Dimosthenis Lygouras, Avgoustos Tsinakos, Konstantinos Vadikolias, Ioannis Seimenis
{"title":"Exploring Usability and User Engagement in Fully Immersive Virtual Reality Systems for Upper Limb Stroke Rehabilitation: A Scoping Review.","authors":"Dimosthenis Lygouras, Avgoustos Tsinakos, Konstantinos Vadikolias, Ioannis Seimenis","doi":"10.2490/prm.20260020","DOIUrl":"https://doi.org/10.2490/prm.20260020","url":null,"abstract":"<p><strong>Objectives: </strong>Fully immersive virtual reality (FIVR) systems are emerging as innovative tools for upper limb stroke rehabilitation. These systems provide immersive, interactive environments that foster motivation, engagement, and functional recovery. This scoping review examines the usability of FIVR systems for upper limb rehabilitation among stroke survivors, focusing on evaluation methods, patient and therapist experiences, and barriers to adoption.</p><p><strong>Methods: </strong>The review followed PRISMA-ScR guidelines. A systematic search of PubMed, IEEE Xplore, and Scopus identified 20 eligible studies. Data were extracted on study design, participant demographics, VR system characteristics, software, task type, game/task elements, usability evaluation methods, and key findings.</p><p><strong>Results: </strong>The findings demonstrate generally positive benefits in terms of usability and engagement, with participants indicating both motivation and enjoyment during FIVR interventions. However, there was considerable variability in assessment methods, including both quantitative and qualitative approaches, as well as in hardware, software, interaction methods and no standardized framework. Common challenges included mild side effects (e.g., dizziness), technical complexity, and the need to adapt to patients' varying abilities. Such limitations highlight gaps in the standardization and replicability of usability assessment across studies.</p><p><strong>Conclusions: </strong>FIVR systems offer potential as supplements to conventional therapy, providing engaging and personalized rehabilitation experiences. Improving usability assessment through standardized frameworks, addressing technical and accessibility barriers, and ensuring the adaptability of interventions to individual patient needs are critical to optimizing effectiveness and supporting broader clinical adoption.</p>","PeriodicalId":74584,"journal":{"name":"Progress in rehabilitation medicine","volume":"11 ","pages":"20260020"},"PeriodicalIF":1.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of Bone Mineral Density and Body Composition in Lower and Upper Limbs of Spina Bifida Patients Using DXA Scans.","authors":"Hiroki Fujita, Misa Kaga, Kazuhisa Yoshifuji, Atsushi Teramoto","doi":"10.2490/prm.20260019","DOIUrl":"https://doi.org/10.2490/prm.20260019","url":null,"abstract":"<p><strong>Objectives: </strong>Several tools are available for the assessment and classification of lesion level in spina bifida (SB) patients. This study aimed to quantitatively investigate potential relationships that lesion level and mobility style may have with bone mineral density (BMD) and body composition in both lower and upper limbs using dual-energy X-ray absorptiometry (DXA) scans in patients with SB.</p><p><strong>Methods: </strong>We investigated 74 patients (34 boys, 40 girls) with SB (mean age 12.8 years, range 10-18 years) using DXA scans to analyze BMD and body composition. Participants were classified by lesion level (upper lumbar or above, mid lumbar, lower lumbar, and sacral) for analysis of lower and upper limbs. Patients were reclassified by functional mobility scale (FMS) 50-m rating (wheelchair users, assisted ambulators, and independent ambulators) for further analysis of upper limbs.</p><p><strong>Results: </strong>The abovementioned lesion level groups contained 18, 17, 20, and 19 patients, respectively. A one-way analysis of variance (ANOVA) of lower limb outcomes showed significant intragroup homogeneity for BMD and body composition and also revealed a stepwise pattern that was consistent across multiple analyses. The FMS-based upper limb groups contained 19, 15, and 40 patients, respectively. Our analysis of BMD and percent bone mineral content did not reveal statistically significant trends in the upper limbs.