African Journal of Urology最新文献

{"title":"Update on prostate cancer epidemiology in Morocco","authors":"Chaimae Samtal, Laila Bouguenouch, Nabil Ismaili, Marwa El Baldi, Badreddine El Makhzen, Karima El Rhazi, Mohammed Mzyiene, Moulay Hassan Farih, Karim Ouldim, Hassan Ghazal, Hicham Bekkari","doi":"10.1186/s12301-024-00419-0","DOIUrl":"https://doi.org/10.1186/s12301-024-00419-0","url":null,"abstract":"Prostate cancer stands as the most frequently diagnosed cancer among men globally, with over 600,000 new cases annually. In-depth epidemiological studies play a pivotal role in delineating the unique characteristics of specific populations. This study endeavors to comprehensively document the histopathological pattern of Moroccan prostate cancer patients while assessing the extent of underdiagnosis risk within the Moroccan population. A retrospective cross-sectional study, encompassing 141 cases of prostate cancer, was conducted. Prostate cancer-confirming biopsies were executed at both the University Hospital Hassan II in Fez and the University Hospital Mohammed VI in Oujda between 2015 and 2021. Statistical analysis employed SPSS version 21 software. The mean age at presentation was 72 years. Prostatic adenocarcinoma emerged as the only histopathological type observed in our patients. Clinically staged diseases (T2, T3, and T4) were manifested in 71.1% of patients. Poorly differentiated tumors (Gleason grades 8, 9, and 10) were identified in 29.2% of cases. The majority of enrolled patients exhibited an intermediate to high-risk disease state. Our findings underscore the significance of prostate cancer as a substantial public health burden, given the severity of this pathology and the limited accessibility to diagnosis within the population. These results substantiate the necessity for further research into the epidemiology of prostate cancer in Morocco.","PeriodicalId":7432,"journal":{"name":"African Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140803135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of neuropathic pain management knowledge, attitudes, and practices among urology trainees and consultants in prostate cancer care: a survey-based study","authors":"O. Sinkila, N. Matjomane, T. Cronje, K. Mathabe","doi":"10.1186/s12301-024-00424-3","DOIUrl":"https://doi.org/10.1186/s12301-024-00424-3","url":null,"abstract":"","PeriodicalId":7432,"journal":{"name":"African Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140659579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tadalafil versus tamsulosin for distal ureteric stone expulsion; a prospective randomized comparative study","authors":"Ahmed M. Ragheb, Ahmed G. Mohamed, Ahmed S. Mostafa, Ahmed Abd Elatif, Akram A. Elmarakbi, Rabie M. Ibrahim, Ahmed M. Elbatanouny","doi":"10.1186/s12301-024-00425-2","DOIUrl":"https://doi.org/10.1186/s12301-024-00425-2","url":null,"abstract":"Tamsulosin, an alpha-blocker in medical expulsive therapy, selectively relaxes ureteral smooth muscle, while Tadalafil, a PDE5-Is, is recommended for treating lower urinary tract symptoms. This study compares the effectiveness of Tadalafil and Tamsulosin as medical expulsive therapy for distal ureteric stones at the Urology Department, Beni-Suef University Hospital, Egypt, using baseline demographics, preoperative data, intraoperative data, and outcome analysis. A randomized comparative study that is prospective and was from March 2019 to March 2021. Although 280 instances were eligible, 30 were eliminated & 250 were randomized, and only 164 patients completed the study. 83 patients were in the study Tadalafil group (Group A), 54 males (65.1%) & 29 (34.9%) and 81 patients were assigned to the Tamsulosin group (Group B), 47 males (58%) &34 females made up the Tadalafil group (Group A). The study was completed by 34 females (42%). Additionally, there was a significant difference in the meantime for stone expulsion between groups A (8.8 ± 3.1 days) and B (10.8 ± 3.4 days, (p = 0.001). With fewer episodes of colic, Group A needed less analgesia than Group B. Tadalafil is a safer and more effective treatment for 5–9 mm lower ureteric end stones, offering a higher stone expulsion rate, earlier passage, lower analgesic requirements, and fewer colic episodes.","PeriodicalId":7432,"journal":{"name":"African Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140597386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal calculus composition analysis using dual-energy CT: a prospective observational study","authors":"Jithin P. Johnson, Arushi Dhall, Arun Chawla, K Prakashini","doi":"10.1186/s12301-024-00412-7","DOIUrl":"https://doi.org/10.1186/s12301-024-00412-7","url":null,"abstract":"To analyze preoperatively the composition of renal calculi using