Receptors & clinical investigation最新文献_第3页

Regulation of ryanodine receptor-mediated calcium signaling by presenilins. 早老素对ryanodine受体介导的钙信号传导的调节。

Receptors & clinical investigation Pub Date : 2015-01-01 DOI: 10.14800/rci.449

Andrew J Payne, Simon Kaja, Peter Koulen

引用次数: 8

Uncovering unique roles of LPA receptors in the tumor microenvironment. 揭示LPA受体在肿瘤微环境中的独特作用。

Receptors & clinical investigation Pub Date : 2015-01-01 DOI: 10.14800/rci.440

Sue-Chin Lee, Yuko Fujiwara, Gabor J Tigyi

{"title":"Uncovering unique roles of LPA receptors in the tumor microenvironment.","authors":"Sue-Chin Lee, Yuko Fujiwara, Gabor J Tigyi","doi":"10.14800/rci.440","DOIUrl":"https://doi.org/10.14800/rci.440","url":null,"abstract":"The role of the lysophospholipase D autotaxin (ATX) and lysophosphatidic acid (LPA) in cancer is emerging and represents two key players in regulating cancer progression. In this brief review, we will discuss some of our recent findings, which highlight a central role that LPA and its receptor plays in orchestrating melanoma-stroma interactions in the establishment of lung metastases. In particular, we evaluated not only the function of LPA receptors on tumor cells but also their role on host tissues and how they can influence melanoma growth and metastasis. Using the syngeneic B16F10 murine melanoma model, we made three key observations. First, our in vitro findings demonstrate that LPA receptors, specifically LPA2 and LPA5 expressed in B16F10 cells appear to have opposing roles in cell invasion; the former seems to be responsible for the high basal invasion rate of B16F10 cells while the latter is anti-invasive upon exogenous LPA stimulation. Second, we observed a profound reduction in the incidence of pulmonary melanoma metastasis in LPA1- and LPA5-knockout (KO) mice, respectively, when compared to wild-type (WT) mice. Third, no differences in terms of subcutaneous tumor growth between LPA1KO, LPA5KO and WT mice were observed. These findings suggest that LPA receptors exert different functions in melanoma cells versus host tissues in terms of invasion and metastasis.","PeriodicalId":74650,"journal":{"name":"Receptors & clinical investigation","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438998/pdf/nihms689338.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33331090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Implications of scavenger receptors in the safe development of nanotherapeutics. 清道夫受体在纳米治疗药物安全开发中的意义。

Receptors & clinical investigation Pub Date : 2015-01-01 DOI: 10.14800/rci.811

Jonathan H Shannahan, Wei Bai, Jared M Brown

{"title":"Implications of scavenger receptors in the safe development of nanotherapeutics.","authors":"Jonathan H Shannahan, Wei Bai, Jared M Brown","doi":"10.14800/rci.811","DOIUrl":"https://doi.org/10.14800/rci.811","url":null,"abstract":"Nanomaterials (NMs) are being utilized in a variety of biomedical applications including drug delivery, diagnostics, and therapeutic targeting. These applications are made possible due to the unique physicochemical properties that are exhibited at the nanoscale. To ensure safe development of NMs for clinical use, it is necessary to understand their interactions with cells and specifically cell surface receptors, which will facilitate either their toxicity and/or clinical function. Recently our research and others have investigated the role of scavenger receptors in mediating NM-cell interactions and responses. Scavenger receptors are expressed by a variety of cell types that are first to encounter NMs during clinical use such as macrophages and endothelial cells. Scavenger receptors are recognized to facilitate uptake of a wide variety of ligands ranging from foreign substances to endogenous lipids/proteins. While interaction of NMs with scavenger receptors may allow therapeutic targeting in some instances, it also presents a challenge for the stealth delivery of NMs and avoidance of the scavenging capability of this class of receptors. Due to their role in facilitating immune responses, scavenger receptor-mediated inflammation is also of concern following NM delivery. The research highlighted in this brief review intends to summarize our current understanding regarding the consequences of NM-scavenger receptor interactions.","PeriodicalId":74650,"journal":{"name":"Receptors & clinical investigation","volume":"2 3","pages":"e811"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437212/pdf/nihms689347.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33331092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Biomimetic Scaffolds for Osteogenesis. 骨生成的仿生支架。

Receptors & clinical investigation Pub Date : 2015-01-01 Epub Date: 2015-07-28

Nance Yuan, Kameron S Rezzadeh, Justine C Lee

引用次数: 0

Vascular protective effects of Angiotensin Receptor Blockers: Beyond Blood pressure. 血管紧张素受体阻滞剂的血管保护作用:超越血压。

Receptors & clinical investigation Pub Date : 2015-01-01 DOI: 10.14800/rci.774

Sandeep Artham, Abdelrahman Y Fouda, Azza B El-Remessy, Susan C Fagan

引用次数: 9

Enhancement of osteoblastogenesis and suppression of osteoclastogenesis by inhibition of de-phosphorylation of eukaryotic translation initiation factor 2 alpha. 通过抑制真核细胞翻译起始因子2 α的去磷酸化促进成骨细胞的形成和抑制破骨细胞的形成。

Receptors & clinical investigation Pub Date : 2015-01-01 DOI: 10.14800/rci.493

Kazunori Hamamura, Andy Chen, Hiroki Yokota

引用次数: 6

Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors. 阻断脊髓运动啡肽A对缓激肽受体的非阿片兴奋作用。

