{"title":"Bone marrow lesions related to bone marrow edema syndromes and osteonecrosis.","authors":"Gad Shabshin, Nogah Shabshin","doi":"10.1007/s00132-025-04640-9","DOIUrl":"https://doi.org/10.1007/s00132-025-04640-9","url":null,"abstract":"<p><p>Bone marrow lesions (BML) are abnormalities in the bone marrow identified on magnetic resonance imaging (MRI) and can generally be classified as traumatic or atraumatic. This review focuses on atraumatic bone marrow edema syndromes (BMES) and their imaging evaluation. The MRI remains the modality of choice for assessing BMES, particularly using fluid-sensitive sequences although other sequences such as Dixon and T1-weighted imaging can be of further assistance. Emerging evidence supports dual-energy CT (DECT) as a reliable alternative, with high sensitivity and specificity for detecting bone marrow edema. The term BMES is a collective term for conditions, such as transient osteoporosis (TO) and regional migratory osteoporosis (RMO), predominantly affect weight-bearing bones in middle-aged individuals and pregnant or postpartum females. Subchondral insufficiency fractures of the knee (SIFK) are a key subset of BMES. These fractures most commonly involve the medial femoral condyle (MFC) and are associated with risk factors, such as meniscal root tears and extrusion of the meniscal body. The MRI findings typically include bone marrow edema-like signals and subchondral fracture lines, with additional features, such as secondary osteonecrosis in advanced cases. Prognostic indicators are crucial for stratifying patients and guiding management. Low-grade or reversible lesions often resolve with conservative treatment, whereas high-grade or irreversible lesions may require surgical intervention.Avascular necrosis, another atraumatic BML entity, differs from BMES by its association with systemic factors, such as steroid use or alcohol abuse. Accurate imaging, particularly in the early stages, is vital to distinguish between reversible and irreversible lesions, facilitating timely and appropriate management.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":"54 5","pages":"324-331"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The value of physical therapy modalities for osteonecrosis and bone marrow edema : Current study situation and practical applicability in everyday clinical practice].","authors":"Lutz Linneweber","doi":"10.1007/s00132-025-04624-9","DOIUrl":"10.1007/s00132-025-04624-9","url":null,"abstract":"<p><p>Physical therapy modalities play an essential role in the treatment of osteonecrosis and bone marrow edema. In addition to an accurate diagnosis, it is essential to understand the pathogenesis of the disease in order to define relevant physiological, cellular and biochemical targets. After careful consideration of efficacy and side effects, these therapies can be used both as adjunctive measures and as stand-alone treatments to prevent disease progression. In particular, shock wave and magnetic field therapies show promising results both clinically and in ongoing trials. In addition, in the acute phase, a targeted unloading phase may be helpful to reduce mechanical pressure on bone tissue. Interdisciplinary treatment planning and patient compliance are of similar importance.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":"361-367"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dietrich Pape, Ben Bertemes, Cristina Dinis, Julien Dessard, Tom Gryson, Yorick Fonteyn, Charlotte Deprouw, Romain Seil, Alexander Hoffmann
{"title":"[Etiology of osteonecrosis and bone marrow edema].","authors":"Dietrich Pape, Ben Bertemes, Cristina Dinis, Julien Dessard, Tom Gryson, Yorick Fonteyn, Charlotte Deprouw, Romain Seil, Alexander Hoffmann","doi":"10.1007/s00132-025-04629-4","DOIUrl":"10.1007/s00132-025-04629-4","url":null,"abstract":"<p><strong>Background: </strong>The frequent use of magnetic resonance imaging (MRI) introduced \"bone marrow edema\" (BME) as a descriptive radiological term for hyperintense signal changes in fluid-sensitive sequences. With the optimization of MRI soft tissue contrast, BME has evolved into a valid prognostic indicator associated with pain genesis, trauma, mechanical overload, and progressive cartilage and joint destruction.</p><p><strong>Diagnostics: </strong>Both osteonecrosis and BME manifest in early MRI as intraosseous fluid accumulation, characterized by hyperintense signals in T2-weighted and STIR sequences. Conventional radiography and computed tomography (CT) are limited in BME detection due to the absence of relevant density alterations or structural osseous lesions early on.