dual-energy computed tomography (DECT) and compare it with reference standard biochemical stone analysis. Eighty-one participants who were diagnosed with renal calculi underwent DECT at 80 kVp and 140 kVp. Spectral analysis was performed, and the energy map generated was used to classify the calculus based on available preset data. Average Hounsfield units (HU) were calculated for the two energy levels, and ratio of HU was derived (DE ratio) and calculus was categorized into different stone compositions. Hounsfield units of each calculus was measured at 120 kVp standard dose CT, and Hounsfield density (HU/largest transverse diameter) was derived. Comparison of results of spectral analysis and DE ratio was done and correlated with the biochemical laboratory analysis as reference standard wherever available. Spectral analysis and CT prediction of stone were performed for all 81 patients. CT prediction of stone based on DE ratio into “uric acid,” “struvite,” “calcium oxalate” and “calcium carbonate apatite” was performed. Assessment of stone composition by biochemical analysis was done for 65 patients who eventually underwent PCNL for stone extraction. Both DE ratio and spectral analysis were able to differentiate calculus into various types based on composition with statistically significant p values. However, spectral analysis proved to be marginally better in renal stone characterization particularly for mixed stones. The DE ratio for uric acid stones was derived as 0.9–1.1, 0.9–2.3 for mixed stones and 1.0–2.4 for calcium stones. Spectral analysis promises a practical approach to predicting calculus composition preoperatively, thereby avoiding unnecessary surgical intervention.","PeriodicalId":7432,"journal":{"name":"African Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140597511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bladder explosion during transurethral resection of bladder tumour: a case report and review of literature","authors":"Mayank Gupta, Gaurav Aggarwal, Sujoy Gupta, Midhun P. Gopalakrishnan","doi":"10.1186/s12301-024-00423-4","DOIUrl":"https://doi.org/10.1186/s12301-024-00423-4","url":null,"abstract":"Bladder explosion during transurethral resection of bladder tumors (TURBTs) is a rare and less recognised, but terrifying complication. We present a case of 72-year-old male patient of a large bladder tumour who sustained an intravesical explosion during TURBT requiring an emergency exploratory laparotomy and repair. Urologists should be cognizant of this unique complication and ensure the necessary techniques and precautions for its prevention.","PeriodicalId":7432,"journal":{"name":"African Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140597561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating cost of prostate cancer management: an experience from Tanzania","authors":"Obadia Venance Nyongole, Nashivai Elias Kivuyo, Larry Onyango Akoko, Happiness Saronga, Njiku Kimu","doi":"10.1186/s12301-024-00422-5","DOIUrl":"https://doi.org/10.1186/s12301-024-00422-5","url":null,"abstract":"Prostate cancer (PC) is a significant public health problem affecting men worldwide and ranks third in incidence and mortality in East Africa. Cost of prostate cancer management is high in low-income countries because majority of patients presents with advanced (metastatic) PC. The cost related to management of PC including castrate resistant cancer in Tanzania has remained unknown; hence, policy makers do not have enough information for planning and resource allocation. This study therefore aimed to document costs related to the management of patients with prostate cancer including castrate resistant prostate cancer (CRPC) at Muhimbili National Hospital in Tanzania. This was a retrospective descriptive hospital-based study which was conducted at Muhimbili National Hospital (MNH). Case notes of patients who were treated for prostate cancer were retrieved from medical records for review. A structured checklist was used to extract information regarding age, clinical presentation, investigations, stage of disease, type of treatment, payment modality and reimbursement. We considered data on the direct costs of prostate cancer management (diagnosis, treatment and follow-up) based on hospital price list of different categories. Costs reported were based on payment category in total and unit cost but also source of funding. Descriptive statistics were prepared and summarized as tables and figures. A total of 292 case notes of patients with prostate cancer were reviewed of which 189 patients received androgen deprivation therapy. Ninety-six (50.8%) met the criteria for the diagnoses of CRPC, and their mean age was 71.23 ± 4.2. Most of the patients had a poorly differentiated histology