</p><p><strong>Conclusions: </strong>Lower limb body composition among children with SB was significantly classified by lesion level using ANOVA. In the upper limbs, our results showed no significant correlation between lesion level and BMD or body composition.</p>","PeriodicalId":74584,"journal":{"name":"Progress in rehabilitation medicine","volume":"11 ","pages":"20260019"},"PeriodicalIF":1.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preoperative Functional Mobility as a Predictor of Exceeding the Planned Length of Hospital Stay after Lumbar Fusion Surgery for Spinal Stenosis.","authors":"Kaisei Kiriyama, Atsushi Endo, Yoshito Kurashima, Yoshinori Hiyama","doi":"10.2490/prm.20260016","DOIUrl":"https://doi.org/10.2490/prm.20260016","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to determine the association between preoperative functional mobility and exceeding the planned length of hospital stay (LOS) after lumbar fusion surgery for lumbar spinal stenosis (LSS) and to identify factors associated with preoperative functional mobility.</p><p><strong>Methods: </strong>A total of 122 patients who underwent lumbar fusion for LSS were included. Preoperative functional mobility was assessed using the Timed Up-and-Go (TUG) test. LOS was categorized as standard (≤14 days) or exceeded (>14 days). Risk ratios (RRs) with 95% confidence intervals (CIs) were estimated using modified Poisson regression to analyze the association between preoperative TUG performance and LOS. Additionally, linear regression was used to identify factors associated with preoperative TUG performance.</p><p><strong>Results: </strong>In the univariate modified Poisson regression model, exceeding the planned LOS was associated with preoperative TUG performance (RR, 1.10; 95% CI, 1.06 to 1.14; P <0.001). In the adjusted model, this association remained significant (RR, 1.10; 95% CI, 1.06 to 1.14; P <0.001). Poorer preoperative TUG performance was also associated with female sex (mean difference, -2.02 s; 95% CI, -3.60 to -0.43; P = 0.014) and psychiatric comorbidities (mean difference, 7.91 s; 95% CI, 1.95 to 13.87; P = 0.010).</p><p><strong>Conclusions: </strong>Poorer preoperative functional mobility is an independent predictor of exceeding the planned LOS after lumbar fusion surgery for LSS. Routine preoperative assessment with the TUG test may help identify high-risk patients, and targeted strategies such as enhanced preoperative and postoperative rehabilitation could reduce the likelihood of prolonged hospitalization.</p>","PeriodicalId":74584,"journal":{"name":"Progress in rehabilitation medicine","volume":"11 ","pages":"20260016"},"PeriodicalIF":1.5,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Toe Grip Strength Shows Stronger Associations with Falls than Knee Extension or Hand Grip in Older Adults: A 1-year Prospective Cohort Study.","authors":"Sayo Miura, Nobuaki Himuro, Masayuki Koyama, Toshiaki Seko, Hirofumi Ohnishi","doi":"10.2490/prm.20260015","DOIUrl":"https://doi.org/10.2490/prm.20260015","url":null,"abstract":"<p><strong>Objectives: </strong>This study examined associations of toe grip strength (TGS) with fall occurrence and the number of falls in community-dwelling older adults and evaluated knee extension strength (KES) and hand grip strength (HGS) as established indicators.</p><p><strong>Methods: </strong>Adults aged 65-94 years (n=208) at 2018 municipal health checkups were enrolled. TGS, KES, and HGS were measured with quantitative devices and normalized to body weight (%BW). Prior-year falls were recorded at baseline, and fall occurrence and the number of falls over the subsequent year were collected at the next annual checkup. Associations were estimated with multivariable logistic regression for fall occurrence and negative binomial regression for the number of falls, adjusted for age, sex, prior-year fall history, cardiovascular disease or stroke, physical activity, and serum albumin. Nonlinearity was assessed with restricted cubic splines.</p><p><strong>Results: </strong>Higher TGS was associated with lower odds of fall occurrence [odds ratio (OR) 0.94, 95% confidence interval (CI) 0.89-0.99, P = 0.015] and fewer falls [risk ratio (RR) 0.95, 95% CI 0.91-0.99, P = 0.015]. KES was weakly associated with falls (OR 0.99, 95% CI 0.98-1.00, P = 0.041; RR 0.99, 95% CI 0.98-1.00, P = 0.042), whereas HGS showed no association. Splines indicated nonlinearity: TGS odds were flat around 17-27 %BW and rose below ~17 %BW; KES odds increased below ~75 %BW; HGS was flat around 45-55 %BW.