</p><p><strong>Classification: </strong>Although BME is not pathognomonic for osteonecrosis, it represents the initial phase of every primary osteonecrosis. BME can be transient (transitory osteoporosis) and regress without residuals or serve as a prodromal stage of manifest osteonecrosis.</p><p><strong>Pathophysiology: </strong>Primarily, it represents a non-specific reaction of bone marrow to various noxious stimuli such as trauma, mechanical overload, inflammatory processes, vascular insufficiency, or metabolic dysregulations. This review explores the pathophysiological mechanisms underlying BME, its clinical significance for osteonecrotic joint diseases, and its role in pain genesis.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":"332-341"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eduardo Sampaio, Jörg Scherer, Jakob Hoffmanns, Jakob Mayr, H-G Palm
{"title":"[Sonography of fractures in childhood-Practice-oriented case examples of frequent entities].","authors":"Eduardo Sampaio, Jörg Scherer, Jakob Hoffmanns, Jakob Mayr, H-G Palm","doi":"10.1007/s00132-025-04642-7","DOIUrl":"10.1007/s00132-025-04642-7","url":null,"abstract":"<p><p>Sonography of fractures is a long-established method in fracture treatment that has not yet achieved widespread acceptance. The Association of the Scientific Medical Societies in Germany (AWMF) guidelines published in 2023 provide healthcare providers with reassurance regarding the ultrasound-guided treatment of frequent fracture entities in childhood. Sonography is recommended as a standard diagnostic procedure for fractures in childhood by the Radiation Protection Commission (SSK). With this work we aim to provide a practice-oriented overview of fracture diagnostics in childhood, considering the advantages and disadvantages. Clinical examples are used to demonstrate the guideline-compliant diagnostics of fractures in childhood.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":"395-409"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Bone marrow edema and osteonecrosis in sport : Relevance, prognosis and therapy].","authors":"Matthias Brockmeyer, Henning Madry, Patrick Orth","doi":"10.1007/s00132-025-04626-7","DOIUrl":"10.1007/s00132-025-04626-7","url":null,"abstract":"<p><strong>Background: </strong>Sports activities lead to loading stress for the osteochondral unit of the joints, especially for the lower extremity. Athletes frequently suffer from articular cartilage defects, meniscus and ligament injuries, which are often associated with subchondral bone marrow edema and osteonecrosis.</p><p><strong>Objectives: </strong>Presentation of relevance, prognosis and therapeutic options for bone marrow edema and osteonecrosis in sport.</p><p><strong>Material and methods: </strong>This review describes the clinical relevance, prognostic aspects and potential treatment options for bone marrow edema and osteonecrosis in athletes.</p><p><strong>Results: </strong>Subchondral bone marrow edema and osteonecrosis frequently occur in athletes. Most commonly, they are caused by mechanical joint overload due to sporting activities, but they are also found posttraumatically and postoperatively. Their clinical relevance to athletes remains unclear. A stepwise treatment concept includes non-surgical as well as surgical treatment options for symptomatic bone marrow edema and osteonecrosis in sport with different clinical prognoses depending on severity and location of the lesion.</p><p><strong>Conclusions: </strong>Bone marrow edema and osteonecrosis may have a relevant impact on the joint function in athletes. They play a decisive role in the rehabilitation following joint injuries and surgeries and are associated with the clinical outcomes following joint injuries and have critical influence on the return to sporting activities.</p><p><strong>Level of evidence: </strong>IV, narrative review.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":"342-348"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thrombophilia, hypofibrinolysis and osteonecrosis.","authors":"Charles J Glueck","doi":"10.1007/s00132-024-04606-3","DOIUrl":"10.1007/s00132-024-04606-3","url":null,"abstract":"<p><p>Anticoagulation in most patients with familial thrombophilia-hypofibrinolysis and primary osteonecrosis (ON) before hip or knee collapse relieves pain, prevents joint collapse and usually averts the need for joint replacement but is not successful in secondary ON or if started after joint collapse. Anticoagulation in Perthes disease and in ON acutely appearing in post-COVID patients, particularly when factor V Leiden is present, may be valuable as an approach to prevent the otherwise high likelihood of subsequent joint failure. Anticoagulation in primary ON with concurrent thrombophilia-hypofibrinolysis should be considered within the treatment spectrum of ON.