with prostate-specific antigen (PSA) over 100 ng/l. Bilateral orchiectomy was the most common treatment modality offered for advanced prostate cancer. Total cost for all PC patients was $148,136.4, equivalent to a unit cost per patient of $507.3. However, patients were in different categories of payment, 53% were public patients with an average cost of $471.3 per patient; 36.6% were cost sharing patients with an average cost of $441.8 per patient; 8.2% were National Health Insurance (NHIF) patients with an average cost of $893.8 per patient; and only 2.2% were private patients with an average cost of $1060.9 per patient. Costs related to prostate cancer management need harmonization to accommodate different categories of patients in need.","PeriodicalId":7432,"journal":{"name":"African Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140597549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Egyptian urinary stones in the COVID-19 outbreak: a multi-center study","authors":"Sameh kotb, Mohamed Ezzat, Mohamed Galal Elsheikh, Galal Mohamed Elshorbagy","doi":"10.1186/s12301-024-00420-7","DOIUrl":"https://doi.org/10.1186/s12301-024-00420-7","url":null,"abstract":"Urolithiasis is a unique disease that can cause emergencies and can impair kidney function over time, especially if infections overlap. This work aimed to compare urolithiasis in the pre- and post-pandemic era and to study the impact of the COVID-19 pandemic on patient preferences and decision-making for symptomatic urolithiasis and consequently complications. This case–control multi-center study was conducted at the Urology Department of two tertiary centers in XXX. Participants were divided into two groups: group A: patients who had urolithiasis from March 1, 2018, to February 29, 2020 (pre-COVID-19 period), and group B: patients who had urolithiasis from March 1, 2020, to February 28, 2022 (during COVID-19 period). Group A had a significantly higher incidence of percutaneous nephrolithotomy (PCNL) without double J stenting (DJ), nephrolithotomy + pyelolithotomy and total PCNL compared to group B which had a lower incidence of URS without DJ and total URS. The operation was delayed among 72 (15.9%) patients during the pandemic. In total, 116 (25.6%) were subjected to previous stone removal surgery. In total, 59 (13%) of patients had COVID-19 infection before stone diagnosis. One hundred thirty-two patients (29.1%) were on vitamin C. The presence of positive family history was statistically significant in patients who underwent ESWL in comparison with patients who underwent endoscopy or surgery (P = 0.03). COVID-19 significantly impacted endourological services for urinary stones in terms of surgical volume and case complexity.","PeriodicalId":7432,"journal":{"name":"African Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140298596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary renal leiomyosarcoma in adult patients: a systematic review and individual patient data analysis","authors":"Kannan Periasamy, Treshita Dey, Shikha Goyal, Renu Madan, Santosh Kumar, Sudheer Kumar Devana, Thiraviyam Elumalai, Prashanth Giridhar, Sushmita Ghoshal, Rakesh Kapoor, Chandan K. Das","doi":"10.1186/s12301-024-00418-1","DOIUrl":"https://doi.org/10.1186/s12301-024-00418-1","url":null,"abstract":"The optimal management of primary renal leiomyosarcomas is unknown owing to its rarity and minimal available information about their primary, adjuvant treatment and clinical outcomes. This study systematically reviews treatment evidence and effects in terms of survival for leiomyosarcomas arising primarily from kidney, renal pelvis and renal vessels. PubMed and Embase databases were searched from inception to March 2023, with manual searches of reference lists. Two investigators independently reviewed the studies reporting management and survival outcomes of renal leiomyosarcomas. A total of 85 publications met inclusion criteria, reporting on 188 cases. The median age was 55.5 years, predominantly female [52.7%]. Pain was the most common presenting symptom [41.5%], and most tumors were high grade [45.8%]. Complete surgical resection with negative margins forms definitive treatment. The median disease-free survival and overall survival (OS) for all reviewed patients were 24 months [95%CI 4.1–43.9] and 42 months [95%CI 32.5–51.4], respectively. The OS of 1 year, 2 year, 3 year and 5 year was 78.8%, 64.4%, 53.8% and 38.9%, respectively. On univariate analysis, favorable factors for OS included tumor size ≤ 5 cm, low-grade histology, tumors of renal vascular origin and non-metastatic disease at presentation. Neoadjuvant or adjuvant treatment with either radiotherapy or chemotherapy has been shown to improve OS (NR vs. 36 months, p < 0.001), especially