Newborn (Clarksville, Md.)最新文献_第3页

Linked Th17 and Calgranulin Responses in Maternal-cord Blood Dyads of Preterm Gestations with Histologic Chorioamnionitis. 组织学绒毛膜炎孕妇脐带血中Th17和钙粒蛋白反应的相关性。

Newborn (Clarksville, Md.) Pub Date : 2023-04-01 Epub Date: 2023-05-07 DOI: 10.5005/jp-journals-11002-0064

Christopher Q Buchanan, Megan L Lawlor, Chukwuebuka Okafor, Shannon R Kurian, Andrea E Philip, Abigael E Finkle, Jay J McQuillan, Seema Haridas, Joyce M Koenig

{"title":"Linked Th17 and Calgranulin Responses in Maternal-cord Blood Dyads of Preterm Gestations with Histologic Chorioamnionitis.","authors":"Christopher Q Buchanan, Megan L Lawlor, Chukwuebuka Okafor, Shannon R Kurian, Andrea E Philip, Abigael E Finkle, Jay J McQuillan, Seema Haridas, Joyce M Koenig","doi":"10.5005/jp-journals-11002-0064","DOIUrl":"10.5005/jp-journals-11002-0064","url":null,"abstract":"Introduction: Maternal-fetal immune crosstalk mechanisms are increasingly identified in the pathogenesis of gestational disorders, including histologic chorioamnionitis (HCA). Although an inflammatory Th17 immune phenotype has been described in preterm neonates with HCA, the associated maternal Th17 response is relatively unknown. To refine our understanding of Th17 biology in this context, we examined Th17 responses in maternal-cord blood dyads of preterm gestations.Materials and methods: Paired maternal and cord blood (CB) samples were prospectively collected from preterm gestations (23-34 weeks) with HCA or controls. Th17-linked cell frequencies and plasma calgranulin (S100A8, S100A12) levels were determined by flow cytometry and enzyme-linked immunoassay, respectively.Results: Analyses of 47 maternal-cord blood pairs showed striking parallel increases in Th17 cell frequencies as well as plasma calgranulin levels in the presence of fetal inflammation. Cord blood S100A12 levels were directly correlated with Th17 cell frequencies. In CB cultures, rh-S100A12 promoted in vitro propagation of Th17-type CD4+ cells.Conclusions: Maternal and CB Th17-linked responses are dually amplified in gestations with HCA, supporting a biological role for maternal-fetal interactions in this disorder. In addition to advancing current knowledge of neonatal Th17 mechanisms, these data shed new light on their association with maternal inflammation.","PeriodicalId":74306,"journal":{"name":"Newborn (Clarksville, Md.)","volume":"2 2","pages":"133-141"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e3/6c/nihms-1914677.PMC10547109.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41169756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enteral Feeding and Antibiotic Treatment Do Not Influence Increased Coefficient of Variation of Total Fecal Bile Acids in Necrotizing Enterocolitis. 肠内喂养和抗生素治疗不影响坏死性小肠结肠炎患者粪便总胆汁酸变异系数的增加。

Newborn (Clarksville, Md.) Pub Date : 2023-01-01 DOI: 10.5005/jp-journals-11002-0063

