Neuronal signaling最新文献_第9页

Targeting opioid receptor signaling in depression: do we need selective κ opioid receptor antagonists? 靶向阿片受体信号在抑郁症中:我们需要选择性κ阿片受体拮抗剂吗?

Neuronal signaling Pub Date : 2018-05-14 eCollection Date: 2018-06-01 DOI: 10.1042/NS20170145

Sarah J Bailey, Stephen M Husbands

{"title":"Targeting opioid receptor signaling in depression: do we need selective κ opioid receptor antagonists?","authors":"Sarah J Bailey, Stephen M Husbands","doi":"10.1042/NS20170145","DOIUrl":"10.1042/NS20170145","url":null,"abstract":"The opioid receptors are a family of G-protein coupled receptors (GPCRs) with close structural homology. The opioid receptors are activated by a variety of endogenous opioid neuropeptides, principally β-endorphin, dynorphins, leu- and met-enkephalins. The clinical potential of targeting opioid receptors has largely focused on the development of analgesics. However, more recent attention has turned to the role of central opioid receptors in the regulation of stress responses, anhedonia and mood. Activation of the κ opioid receptor (KOP) subtype has been shown in both human and rodent studies to produce dysphoric and pro-depressive like effects. This has led to the idea that selective KOP antagonists might have therapeutic potential as antidepressants. Here we review data showing that mixed μ opioid (MOP) and KOP antagonists have antidepressant-like effects in rodent behavioural paradigms and highlight comparable studies in treatment-resistant depressed patients. We propose that developing multifunctional ligands which target multiple opioid receptors open up the potential for fine-tuning hedonic responses mediated by opioids. This alternative approach towards targeting multiple opioid receptors may lead to more effective treatments for depression.","PeriodicalId":74287,"journal":{"name":"Neuronal signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/NS20170145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38196948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

A role for viral infections in Parkinson's etiology? 病毒感染在帕金森病病因学中的作用?

Neuronal signaling Pub Date : 2018-04-16 eCollection Date: 2018-06-01 DOI: 10.1042/NS20170166

Laura K Olsen, Eilis Dowd, Declan P McKernan

引用次数: 35

Cross-talk between blood vessels and neural progenitors in the developing brain. 发育中的大脑中血管和神经祖细胞之间的串扰。

Neuronal signaling Pub Date : 2018-03-30 eCollection Date: 2018-03-01 DOI: 10.1042/NS20170139

Mathew Tata, Christiana Ruhrberg

{"title":"Cross-talk between blood vessels and neural progenitors in the developing brain.","authors":"Mathew Tata, Christiana Ruhrberg","doi":"10.1042/NS20170139","DOIUrl":"https://doi.org/10.1042/NS20170139","url":null,"abstract":"The formation of the central nervous system (CNS) involves multiple cellular and molecular interactions between neural progenitor cells (NPCs) and blood vessels to establish extensive and complex neural networks and attract a vascular supply that support their function. In this review, we discuss studies that have performed genetic manipulations of chick, fish and mouse embryos to define the spatiotemporal roles of molecules that mediate the reciprocal regulation of NPCs and blood vessels. These experiments have highlighted core functions of NPC-expressed ligands in initiating vascular growth into and within the neural tube as well as establishing the blood-brain barrier. More recent findings have also revealed indispensable roles of blood vessels in regulating NPC expansion and eventual differentiation, and specific regional differences in the effect of angiocrine signals. Accordingly, NPCs initially stimulate blood vessel growth and maturation to nourish the brain, but blood vessels subsequently also regulate NPC behaviour to promote the formation of a sufficient number and diversity of neural cells. A greater understanding of the molecular cross-talk between NPCs and blood vessels will improve our knowledge of how the vertebrate nervous system forms and likely help in the design of novel therapies aimed at regenerating neurons and neural vasculature following CNS disease or injury.","PeriodicalId":74287,"journal":{"name":"Neuronal signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/NS20170139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38203078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Inhibition of miR-181a promotes midbrain neuronal growth through a Smad1/5-dependent mechanism: implications for Parkinson's disease. 抑制miR-181a通过smad1 /5依赖机制促进中脑神经元生长:对帕金森病的影响

Neuronal signaling Pub Date : 2018-01-26 eCollection Date: 2018-03-01 DOI: 10.1042/NS20170181