Receptors & clinical investigation Pub Date : 2015-01-01 DOI: 10.14800/rci.517

Yeon Sun Lee, Sara M Hall, Cyf Ramos-Colon, Michael Remesic, David Rankin, Todd W Vanderah, Frank Porreca, Josephine Lai, Victor J Hruby

{"title":"Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors.","authors":"Yeon Sun Lee, Sara M Hall, Cyf Ramos-Colon, Michael Remesic, David Rankin, Todd W Vanderah, Frank Porreca, Josephine Lai, Victor J Hruby","doi":"10.14800/rci.517","DOIUrl":"https://doi.org/10.14800/rci.517","url":null,"abstract":"Dynorphin A (Dyn A) is an endogenous opioid ligand that possesses neuroinhibitory (antinociceptive) effects via μ, δ, and κ opioid receptors. However, under chronic pain conditions, up-regulated spinal Dyn A can also interact with bradykinin receptors (BRs) to promote hyperalgesia through a neuroexcitatory(pronociceptive) effect. These excitatory effects cannot be blocked by an opioid antagonist, and thus are non-opioid in nature. On the basis of the structural dissimilarity between Dyn A and endogenous BR ligands, bradykinin(BK) and kallidin (KD), Dyn A's interaction with BRs could not be predicted, and provided an opportunity to identify a novel potential neuroexcitatory target. Systematic structure-activity relationship (SAR) studies discovered a minimum pharmacophore of Dyn A, [des-Arg7]-Dyn A-(4-11) LYS1044 for antagonist activity at the BRs, along with insights into the key structural features for BRs recognition, i.e., amphipathicity. The des-Tyr fragment of dynorphin does not bind to opioid receptors. Intrathecal administration of des-Tyr dynorphin produces hyperalgesia reminiscent of behaviors seen in peripheral n europathic pain models and at higher doses, neurotoxicity. Our lead ligand LYS1044 negatively modulated Dyn A-(2-13)-induced neuroexcitatory effects in naïve animals and blocked mechanical hypersensitivity and thermal hyperalgesia in a dose-dependent manner in animals with experimental neuropathic pain. Based on these results, ligand LYS1044 might prevent abnormal pain states by blocking the neuroexcitatory effects of increased levels of Dyn A that are seen in experimental models of neuropathic pain and that likely promote excitation mediated by BRs in the spinal cord.","PeriodicalId":74650,"journal":{"name":"Receptors & clinical investigation","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515361/pdf/nihms-669984.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33876746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Fibronectin signaling via toll-like receptprs: a novel paradigm for persistent fibrosis in scleroderma. 通过toll样受体的纤维连接蛋白信号传导:硬皮病持续纤维化的新范例。

Receptors & clinical investigation Pub Date : 2014-09-05 DOI: 10.14800/RCI.235

S. Bhattacharyya, J. Varga

引用次数: 0

In vivo neuronal co-expression of mu and delta opioid receptors uncovers new therapeutic perspectives. 阿片受体和阿片受体在体内的神经元共表达揭示了新的治疗前景。

Receptors & clinical investigation Pub Date : 2014-09-01 DOI: 10.14800/rci.210

Eric Erbs, Lauren Faget, Pierre Veinante, Brigitte L Kieffer, Dominique Massotte

{"title":"In vivo neuronal co-expression of mu and delta opioid receptors uncovers new therapeutic perspectives.","authors":"Eric Erbs, Lauren Faget, Pierre Veinante, Brigitte L Kieffer, Dominique Massotte","doi":"10.14800/rci.210","DOIUrl":"https://doi.org/10.14800/rci.210","url":null,"abstract":"Opioid receptors belong to the G protein coupled receptor family. They modulate brain function at all levels of neural integration and therefore impact on autonomous, sensory, emotional and cognitive processing. In vivo functional interaction between mu and delta opioid receptors are known to take place though it is still debated whether interactions occur at circuitry, cellular or molecular level. Also, the notion of receptor crosstalk via mu-delta heteromers is well documented in vitro but in vivo evidence remains scarce. To identify neurons in which receptor interactions could take place, we designed a unique double mutant knock-in mouse line that expresses functional red-fluorescent mu receptors and green-fluorescent delta receptors. We mapped mu and delta receptor distribution and co-localization throughout the nervous system and created the first interactive brain atlas with concomitant mu-delta visualization at subcellular resolution (http://mordor.ics-mci.fr/). Mu and delta receptors co-localize in neurons from subcortical networks but are mainly detected in separate neurons in the forebrain. Also, co-immunoprecipitation experiments indicated physical proximity in the hippocampus, a prerequisite to mu-delta heteromerization. Altogether, data suggest that mu-delta functional interactions take place at systems level for high-order emotional and cognitive processing whereas mu-delta may interact at cellular level in brain networks essential for survival, which has potential implications for innovative drug design in pain control, drug addiction and eating disorders.","PeriodicalId":74650,"journal":{"name":"Receptors & clinical investigation","volume":"1 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415729/pdf/nihms672723.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33152403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

The pERK of being a target: Kinase regulation of the orphan nuclear receptor ERRγ. 作为靶标的好处:孤儿核受体ERRγ的激酶调控。

Receptors & clinical investigation Pub Date : 2014-08-13 DOI: 10.14800/RCI.207

R. Riggins

引用次数: 3