American journal of cancer research最新文献

{"title":"Erratum: MiR-1205 functions as a tumor suppressor by disconnecting the synergy between KRAS and MDM4/E2F1 in non-small cell lung cancer.","authors":"Hong Yan, Xiaoying Chen, Yu Li, Lei Fan, Yusi Tai, Yang Zhou, Yuxiang Chen, Xinming Qi, Ruimin Huang, Jin Ren","doi":"10.62347/XVNE7528","DOIUrl":"https://doi.org/10.62347/XVNE7528","url":null,"abstract":"<p><p>[This corrects the article on p. 312 in vol. 9, PMID: 30906631.].</p>","PeriodicalId":7437,"journal":{"name":"American journal of cancer research","volume":"15 6","pages":"2908-2910"},"PeriodicalIF":3.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of clinicopathological features of meibomian gland adenocarcinoma on the outcomes of surgical resection combined with eyelid reconstruction.","authors":"Huiqin Zhan, Hanyan Mao, De Wu, Jilin Zhou","doi":"10.62347/QRFV7325","DOIUrl":"10.62347/QRFV7325","url":null,"abstract":"<p><p>This study aims to investigate the clinical and pathological characteristics of meibomian gland carcinoma (MGC) and their impact on the outcomes of surgical resection combined with eyelid defect reconstruction. A retrospective study was conducted on 128 patients diagnosed with MGC between December 2020 and January 2022. Demographic, clinical, pathological, surgical, and postoperative follow-up data were collected from the medical records. Patients were divided into two groups based on their total aesthetic outcome score: the satisfied group (score ≥27, n=87) and the dissatisfied group (score <27, n=41). Additionally, patients were categorized into recurrence (n=29) and non-recurrence groups (n=99) based on postoperative recurrence status. Results showed that age (OR=1.080, 95% CI: 1.015~1.149, P=0.015), tumor size (OR=1.625, 95% CI: 0.681~0.887, P<0.001), and tumor stage (OR1=0.007, 95% CI: 0.001~0.070; OR2=0.019, 95% CI: 0.003~0.145, P<0.001) significantly influenced aesthetic outcomes following surgical resection combined with eyelid defect reconstruction. Recurrence analysis indicated that tumor size (HR=1.224, 95% CI: 1.091~1.374, P<0.001) and stage (HR1=0.008, 95% CI: 0.001~0.084; HR2=0.051, 95% CI: 0.011~0.242, P<0.001) were significant factors affecting the recurrence. Receiver operating characteristic (ROC) curve analysis demonstrated that the combined prediction of clinical and pathological features had the highest efficacy in predicting aesthetic outcomes and tumor recurrence following surgical resection and reconstruction (aesthetic outcome: Z=5.544, 3.110, 4.527; recurrence: Z=3.319, 2.986; all P<0.05). The Kaplan-Meier survival curve revealed significant differences in disease-free survival rates across different stages of tumors (χ²=29.275, P=0.005). In conclusion, the surgical treatment of MGC should consider clinical and pathological characteristics such as patient age, tumor size and stage, and individualized surgical and reconstruction plans should be developed accordingly. The combined prediction of aesthetic outcomes and recurrence risk can enhance surgical efifcacy and improve patient prognosis.</p>","PeriodicalId":7437,"journal":{"name":"American journal of cancer research","volume":"15 6","pages":"2765-2778"},"PeriodicalIF":3.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GDF15 promotes gallbladder cancer progression by activating the NF-κB mediated Vascular Endothelial Growth Factor A (VEGFA) expression.","authors":"Mina Joo, Hyo Jin Lee, Jin-Man Kim","doi":"10.62347/NAZM2261","DOIUrl":"10.62347/NAZM2261","url":null,"abstract":"<p><p>Growth differentiation factor 15 (GDF15) has been found to be elevated in several different types of cancer, thus demonstrating its potential for use as a biomarker. Although its physiological and pathophysiological roles in cancer are increasingly understood, the specific functions and molecular mechanisms of GDF15 in gallbladder cancer remain unclear and require further investigation. Immunohistochemical staining was performed to evaluate the expression of GDF15 in tissue samples from 57 patients with gallbladder cancer. The biological function of GDF15 and the molecular mechanism underlying this were further elucidated through knockdown experiments in NOZ and OCUG-1 gallbladder cancer cell lines. Our results demonstrate that there was a significant correlation be-tween high GDF15 expression and poor survival indicating a poor prognosis in individuals with gallbladder cancer. NanoString analysis results showed that VEGFA, a key angiogenic factor, was significantly upregulated in the GDF15 high-expression group. Moreover, GDF15 knockdown significantly reduced cell motility, as well as migration and invasion. Additionally, GDF15 knockdown in gallbladder cancer cells decreased VEGFA expression via the AKT/NF-κB pathway. Taken together, these results suggest that GDF15 contributes to the aggressive behavior of gallbladder cancer by promoting activation of the AKT/NF-κB pathway. These findings suggest that the GDF15 signaling pathway may represent a promising therapeutic target for gallbladder cancer treatment.