Shane V Hegarty, Aideen M Sullivan, Gerard W O'Keeffe

{"title":"Inhibition of miR-181a promotes midbrain neuronal growth through a Smad1/5-dependent mechanism: implications for Parkinson's disease.","authors":"Shane V Hegarty, Aideen M Sullivan, Gerard W O'Keeffe","doi":"10.1042/NS20170181","DOIUrl":"https://doi.org/10.1042/NS20170181","url":null,"abstract":"Parkinson's disease (PD) is the second most common neurodegenerative disease, and is characterized by the progressive degeneration of nigrostriatal dopaminergic (DA) neurons. Current PD treatments are symptomatic, wear off over time and do not protect against DA neuronal loss. Finding a way to re-grow midbrain DA (mDA) neurons is a promising disease-modifying therapeutic strategy for PD. However, reliable biomarkers are required to allow such growth-promoting approaches to be applied early in the disease progression. miR-181a has been shown to be dysregulated in PD patients, and has been identified as a potential biomarker for PD. Despite studies demonstrating the enrichment of miR-181a in the brain, specifically in neurites of postmitotic neurons, the role of miR-181a in mDA neurons remains unknown. Herein, we used cell culture models of human mDA neurons to investigate a potential role for miR-181a in mDA neurons. We used a bioninformatics analysis to identify that miR-181a targets components of the bone morphogenetic protein (BMP) signalling pathway, including the transcription factors Smad1 and Smad5, which we find are expressed by rat mDA neurons and are required for BMP-induced neurite growth. We also found that inhibition of neuronal miR-181a, resulted in increased Smad signalling, and induced neurite growth in SH-SY5Y cells. Finally, using embryonic rat cultures, we demonstrated that miR-181a inhibition induces ventral midbrain (VM) and cortical neuronal growth. These data describe a new role for miR-181a in mDA neurons, and provide proof of principle that miR-181a dysresgulation in PD may alter the activation state of signalling pathways important for neuronal growth in neurons affected in PD.","PeriodicalId":74287,"journal":{"name":"Neuronal signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/NS20170181","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38196947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain. CRMP2和电压门控离子通道:在神经性疼痛中的潜在作用。

Neuronal signaling Pub Date : 2018-01-01 Epub Date: 2018-03-30 DOI: 10.1042/NS20170220

Lindsey A Chew, Rajesh Khanna

引用次数: 35

Novel rapid-acting antidepressants: molecular and cellular signaling mechanisms. 新型速效抗抑郁药:分子和细胞信号机制。

Neuronal signaling Pub Date : 2017-12-01 Epub Date: 2017-09-05 DOI: 10.1042/NS20170010

Alexandra M Thomas, Ronald S Duman

引用次数: 12

Extracellular microRNAs as messengers in the central and peripheral nervous system. 细胞外微rna在中枢和外周神经系统中的信使作用。

Neuronal signaling Pub Date : 2017-11-02 eCollection Date: 2017-12-01 DOI: 10.1042/NS20170112

Hannah Scott

引用次数: 13

SUMOylation and calcium signalling: potential roles in the brain and beyond. sumo酰化和钙信号传导:在大脑内外的潜在作用。

Neuronal signaling Pub Date : 2017-07-19 eCollection Date: 2017-08-01 DOI: 10.1042/NS20160010

Leticia Coelho-Silva, Gary J Stephens, Helena Cimarosti

{"title":"SUMOylation and calcium signalling: potential roles in the brain and beyond.","authors":"Leticia Coelho-Silva, Gary J Stephens, Helena Cimarosti","doi":"10.1042/NS20160010","DOIUrl":"https://doi.org/10.1042/NS20160010","url":null,"abstract":"Small ubiquitin-like modifier (SUMO) conjugation (or SUMOylation) is a post-translational protein modification implicated in alterations to protein expression, localization and function. Despite a number of nuclear roles for SUMO being well characterized, this process has only started to be explored in relation to membrane proteins, such as ion channels. Calcium ion (Ca2+) signalling is crucial for the normal functioning of cells and is also involved in the pathophysiological mechanisms underlying relevant neurological and cardiovascular diseases. Intracellular Ca2+ levels are tightly regulated; at rest, most Ca2+ is retained in organelles, such as the sarcoplasmic reticulum, or in the extracellular space, whereas depolarization triggers a series of events leading to Ca2+ entry, followed by extrusion and reuptake. The mechanisms that maintain Ca2+ homoeostasis are candidates for modulation at the post-translational level. Here, we review the effects of protein SUMOylation, including Ca2+ channels, their proteome and other proteins associated with Ca2+ signalling, on vital cellular functions, such as neurotransmission within the central nervous system (CNS) and in additional systems, most prominently here, in the cardiac system.","PeriodicalId":74287,"journal":{"name":"Neuronal signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/NS20160010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38203075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Stochastic, structural and functional factors influencing AMPA and NMDA synaptic response variability: a review. 影响AMPA和NMDA突触反应变异性的随机、结构和功能因素综述。

Neuronal signaling Pub Date : 2017-06-14 eCollection Date: 2017-08-01 DOI: 10.1042/NS20160051

Vito Di Maio, Francesco Ventriglia, Silvia Santillo

引用次数: 7

Conventional protein kinase C in the brain: 40 years later. 脑中的常规蛋白激酶C: 40年后。

Neuronal signaling Pub Date : 2017-04-10 eCollection Date: 2017-04-01 DOI: 10.1042/NS20160005

Julia A Callender, Alexandra C Newton

引用次数: 56