</p><p><strong>Conclusions: </strong>TGS was associated with fall occurrence and the number of falls, whereas KES showed weak associations and HGS showed no association, indicating that the TGS measurement may be useful for risk assessment.</p>","PeriodicalId":74584,"journal":{"name":"Progress in rehabilitation medicine","volume":"11 ","pages":"20260015"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prognostic Value of the Kihon Checklist in Older Cardiovascular Disease Patients.","authors":"Kakeru Hashimoto, Akihiro Hirashiki, Koki Kawamura, Ikue Ueda, Tatsuya Yoshida, Takahiro Kamihara, Manabu Kokubo, Atsuya Shimizu, Hitoshi Kagaya","doi":"10.2490/prm.20260014","DOIUrl":"10.2490/prm.20260014","url":null,"abstract":"<p><strong>Objectives: </strong>Of various frailty indicators, none are suitable for cardiovascular disease (CVD). We aimed to verify the association between the Kihon checklist (KCL) score and prognosis of older adults with CVD.</p><p><strong>Methods: </strong>Participants (n = 336) were adults with CVD (aged ≥ 65 years, mean age 81 years) who required hospitalization. They were assessed with the KCL, and data were obtained for left ventricular ejection fraction (LVEF) and brain natriuretic peptide (BNP) at discharge, and the occurrence of all-cause death, CVD composite endpoint, CVD death, and CVD hospitalization after discharge. The cutoff value of the KCL score for all-cause death was calculated using receiver operating characteristic analysis, and participants were divided into two groups. The relationship between KCL score and prognosis was examined using survival time (Kaplan-Meier method) and Cox proportional hazards analyses.</p><p><strong>Results: </strong>The KCL cutoff value was 8 (KCL < 8, n=155). Survival time analysis showed significant differences in all-cause death, CVD composite endpoint, and CVD death (log-rank test: P < 0.001, each). Cox proportional hazards analysis showed that KCL score of 8 or higher was significantly associated with all-cause death [hazard ratio (HR), 2.731; 95% confidence interval (CI), 1.202-6.205] and CVD death (HR, 2.875; 95% CI, 1.124-7.353). In the HF only group, KCL score of 8 or higher was not significantly associated with all-cause death, CVD death, or CVD composite endpoint.</p><p><strong>Conclusions: </strong>Total KCL score was associated with mortality in the overall cohort of older adults with CVD, although the association in the HF subgroup alone showed a borderline trend.</p>","PeriodicalId":74584,"journal":{"name":"Progress in rehabilitation medicine","volume":"11 ","pages":"20260014"},"PeriodicalIF":1.5,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13034008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ankle Dorsiflexor Strength on the Affected Side in Acute Stroke Patients is Related to the Use of Orthoses at Discharge: A Retrospective Cohort Study.","authors":"Yuji Okada, Katsushi Kuniyasu, Yosuke Yoshimura, Takashi Hiraoka, Kozo Hanayama","doi":"10.2490/prm.20260013","DOIUrl":"10.2490/prm.20260013","url":null,"abstract":"<p><strong>Objectives: </strong>Approximately 40% of stroke patients discharged from rehabilitation hospitals achieve restored gait using an ankle-foot orthosis. However, whether the use of lower-limb orthoses (LLO) at discharge is required is unknown in the acute phase. Therefore, it is difficult to explain the use of LLO to patients and their families. The aim of this study was to investigate the factors associated with the use of LLO at discharge based on acute functional impairment.</p><p><strong>Methods: </strong>This study retrospectively investigated 152 patients who were transferred to a convalescent rehabilitation ward (CRW) after undergoing acute rehabilitation between 1 May 2009 and 31 March 2018 and regained gait ability. The user (U) group included patients who used LLO. Multivariate analysis was performed for factors related to acute functional impairment 1 week after starting physical therapy and the use of LLO at discharge from the CRW. The predictive performance of each factor was analyzed. Acute functional impairment was measured in terms of paralyzed lower-limb motor function, trunk function, non-paralyzed side function, and higher brain function.