhinolaryngology for evaluation by an ENT specialist. All patients completed the Sino Nasal Outcome test 22 (QoL) and underwent nasal endoscopy and smell test. Results : A total of 46 patients with NSAID hypersensitivity participated in ENT evaluation. Chronic rhinosinusitis was diagnosed in 19 patients. The mean Sino Nasal Outcome test 22 score was 39 in patients with chronic rhinosinusitis and 17 in patients without chronic rhinosinusitis. The sense of smell was decreased in patients with chronic rhinosinusitis. Nasal steroid was indicated in 22 patients. Seven patients had former sinus surgery and 10 patients underwent new sinus or nasal surgery. Conclusion : With a prevalence of 41% more than one third of patients with NSAID hypersensitivity have chronic rhinosinusitis with decreased QoL. In patients with sino-nasal problems medical and surgical advice and treatment is important. It is recommended that patients with NSAID hypersensitivity are screened for sino-nasal symptoms and referred for ENT evaluation.","PeriodicalId":74737,"journal":{"name":"Rhinology online","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49419776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Animal models for inflammatory mucosal disease and their potential for studying the microbiome in chronic rhinosinusitis 炎症性粘膜疾病的动物模型及其在慢性鼻窦炎微生物组研究中的潜力

Rhinology online Pub Date : 2019-05-01 DOI: 10.4193/RHINOL/19.015

C. Lux, R. Douglas, D. Cho, Michael W Taylor, K. Biswas

{"title":"Animal models for inflammatory mucosal disease and their potential for studying the microbiome in chronic rhinosinusitis","authors":"C. Lux, R. Douglas, D. Cho, Michael W Taylor, K. Biswas","doi":"10.4193/RHINOL/19.015","DOIUrl":"https://doi.org/10.4193/RHINOL/19.015","url":null,"abstract":"Chronic rhinosinusitis (CRS) is a morbid condition of the paranasal sinuses which severely impairs patients’ quality of life. CRS represents one of the leading diseases that are responsible for antibiotic prescriptions. However, there is little evidence to support the efficacy of antibiotics in CRS. Due to the highly heterogeneous nature of CRS determining the underlying etiology is challenging. The mucosal microbiome has been hypothesised to play a role in the pathophysiology of CRS. Several attempts to establish a representative model of CRS have been made to help determine the pathogenesis of this condition. This review summarises the current literature on model systems for inflammatory sinus disease. Fourteen different studies are discussed, including mouse, rabbit and sheep as model organisms. A detailed description of the methods for model development and examples for their application are provided. Focus is put on animal models that should be suitable for studying the sinonasal microbiome in CRS. To date, only two studies sought to employ their model for microbiome analysis. Other models are included for which there is currently no microbiome information, however they are of potential use in this regard and we thus discuss their suitability. This review identifies a need for further employment of animal models of CRS for microbiome research. Recently, a rabbit model of CRS featuring several qualities that make it particularly suitable for microbiological research has been described. This model system represents a further advance of translational research in the field of CRS.","PeriodicalId":74737,"journal":{"name":"Rhinology online","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45849881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

In vitro surface temperature of nasal balloons during hot water inflation 热水充气过程中鼻球囊体外表面温度的测定

Rhinology online Pub Date : 2019-05-01 DOI: 10.4193/rhinol/19.012

C. A. Moene, M. Hauge, J. Silvola, G. Bachmann-Harildstad

{"title":"In vitro surface temperature of nasal balloons during hot water inflation","authors":"C. A. Moene, M. Hauge, J. Silvola, G. Bachmann-Harildstad","doi":"10.4193/rhinol/19.012","DOIUrl":"https://doi.org/10.4193/rhinol/19.012","url":null,"abstract":"Background: Posterior epistaxis is often treated with nasal packing by balloon compression or gauzes, and in refractory cases, with ligation of the sphenopalatine artery. These methods are painful, require admission and imply a substantial risk of complications. It has been shown that hot water irrigation is effective to stop bleeding. However, the hot water procedure is associated with patient discomfort, and temperatures over 520C may cause tissue necrosis. The use of nasal balloons filled with hot water may potentially be equally effective and cause less discomfort, but has not yet been studied. The aim of this study was to determine the surface temperature of nasal balloons when filled with hot water. Methodology: An in vitro study was performed to determine surface temperature of Epistat® and Rapid Rhino® nasal balloons when filled with water at different temperatures. Results: There was a strong correlation between inserted water temperature and maximum temperature at Epistat® balloon surface. Maximum surface temperature occurred during the first 30 seconds after water insertion and there was a rapid temperature decline irrespective of inserted water temperature. There was a similar correlation for Rapid Rhino®. However, surface temperatures were in general lower, maintained for a longer period and the peak temperature occurred later. Conclusions: Hot water inflation in nasal balloons seems to be feasible and is unlikely to cause tissue necrosis with inserted water temperatures of 600C or less.","PeriodicalId":74737,"journal":{"name":"Rhinology online","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43723269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nasal valve elastography: quantitative determination of the mobility of the nasal valve 鼻瓣膜弹性成像：鼻瓣膜活动度的定量测定

