{"title":"Thrombophilia, hypofibrinolysis and osteonecrosis.","authors":"Charles J Glueck","doi":"10.1007/s00132-024-04606-3","DOIUrl":"10.1007/s00132-024-04606-3","url":null,"abstract":"<p><p>Anticoagulation in most patients with familial thrombophilia-hypofibrinolysis and primary osteonecrosis (ON) before hip or knee collapse relieves pain, prevents joint collapse and usually averts the need for joint replacement but is not successful in secondary ON or if started after joint collapse. Anticoagulation in Perthes disease and in ON acutely appearing in post-COVID patients, particularly when factor V Leiden is present, may be valuable as an approach to prevent the otherwise high likelihood of subsequent joint failure. Anticoagulation in primary ON with concurrent thrombophilia-hypofibrinolysis should be considered within the treatment spectrum of ON.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":"376-385"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna-Lena Hauser, Alexander Von Glinski, Javier Fernando Noriega Urena, Tobias Lange, Samira Murad, Guido Lewik, Tobias Schulte
{"title":"[Bertolotti syndrome: an often overlooked cause of specific back pain].","authors":"Anna-Lena Hauser, Alexander Von Glinski, Javier Fernando Noriega Urena, Tobias Lange, Samira Murad, Guido Lewik, Tobias Schulte","doi":"10.1007/s00132-025-04656-1","DOIUrl":"https://doi.org/10.1007/s00132-025-04656-1","url":null,"abstract":"<p><strong>Background: </strong>Lumbosacral transitional vertebrae (LSTV) are common, with a prevalence of 15-35%, and can be a cause of specific low back pain. The insufficient awareness of this anomaly often leads to delayed diagnosis and treatment.</p><p><strong>Objective: </strong>This study explains the anatomical and biomechanical basis of Bertolotti syndrome and discusses diagnostic and therapeutic options.</p><p><strong>Materials and methods: </strong>This systematic review was conducted in accordance with the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). The SCOPE criteria (Structuring Comparative Outcome Reporting in Epidemiology) were considered to ensure comprehensive and transparent reporting. A systematic search was performed in PubMed using the search terms 'Bertolotti', 'Bertolotti syndrome', and 'Lumbosacral transitional vertebrae' by a single investigator, resulting in the inclusion of 112 studies. Articles that were not available in English or German were excluded.</p><p><strong>Results: </strong>Patients with symptomatic Bertolotti syndrome often suffer from chronic low back pain and radiculopathies. Imaging techniques, particularly X‑rays and MRI, play a key role in diagnosis. Conservative treatments show limited success. Surgical resection of the transverse process (processectomy), especially after positive test infiltrations, leads to significant pain relief, particularly in younger patients without degenerative changes.</p><p><strong>Discussion: </strong>Treatment choice depends on individual anatomy and the presence of degenerative changes. While conservative measures are initially recommended, processectomy shows promising results in carefully selected patients. Fusion surgeries should only be considered in cases of instability. Further studies are needed to confirm the effectiveness of invasive procedures.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexander Schuh, Maria Dietrich, Liudmilla Bragina, Philipp Koehl
{"title":"[Influence of macromastia on cervical spine and thoracic spine].","authors":"Alexander Schuh, Maria Dietrich, Liudmilla Bragina, Philipp Koehl","doi":"10.1007/s00132-025-04646-3","DOIUrl":"https://doi.org/10.1007/s00132-025-04646-3","url":null,"abstract":"<p><p>Macromastia refers to an excessively large breast volume, which can occur on one or both sides and is disproportionate to the patient's body proportions. Patients with macromastia often suffer from chronic pain of the breasts, shoulders, back and neck, degenerative changes of the spine, increased kyphosis of the thoracic spine, increased lordosis of the cervical and lumbar spine, headache, neurological problems such as dysesthesia of the ulnar nerve and carpal tunnel syndrome. Reduction mammoplasty is the gold standard in the treatment of symptomatic macromastia. A resection weight of more than 500 g per side is considered a medically indicated breast reduction by most health insurance companies if weight loss and comprehensive conservative treatment have not led to the desired success. Reduction mammoplasty results in a significant reduction of pain, improved posture and gait with a low complication rate.