</p>","PeriodicalId":7437,"journal":{"name":"American journal of cancer research","volume":"15 6","pages":"2779-2793"},"PeriodicalIF":3.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Baicalein suppress EMT of breast cancer by mediating tumor-associated macrophages polarization.","authors":"Xixi Zhao, Jingkun Qu, Xu Liu, Jizhao Wang, Xingcong Ma, Xiaoyao Zhao, Qian Yang, Wanjun Yan, Zitong Zhao, Yuxin Hui, Haocheng Bai, Shuqun Zhang","doi":"10.62347/RFQT4858","DOIUrl":"https://doi.org/10.62347/RFQT4858","url":null,"abstract":"<p><p>[This corrects the article on p. 1528 in vol. 8, PMID: 30210921.].</p>","PeriodicalId":7437,"journal":{"name":"American journal of cancer research","volume":"15 6","pages":"2905-2907"},"PeriodicalIF":3.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for postoperative vascular crisis in squamous cell carcinoma reconstruction using supraclavicular artery flaps.","authors":"Peipei Sun, Mingzhe Zhao, Hanying Tang","doi":"10.62347/ZHMS1734","DOIUrl":"10.62347/ZHMS1734","url":null,"abstract":"<p><strong>Objectives: </strong>To identify risk factors associated with vascular crisis in patients undergoing reconstruction with supraclavicular artery flaps for squamous cell carcinoma (SCC) of the tongue and buccal mucosa.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 777 patients with tongue or buccal SCC who underwent supraclavicular artery flap reconstruction between January 2019 and December 2023. Patients were divided into two groups based on the occurrence of postoperative vascular crisis: Occurred Group (n = 101) and No Occurred Group (n = 676). Demographic data, clinical history, hematologic and biochemical parameters were collected. Pearson and Spearman correlation analyses, univariate analysis, and multivariate logistic regression were performed to identify independent risk factors. An external validation cohort was used to verify the findings, and a predictive model was developed using ROC curve and nomogram analysis.</p><p><strong>Results: </strong>Independent risk factors for vascular crisis included higher BMI, long-term smoking, long-term alcohol consumption, elevated fasting blood glucose, increased C-reactive protein, higher white blood cell count, and elevated SCC antigen (all P < 0.05). Platelet count was inversely associated with risk. Flap survival rate was significantly lower in the vascular crisis group. The predictive model demonstrated strong discriminatory power (AUC = 0.975).</p><p><strong>Conclusions: </strong>Several modifiable clinical and biochemical factors are significantly associated with postoperative vascular crisis. Preoperative optimization of these variables may improve flap survival and surgical outcomes.</p>","PeriodicalId":7437,"journal":{"name":"American journal of cancer research","volume":"15 6","pages":"2855-2871"},"PeriodicalIF":3.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and prognostic value of coagulation markers and platelet-derived growth factor-BB in evaluating intensity-modulated radiotherapy efficacy in nasopharyngeal carcinoma.","authors":"Haizhong Zhang, Deli Ye","doi":"10.62347/MQBC5709","DOIUrl":"10.62347/MQBC5709","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the diagnostic and prognostic value of coagulation markers - including activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (FIB), platelet count (PLT), and D-dimer (DD) - and platelet-derived growth factor-BB (PDGF-BB) in patients with nasopharyngeal carcinoma (NPC) undergoing intensity-modulated radiotherapy (IMRT).</p><p><strong>Methods: </strong>A total of 210 NPC patients receiving IMRT and 160 healthy controls were enrolled. Baseline levels of PDGF-BB and coagulation markers were compared between groups. The association of PDGF-BB with clinical staging was analyzed, and receiver operating characteristic (ROC) curve analysis was used to assess its diagnostic performance. Cox regression analyses were performed to identify independent predictors of five-year survival. A dynamic nomogram was developed to provide individualized survival predictions.</p><p><strong>Results: </strong>NPC patients exhibited significantly higher levels of PDGF-BB, APTT, PT, FIB, PLT, and DD compared to healthy controls (all P < 0.001). PDGF-BB was positively correlated with TNM stage (stage III/IV vs. I/II, P < 0.001), T stage (P = 0.005), and N stage (P = 0.020). Multivariate Cox regression identified low PDGF-BB (< 628.18) (HR = 0.492, P = 0.009), low DD (< 746.1) (HR = 0.456, P = 0.002), age 51-64 years (HR = 2.057, P = 0.032) and ≥ 65 years (HR = 4.138, P < 0.001), EBV DNA negativity (HR = 0.273, P = 0.012), and TNM stage III/IV (HR = 3.042, P = 0.023) as independent prognostic factors.