Rhinology online Pub Date : 2019-05-01 DOI: 10.4193/RHINOL/18.086

L. Akmenkalne, M. Prill, K. Vogt

{"title":"Nasal valve elastography: quantitative determination of the mobility of the nasal valve","authors":"L. Akmenkalne, M. Prill, K. Vogt","doi":"10.4193/RHINOL/18.086","DOIUrl":"https://doi.org/10.4193/RHINOL/18.086","url":null,"abstract":"Background: The nasal valve area is the narrowest region of the entire upper airway. Numerous procedures and spreader devices are published to widen the nasal valve or to stabilize it, but the indications are based only on the surgeon’s experience. Methods: In 30 healthy volunteers the deflection of elastic steel elements touching the lower nasal side at its deepest point was precisely measured by means of strain gauges. The deflection was calibrated by standard calibration devices. A special 4-phaserhinomanometer (4RHINO/ Rhinolab/Germany) with a protective face mask allowed simultaneous measurements of the airflow and differential pressure. All signals were recorded simultaneously on both sides. The measurements have been carried out as unilateral measurements according to anterior rhinomanometry. Results: Surprisingly the lateral nasal wall is already moving during quiet breathing. The airflow and its acceleration as well as the pressure difference generating a complete closure of the nose can be determined and has expectedly a high variance between individuals. Conclusions: The elastography confirms the loops in 4-phase-rhinomanometry as symptomatic for the nasal valve elongation and will after developing as medical product allow the systematic quantitative measurement of the influence of the nasal valve on the nasal air stream.","PeriodicalId":74737,"journal":{"name":"Rhinology online","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41379092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Anti-Staphylococcal humoral immune response in patients with chronic rhinosinusitis 慢性鼻窦炎患者的抗葡萄球菌体液免疫反应

Rhinology online Pub Date : 2019-03-01 DOI: 10.4193/rhinol/19.002

U. Thunberg, S. Hugosson, H. Fredlund, Y. Cao, R. Ehricht, S. Monecke, E. Müller, S. Engelmann, B. Söderquist

引用次数: 1

Nasal and salivary pepsin as a biomarker for gastroesophageal reflux in chronic rhinosinusitis 鼻和唾液胃蛋白酶作为慢性鼻窦炎胃食管反流的生物标志物

Rhinology online Pub Date : 2019-03-01 DOI: 10.4193/RHINOL/19.003

E. Katle, J. Hatlebakk, R. Omdal, J. Kvaløy, S. Steinsvåg

引用次数: 3

Advanced CT imaging demonstrating the bulla lamella and the basal lamella of the middle turbinate as endoscopic landmarks for the anterior ethmoid artery 高级CT成像显示中鼻甲大板和基底板是前筛动脉的内窥镜标志