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Literature review on kyphoplasty as a treatment for osteoporotic fractures of the spine].","authors":"Celine Zöllinger, Franz Landauer, Klemens Trieb","doi":"10.1007/s00132-025-04648-1","DOIUrl":"https://doi.org/10.1007/s00132-025-04648-1","url":null,"abstract":"<p><strong>Background: </strong>Osteoeporotic vertebral fractures are one of the most common injuries in the elderly, with a prevalence of 10 to 15% in the population over 50 years of age. This type of fracture can be treated with minimally invasive surgery using kyphoplasty. The aim of this analysis is to show the advantages and disadvantages of treatment with kyphoplasty and to weigh up the different ways of performing this operation.</p><p><strong>Methods: </strong>The systematic literature search included randomized controlled trials and clinical studies in the period from 01/09/2018-31/08/2024. The updated 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were used for evaluation.</p><p><strong>Results: </strong>A total of 16 studies from 4347 datasets were included. The most relevant outcome indices showed that the sole choice of surgical side (surgery from the symptom-dominant side) positively influences the VAS. In addition, the unilateral approach is recommended, as this is associated with a shorter operation time, as well as reduced cement volume and radiation exposure. Furthermore, bone density, different scores and certain biomarkers, such as NMID, beta-CTX and P1NP, can be positively influenced by the intravenous administration of zoledronic acid. PMMA bone cement loaded with gentamicin should be used as cement. Finally, drug treatment for osteoporosis and physical therapy are essential for postoperative recovery.</p><p><strong>Conclusion: </strong>Surgical treatment of an osteoporotic vertebral fracture by means of kyphoplasty leads to improved results, even with the inclusion of additional therapies.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Diabetes mellitus and obesity: risk optimization before surgical interventions].","authors":"Stephan Martin","doi":"10.1007/s00132-024-04604-5","DOIUrl":"10.1007/s00132-024-04604-5","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of obesity has increased significantly in recent years and is a causal risk factor for the development of type 2 diabetes. Moreover, chronic degenerative joint diseases are also triggered by obesity.</p><p><strong>Weight loss: </strong>Both obesity-related secondary diseases-type 2 diabetes and chronic degenerative joint disease-can be prevented or at least delayed by lifestyle intervention aimed at weight reduction. The progression of these diseases can also be favourably influenced by radical weight loss. Diets with a reduction in carbohydrates-a so-called \"low-carb\" or ketogenic diet-appear to be superior to a low-fat diet.</p><p><strong>Surgical treatment: </strong>If joint replacement surgery is necessary, preoperative and perioperative interdisciplinary care by a team of experienced therapists from the fields of orthopaedics and obesity/type 2 diabetes is required. The Düsseldorf TeDia model in the network of Catholic hospitals in Düsseldorf takes these requirements into account by providing interdisciplinary care for such patients at the orthopaedic centre at St. Vinzenz Hospital Düsseldorf and the West German Diabetes and Health Centre (WDGZ). Patients with pronounced obesity or diabetes mellitus are presented preoperatively at the WDGZ on an outpatient basis, and weight reduction therapy or optimization of the diabetic metabolic situation is initiated. If joint problems persist despite weight reduction or pronounced degenerative changes that require surgery, the WDGZ provides inpatient diabetology care in the orthopaedic clinic with the option of further outpatient follow-up care.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":"271-277"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The weight-loss injection : An orthopaedic overview].","authors":"Saif Al Basri, Wiebke K Fenske","doi":"10.1007/s00132-025-04609-8","DOIUrl":"10.1007/s00132-025-04609-8","url":null,"abstract":"<p><strong>Background: </strong>The increasing prevalence of obesity represents a significant and growing challenge in orthopaedic surgery. This is particularly true for patients with morbid obesity, who have a significantly increased risk of postoperative complications. The newer incretin-based therapies (such as semaglutide and tirzepatide), these so-called \"weight loss injections\", offer promising potential for preoperative weight reduction and minimisation of peri- and postoperative complications.</p><p><strong>Study situation: </strong>However, the evidence regarding their influence on postoperative outcomes is inconsistent. Retrospective studies suggest that rapid weight loss immediately prior to orthopaedic surgery may increase the risk of complications, including septic shock and revision surgery. Meta-analyses, on the other hand, indicate potential protective effects in surgical outcomes with prior long-term weight reduction.