Phenomics (Cham, Switzerland)最新文献

{"title":"Progress in Intestinal Homeostasis and Mechanisms of Pancreatic Cancer.","authors":"Zhonghua Qi, Peng Qi, Xiansen Jiang, Ping Qi","doi":"10.1007/s43657-024-00189-3","DOIUrl":"10.1007/s43657-024-00189-3","url":null,"abstract":"<p><p>Pancreatic cancer is a highly invasive and heterogeneous malignancy, with its incidence witnessed a global escalation in recent years. This tumor type is typically asymptomatic in its early stages, and the anatomical location of the pancreas renders it obscured, frequently leading to late detection. Its highly invasive growth pattern can readily invade surrounding tissues and organs, and pancreatic cancer exhibits poor sensitivity to radiotherapy and chemotherapy. Surgical resection remains the primary treatment modality, but due to delayed diagnosis, most patients lose the opportunity for curative resection. Pancreatic cancer is one of the most challenging malignancies, with a grave prognosis, and its incidence and mortality rates continue to rise annually. In recent years, the interplay between intestinal homeostasis and pancreatic cancer development has emerged as a burgeoning area of research. Intestinal homeostasis is a dynamic equilibrium state formed by the intricate interplay between the intestinal barrier and the intestinal environment (including intestinal microbiota). Further elucidating intestinal homeostasis and its association with pancreatic cancer pathogenesis will aid in exploring novel therapeutic strategies to combat this devastating disease.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"5 4","pages":"446-456"},"PeriodicalIF":6.2,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topology of gut Microbiota Network and Guild-Based Analysis in Chinese Adults.","authors":"Jiongxing Fu, Danxia Yu, Wei Zheng, Yu Jiang, Lei Wang, Hui Cai, Qinghua Xia, Xiao-Ou Shu, Wanghong Xu","doi":"10.1007/s43657-024-00211-8","DOIUrl":"10.1007/s43657-024-00211-8","url":null,"abstract":"<p><p>Gut microbiota with co-abundant behaviors is considered belonging to the same guild in micro-ecosystem. In this study, we established co-abundance networks of operational taxonomic units (OTUs) among 2944 Chinese adults from the Shanghai Men's and Women's Health Studies and observed a positive connection-dominated scale-free network using Sparse Correlations for Compositional data (SparCC). The closeness centrality was negatively correlated with other degree-based topological metrics in the network, indicating the isolated modularization of the bacteria. A total of 130 guilds were constructed, with a high modularity of 0.68, and retaining more diversity of OTUs than genus classification. The scores of guild structure similarity for comparisons between all, the healthy and the unhealthy subjects were higher than those derived from randomized permutations, suggesting a robust guild structure. We further used the constructed 130 guilds as the aggregation units to identify gut microbiota that may be associated with type 2 diabetes, and found that the OTUs in 21 significant guilds relevant to diabetes belonged to 19 of 41 (46.3%) previously reported genera (derived from Disbiome database), while only 10 (24.4%) showed different abundances between diabetes patients and healthy subjects in genus-based analysis. Our study reveals modularization of gut microbiota as guilds in Chinese populations, and demonstrates advantages of guild-based analysis in identifying diabetes-related gut bacteria. The analytical method based on microbial networks should be widely used to deepen our understanding of the role of gut microbiota in human health.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43657-024-00211-8.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"5 1","pages":"91-108"},"PeriodicalIF":6.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for Retinal Imaging and Extraction of Imaging-Derived Phenotypes from the Chinese Human Phenome Project.","authors":"Lizhen Lan, Binxin Xu, Zhiqiang Yan, Yating Tang, Shengli Shen, Xuan Lan, Yidan Gao, Jianhua Jin, Yan Zheng, Chengyan Wang, Jingchun Luo, Mei Tian","doi":"10.1007/s43657-023-00155-5","DOIUrl":"10.1007/s43657-023-00155-5","url":null,"abstract":"<p><p>Retinal imaging is pivotal in the evaluation of ocular and systemic health, presenting significant promise for extensive population studies. However, the lack of standardized and automated techniques for extracting Imaging-Derived Phenotypes (IDPs) from retinal images is a major impediment. To counteract this challenge, the Chinese Human Phenome Project (CHPP) has developed a comprehensive protocol that includes Quality Control (QC), preprocessing, and automated or semi-automated extraction of IDPs from fundus photography and Optical Coherence Tomography (OCT) images. This protocol incorporates Artificial Intelligence (AI)-based methods to achieve accurate and efficient IDP extraction, facilitating standardized analysis of large-scale populations. We hope that this Standard Operating Procedure (SOP) guideline will impart valuable insights for ophthalmology-related disciplines and provides support for future research endeavors utilizing retinal imaging data.