</p><p><strong>Conclusions: </strong>PDGF-BB and DD, alongside age, EBV DNA status, and TNM stage, are promising biomarkers for NPC prognosis. A dynamic nomogram integrating these factors offers accurate survival prediction and supports personalized treatment strategies in NPC management.</p>","PeriodicalId":7437,"journal":{"name":"American journal of cancer research","volume":"15 6","pages":"2451-2468"},"PeriodicalIF":3.6,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early detection of biliary adenocarcinoma using probe-based confocal laser endomicroscopy: a case report.","authors":"Jiangshan Wu, Jingnan Lin, Chenglong Fan, Chengli Liu","doi":"10.62347/LEUO1423","DOIUrl":"10.62347/LEUO1423","url":null,"abstract":"<p><strong>Background: </strong>Adenocarcinoma is the most common malignant tumor of the bile duct, originating from the mucosal epithelium. Surgical resection is typically recommended for biliary adenocarcinoma to achieve the best therapeutic outcome and prognosis. However, early detection and diagnosis remain significant global challenges.</p><p><strong>Case presentation: </strong>This paper presents a case of a 55-year-old female patient who was admitted to the Second People's Hospital of Nanning with complaints of dull pain in the right upper abdomen for 4 months and yellowing of the skin and sclera for the past half month. The patient was diagnosed as early well-differentiated biliary adenocarcinoma by probe-based confocal laser endomicroscopy (pCLE), biliary ultrasonography, choledochoscopy and biopsy. After pancreaticoduodenectomy, exploratory laparotomy, partial bowel resection, afferent loop and efferent loop anastomosis, the patient underwent surgery successfully. After 1 year of surgical treatment, no significant postoperative complications were found in the follow-up. There was no recurrence after operation and the patient made a full recovery.</p><p><strong>Conclusion: </strong>Bile duct adenocarcinoma is a malignant tumor, and early screening, diagnosis and treatment are crucial for improving patient prognosis. In this case, early cholangiocarcinoma was detected by a combination of choledochoscopy, biliary ultrasound, and biliary confocal endoscopy. The tumor and surrounding tissues were completely removed through pancreaticoduodenectomy. The operation was successful and the patient recovered well. Confocal microendoscopy shows great promise in the early diagnosis of digestive tract diseases, owing to its high-resolution imaging capabilities and potential to detect early lesions.</p>","PeriodicalId":7437,"journal":{"name":"American journal of cancer research","volume":"15 6","pages":"2642-2649"},"PeriodicalIF":3.6,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid hormone suppresses cell growth by regulating CDK2 and cyclin E1 expression via Hepsin.","authors":"Yang-Hsiang Lin, Meng-Han Wu, Chia-Jung Liao, Yu-Tung Lin, Chau-Ting Yeh, Kwang-Huei Lin","doi":"10.62347/AKVV2832","DOIUrl":"10.62347/AKVV2832","url":null,"abstract":"<p><p>Thyroid hormone (T3) and its receptor (TR) play crucial roles in regulating cell proliferation and cancer progression, including hepatocellular carcinoma (HCC). However, the specific mechanisms underlying HCC development mediated by T3/TR remain unclear. This study aimed to identify differentially expressed target genes influenced by T3/TR in HCC progression. Microarray profiling analysis revealed hepsin (HPN) as a potential target gene regulated by T3/TR. Quantitative reverse transcription-PCR (qRT-PCR) confirmed that T3/TR upregulates HPN expression. Promoter assays and chromatin immunoprecipitation (ChIP) analysis further demonstrated that TR directly binds to the HPN promoter region (+506/+523), activating its transcription. Functional studies showed that ectopic expression of HPN significantly inhibited cell proliferation. Furthermore, HPN was found to be involved in T3/TR-mediated suppression of cell growth by modulating the expression of CDK2 and cyclin E1. Clinically, HPN expression levels were inversely correlated with CDK2 and cyclin E1 in HCC tissues. These findings establish a novel regulatory relationship among T3/TR, HPN, CDK2, and cyclin E1, highlighting their potential role in controlling liver cancer cell proliferation.