</p><p><strong>Conclusion: </strong>There are currently no sufficiently qualitative studies on the safety and efficacy of these new drugs in the orthopaedic surgery sector. An individualised and multidisciplinary approach, therefore, remains relevant in order to achieve an optimal surgical outcome for the individual patient.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":"278-282"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Obesity in Orthopedics].","authors":"Christoph Schnurr, Christian Lüring","doi":"10.1007/s00132-025-04608-9","DOIUrl":"https://doi.org/10.1007/s00132-025-04608-9","url":null,"abstract":"","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":"54 4","pages":"241-243"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Chronic lateral epicondylopathy : What do we know about tennis elbow?]","authors":"Gerhard Opitz","doi":"10.1007/s00132-025-04630-x","DOIUrl":"10.1007/s00132-025-04630-x","url":null,"abstract":"<p><p>Pain associated with lateral epicondylopathy is often attributed to some form of mechanical overstrain. However, the possibility of spontaneous pain without a causal mechanical background is rarely part of our differential diagnostic considerations. The data do not exclusively support mechanical causality in lateral epicondylopathy. Neurovegetative factors play a crucial role in chronic myofascial disorders and segmental dysfunctions. These relationships must be taken into account. A unilateral focus on local findings fails to adequately address the consequences of central sensitization effects. Current therapeutic approaches need to place greater emphasis on addressing dysfunctions in myofascial chains and vertebrogenic blockages to prevent chronic courses of lateral epicondylopathy.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":"302-308"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The connection between back pain and obesity].","authors":"Martin Enge, Clayton N Kraft","doi":"10.1007/s00132-025-04612-z","DOIUrl":"10.1007/s00132-025-04612-z","url":null,"abstract":"<p><strong>Background: </strong>Obesity is increasingly being recognized as a significant risk factor for the development and worsening of back pain. In order to make possible adjustments to therapies and lifestyle, the relationship must first be understood.</p><p><strong>Method: </strong>This article attempts to explain the relationship between obesity and back pain based on the existing literature.</p><p><strong>Results: </strong>The significant underlying factors are biomechanical overload and altered posture due to increased body fat percentages. Systemic reactions to the adipose tissue itself are also under discussion. Nevertheless, the connections between obesity and back pain are likely to be more complex than previously assumed.</p><p><strong>Conclusion: </strong>The relationship between obesity and back pain is multifactorial. Obesity increases the risk of back pain due to biomechanical stress, systemic inflammation, and altered posture. Further research is needed to respond to the anticipated increase in the number of obese patients.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":"267-270"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Surgical treatment for obesity - metabolic surgery].","authors":"Maximilian Schmeding","doi":"10.1007/s00132-024-04607-2","DOIUrl":"10.1007/s00132-024-04607-2","url":null,"abstract":"<p><strong>Background: </strong>Over the past 20 years, surgical treatment of obesity, or metabolic surgery, has established itself as an extremely efficient and sustainable therapy for treating severely overweight patients. Compared to non-surgical weight reduction procedures, surgical techniques have been shown to be superior in all studies, both in terms of short-term and long-term effectiveness. On the other hand, the invasiveness of the procedures is something that many patients view critically.</p><p><strong>Procedures: </strong>Many years of experience with the two most commonly used procedures, laparoscopic sleeve gastrectomy and minimally invasive gastric bypass, show that both procedures are associated with very low morbidity. The comparatively high costs of the surgical procedure are more than offset by the long-term savings in other therapeutic needs (diabetes mellitus, hepatic steatosis, arthritis, osteoarthritis, etc.). The S3 guideline for carrying out metabolic surgical procedures has clear specifications for the criteria to be met. Embedding in a multi-modal concept both pre- and post-operatively is obligatory. The following article provides an overview of the indications, treatment, and aftercare in the field of metabolic surgery.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":"283-286"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}