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43657-023-00155-5.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"5 5","pages":"607-622"},"PeriodicalIF":6.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12881225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of DNA Extraction Methods on Gut Microbiome Profiles: A Comparative Metagenomic Study.","authors":"Yanni Pu, Xiaofeng Zhou, Hao Cai, Tao Lou, Chenglin Liu, Mengmeng Kong, Zhonghan Sun, Yanren Wang, Ruyi Zhang, Yuxuan Zhu, Lin Ye, Yuanting Zheng, Baoli Zhu, Zhexue Quan, Guoping Zhao, Yan Zheng","doi":"10.1007/s43657-025-00232-x","DOIUrl":"10.1007/s43657-025-00232-x","url":null,"abstract":"<p><p>In gut microbial research, DNA extraction remarkably influences study outcomes and biological interpretations. Rapid advancements in the research scale and technological upgrades necessitate evaluating new methods to ensure reliability and precision in microbial community profiling. We systematically evaluated the performance of eight recent and commonly used extraction methods using a microbial mock community (MMC) and fecal samples from two healthy volunteers, incorporating bacterial, archaeal, and fungal constituents. Performance metrics included nucleic acid assessment, microbial profile assessment, and scalability for large-scale studies, leveraging shotgun metagenomics for in-depth analysis. Despite variations in DNA quantity and quality, all methods yielded sufficient DNA for shotgun metagenomic sequencing. In the MMC microbial profile assessment, the QIAamp PowerFecal pro Kit (PF) and DNeasy PowerSoil HTP kit (PS) methods exhibited higher similarity with the theoretical composition and lower variability across technical replicates compared to other methods. For fecal samples, the extraction method accounted for 21.4% of the overall microbiome variation and significantly affected the abundances of 32% of detected microbial species. Methods using mechanical lysis with small beads, such as PF and PS, demonstrated better efficiency, indicated by increased microbial diversity in extracting DNA from Gram-positive bacteria. Furthermore, the PF and PS methods are notably simple to execute and automation-friendly, though relatively costly. Our study underscores the importance of maintaining consistency in DNA extraction methods for reliable comparative metagenomic analyses. We recommend PF and PS methods as optimal for expansive gut metagenomic research, emphasizing the critical role of mechanical lysis in DNA extraction.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43657-025-00232-x.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"5 1","pages":"76-90"},"PeriodicalIF":6.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein Subfractions Predict All-cause and Cardiovascular Mortality in CKD Patients Undergoing Hemodialysis: A Prospective Cohort Study Based on NMR Metabolomics.","authors":"Qingxia Huang, Han Zhang, Ziyan Shen, Jing Chen, Xuesen Cao, Linghan Xu, Cheng Zhu, Shiqi Lv, Xixi Yu, Xiaoqiang Ding, Huiru Tang, Xiaoyan Zhang","doi":"10.1007/s43657-024-00179-5","DOIUrl":"10.1007/s43657-024-00179-5","url":null,"abstract":"<p><p>Lipoprotein metabolism is markedly altered in chronic kidney disease (CKD). Studies on the association between nuclear magnetic resonance (NMR) derived lipoprotein subfraction signature and mortality in CKD patients undergoing hemodialysis are limited. NMR based metabolomics was performed on the baseline plasma samples from 368 maintenance hemodialysis patients. Survival analyses were used to investigate the effect of lipoproteins on all-cause mortality and cardiovascular disease (CVD) mortality. Prediction models were further developed using stepwise regression combined cox proportional-hazards model. During the average follow-up of 45.1 months, we observed 144 all-cause deaths and 67 CVD deaths. After adjustment for 14 important covariates, we identified 18 and 35 lipoprotein parameters associated with all-cause mortality and CVD mortality, separately. Cholesterol in total low-density lipoprotein (LDL-C) and total high-density lipoprotein (HDL-C) were correlated with neither all-cause death nor CVD death. For lipoprotein subfractions, triglyceride levels in large very-low density lipoprotein (VLDL) were positively correlated only with all-cause mortality. Lipids (triglyceride, cholesterol and phospholipid) in medium VLDL, cholesterol/total lipids in intermediate-density lipoprotein (IDL) and free cholesterol/total lipids in small high-density lipoprotein (HDL) were positively associated with both all-cause and CVD mortality. The addition of lipoprotein parameters to traditional risk factors significantly improved the mortality risk prediction: the area under the receiver operating characteristic curve (AUC) was improved from 0.811 to 0.842 (<i>p</i>-value = 0.020) for all-cause mortality and 0.806 to 0.854 (<i>p</i>-value = 0.005) for CVD mortality. Our results highlight the lipoprotein subfractions related to all-cause and CVD mortality of maintenance hemodialysis patients, and the lipoproteins-driven prediction models significantly outperform traditional risk factors.