</p><p><strong>Results: </strong>Seventy-four patients (49%) were in the U group, and acute functional impairment was more severe than that in the non-user group, except for the non-paralyzed side function. Multivariate analysis showed that a paralyzed ankle dorsiflexor muscle, as assessed by the foot pat test, was associated with LLO use at discharge (P=0.003).</p><p><strong>Conclusions: </strong>A paralyzed dorsiflexor muscle during the acute phase is a factor that helps determine whether to use LLO at discharge from the CRW.</p>","PeriodicalId":74584,"journal":{"name":"Progress in rehabilitation medicine","volume":"11 ","pages":"20260013"},"PeriodicalIF":1.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13016960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Masatsugu Okamura, Kengo Shirado, Nobuyuki Shirai, Takuma Yagi, Tatsuro Inoue, Masato Ogawa, Erin Stella Sullivan, Stephan Von Haehling, Jochen Springer, Stefan D Anker, Ryo Momosaki
{"title":"Combined Nutritional and Exercise Interventions for Cachexia in Chronic Diseases: A Systematic Review and Meta-analysis Limited to Cancer Cachexia.","authors":"Masatsugu Okamura, Kengo Shirado, Nobuyuki Shirai, Takuma Yagi, Tatsuro Inoue, Masato Ogawa, Erin Stella Sullivan, Stephan Von Haehling, Jochen Springer, Stefan D Anker, Ryo Momosaki","doi":"10.2490/prm.20260012","DOIUrl":"10.2490/prm.20260012","url":null,"abstract":"<p><strong>Objectives: </strong>Cachexia is a condition marked by weight loss and reduced skeletal muscle mass, with or without the loss of fat mass, commonly occurring in patients with chronic diseases such as cancer and heart failure, on a background of inflammation. Interventions that combine nutrition and exercise may offer greater benefits than either approach alone in mitigating cachexia-related impairments. Nevertheless, their overall impact remains unclear. The aim of this review was to evaluate the effectiveness of combined nutritional and exercise interventions for cachexia in patients with chronic diseases.</p><p><strong>Methods: </strong>We conducted searches via PubMed, the Cochrane Library, Embase, CINAHL, PEDro, ICTRP, and ClinicalTrials.gov through to 3 December 2024. Eligible studies were intervention studies or observational studies comparing combined nutritional and exercise interventions with control conditions, which included usual care or unimodal interventions (nutrition or exercise alone), in patients diagnosed with cachexia according to the Evans or Fearon criteria. The assessed outcomes included body weight, body composition, mortality, activities of daily living, physical function, exercise tolerance, and quality of life.</p><p><strong>Results: </strong>Of 1926 identified records, five studies involving only patients with cancer met the inclusion criteria. There is significant uncertainty regarding how combined interventions impact mortality rates compared to control groups (two studies, 66 participants: odds ratio 1.15, 95% confidence interval 0.13-9.97; I<sup>2</sup> = 0%; evidence of very low certainty). Meta-analyses for other outcomes could not be performed because of sparse and heterogeneous data. We also identified 22 ongoing trials involving patients with cancer, chronic kidney disease, and AIDS, with results pending.</p><p><strong>Conclusions: </strong>Current evidence regarding combined nutritional and exercise interventions for cachexia is of very low certainty, and no high-quality evidence currently exists to support their effectiveness. Findings across studies are inconsistent, and further rigorous, well-designed trials are urgently needed. The development and adoption of core outcome sets will be essential to enable future meta-analyses. Results from ongoing trials are awaited.</p>","PeriodicalId":74584,"journal":{"name":"Progress in rehabilitation medicine","volume":"11 ","pages":"20260012"},"PeriodicalIF":1.5,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factors Associated with Inconveniences in Daily At-home Living among Adults with Achondroplasia.","authors":"Akiko Ajimi, Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Kenta Sawamura, Shiro Imagama","doi":"10.2490/prm.20260011","DOIUrl":"https://doi.org/10.2490/prm.20260011","url":null,"abstract":"","PeriodicalId":74584,"journal":{"name":"Progress in rehabilitation medicine","volume":"11 ","pages":"20260011"},"PeriodicalIF":1.5,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}