for high-grade tumors > 5 cm in size. Radical nephrectomy with en bloc tumor resection with negative margins forms the mainstay of treatment for renal leiomyosarcomas. Adjuvant radiotherapy or chemotherapy appears to improve OS. To validate this treatment strategy, prospective multicentric efforts are required to acquire reliable data from randomized trials.","PeriodicalId":7432,"journal":{"name":"African Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140196751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of partial penectomy under local anesthesia: a case–control study","authors":"Madhur Anand, Apul Goel, Bhupendra Pal Singh, Swati Aggarwal, Manoj Kumar, Vivek Kumar Singh, Vishwajeet Singh","doi":"10.1186/s12301-024-00416-3","DOIUrl":"https://doi.org/10.1186/s12301-024-00416-3","url":null,"abstract":"To assess the feasibility of partial penectomy under local anesthesia and penile nerve blocks. A total of 45 patients underwent partial penectomy under local anesthesia over the last 15 years at our institute. These patients were included in group A. We took 45 age-matched controls for comparison in group B. All patients underwent partial penectomy with the standard technique. The control group underwent partial penectomy under general or spinal anesthesia, and the intervention group underwent partial penectomy under local anesthesia. Patients’ tolerance to anesthesia and surgery was compared, and postoperative pain and other complications were assessed. Mean age was 53.5 years in group A (case) and 52.8 years in group B (controls). Out of 45 patients in group A, 9 were ASA I, 16 were ASA II, 8 were ASA III, and 12 were ASA IV patients. Out of control patients, 35 underwent surgery under spinal and 10 underwent surgery under general anesthesia. All patients tolerated the anesthesia and surgery well. The duration of anesthesia and surgery was shorter in group A (p < 0.05). Postoperative pain scores between the two groups were comparable after 6 h. Postoperative recovery was comparable in both groups, and hospital stays were shorter in local anesthesia/nerve block group but were statistically insignificant. There was no positive margin in any group. Partial penectomy under local anesthesia is a satisfactory alternative in selected cases or with limited availability of anesthesia services.","PeriodicalId":7432,"journal":{"name":"African Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140127817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of burnout among urologist and its risk factors in Indonesia","authors":"Reginald Rustandi, Fakhri Rahman, Raga Manduaru, Chaidir Arif Mochtar","doi":"10.1186/s12301-024-00417-2","DOIUrl":"https://doi.org/10.1186/s12301-024-00417-2","url":null,"abstract":"To evaluate burnout syndrome among Indonesian urologists by describing its prevalence and risk factors. This is a cross-sectional study conducted from February to April 2020. A validated Indonesian version of the Maslach Burnout Inventory that consists of 22 questions addressing emotional exhaustion, depersonalization, and personal achievement was utilized. The questionnaire was constructed using Google Forms (Google, Inc.) and was distributed via e-mail and WhatsApp Messenger (Facebook, Inc.). Burnout was defined as either high score on emotional exhaustion, or high score on depersonalization, or low score on personal achievement. Several variables were analyzed as risk factors to burnout using multivariate analysis. All statistical analyses were carried out using Statistical Software for Social Science (SPSS) version 23. From 486 eligible members of IUA, 184 (37%) respondents completed the questionnaire. Burnout syndrome was detected in 43 respondents (23.4%). From the results, most of the respondents have low EE (54.9%), low DP (77.7%), and moderate PA (45.7%). Bivariate analysis showed that age of less than 44 years old and being single were associated with increased risk of burnout with OR 2.2 (1.0–5.1, 95% CI, p-value 0.04) while being married decreases risk of burnout with OR 0.2 (0.1–0.8, 95% CI, p-value < 0.01). Lower work load in COVID-19–19 era was related to protective results with OR 0.4 (0.2–0.9, 95% CI, p-value 0.03). Multivariate analysis showed that being married decreases risk of burnout with OR 0.3 (0.1–0.9, 95% CI, p-value 0.04). Multivariate analysis showed that being married was the only significantly protective factor from burnout. Burnout syndrome among majority of urologists in Indonesia has a moderate degree of burnout, with being married the only significant factor influencing burnout in this study.","PeriodicalId":7432,"journal":{"name":"African Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140106367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}