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43657-024-00179-5.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"5 4","pages":"361-373"},"PeriodicalIF":6.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embracing Interpersonal Variability of Microbiome in Precision Medicine.","authors":"Xin Zhou, Xin Chen, Mark M Davis, Michael P Snyder","doi":"10.1007/s43657-024-00201-w","DOIUrl":"10.1007/s43657-024-00201-w","url":null,"abstract":"","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"5 1","pages":"8-13"},"PeriodicalIF":6.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Pathogenetic Mechanism Between Tibetan and Han High-Altitude Polycythemia Based on a Whole Genome-Wide Association Study.","authors":"Zhuoma Basang, Shixuan Zhang, Xianwei Ke, Zhuoma Duoji, La Yang, Danzeng Qiangba, Yang De, Deji Gesang, Zixin Hu, Yanyun Ma, Meng Hao, Ruidong Fan, Li Han, Zeshan Lin, Yi Li, Jiucun Wang, Juan Wu","doi":"10.1007/s43657-024-00180-y","DOIUrl":"10.1007/s43657-024-00180-y","url":null,"abstract":"<p><p>High-altitude polycythemia (HAPC) is a prevalent chronic condition affecting individuals at high altitudes, including both highland and plains populations. This study, involving 2248 participants, explored genetic susceptibility to HAPC among ethnic groups, with 898 HAPC patients (450 Han, 448 Tibetan). The Genome-wide Association Study, encompassing 198 cases (100 Han, 98 Tibetan), identified eight Tibetan HAPC-susceptibility single-nucleotide polymorphisms and four in Han individuals. The common polymorphism locus rs7618658 (<i>SNX4</i>, <i>p</i> _combine < 5 × 10^-8) was validated in both populations. The investigation of Tibetan <i>EPAS1</i> revealed the rs1374749 locus, along with linked loci, as a potential prevalence factor for HAPC. The GGTAC haplotype containing this locus emerged as a Protect haplotype for HAPC (<i>p</i> = 2.461 × 10^-12, OR = 0.344). Enrichment analysis revealed that Tibetans exhibited susceptibility in oxygen-sensing pathways, such as EPAS1, associated with phenotypes like hemoglobin and platelets. In contrast, Han Chinese showed significant sensitivity in cell differentiation and angiogenesis, closely linked to hemoglobin, hematocrit, and platelets.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43657-024-00180-y.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"5 2","pages":"169-182"},"PeriodicalIF":6.2,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Dietary Intervention: Gut Microbiome and Meta-metabolome as Functional Readouts.","authors":"Jing Luo, Yulan Wang","doi":"10.1007/s43657-024-00193-7","DOIUrl":"10.1007/s43657-024-00193-7","url":null,"abstract":"<p><p>Gut microbiome, the group of commensals residing within the intestinal tract, is closely associated with dietary patterns by interacting with food components. The gut microbiome is modifiable by the diet, and in turn, it utilizes the undigested food components as substrates and generates a group of small molecule-metabolites that addressed as \"meta-metabolome\" in this review. Profiling and mapping of meta-metabolome could yield insightful information at higher resolution and serve as functional readouts for precision nutrition and formation of personalized dietary strategies. For assessing the meta-metabolome, sample preparation is important, and it should aim for retrieval of gut microbial metabolites as intact as possible. The meta-metabolome can be investigated via untargeted and targeted meta-metabolomics with analytical platforms such as nuclear magnetic resonance spectroscopy and mass spectrometry. Employing flux analysis with meta-metabolomics using available database could further elucidate metabolic pathways that lead to biomarker discovery. In conclusion, integration of gut microbiome and meta-metabolomics is a promising supplementary approach to tailor precision dietary intervention. In this review, relationships among diet, gut microbiome, and meta-metabolome are elucidated, with an emphasis on recent advances in alternative analysis techniques proposed for nutritional research. We hope that this review will provide information for establishing pipelines complementary to traditional approaches for achieving precision dietary intervention.