</p>","PeriodicalId":7437,"journal":{"name":"American journal of cancer research","volume":"15 6","pages":"2595-2603"},"PeriodicalIF":3.6,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic profiling of PBMCs from mammary tumor dogs reveals two distinct immune states.","authors":"Kang-Hoon Lee, Dabin Lee, Jeong-Woon Lee, Hyeon-Ji Hwang, Je-Yoel Cho","doi":"10.62347/LOJB9067","DOIUrl":"10.62347/LOJB9067","url":null,"abstract":"<p><p>This study analyzed cancer-specific systemic immune responses in peripheral blood mononuclear cells (PBMCs) from dogs with benign tumors, malignant tumors, and normal conditions. By examining gene expression patterns - particularly immune checkpoint and TNFRSF genes - the study aimed to assess the immune state of cancer PBMCs. Surprisingly, half of the tumor PBMCs exhibited downregulation of both immunosuppressive genes (Pdcd1, Ctla4, Tigit) and immune activation molecules (CD27, CD357), suggesting immune inactivity rather than suppression. Additionally, cytokine expression varied significantly, with upregulation of IL-18 and IL-7, despite their controversial roles in tumor progression. Analysis of T-cell exhaustion markers did not reflect established exhaustion signatures, implying a naive-like immune state. Instead, a distinct immune signature emerged, characterized by the broad downregulation of TNFRSF genes (TNFRSF18, TNFRSF14, TNFRSF6, and CD27). We designated this group as PI (PBMC-impaired). Deconvolution of bulk RNA-seq data further revealed a significant reduction in CD4+ T cells and a lower CD4+/CD8+ ratio in the PI group. Gene Ontology (GO) and pathway analyses linked CD4+ cell differentially expressed genes (DEGs) to regulatory T-cell differentiation, inflammatory responses, and key immune pathways (IL-2/STAT5, NF-kappa B). Notably, CD7, CXCL6, FASN, FLT3LG, LTB, and TNFRSF18 were significantly downregulated, marking a potential transcriptomic signature of systemic immune impairment. These findings suggest that immune dysfunction in the PI group is not solely attributable to conventional immune suppression but rather to a diminished immune activation state driven by reduced TNFRSF gene expression.</p>","PeriodicalId":7437,"journal":{"name":"American journal of cancer research","volume":"15 6","pages":"2564-2578"},"PeriodicalIF":3.6,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The therapeutic potential of repurposed mebendazole, alone and in synergistic combination with ONC201, in the treatment of diffuse midline glioma.","authors":"Serena Gentile, Federica Toma, Donatella Lucchetti, Lucia Lisi, Pierluigi Navarra, Alessandro Sgambato, Tiziana Servidei, Antonio Ruggiero","doi":"10.62347/MXZH5646","DOIUrl":"10.62347/MXZH5646","url":null,"abstract":"<p><p>H3K27-altered diffuse midline glioma (DMG) is a universally fatal disease with no available therapeutic strategies apart from palliative radiotherapy. Repurposing marketed non-cancer drugs in oncology is emerging as a fast-tracking approach to speed up the development of new treatment options, urgently needed for DMG. Repurposed anthelmintic mebendazole (MBZ) is in the spotlight against brain tumors, because it joins promising anticancer properties with high neuropenetrance, favorable pharmacokinetic and safety profile. Although MBZ is undergoing Phase I/II trials against brain tumors, including DMG, MBZ anticancer properties and the underlying mechanisms of actions have poorly been characterized in DMG preclinical models. We found that MBZ robustly reduced cell viability in six out of seven DMG cell lines with either K27M-mutated or wild-type H3. All IC₅₀ values (range 102 to 958 nM) fell in a clinically attainable range. The antiproliferative MBZ properties were mediated by an arrest of DMG cells in the G₂/M phase with a concomitant upregulation of the key cell cycle regulators p21 and p27, whereas p53 upregulation and activation were cell context-dependent. At the same growth-inhibitory concentrations, MBZ triggered apoptotic cell death, as evidenced by higher levels of the apoptotic markers caspase-3 and PARP cleavage. Consistently, Annexin V-Propidium iodide (PI) double staining showed MBZ dose-dependent increase in both stages of apoptosis. Of interest, the combination of MBZ with the first-in-class imipridone ONC201 sinergistically increased the antiproliferative effects in two DMG cell lines as assessed by combination scores with different algorithms, showing additive effects in two others cell lines. Mechanistically, the combination potentiated the proapoptotic activity of either MBZ or ONC201, while not changing the cytokinetic perturbations induced by the single drugs. Finally, one pair of ONC201-sensitive and ONC201-resistant DMG cell lines with acquired resistance showed same responsiveness to MBZ with similar values of IC₅₀ and E_max. In conclusion, MBZ demonstrates high growth-inhibitory/proapoptotic activity, chemosensitization property to ONC201 and the ability to overcome ONC201 resistance in DMG cell cultures, proposing as a new low-toxicity therapeutic for DMG, with a potential to be used in second-line treatment and/or in combination protocols.</p>","PeriodicalId":7437,"journal":{"name":"American journal of cancer research","volume":"15 6","pages":"2701-2718"},"PeriodicalIF":3.6,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}