Rhinology online Pub Date : 2019-03-01 DOI: 10.4193/RHINOL/18.082

S. Zinreich, H. Stammberger, W. Bolger, M. Solaiyappan, M. Ishii

{"title":"Advanced CT imaging demonstrating the bulla lamella and the basal lamella of the middle turbinate as endoscopic landmarks for the anterior ethmoid artery","authors":"S. Zinreich, H. Stammberger, W. Bolger, M. Solaiyappan, M. Ishii","doi":"10.4193/RHINOL/18.082","DOIUrl":"https://doi.org/10.4193/RHINOL/18.082","url":null,"abstract":"Objective: Our objective is to show how the use of Computer Tomography (CT) multiplanar displays (MPR) and 3D Stereoscopic Imaging (3DSI), can provide precise anatomical landmarks to identify the location of the Anterior Ethmoid Artery (AEA) during endoscopic sinus surgery (FESS). Materials and Methods: The study comprised 48 patients, representing 96 nasal cavity/sinus sides. The anterior ethmoid foramen was the landmark that defined the entry of the AEA into the ethmoid on CT MPR and 3DSI, and anatomic relationships closely related to to the AEA were recorded. Results: The anterior ethmoidal foramen (AEF) was associated with the bulla lamella (BL) in 46.9% of cases, and the basal lamella of the middle turbinate (BLMT) in 31.6%. In 7.1% of cases, the AEF was associated with both lamellae. Similarly, at the AES, the AEF was associated with the BL and BLMT in 72.5% and 46.9% of cases, respectively. In 29.6%, the AEA was associated with both lamellae. In 48%, the AEF and AES were at or in the bone of the ethmoidal roof/ skull base. In 48%, the AEA, the AEF, and the AES were in the same coronal plane, indicating a straight horizontal course across the ethmoid. In the remaining samples, the AES was anterior to the AEF, indicating an oblique course of the AEA. Conclusion: This study demonstrates that 3DSI imaging provides improved localization of the AEA, and establishes recognizable anatomic landmarks for endoscopically guided surgery, thus, preventing inadvertent complications.","PeriodicalId":74737,"journal":{"name":"Rhinology online","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46697032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Modeling Microdebrider-Mediated Ophthalmic Damage: A Word of Caution in Endoscopic Sinus Surgery. 模拟微除颤器介导的眼部损伤:内窥镜鼻窦手术的一个警告。

Rhinology online Pub Date : 2019-03-01 DOI: 10.4193/RHINOL/19.004

Cameron P Worden, Carly A. Clark, A. Senior, R. Schlosser, A. Kimple, B. Senior

{"title":"Modeling Microdebrider-Mediated Ophthalmic Damage: A Word of Caution in Endoscopic Sinus Surgery.","authors":"Cameron P Worden, Carly A. Clark, A. Senior, R. Schlosser, A. Kimple, B. Senior","doi":"10.4193/RHINOL/19.004","DOIUrl":"https://doi.org/10.4193/RHINOL/19.004","url":null,"abstract":"Background\u0000The microdebrider has become nearly universal in the treatment of sinonasal pathology; however, recent case reports have demonstrated the potential for major ophthalmic complications. The goal of this study was twofold: 1) determine the anatomical proximity of ophthalmic structures to the paranasal sinuses, and 2) assess the timeframe at which ophthalmic injury may occur with the use of a microdebrider during FESS utilizing a cadaveric model.\u0000\u0000\u0000Methodology/Principal\u0000Computed tomography scans from 50 patients were accessed retrospectively. The distances between the lamina papyracea (LP) and orbital structures were determined at varying depths. Seven cadavers (14 sides) were studied using three microdebrider systems operated by otolaryngology residents. Following removal of a window of LP, the time from activation of the microdebrider on the periorbita until transection of the medial rectus (MR), optic nerve (ON), and to aspiration of the globe were measured.\u0000\u0000\u0000Results\u0000The mean distance between the LP and MR at the level of the anterior aspect of the anterior ethmoid and basal lamella were 3.59 ±1.2mm and 1.5 ±0.8mm, respectively. The mean distance between the LP and ON at the level of the basal lamella was 8.1 ±2.1mm. Mean transection times for the MR and ON were 13.4 ± 7.3 seconds and 37.3 ± 9.2 seconds, respectively, with minimum times of 4 seconds and 26 seconds.\u0000\u0000\u0000Conclusions\u0000The proximity of orbital structures to the paranasal sinuses and the rapidity of ophthalmic damage following violation of the periorbita reaffirms the need for cautious use of the microdebrider during FESS.","PeriodicalId":74737,"journal":{"name":"Rhinology online","volume":"2 1","pages":"44-49"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41646427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Resection of intracranial nasal dermoid sinus cyst by endoscopic-assisted open rhinoplasty approach 内镜辅助开鼻成形术切除颅内鼻皮样窦囊肿

Rhinology online Pub Date : 2019-03-01 DOI: 10.4193/RHINOL/19.005

A. Santamaría-Gadea, G. Santos, I. Cobeta, S. Dominguez-Carames, F. Mariño‐Sánchez

引用次数: 0

Cocaine contaminant Levamisole-induced polyangiitis and necrosis of the nasal cavity – a Scottish case series 可卡因污染物左旋咪唑引起的鼻腔多血管炎和坏死——苏格兰病例系列

Rhinology online Pub Date : 2019-02-01 DOI: 10.4193/rhinol/18.069

D. Andrew, R. Scott, A. Kochman, N. Balaji

引用次数: 0