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"5 1","pages":"23-50"},"PeriodicalIF":6.2,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a Novel Pyroptosis-Related lncRNAs Prognosis Model and Subtypes in Ovarian Cancer.","authors":"Xiao-Feng Xie, Xiao-Qian Hu, Deng-Xiang Liu, Wei Wang, Tian Hua","doi":"10.1007/s43657-024-00173-x","DOIUrl":"10.1007/s43657-024-00173-x","url":null,"abstract":"<p><p>Ovarian cancer (OC), a predominant gynecological malignancy, has consistently showcased grim prognostic outcomes. This investigation delves into the emerging field of pyroptosis and the intricacies of long non-coding RNAs (lncRNAs), specifically the lesser-studied pyroptosis-related lncRNAs (PRlncRNAs), and their roles in OC prognosis. By harnessing transcriptome, and clinic data from the genotype-tissue expression (GTEx) and the cancer genome Atlas (TCGA), we formulated a unique PRlncRNAs risk model consisting of five prognostic lncRNAs by Cox regression and least absolute shrinkage and selection operator (LASSO) regression. Next, the Kaplan-Meier analysis, receiver operating characteristic (ROC) curve, nomogram, and calibration were implemented to verify and evaluate the model. The model also showed general applicability in pan-cancer analysis. Remarkably, our model, upon rigorous validation, outperformed 16 pre-existing counterparts, offering a promising avenue for prognosis prediction. The risk score was used to classify patients into high and low-risk subgroups. The low-risk group showed improved overall survival (OS) and progression-free survival (PFS). The risk score was proved to be an independent prognosis factor. The low-risk group patients also exhibited a higher immune infiltration score and homologous recombination deficiency (HRD) score. Moreover, consensus clustering analysis was utilized to categorize OC patients into three distinct groups, predicated on the expression of the five prognostic lncRNAs. Patients within the third cluster exhibited noteworthy traits, encompassing elevated survival, heightened immune checkpoint expression, and the HRD score. Finally, the expressions of five PRlncRNAs were validated by quantitative real-time PCR (qRT-PCR) in OC cell lines and tissues. In conclusion, the risk model based on the five PRlncRNAs might function as prognostic biomarkers to predict the immune and target drug treatment in OC.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43657-024-00173-x.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"5 3","pages":"284-300"},"PeriodicalIF":6.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12390916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to Aldehydes, Heterocyclic Aromatic Amines and Terpenes With Sex Hormones in U.S. Children and Adolescents: Sex-, Age-Dependent Patterns and Vitamin D Effect Modification.","authors":"Yayuan Mei, Ang Li, Xinyu Wang, Hui Xu, Guoshuang Feng","doi":"10.1007/s43657-024-00190-w","DOIUrl":"https://doi.org/10.1007/s43657-024-00190-w","url":null,"abstract":"<p><p>Aldehydes, heterocyclic aromatic amines (HAAs) and terpenes were sparsely studied for their sex-hormone disrupting effect in children and adolescents, although people are widely exposed. This study aimed to investigate the individual and mixture effect of aldehydes, HAAs and terpenes on sex hormones among children and adolescents and explore the effect modification of Vitamin D (VD). Six aldehydes, three HAAs and three terpenes were collected from the National Health and Nutrition Examination Survey 2013-2014, which sampled representative U.S. population. Five sex hormone indicators [testosterone (TT), estradiol (E₂), sex hormone binding globulin (SHBG), free androgen index (FAI) and ratio of TT to E₂ (TT/E₂)] were measured. Multiple linear regression and Bayesian kernel machine regression were used to explore the individual- and joint- exposure to these chemicals with each sex hormone, respectively. We primarily found some chemicals were positively associated with SHBG and negatively associated with TT, E₂, and FAI among male adolescents. In addition, when stratified by pubertal status, we mainly found certain chemicals were negatively associated with TT, E₂, FAI and TT/E₂ in pubertal male and prepubertal female. Joint exposure to HAAs were associated with significant decrease in TT and FAI in male adolescent. These associations present age-, sex- and development-dependent patterns. VD modified these associations with significant results more pronounced in VD ≥ 75 nmol/L group. Our study provided novel findings for the hormonal effect of aldehydes, HAAs and terpenes in children and adolescents, and is also significant for potential avenues for public health action and intervention.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43657-024-00190-w.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"5 6","pages":"664-680"},"PeriodicalIF":6.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12886689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}