Janet L Rothers, Christine M Calton, Jennifer Mb Stepp, Melissa D Halpern

{"title":"Enteral Feeding and Antibiotic Treatment Do Not Influence Increased Coefficient of Variation of Total Fecal Bile Acids in Necrotizing Enterocolitis.","authors":"Janet L Rothers, Christine M Calton, Jennifer Mb Stepp, Melissa D Halpern","doi":"10.5005/jp-journals-11002-0063","DOIUrl":"https://doi.org/10.5005/jp-journals-11002-0063","url":null,"abstract":"Introduction: Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in preterm infants. In animal models, the accumulation of ileal bile acids (BAs) is a crucial component of NEC pathophysiology. Recently, we showed that the coefficient of variation of total fecal BAs (CV-TBA) was elevated in infants who develop NEC compared to matched controls. However, neither the type of enteral nutrition nor antibiotic treatments-parameters that could potentially influence BA levels-were used to match pairs. Thus, we assessed the relationships between exposure to enteral feeding types and antibiotic treatments with NEC status and CV-TBA.Materials and methods: Serial fecal samples were collected from 79 infants born with birth weight (BW) ≤1800 gm and estimated gestational age (EGA) ≤32 weeks; eighteen of these infants developed NEC. Total fecal BA levels (TBA) were determined using a commercially available enzyme cycling kit. Relationships between CV-TBA and dichotomous variables (NEC status, demographics, early exposure variables) were assessed by independent samples t-tests. Fisher's exact tests were used to assess relationships between NEC status and categorical variables.Results: High values for CV-TBA levels perfectly predicted NEC status among infants in this study. However, feeding type and antibiotic usage did not drive this relationship.Conclusions: As in previous studies, high values for the CV-TBA levels in the first weeks of life perfectly predicted NEC status among infants. Importantly, feeding type and antibiotic usage-previously identified risk factors for NEC-did not drive this relationship.","PeriodicalId":74306,"journal":{"name":"Newborn (Clarksville, Md.)","volume":"2 2","pages":"128-132"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/92/60/nihms-1914676.PMC10411330.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9999405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathophysiology of Enteropathogenic Escherichia coli-induced Diarrhea. 肠致病性大肠杆菌引起腹泻的病理生理学研究。

Newborn (Clarksville, Md.) Pub Date : 2023-01-01 Epub Date: 2023-04-06 DOI: 10.5005/jp-journals-11002-0056

Prabhdeep Kaur, Pradeep K Dudeja

{"title":"Pathophysiology of Enteropathogenic Escherichia coli-induced Diarrhea.","authors":"Prabhdeep Kaur, Pradeep K Dudeja","doi":"10.5005/jp-journals-11002-0056","DOIUrl":"10.5005/jp-journals-11002-0056","url":null,"abstract":"Enteropathogenic Escherichia coli (EPEC) are important diarrheal pathogens of infants and young children. Since the availability of molecular diagnosis methods, we now have new insights into the incidence and prevalence of these infections. Recent epidemiological studies indicate that atypical EPEC (aEPEC) are seen more frequently than typical EPEC (tEPEC) worldwide, including in both endemic diarrhea and diarrhea outbreaks. Therefore, it is important to further characterize the pathogenicity of these emerging strains. The virulence mechanisms and pathophysiology of the attaching and effacing lesion (A/E) and the type-three-secretion-system (T3SS) are complex but well-studied. A/E strains use their pool of locus of enterocyte effacement (LEE)-encoded and non-LEE-encoded effector proteins to subvert and modulate cellular and barrier properties of the host. However, the exact mechanisms of diarrhea in EPEC infection are not completely understood. From the clinical perspective, there is a need for fast, easy, and inexpensive diagnostic methods to define optimal treatment and prevention for children in endemic areas. In this article, we present a review of the classification of EPEC, epidemiology, pathogenesis of the disease caused by these bacteria, determinants of virulence, alterations in signaling, determinants of colonization vs. those of disease, and the limited information we have on the pathophysiology of EPEC-induced diarrhea. This article combines peer-reviewed evidence from our own studies and the results of an extensive literature search in the databases PubMed, EMBASE, and Scopus.","PeriodicalId":74306,"journal":{"name":"Newborn (Clarksville, Md.)","volume":"2 1","pages":"102-113"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ec/9f/nihms-1890245.PMC10308259.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10103053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial Dynamics during Development. 发育过程中的线粒体动力学。

Newborn (Clarksville, Md.) Pub Date : 2023-01-01 Epub Date: 2023-04-06 DOI: 10.5005/jp-journals-11002-0053