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":"376-385"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Diabetes mellitus and obesity: risk optimization before surgical interventions].","authors":"Stephan Martin","doi":"10.1007/s00132-024-04604-5","DOIUrl":"10.1007/s00132-024-04604-5","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of obesity has increased significantly in recent years and is a causal risk factor for the development of type 2 diabetes. Moreover, chronic degenerative joint diseases are also triggered by obesity.</p><p><strong>Weight loss: </strong>Both obesity-related secondary diseases-type 2 diabetes and chronic degenerative joint disease-can be prevented or at least delayed by lifestyle intervention aimed at weight reduction. The progression of these diseases can also be favourably influenced by radical weight loss. Diets with a reduction in carbohydrates-a so-called \"low-carb\" or ketogenic diet-appear to be superior to a low-fat diet.</p><p><strong>Surgical treatment: </strong>If joint replacement surgery is necessary, preoperative and perioperative interdisciplinary care by a team of experienced therapists from the fields of orthopaedics and obesity/type 2 diabetes is required. The Düsseldorf TeDia model in the network of Catholic hospitals in Düsseldorf takes these requirements into account by providing interdisciplinary care for such patients at the orthopaedic centre at St. Vinzenz Hospital Düsseldorf and the West German Diabetes and Health Centre (WDGZ). Patients with pronounced obesity or diabetes mellitus are presented preoperatively at the WDGZ on an outpatient basis, and weight reduction therapy or optimization of the diabetic metabolic situation is initiated. If joint problems persist despite weight reduction or pronounced degenerative changes that require surgery, the WDGZ provides inpatient diabetology care in the orthopaedic clinic with the option of further outpatient follow-up care.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":"271-277"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The weight-loss injection : An orthopaedic overview].","authors":"Saif Al Basri, Wiebke K Fenske","doi":"10.1007/s00132-025-04609-8","DOIUrl":"10.1007/s00132-025-04609-8","url":null,"abstract":"<p><strong>Background: </strong>The increasing prevalence of obesity represents a significant and growing challenge in orthopaedic surgery. This is particularly true for patients with morbid obesity, who have a significantly increased risk of postoperative complications. The newer incretin-based therapies (such as semaglutide and tirzepatide), these so-called \"weight loss injections\", offer promising potential for preoperative weight reduction and minimisation of peri- and postoperative complications.</p><p><strong>Study situation: </strong>However, the evidence regarding their influence on postoperative outcomes is inconsistent. Retrospective studies suggest that rapid weight loss immediately prior to orthopaedic surgery may increase the risk of complications, including septic shock and revision surgery. Meta-analyses, on the other hand, indicate potential protective effects in surgical outcomes with prior long-term weight reduction.</p><p><strong>Conclusion: </strong>There are currently no sufficiently qualitative studies on the safety and efficacy of these new drugs in the orthopaedic surgery sector. An individualised and multidisciplinary approach, therefore, remains relevant in order to achieve an optimal surgical outcome for the individual patient.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":"278-282"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Chronic lateral epicondylopathy : What do we know about tennis elbow?]","authors":"Gerhard Opitz","doi":"10.1007/s00132-025-04630-x","DOIUrl":"10.1007/s00132-025-04630-x","url":null,"abstract":"<p><p>Pain associated with lateral epicondylopathy is often attributed to some form of mechanical overstrain. However, the possibility of spontaneous pain without a causal mechanical background is rarely part of our differential diagnostic considerations. The data do not exclusively support mechanical causality in lateral epicondylopathy. Neurovegetative factors play a crucial role in chronic myofascial disorders and segmental dysfunctions. These relationships must be taken into account. A unilateral focus on local findings fails to adequately address the consequences of central sensitization effects. Current therapeutic approaches need to place greater emphasis on addressing dysfunctions in myofascial chains and vertebrogenic blockages to prevent chronic courses of lateral epicondylopathy.</p>","PeriodicalId":74375,"journal":{"name":"Orthopadie (Heidelberg, Germany)","volume":" ","pages":"302-308"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}