Ling He, Karl Johan Tronstad, Akhil Maheshwari

引用次数: 5

Sodium and Growth in Preterm Infants: A Review. 钠与早产儿生长:综述。

Newborn (Clarksville, Md.) Pub Date : 2023-01-01 DOI: 10.5005/jp-journals-11002-0060

Benjamin R Araya, Alisha A Ziegler, Connie C Grobe, Justin L Grobe, Jeffrey L Segar

{"title":"Sodium and Growth in Preterm Infants: A Review.","authors":"Benjamin R Araya, Alisha A Ziegler, Connie C Grobe, Justin L Grobe, Jeffrey L Segar","doi":"10.5005/jp-journals-11002-0060","DOIUrl":"https://doi.org/10.5005/jp-journals-11002-0060","url":null,"abstract":"Aim: This article is intended to review the relationship between sodium homeostasis and growth, outline reasons why preterm infants may become sodium deficient, and share data from our group and others regarding the potential benefits of dietary sodium supplementation.Background: Despite tremendous efforts over the past 20 years to optimize neonatal nutrition, postnatal growth failure in preterm infants remains a significant problem. Compelling associations have been identified between in-hospital growth failure and cardiometabolic and neurodevelopmental disorders, heightening the need to further identify the optimal nutritional needs of preterm infants.Results: The impact of sodium deficiency may have on somatic growth is poorly studied and reported upon within the human literature. In contrast, animal studies dating back almost 100 years highlight the nutritional importance of dietary sodium. Sodium homeostasis during early postnatal life is understudied and underappreciated by neonatologists.Conclusion: Insufficient sodium intake during early life is likely a critical yet underappreciated contributor to growth failure. Total body sodium depletion may be an important risk factor driving complications of premature birth.Clinical significance: Increased awareness of sodium homeostasis in preterm infants may improve outcomes in this population. Sodium intake recommendations are provided based on the interpretation of currently available literature.","PeriodicalId":74306,"journal":{"name":"Newborn (Clarksville, Md.)","volume":"2 2","pages":"142-147"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/25/nihms-1914675.PMC10445331.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10104456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Innate Immune Memory in Macrophages. 巨噬细胞中的先天免疫记忆。

Newborn (Clarksville, Md.) Pub Date : 2023-01-01 Epub Date: 2023-04-06 DOI: 10.5005/jp-journals-11002-0058

Akhil Maheshwari

引用次数: 3

Use of Cryoprecipitate in Newborn Infants. 冷冻沉淀物在新生儿中的应用。

Newborn (Clarksville, Md.) Pub Date : 2023-01-01 Epub Date: 2023-04-06 DOI: 10.5005/jp-journals-11002-0045

Manvi Tyagi, Brunetta Guaragni, Alvaro Dendi, Atnafu Mekonnen Tekleab, Mario Motta, Akhil Maheshwari

引用次数: 0

Neurological Manifestations of Perinatal Dengue. 围产期登革热的神经学表现。

Newborn (Clarksville, Md.) Pub Date : 2023-01-01 DOI: 10.5005/jp-journals-11002-0066

Srijan Singh, Jubara Alallah, Astha Amrit, Akhil Maheshwari, Suresh Boppana

引用次数: 0

Prevalence of Gram-negative Bacteria in Maternal Cervical Secretions: A Systematic Review and Meta-analysis 母体宫颈分泌物中革兰氏阴性菌的患病率：系统评价和Meta分析

Newborn (Clarksville, Md.) Pub Date : 2022-12-23 DOI: 10.5005/jp-journals-11002-0051

A. Maheshwari, R. Sah, Jogender Kumar, B. Padhi, Subhanwita Manna, D. R. Pallepogula, Bharti Joshi, A. Aggarwal

引用次数: 1

Understanding the Impact of Maternal Health on Neonatal Disease: A New Horizon 了解孕产妇健康对新生儿疾病的影响：一个新的视角

Newborn (Clarksville, Md.) Pub Date : 2022-12-23 DOI: 10.5005/newborn-1-4-iv

A. Maheshwari, M. Motta, K. Lui

引用次数: 2